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Home / Equine Research Bank / Animals (Basel) / Lipids in Equine Airway Inflammation: An Overview of Current...
Animals : an open access journal from MDPI2024; 14(12); 1812; doi: 10.3390/ani14121812

Lipids in Equine Airway Inflammation: An Overview of Current Knowledge.

Abstract: Mild-moderate and severe equine asthma (MEA and SEA) are prevalent inflammatory airway conditions affecting horses of numerous breeds and disciplines. Despite extensive research, detailed disease pathophysiology and the differences between MEA and SEA are still not completely understood. Bronchoalveolar lavage fluid cytology, broadly used in clinical practice and in equine asthma research, has limited means to represent the inflammatory status in the lower airways. Lipidomics is a field of science that can be utilized in investigating cellular mechanisms and cell-to-cell interactions. Studies in lipidomics have a broad variety of foci, of which fatty acid and lipid mediator profile analyses and global lipidomics have been implemented in veterinary medicine. As many crucial proinflammatory and proresolving mediators are lipids, lipidomic studies offer an interesting yet largely unexplored means to investigate inflammatory reactions in equine airways. The aim of this review article is to collect and summarize the findings of recent lipidomic studies on equine airway inflammation.
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Publication Date: 2024-06-18 PubMed ID: 38929431PubMed Central: PMC11200544DOI: 10.3390/ani14121812Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews the use of lipidomics in investigating the role lipids play in equine asthma, a common inflammatory airway condition affecting horses.

Background on Equine Asthma

  • The research starts by highlighting mild-moderate and severe equine asthma (MEA and SEA), which are common conditions affecting the airways of various horse breeds and disciplines.
  • Despite significant research, the detailed disease mechanisms and the differences between MEA and SEA are still not fully understood.
  • Bronchoalveolar lavage fluid cytology, a method commonly used in clinical practice and research to evaluate the health of the lower airways, has limited ability to reflect the overall inflammatory status.

Introduction to Lipidomics

  • The article then introduces lipidomics, a field of study that investigates cellular mechanisms and interactions. It’s a unique approach where focus varies from studying fatty acid and lipid mediator profiles to global lipidomics.
  • With a wide implementation in veterinary medicine, lipidomics studies provide a novel and largely unexplored means to study the inflammatory responses in equine airways.

Motivation for the Review

  • As many vital pro-inflammatory and pro-resolving mediators are lipids, the review is motivated by the potential of lipidomic studies to provide an interesting insight into the role of lipids in inflammatory reactions.
  • The primary objective of the review article is to aggregate and summarize the results of recent lipidomic studies on equine airway inflammation.

Cite This Article

APA
Mönki J, Mykkänen A. (2024). Lipids in Equine Airway Inflammation: An Overview of Current Knowledge. Animals (Basel), 14(12), 1812. https://doi.org/10.3390/ani14121812

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 12
PII: 1812

Researcher Affiliations

Mönki, Jenni
  • Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, P.O. Box 57, 00014 Helsinki, Finland.
Mykkänen, Anna
  • Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, P.O. Box 57, 00014 Helsinki, Finland.

