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Home / Equine Research Bank / BMC Vet Res / Low MRSA prevalence in horses at farm level.
BMC veterinary research2012; 8; 213; doi: 10.1186/1746-6148-8-213

Low MRSA prevalence in horses at farm level.

Abstract: In Europe, methicillin-resistant Staphylococcus aureus (MRSA) belonging to the clonal complex (CC) 398 has become an important pathogen in horses, circulating in equine clinics and causing both colonization and infection. Whether equine MRSA is bound to hospitals or can also circulate in the general horse population is currently unknown. This study, therefore, reports the nasal and perianal MRSA screening of 189 horses on 10 farms in a suspected high prevalence region (East- and West-Flanders, Belgium). Results: Only one horse (0.53%) from one farm (10%) tested positive in the nose. It carried a spa type t011-SCCmecV isolate, resistant to β-lactams and tetracycline, which is typical for livestock-associated MRSA CC398. Conclusions: In the region tested here, horses on horse farms seem unlikely to substantially contribute to the large animal associated ST398 MRSA reservoir present at intensive animal production units.
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Publication Date: 2012-11-07 PubMed ID: 23134703PubMed Central: PMC3536571DOI: 10.1186/1746-6148-8-213Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article looks into the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in horses in Belgium, revealing a lower than expected incidence. The study investigated if horses contribute significantly to the reservoir of this bacterium typically associated with large animal production units.

Background of the Study

  • Methicillin-resistant Staphylococcus aureus (MRSA), specifically the clonal complex 398 (CC398), is a significant pathogen in horses in Europe.
  • MRSA can cause both colonization and infections in horses, often circulating in equine clinics.
  • It was previously unclear if MRSA in horses was limited to equine clinics or also present in the general horse population.

Details and Method of the Study

  • The researchers tested for MRSA in both the noses and perianal areas of 189 horses on 10 different farms in East and West-Flanders, Belgium. The region was chosen due to its suspected high prevalence of MRSA.
  • The goal was to determine the prevalence of MRSA on these farms and to identify the type of MRSA present.

Results of the Study

  • Results showed that only one horse from one farm tested positive in the nose for MRSA. That’s just 0.53% of the horses sampled and 10% of the farms involved.
  • This horse was found to carry an isolate type t011-SCCmecV in its nasal cavities, a type of MRSA resistant to β-lactams and tetracycline. This is typical for livestock-associated MRSA (LA-MRSA) CC398.

Conclusions of the Study

  • Contrary to expectations, the prevalence of MRSA among horses in these farms was low.
  • Based on these findings, it seems horses in this region do not significantly contribute to the LA-MRSA reservoir, usually associated with intensive animal production units.

This study provides important insights into MRSA in horses in the tested region, which could guide future research and control strategies for MRSA in equine and livestock contexts.

Cite This Article

APA
Van den Eede A, Martens A, Feryn I, Vanderhaeghen W, Lipinska U, Gasthuys F, Butaye P, Haesebrouck F, Hermans K. (2012). Low MRSA prevalence in horses at farm level. BMC Vet Res, 8, 213. https://doi.org/10.1186/1746-6148-8-213

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 8
Pages: 213

Researcher Affiliations

Van den Eede, Annelies
  • Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Martens, Ann
    Feryn, Isabelle
      Vanderhaeghen, Wannes
        Lipinska, Urszula
          Gasthuys, Frank
            Butaye, Patrick
              Haesebrouck, Freddy
                Hermans, Katleen

                  MeSH Terms

                  • Animal Husbandry
                  • Animals
                  • Belgium / epidemiology
                  • Carrier State
                  • Disease Reservoirs / veterinary
                  • Female
                  • Horse Diseases / epidemiology
                  • Horse Diseases / microbiology
                  • Horses
                  • Male
                  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
                  • Nose / microbiology
                  • Prevalence
                  • Staphylococcal Infections / microbiology
                  • Staphylococcal Infections / veterinary

                  References

                  This article includes 45 references
                  1. Anzai T, Kamada M, Kanemaru T, Sugita S, Shimizu A, Higuchi T. Isolation of methicillin-resistant Staphylococcus aureus (MRSA) from mares with metritis and its zooepidemiology.. J Equine Sci 1996;7:7–11.
                    doi: 10.1294/jes.7.7google scholar: lookup
                  2. Weese JS, Archambault M, Willey BM, Hearn P, Kreiswirth BN, Said-Salim B, McGeer A, Likhoshvay Y, Prescott JF, Low DE. Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002.. Emerg Infect Dis 2005;11:430–435.
                    doi: 10.3201/eid1103.040481pmc: PMC3298236pubmed: 15757559google scholar: lookup
                  3. Weese JS, Rousseau J, Willey BM, Archambault M, McGeer A, Low DE. Methicillin-resistant Staphylococcus aureus in horses at a veterinary teaching hospital: frequency, characterization, and association with clinical disease.. J Vet Intern Med 2006;20:182–186.
                    pubmed: 16496939
                  4. Weese JS, Caldwell F, Willey BM, Kreiswirth BN, McGeer A, Rousseau J, Low DE. An outbreak of methicillin-resistant Staphylococcus aureus skin infections resulting from horse to human transmission in a veterinary hospital.. Vet Microbiol 2006;114:160–164.
                    doi: 10.1016/j.vetmic.2005.11.054pubmed: 16384660google scholar: lookup
                  5. Hermans K, Lipinska U, Denis O, Deplano A, Struelens MJ, Nemati M, Pasmans F, Butaye P, Martens A, Deprez P, Haesebrouck F. MRSA clone ST398-SCCmec IV as a cause of infections in an equine clinic.. Vlaams Diergen Tijds 2008;77:429–433.
                  6. Van den Eede A, Martens A, Lipinska U, Struelens M, Deplano A, Denis O, Haesebrouck F, Gasthuys F, Hermans K. High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples.. Vet Microbiol 2009;133:138–144.
                    doi: 10.1016/j.vetmic.2008.06.021pubmed: 18701224google scholar: lookup
                  7. van Duijkeren E, Moleman M, van Oldruitenborgh-Oosterbaan MMS, Multem J, Troelstra A, Fluit AC, van Wamel WJB, Houwers DJ, de Neeling AJ, Wagenaar JA. Methicillin-resistant Staphylococcus aureus in horses and horse personnel: An investigation of several outbreaks.. Vet Microbiol 2010;141:96–102.
                    doi: 10.1016/j.vetmic.2009.08.009pubmed: 19740613google scholar: lookup
                  8. Sieber S, Gerber V, Jandova V, Rossano A, Evison JM, Perreten V. Evolution of multidrug-resistant Staphylococcus aureus infections in horses and colonized personnel in an equine clinic between 2005 and 2010.. Microb Drug Resist 2011;17:471–478.
                    doi: 10.1089/mdr.2010.0188pubmed: 21875361google scholar: lookup
                  9. Catry B, van Duijkeren E, Pomba MC, Greko C, Moreno MA, Pyörälä S, Ruzauskas M, Sanders P, Threlfall EJ, Ungemach F, Torneke K, Munoz-Madero C, Torren-Edo J. Reflection paper on MRSA in food-producing and companion animals: epidemiology and control options for human and animal health.. Epidemiol Infect 2010;138:626–644.
                    doi: 10.1017/S0950268810000014pubmed: 20141646google scholar: lookup
                  10. Weese JS. Methicillin-resistant Staphylococcus aureus in animals.. Inst Lab Anim Res J 2010;51(3):233–244.
                    pubmed: 21131724
                  11. Weese JS, van Duijkeren E. Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine.. Vet Microbiol 2010;140(3–4):418–429.
                    pubmed: 19246166
                  12. Weese JS, Rousseau J, Traub-Dargatz JL, Willey BM, McGeer AJ, Low DE. Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses.. J Am Vet Med Assoc 2005;226:580–583.
                    doi: 10.2460/javma.2005.226.580pubmed: 15742700google scholar: lookup
                  13. Busscher JF, van Duijkeren E, van Oldruitenborgh-Oosterbaan MMS. The prevalence of methicillin-resistant staphylococci in healthy horses in the Netherlands.. Vet Microbiol 2006;113:131–136.
                    doi: 10.1016/j.vetmic.2005.10.028pubmed: 16303264google scholar: lookup
                  14. Vengust M, Anderson ME, Rousseau J, Weese JS. Methicillin-resistant staphylococcal colonization in clinically normal dogs and horses in the community.. Lett Appl Microbiol 2006;43:602–606.
                    doi: 10.1111/j.1472-765X.2006.02018.xpubmed: 17083704google scholar: lookup
                  15. Burton S, Reid-Smith R, McClure JT, Weese JS. Staphylococcus aureus colonization in healthy horses in Atlantic Canada.. Can Vet J 2008;49:797–799.
                    pmc: PMC2465786pubmed: 18978975
                  16. Maddox TW, Clegg PD, Diggle PJ, Wedley AL, Dawson S, Pinchbeck GL, Williams NJ. Cross-sectional study of antimicrobial-resistant bacteria in horses. Part 1: Prevalence of antimicrobial-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus.. Equine Vet J 2011;44:289–296.
                    pubmed: 21848534
                  17. Nakamura MM, Rohling KJ, Shashaty M, Hongzhou L, Tang YW, Edwards KM. Prevalence of methicillin-resistant Staphylococcus aureus nasal carriage in the community pediatric population.. Pediatr Infect Dis J 2002;21:917–921.
                    doi: 10.1097/00006454-200210000-00006pubmed: 12394812google scholar: lookup
                  18. Cuny C, Friedrich A, Kozytska S, Layer F, Nubel U, Ohlsen K, Strommenger B, Walther B, Wieler L, Witte W. Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species.. Int J Med Microbiol 2010;300:109–117.
                    doi: 10.1016/j.ijmm.2009.11.002pubmed: 20005777google scholar: lookup
                  19. Johnson AP. Methicillin-resistant Staphylococcus aureus: the European landscape.. J Antimicrob Chemoth 2011;66(Suppl 4):iv43–iv48.
                    pubmed: 21521706
                  20. Voss A, Loeffen F, Bakker J, Klaassen C, Wulf M. Methicillin-resistant Staphylococcus aureus in pig farming.. Emerg Infect Dis 2005;11:1965–1966.
                    doi: 10.3201/eid1112.050428pmc: PMC3367632pubmed: 16485492google scholar: lookup
                  21. Nemati M, Hermans K, Lipinska U, Denis O, Deplano A, Struelens M, Devriese LA, Pasmans F, Haesebrouck F. Antimicrobial resistance of old en recent Staphylococcus aureus isolates from poultry: first detection of livestock-associated methicillin-resistant strain ST398.. Antimicrob Agents Ch 2008;52:3817–3819.
                    doi: 10.1128/AAC.00613-08pmc: PMC2565892pubmed: 18663024google scholar: lookup
                  22. Persoons D, Van Hoorebeke S, Hermans K, Butaye P, de Kruif A, Haesebrouck F, Dewulf J. Methicillin-resistant Staphylococcus aureus in poultry.. Emerg Infect Dis 2009;15:452–453.
                    doi: 10.3201/eid1503.080696pmc: PMC2666289pubmed: 19239762google scholar: lookup
                  23. Vanderhaeghen W, Cerpentier T, Adriaensen C, Vicca J, Hermans K, Butaye P. Methicillin-resistant Staphylococcus aureus (MRSA) ST398 associated with clinical and subclinical mastitis in Belgian cows.. Vet Microbiol 2010;144:166–171.
                    doi: 10.1016/j.vetmic.2009.12.044pubmed: 20092969google scholar: lookup
                  24. Floras A, Lawn K, Slavic D, Golding GR, Mulvey MR, Weese JS. Sequence type 398 meticillin-resistant Staphylococcus aureus infection and colonisation in dogs.. Vet Rec 2010;166:826–827.
                    doi: 10.1136/vr.b4870pubmed: 20581361google scholar: lookup
                  25. Cuny C, Strommenger B, Witte W, Stanek C. Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospital.. