Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses.
Abstract: The purpose of this study was to determine if ginseng fed at low levels enhances a horse's antibody response to vaccination against Equid herpesvirus 1 (EHV-1). For 28 d, 5 horses received ground, powdered ginseng (35 mg/kg body weight, 1.7 mg/kg total ginsenosides) in molasses as a carrier, and 5 received molasses only. On day 14, each horse was vaccinated against EHV-1. The time course of the antibody response to vaccination was significantly altered in the horses receiving ginseng, a clinically relevant increase in antibody titer being observed by postvaccination day 2 compared with day 6 in the control horses. The horses receiving ginseng also had a significant decrease in serum levels of sodium and a significant increase in serum levels of potassium. No adverse effects of ginseng treatment were identified by hematologic and blood biochemistry profiles. Thus, low-dose dietary supplementation with ginseng in healthy horses may be a useful adjunct to vaccination. L’objectif de la présente étude était de déterminer si le ginseng nourri à petites doses augmente la production d’anticorps induits par la vaccination chez un cheval immunisé contre l’herpèsvirus équin 1 (EHV-1). Pendant 28 jours, 5 chevaux ont reçu du ginseng moulu (35 mg/kg de poids corporel; 1,7 mg/kg de ginsenosides total) dans de la mélasse comme véhiculant, et 5 ont reçu uniquement de la mélasse. Au jour 14, chaque cheval a été vacciné contre le EHV-1. La courbe de production d’anticorps suite à la vaccination était modifiée de manière significative chez les chevaux recevant du ginseng, une augmentation cliniquement significative du titre d’anticorps étant observée au jour 2 post-vaccination comparativement au jour 6 chez les chevaux témoins. Les chevaux recevant du ginseng montraient également une réduction significative des niveaux sériques de sodium et une augmentation significative des niveaux sériques de potassium. Aucun effet adverse du traitement au ginseng n’a été identifié par les profils hématologiques et biochimiques sanguins. Ainsi, un supplément alimentaire à faible dose avec du ginseng chez des chevaux en santé pourrait être un ajout utile à la vaccination. (Traduit par Docteur Serge Messier)
Publication Date: 2007-08-19 PubMed ID: 17695597PubMed Central: PMC1899868
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research aimed to find out if horses fed with low-level ginseng could have an improved antibody response to vaccination for Equid herpesvirus 1 (EHV-1). The findings showed that horses receiving ginseng did have an amplified and quicker antibody response compared to those without ginseng, with no negative side effects observed.
Research Methodology
- The study involved a total of 10 horses. For 28 days, five of these horses were fed with ground powdered ginseng, while the remaining five only received molasses.
- The dosage of the ginseng used was 35 mg/kg body weight, including 1.7 mg/kg of total ginsenosides, and was mixed in molasses for easy ingestion.
- On the 14th day, all horses were vaccinated against EHV-1.
Findings
- The horses that were included in the ginseng group showed a significant alteration in the time course of the antibody response to the vaccination. Notably, the increment in their antibody titer was clinically relevant, and it was observed as early as the 2nd day after the vaccination, compared to the control group who showed an increase only by the 6th day post-vaccination.
- Additionally, the ginseng group showed a significant decrease in serum levels of sodium and a significant increase in serum levels of potassium.
- No harmful side effects from the ginseng treatment were detected from the blood profiles in terms of hematology and blood biochemistry.
Conclusion
- From the findings of the study, it can be concluded that low-dose dietary supplementation with ginseng in healthy horses may enhance the antibody response to an EHV-1 vaccination. This is evident in the early and significant rise in their antibody titer with no observed harm.
- The resultant changes in the sodium and potassium serum levels can also be indicative of the ginseng’s effect, although effects in performance or overall health weren’t part of this research.
Cite This Article
APA
Pearson W, Omar S, Clarke AF.
(2007).
Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses.
Can J Vet Res, 71(3), 213-217.
Publication
Researcher Affiliations
- Equine Research Centre, University of Guelph, Guelph, Ontario. wpearson@uoguelph.ca
MeSH Terms
- Adjuvants, Immunologic
- Animals
- Antibodies, Viral / blood
- Female
- Herpesviridae Infections / prevention & control
- Herpesviridae Infections / veterinary
- Herpesvirus 1, Equid / immunology
- Herpesvirus Vaccines / immunology
- Horse Diseases / prevention & control
- Horses
- Male
- Panax / immunology
- Potassium / blood
- Sodium / blood
- Vaccination / methods
- Vaccination / veterinary
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Citations
This article has been cited 3 times.- Kwak YB, Stambler I, Yoo HH, Yoon J. Metabolomic analysis of the impact of red ginseng on equine physiology. Front Vet Sci 2024;11:1425089.
- Kwak YB, Yoo HH, Yoon J. The impact of the administration of red ginseng (Panax ginseng) on lipid metabolism and free fatty acid profiles in healthy horses using a molecular networking approach. Front Vet Sci 2024;11:1285000.
- Kwak YB, Lee E, Choi H, Park T, Kim A, Kim J, Yoon J, Yoo HH. A pharmacokinetic study on red ginseng with furosemide in equine. Front Vet Sci 2023;10:1319998.
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