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 117 references
  1. Brown H.A., Murphy R.C.. Working towards an exegesis for lipids in biology. Nat. Chem. Biol. 2009;5:602–606.
    doi: 10.1038/nchembio0909-602pmc: PMC3785062pubmed: 19690530google scholar: lookup
  2. Harayama T., Riezman H.. Organism lipid diversity: Understanding the diversity of membrane lipid composition. Nat. Rev. Mol. Cell Biol. 2018;19:281–296.
    doi: 10.1038/nrm.2017.138pubmed: 29410529google scholar: lookup
  3. Hewitt S.C., Harrell J.C., Korach K.S.. Lessons in estrogen biology from knockout and transgenic animals. Annu. Rev. Physiol. 2005;67:285–308.
    doi: 10.1146/annurev.physiol.67.040403.115914pubmed: 15709960google scholar: lookup
  4. Swinnen J., Dehairs J.. A beginner’s guide to lipidomics. Biochem. Soc. Trans. 2022;44:20–24.
    doi: 10.1042/bio_2021_181google scholar: lookup
  5. Han X.. Lipidomics for studying metabolism. Nat. Rev. Endocrinol. 2016;12:668–679.
    doi: 10.1038/nrendo.2016.98pubmed: 27469345google scholar: lookup
  6. Dennis E.A.. Lipidomics joins the omics evolution. Proc. Natl. Acad. Sci. USA. 2009;106:2089–2090.
    doi: 10.1073/pnas.0812636106pmc: PMC2650110pubmed: 19211786google scholar: lookup
  7. Anderson J.. Science-in-brief: Proteomics and metabolomics in equine veterinary science. Equine Vet. J. 2022;54:449–452.
    doi: 10.1111/evj.13550pubmed: 35133023google scholar: lookup
  8. Calder P.. n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr. 2006;83:1505S–1519S.
    doi: 10.1093/ajcn/83.6.1505Spubmed: 16841861google scholar: lookup
  9. Ghidoni R., Caretti A., Signorelli P.. Role of Sphingolipids in the Pathobiology of Lung Inflammation. Mediators Inflamm. 2015;2015:487508.
    doi: 10.1155/2015/487508pmc: PMC4681829pubmed: 26770018google scholar: lookup
  10. Hough K., Wilson L., Trevor J., Strenkowski J., Maina N., Kim Y., Spell M.L., Wang Y., Chanda D., Dager J.R.. Unique lipid signatures of extracellular vesicles from the airways of asthmatics. Sci. Rep. 2018;81:10340.
    doi: 10.1038/s41598-018-28655-9pmc: PMC6037776pubmed: 29985427google scholar: lookup
  11. Christmann U., Hite R., Witonsky S., Buechner-Maxwell V., Wood P.. Evaluation of lipid markers in surfactant obtained from asthmatic horses exposed to hay. Am. J. Vet. Res. 2019;803:300–305.
    doi: 10.2460/ajvr.80.3.300pubmed: 30801214google scholar: lookup
  12. Albornoz A., Alarcon P., Morales N., Uberti B., Henriquez C., Manosalva C., Burgos R.A., Moran G.. Metabolomics analysis of bronchoalveolar lavage fluid samples in horses with naturally-occurring asthma and experimentally-induced airway inflammation. Res. Vet. Sci. 2020;133:276–282.
    doi: 10.1016/j.rvsc.2020.09.033pubmed: 33039879google scholar: lookup
  13. Bazzano M., Laghi L., Zhu C., Magi G., Tesei B., Laus F.. Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses. BMC Vet. Res. 2020;161:1–9.
    doi: 10.1186/s12917-020-02446-9pmc: PMC7346432pubmed: 32641035google scholar: lookup
  14. Basil M., Levy B.. Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation. Nat. Rev. Immunol. 2016;16:51–67.
    doi: 10.1038/nri.2015.4pmc: PMC5242505pubmed: 26688348google scholar: lookup
  15. Leuti A., Fazio D., Fava M., Piccoli A., Oddi S., Maccarrone M.. Bioactive lipids, inflammation and chronic diseases. Adv. Drug Deliv. Rev. 2020;159:133–169.
    doi: 10.1016/j.addr.2020.06.028pubmed: 32628989google scholar: lookup
  16. Zehethofer N., Bermbach S., Hagner S., Garn H., Müller J., Goldmann T., Lindner B., Schwudke D., König P.. Lipid analysis of airway epithelial cells for studying respiratory diseases. Chromatographia 2015;78:403–413.
    doi: 10.1007/s10337-014-2787-5pmc: PMC4346681pubmed: 25750457google scholar: lookup
  17. To K.K., Lee K.C., Wong S.S., Sze K.H., Ke Y.H., Lui Y.M., Tang B.S., Li I.W., Lau S.K., Hung I.F.. Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia. Diagn. Microbiol. Infect. Dis. 2016;85:249–254.
    doi: 10.1016/j.diagmicrobio.2016.03.012pmc: PMC7173326pubmed: 27105773google scholar: lookup
  18. Seidl E., Kiermeier H., Liebisch G., Ballmann M., Hesse S., Paul-Buck K., Ratjen F., Rietschel E., Griese M.. Lavage lipidomics signatures in children with cystic fibrosis and protracted bacterial bronchitis. J. Cyst. Fibros. 2019;18:790–795.
    doi: 10.1016/j.jcf.2019.04.012pubmed: 31029606google scholar: lookup
  19. Kirkwood K.I., Christopher M.W., Burgess J.L., Littau S.R., Foster K., Richey K., Pratt B.S., Shulman N., Tamura K., MacCoss M.J.. Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity. J. Proteome Res. 2021;21:232–242.
    doi: 10.1021/acs.jproteome.1c00820pmc: PMC8741653pubmed: 34874736google scholar: lookup
  20. Schwarz B., Sharma L., Roberts L., Peng X., Bermejo S., Leighton I., Casanovas-Massana A., Minasyan M., Farhadian S., Ko A.I.. Cutting edge: Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome, resulting in dysregulation of eicosanoid immune mediators. J. Immunol. 2021;206:329–334.
    doi: 10.4049/jimmunol.2001025pmc: PMC7962598pubmed: 33277388google scholar: lookup
  21. Sim S., Choi Y., Park H.. Potential metabolic biomarkers in adult asthmatics. Metabolites 2021;11:430.
    doi: 10.3390/metabo11070430pmc: PMC8306564pubmed: 34209139google scholar: lookup
  22. Christmann U., Page A.E., Horohov D.W., Adams A.A., Chapman S.E., Hancock C.L., Emery A.L., Poovey J.R., Hagg C., Morales S.M.O.. Lipidomic analysis of surfactant and plasma from horses with asthma and age-matched healthy horses. Am. J. Vet. Res. 2022;83:1–9.
    doi: 10.2460/ajvr.21.11.0179pubmed: 35895773google scholar: lookup
  23. Mönki J., Holopainen M., Ruhanen H., Karikoski N., Käkelä R., Mykkänen A.. Lipid species profiling of bronchoalveolar lavage fluid cells of horses housed on two different bedding materials. Sci. Rep. 2023;13:21778.
    doi: 10.1038/s41598-023-49032-1pmc: PMC10709413pubmed: 38066223google scholar: lookup
  24. Höglund N., Nieminen P., Mustonen A.M., Käkelä R., Tollis S., Koho N., Holopainen M., Ruhanen H., Mykkänen A.. Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity. Sci. Rep. 2023;13:9821.
    doi: 10.1038/s41598-023-36697-xpmc: PMC10276833pubmed: 37330591google scholar: lookup
  25. Santos A.S., Rodrigues M.A.M., Bessa R.J.B., Ferreira L.M., Martin-Rosset W.. Understanding the equine cecum-colon ecosystem: Current knowledge and future perspectives. Animal 2011;5:48–56.
    doi: 10.1017/S1751731110001588pubmed: 22440701google scholar: lookup
  26. Warren L., Vineyard K. Fat and fatty acids. In: Geor R.J., Harris P.A., Coenen M., editors. Equine Applied and Clinical Nutrition. 1st ed. W.B. Saunders; Philadelphia, PA, USA: 2013. pp. 136–155.
  27. Harris P., Geor R. Nutrition for the equine athlete: Nutrient requirements and key principles in ration design. In: Hinchcliff K.W., Kaneps A.J., Geor R.J., editors. Equine Sports Medicine and Surgery. 2nd ed. W.B. Saunders; Philadelphia, PA, USA: 2014. pp. 797–817.
  28. Mueller E.. Understanding the variegation of fat: Novel regulators of adipocyte differentiation and fat tissue biology. Bioch. Biophys. Acta -Mol. Basis Dis. 2014;1842:352–357.
    doi: 10.1016/j.bbadis.2013.05.031pubmed: 23735215google scholar: lookup
  29. Radin M.J., Sharkey L.C., Holycross B.J.. Adipokines: A review of biological and analytical principles and an update in dogs, cats, and horses. Vet. Clin. Pathol. 2009;38:136–156.
    doi: 10.1111/j.1939-165X.2009.00133.xpubmed: 19392760google scholar: lookup
  30. Vick M.M., Adams A.A., Murphy B.A., Sessions D.R., Horohov D.W., Cook R.F., Shelton B.J., Fitzgerald B.P.. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J. Anim. Sci. 2007;85:1144–1155.
    doi: 10.2527/jas.2006-673pubmed: 17264235google scholar: lookup
  31. Giralt M., Cereijo R., Villarroya F.. Adipokines and the endocrine role of adipose tissues. .
    pubmed: 25903415
  32. Carlberg C., Ulven S.M., Molnár F.. Nutrigenomics. .
  33. Ertelt A., Barton A.K., Schmitz R.R., Gehlen H.. Metabolic syndrome: Is equine disease comparable to what we know in humans?. Endocr. Connect. 2014;3:R81–R93.
    doi: 10.1530/EC-14-0038pmc: PMC4068110pubmed: 24894908google scholar: lookup
  34. Lipid Metabolites and Pathways Strategy (LIPID MAPS) Consortium. [(accessed on 1 January 2024)]. Available online: https://www.lipidmaps.org/
  35. Cockcroft S.. Mammalian lipids: Structure, synthesis and function. Essays Biochem. 2021;65:813–845.
    doi: 10.1042/EBC20200067pmc: PMC8578989pubmed: 34415021google scholar: lookup
  36. Clayden J., Warren S., Greeves N.. Organic Chemistry. 2012. Organic structures; pp. 16–33.
  37. Baccouch R., Shi Y., Vernay E., Mathelié-Guinlet M., Taib-Maamar N., Villette S., Feuillie C., Rascol E., Nuss P., Lecomte S.. The impact of lipid polyunsaturation on the physical and mechanical properties of lipid membranes. Biochim. Biophys. Acta Biomembr. 2022;1865:184084.
    doi: 10.1016/j.bbamem.2022.184084pubmed: 36368636google scholar: lookup
  38. Pollard T., Earnshaw W., Lippincott-Schwartz J.. Cell Biology. 2023. Membrane structure and dynamics; pp. 237–250.
  39. Vance J.E.. Phospholipid synthesis and transport in mammalian cells. Traffic 2015;16:1–18.
    doi: 10.1111/tra.12230pubmed: 25243850google scholar: lookup
  40. Gil-de-Gómez L., Monge P., Rodríguez J.P., Astudillo A.M., Balboa M.A., Balsinde J.. Phospholipid arachidonic acid remodeling during phagocytosis in mouse peritoneal macrophages. Biomedicines 2020;8:274.
    doi: 10.3390/biomedicines8080274pmc: PMC7459916pubmed: 32764331google scholar: lookup
  41. Agassandian M., Mallampalli R.K.. Surfactant phospholipid metabolism. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2013;1831:612–625.
    doi: 10.1016/j.bbalip.2012.09.010pmc: PMC3562414pubmed: 23026158google scholar: lookup
  42. Mishra S., Chakraborty H.. Phosphatidylethanolamine and cholesterol promote hemifusion formation: A tug of war between membrane interfacial order and intrinsic negative curvature of lipids. J. Phys. Chem. B 2023;127:7721–7729.
    doi: 10.1021/acs.jpcb.3c04489pubmed: 37644708google scholar: lookup
  43. van Meer G., Voelker D.R., Feigenson G.W.. Membrane lipids: Where they are and how they behave. Nat. Rev. Mol. Cell Biol. 2008;9:112–124.
    doi: 10.1038/nrm2330pmc: PMC2642958pubmed: 18216768google scholar: lookup
  44. Vance J.E., Tasseva G.. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim. Biophys. Acta 2013;1831:543–554.
    doi: 10.1016/j.bbalip.2012.08.016pubmed: 22960354google scholar: lookup
  45. Numata M., Kandasamy P., Nagashima Y., Fickes R., Murphy R.C., Voelker D.R.. Phosphatidylinositol inhibits respiratory syncytial virus infection. J. Lipid Res. 2015;56:578–587.
    doi: 10.1194/jlr.M055723pmc: PMC4340305pubmed: 25561461google scholar: lookup
  46. Balla T.. Phosphoinositides: Tiny lipids with giant impact on cell regulation. Physiol. Rev. 2013;93:1019–1137.
    doi: 10.1152/physrev.00028.2012pmc: PMC3962547pubmed: 23899561google scholar: lookup
  47. Slotte J.P.. Biological functions of sphingomyelins. Prog. Lipid Res. 2013;52:424–437.
    doi: 10.1016/j.plipres.2013.05.001pubmed: 23684760google scholar: lookup
  48. Ogiso H., Taniguchi M., Okazaki T.. Analysis of lipid-composition changes in plasma membrane microdomains. J. Lipid Res. 2015;56:1594–1605.
    doi: 10.1194/jlr.M059972pmc: PMC4514000pubmed: 26116739google scholar: lookup
  49. Hammerschmidt P., Brüning J.C.. Contribution of specific ceramides to obesity-associated metabolic diseases. Cell. Mol. Life Sci. 2022;79:395.
    doi: 10.1007/s00018-022-04401-3pmc: PMC9252958pubmed: 35789435google scholar: lookup
  50. Kim S.H., Jung H.W., Kim M., Moon J.Y., Ban G.Y., Kim S.J., Yoo H.J., Park H.S.. Ceramide/sphingosine-1-phosphate imbalance is associated with distinct inflammatory phenotypes of uncontrolled asthma. Allergy 2020;75:1991–2004.
    doi: 10.1111/all.14236pubmed: 32072647google scholar: lookup
  51. Quinville B.M., Deschenes N.M., Ryckman A.E., Walia J.S.. A comprehensive review: Sphingolipid metabolism and implications of disruption in sphingolipid homeostasis. Int. J. Mol. Sci. 2021;22:5793.
    doi: 10.3390/ijms22115793pmc: PMC8198874pubmed: 34071409google scholar: lookup
  52. Duan Y., Gong K., Xu S., Zhang F., Meng X., Han J.. Regulation of cholesterol homeostasis in health and diseases: From mechanisms to targeted therapeutics. Signal Transduct. Target Ther. 2022;7:265.
    doi: 10.1038/s41392-022-01125-5pmc: PMC9344793pubmed: 35918332google scholar: lookup
  53. Deng L., Kersten S., Stienstra R.. Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins. Prog. Lipid Res. 2023;92:101250.
    doi: 10.1016/j.plipres.2023.101250pubmed: 37619883google scholar: lookup
  54. Masoodi M., Kuda O., Rossmeisl M., Flachs P., Kopecky J.. Lipid signaling in adipose tissue: Connecting inflammation & metabolism. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2015;1851:503–518.
    pubmed: 25311170
  55. Warren L., Kivipelto J., Gettinger E.. Evaluation of the capacity for maternal transfer and foal synthesis of long-chain polyunsaturated fatty acids. J. Anim. Sci. 2010;88:203.
  56. Nogradi N.. Omega-3 fatty acid supplementation in the management of chronic lower airway inflammatory conditions in horses. Open Access Theses 2013;140.
  57. Bannenberg G., Serhan C.N.. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2010;1801:1260–1273.
    doi: 10.1016/j.bbalip.2010.08.002pmc: PMC2994245pubmed: 20708099google scholar: lookup
  58. Olave C., Ivester K., Couëtil L., Burgess J., Park J., Mukhopadhyay A.. Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial. J. Vet. Inter. Med. 2022;37:338–348.
    doi: 10.1111/jvim.16598pmc: PMC9889630pubmed: 36478588google scholar: lookup
  59. Serhan C.. Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu. Rev. Immunol. 2007;25:101–137.
    doi: 10.1146/annurev.immunol.25.022106.141647pubmed: 17090225google scholar: lookup
  60. Chiurchiù V., Leuti A., Dalli J., Jacobsson A., Battistini L., Maccarrone M., Serhan C.N.. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci. Transl. Med. 2016;8:353ra111.
    doi: 10.1126/scitranslmed.aaf7483pmc: PMC5149396pubmed: 27559094google scholar: lookup
  61. Kasuga K., Yang R., Porter T.F., Agrawal N., Petasis N.A., Irimia D., Toner M., Serhan C.N.. Rapid appearance of resolvin precursors in inflammatory exudates: Novel mechanisms in resolution. J. Immunol. 2008;181:8677–8687.
    doi: 10.4049/jimmunol.181.12.8677pmc: PMC2664686pubmed: 19050288google scholar: lookup
  62. Miyata J., Arita M.. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol. Int. 2015;64:27–34.
    doi: 10.1016/j.alit.2014.08.003pubmed: 25572556google scholar: lookup
  63. Barnig C., Frossard N., Levy B.. Towards targeting resolution pathways of airway inflammation in asthma. Pharmacol. Ther. 2018;186:98–113.
    doi: 10.1016/j.pharmthera.2018.01.004pubmed: 29352860google scholar: lookup
  64. Folch J., Lees M., Stanley G.. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957;226:497–509.
    doi: 10.1016/S0021-9258(18)64849-5pubmed: 13428781google scholar: lookup
  65. Wood P., Scoggin K., Ball B., Troedsson M., Squires E.. Lipidomics of equine sperm and seminal plasma: Identification of amphiphilic (O-acyl)-ω-hydroxy-fatty acids. Theriogenology 2016;86:1212–1221.
    doi: 10.1016/j.theriogenology.2016.04.012pubmed: 27180330google scholar: lookup
  66. Wood P., Ball B., Scoggin K., Troedsson M., Squires E.. Lipidomics of equine amniotic fluid: Identification of amphiphilic (O-acyl)-ω-hydroxy-fatty acids. Theriogenology 2018;105:120–125.
    doi: 10.1016/j.theriogenology.2017.09.012pubmed: 28950169google scholar: lookup
  67. Barreto Í.M., Urbano S.A., Oliveira C.A., Macêdo C.S., Borba L.H., Chags B.M., Rangel A.H.. Chemical composition and lipid profile of mare colostrum and milk of the quarter horse breed. PLoS ONE 2020;15:e0238921.
    doi: 10.1371/journal.pone.0238921pmc: PMC7489553pubmed: 32925944google scholar: lookup
  68. Yuan M., Breitkopf S., Asara J.. Serial-omics characterization of equine urine. PLoS ONE 2017;12:e0186258.
    doi: 10.1371/journal.pone.0186258pmc: PMC5640239pubmed: 29028822google scholar: lookup
  69. Kosinska M., Eichner G., Schmitz G., Liebisch G., Steinmeyer J.. Comparative study on the lipidome of normal knee synovial fluid from humans and horses. PLoS ONE 2021;16:e0250146.
    doi: 10.1371/journal.pone.0250146pmc: PMC8051782pubmed: 33861772google scholar: lookup
  70. Elzinga S., Wood P., Adams A.. Plasma lipidomic and inflammatory cytokine profiles of horses with equine metabolic syndrome. J. Equine Vet. Sci. 2016;40:49–55.
    doi: 10.1016/j.jevs.2016.01.013google scholar: lookup
  71. Coleman M., Whitfield-Cargile C., Madrigal R., Cohen N.. Comparison of the microbiome, metabolome, and lipidome of obese and non-obese horses. PLoS ONE 2019;14:e0215918.
    doi: 10.1371/journal.pone.0215918pmc: PMC6478336pubmed: 31013335google scholar: lookup
  72. Wood P., Steinman M., Erol E., Carter G., Christmann U., Verma A.. Lipidomic analysis of immune activation in equine leptospirosis and Leptospira-vaccinated horses. PLoS ONE 2018;13:e0193424.
    doi: 10.1371/journal.pone.0193424pmc: PMC5825116pubmed: 29474474google scholar: lookup
  73. Sanclemente J., Rivera-Velez S., Dasgupta N., Horohov D., Wood P., Sanz M.. Plasma lipidome of healthy and Rhodococcus equi-infected foals over time. Equine Vet. J. 2022;54:121–131.
    doi: 10.1111/evj.13422pubmed: 33445210google scholar: lookup
  74. Hallamaa R., Batchu K.. Phospholipid analysis in sera of horses with allergic dermatitis and in matched healthy controls. Lipids Health Dis. 2016;15:1–9.
    doi: 10.1186/s12944-016-0209-4pmc: PMC4774145pubmed: 26932514google scholar: lookup
  75. Schauberger E., Peinhaupt M., Cazares T., Lindsley A.. Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. Curr. Allergy Asthma Rep. 2016;16:48.
    doi: 10.1007/s11882-016-0628-3pmc: PMC5515624pubmed: 27333777google scholar: lookup
  76. Yan F., Wen Z., Wang R., Luo W., Du Y., Wang W., Chen X.. Identification of the lipid biomarkers from plasma in idiopathic pulmonary fibrosis by Lipidomics. BMC Pulm. Med. 2017;17:1–12.
    doi: 10.1186/s12890-017-0513-4pmc: PMC5719761pubmed: 29212488google scholar: lookup
  77. Snider J.M., You J.K., Wang X., Snider A.J., Hallmark B., Zec M.M., Seeds M.C., Sergeant S., Johnstone L., Wang Q.. Group IIA secreted phospholipase A 2 is associated with the pathobiology leading to COVID-19 mortality. J. Clin. Investig. 2021;131:e149236.
    doi: 10.1172/JCI149236pmc: PMC8483752pubmed: 34428181google scholar: lookup
  78. Bullone M., Lavoie J.-P.. Asthma “of horses and men”—How can equine heaves help us better understand human asthma immunopathology and its functional consequences?. Mol. Immunol. 2015;66:97–105.
    doi: 10.1016/j.molimm.2014.12.005pubmed: 25547716google scholar: lookup
  79. Uhlig S., Gulbins E.. Sphingolipids in the lungs. Am. J. Respir. Crit. Care Med. 2008;178:1100–1114.
    doi: 10.1164/rccm.200804-595SOpubmed: 18755926google scholar: lookup
  80. Kowal K., Zebrowska E., Chabowski A.. Altered sphingolipid metabolism is associated with asthma phenotype in house dust mite-allergic patients. Allergy Asthma Immunol. Res. 2019;11:330–342.
    doi: 10.4168/aair.2019.11.3.330pmc: PMC6439195pubmed: 30912323google scholar: lookup
  81. Pond C.M.. An evolutionary and functional view of mammalian adipose tissue. Proc. Nutr. Soc. 1992;51:367–377.
    doi: 10.1079/PNS19920050pubmed: 1480631google scholar: lookup
  82. Jiang T., Dai L., Li P., Zhao J., Wang X., An L., Liu M., Wu S., Wang Y., Peng Y.. Lipid metabolism and identification of biomarkers in asthma by lipidomic analysis. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2021;1866:158853.
    doi: 10.1016/j.bbalip.2020.158853pubmed: 33160078google scholar: lookup
  83. Wang S., Tang K., Lu Y., Tian Z., Huang Z., Wang M., Zhao J., Xie J.. Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics. Clin. Chim. Acta. 2021;513:34–42.
    doi: 10.1016/j.cca.2020.11.026pubmed: 33307061google scholar: lookup
  84. Kang Y.P., Lee W.J., Hong J.Y., Lee S.B., Park J.H., Kim D., Park S., Park C.S., Park S.W., Kwon S.W.. Novel approach for analysis of bronchoalveolar lavage fluid (BALF) using HPLC-QTOF-MS-based lipidomics: Lipid levels in asthmatics and corticosteroid-treated asthmatic patients. J. Proteome Res. 2014;13:3919–3929.
    doi: 10.1021/pr5002059pubmed: 25040188google scholar: lookup
  85. Berry K., Murphy R., Kosmide B., Mason R.. Lipidomic characterization and localization of phospholipids in the human lung [S]. J. Lipid Res. 2017;58:926–933.
    doi: 10.1194/jlr.M074955pmc: PMC5408611pubmed: 28280112google scholar: lookup
  86. Brandsma J., Goss V.M., Yang X., Bakke P.S., Caruso M., Chanez P., Dahlén S.E., Fowler S.J., Horvath I., Krug N.. Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers. Metabolomics 2018;14:1–12.
    doi: 10.1007/s11306-018-1412-2pmc: PMC6153688pubmed: 30830396google scholar: lookup
  87. Sanak M., Mastalerz L., Gielicz A., Sokolowska B., Celejewska-Wόjcik N., Szczeklik A.. Targeted eicosanoid lipidomics of induced sputum as compared to exhaled breath condensate in asthmatics. Eur. Respir. J. 2011;38:4789.
  88. Christmann U., Hancock C.L., Poole C.M., Emery A.L., Poovey J.R., Hagg C., Mattson E.A., Scarborough J.J., Christopher J.S., Dixon A.T.. Dynamics of DHA and EPA supplementation: Incorporation into equine plasma, synovial fluid, and surfactant glycerophosphocholines. Metabolomics 2021;17:1–10.
    doi: 10.1007/s11306-021-01792-5pubmed: 33866431google scholar: lookup
  89. Lam M., Bourke J.. Solving the riddle: Targeting the imbalance of sphingolipids in asthma to oppose airway hyper-responsiveness. Am. J. Respir. Cell Mol. Biol. 2020;63:555–557.
    doi: 10.1165/rcmb.2020-0324EDpmc: PMC7605168pubmed: 32822217google scholar: lookup
  90. Horbay R., Hamraghani A., Ermini L., Holcik S., Beug S.T., Yeganeh B.. Role of ceramides and lysosomes in extracellular vesicle biogenesis, cargo sorting and release. Int. J. Mol. Sci. 2022;23:15317.
    doi: 10.3390/ijms232315317pmc: PMC9735581pubmed: 36499644google scholar: lookup
  91. Masini E., Giannini L., Nistri S., Cinci L., Mastroianni R., Xu W., Comhair S.A., Li D., Cuzzocrea S., Matuschak G.M.. Ceramide: A key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. J. Pharmacol. Exp. Ther. 2008;324:548–557.
    doi: 10.1124/jpet.107.131565pubmed: 18042827google scholar: lookup
  92. Christmann U., Livesey L., Taintor J., Waldridge B., Schumacher J., Grier B., Hite R.D.. Lung surfactant function and composition in neonatal foals and adult horses. J. Vet. Intern. Med. 2006;20:1402–1407.
    doi: 10.1111/j.1939-1676.2006.tb00758.xpubmed: 17186857google scholar: lookup
  93. Howlett A., Ohlsson A., Plakkal N.. Inositol in preterm infants at risk for or having respiratory distress syndrome. Cochrane Database Syst. Rev. 2019;2019:CD000366.
    doi: 10.1002/14651858.CD000366.pub4pmc: PMC6613728pubmed: 31283839google scholar: lookup
  94. Murphy R.C., Folco G.. Lysophospholipid acyltransferases and leukotriene biosynthesis: Intersection of the Lands cycle and the arachidonate PI cycle. J. Lipid Res. 2019;60:219–226.
    doi: 10.1194/jlr.S091371pmc: PMC6358305pubmed: 30606731google scholar: lookup
  95. Astudillo A., Pérez-Chacón G., Meana C., Balgoma D., Pol A., Del Pozo M., Balboa M.A., Balsinde J.. Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to reduced eicosanoid synthesis. J. Biol. Chem. 2011;286:5299–5307.
    doi: 10.1074/jbc.M111.277137pmc: PMC3186424pubmed: 21852231google scholar: lookup
  96. Wenzel S.. The role of leukotrienes in asthma. Prostaglandins Leukot. Essent. Fatty Acids. 2003;69:145–155.
    doi: 10.1016/S0952-3278(03)00075-9pubmed: 12895597google scholar: lookup
  97. Hallstrand T., Henderson W., Jr.. An update on the role of leukotrienes in asthma. Curr. Opin. Allergy Clin. Immunol. 2010;10:60–66.
    doi: 10.1097/ACI.0b013e32833489c3pmc: PMC2838730pubmed: 19915456google scholar: lookup
  98. Bernhard W., Hoffmann S., Dombrowsky H., Rau G., Kamlage A., Kappler M., Haitsma J.J., Freihorst J., von der Hardt H., Poets C.F.. Phosphatidylcholine molecular species in lung surfactant: Composition in relation to respiratory rate and lung development. Am. J. Respir. Cell Mol. Biol. 2001;25:725–731.
    doi: 10.1165/ajrcmb.25.6.4616pubmed: 11726398google scholar: lookup
  99. Hohlfeld J.. The role of surfactant in asthma. Respir. Res. 2001;3:1–8.
    doi: 10.1186/rr176pmc: PMC64815pubmed: 11806839google scholar: lookup
  100. Christmann U., Buechner-Maxwell V., Witonsky S., Hite R.. Role of lung surfactant in respiratory disease: Current knowledge in large animal medicine. J. Vet. Intern. Med. 2009;23:227–242.
    doi: 10.1111/j.1939-1676.2008.0269.xpubmed: 19192153google scholar: lookup
  101. Forbes A., Pickell M., Foroughian M., Yao L.J., Lewis J., Veldhuizen R.. Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats. J. Appl. Physiol. 2007;103:637–645.
    doi: 10.1152/japplphysiol.00995.2006pubmed: 17446406google scholar: lookup
  102. Brandsma J., Postle A.D.. Analysis of the regulation of surfactant phosphatidylcholine metabolism using stable isotopes. Ann. Anat. 2017;211:176–183.
    doi: 10.1016/j.aanat.2017.02.008pubmed: 28351529google scholar: lookup
  103. de Aguiar Vallim T., Lee E., Merriott D., Goulbourne C., Cheng J., Cheng A., Gonen A., Allen R.M., Palladino E.N., Ford D.A.. ACG1 regulates pulmonary surfactant metabolism in mice and men. J. Lipid Res. 2017;58:941–954.
    doi: 10.1194/jlr.M075101pmc: PMC5408613pubmed: 28264879google scholar: lookup
  104. Bartussio A.. Lung surfactant, asthma, and allergens: A story in evolution. Am. J. Respir. Crit. 2004;169:550–551.
    doi: 10.1164/rccm.2312019pubmed: 14982818google scholar: lookup
  105. Christmann U. Ph.D. Thesis. Virginia Tech; Blacksburg, VA, USA: 2008. Relationship between surfactant alterations and severity of disease in horses with recurrent airway obstruction (RAO)
  106. Treede I., Braun A., Sparla R., Kühnel M., Giese T., Turner J., Anes E., Kulaksiz H., Fullekrug J., Stremmel W.. Anti-inflammatory effects of phosphatidylcholine. J. Biol. Chem. 2007;282:27155–27164.
    doi: 10.1074/jbc.M704408200pmc: PMC2693065pubmed: 17636253google scholar: lookup
  107. Dewhurst R., Scollan N., Youell S., Tweed J., Humphreys M.. Influence of species, cutting date and cutting interval on the fatty acid composition of grasses. Grass Forage Sci. 2001;56:68–74.
    doi: 10.1046/j.1365-2494.2001.00247.xgoogle scholar: lookup
  108. Lorenzo J., Fuciños C., Purriños L., Franco D.. Intramuscular fatty acid composition of “Galician Mountain” foals breed: Effect of sex, slaughtered age and livestock production system. Meat. Sci. 2010;86:825–831.
    doi: 10.1016/j.meatsci.2010.07.004pubmed: 20675062google scholar: lookup
  109. Hansen R., Savage C., Reidlinger K., Traub-Dargatz J., Ogilvie G., Mitchell D.. Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. J. Vet. Intern. Med. 2002;16:457–463.
    doi: 10.1111/j.1939-1676.2002.tb01265.xpubmed: 12141309google scholar: lookup
  110. Vineyard K., Warren L., Kivipelto J.. Effect of dietary omega-3 fatty acid source on plasma and red blood cell membrane composition and immune function in yearling horses. J. Anim. Sci. 2010;88:248–257.
    doi: 10.2527/jas.2009-2253pubmed: 19783695google scholar: lookup
  111. Ross-Jones T., Hess T., Rexford J., Ahrens N., Engle T., Hansen D.. Effects of omega-3 long chain polyunsaturated fatty acid supplementation on equine synovial fluid fatty acid composition and prostaglandin E2. J. Equine Vet. Sci. 2014;34:779–783.
    doi: 10.1016/j.jevs.2014.01.014google scholar: lookup
  112. Pagan J., Hauss A., Pagan E., Simons J., Waldridge B.. Long-chain polyunsaturated fatty acid supplementation increases levels in red blood cells and reduces the prevalence and severity of squamous gastric ulcers in exercised Thoroughbreds. J. Am. Vet. Med. Assoc. 2022;260:S121–S128.
    doi: 10.2460/javma.22.06.0275pubmed: 36269687google scholar: lookup
  113. Sembratowicz I., Zięba G., Cholewinska E., Czech A.. Effect of dietary flaxseed oil supplementation on the redox status, haematological and biochemical parameters of horses’ blood. Animals 2020;10:2244.
    doi: 10.3390/ani10122244pmc: PMC7760300pubmed: 33265987google scholar: lookup
  114. Gordon M., Jacobs R.. Feeding stalled horses a diet high omega-3 fatty acids results in a plasma fatty acid profile similar to horses on pasture. J. Equine Vet. Sci. 2021;100:103505.
    doi: 10.1016/j.jevs.2021.103505google scholar: lookup
  115. Olave C., Ivester K., Couëtil L., Franco-Marmolejo J., Mukhopadhyay A., Robinson J., Park J.H.. Effects of forages, dust exposure and proresolving lipids on airway inflammation in horses. Am. J. Vet. Res. 2021;83:153–161.
    doi: 10.2460/ajvr.21.08.0126pubmed: 34843444google scholar: lookup
  116. Khol-Parisini A., van den Hoven R., Leinker S., Hulan H., Zentek J.. Effects of feeding sunflower oil or seal blubber oil to horses with recurrent airway obstruction. Can. J. Vet. Res. 2007;71:59.
    pmc: PMC1635996pubmed: 17193883
  117. Nogradi N., Couëtil L., Messick J., Stochelski M., Burgess J.. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease. J. Vet. Intern. Med. 2015;29:299–306.
    doi: 10.1111/jvim.12488pmc: PMC4858086pubmed: 25307169google scholar: lookup

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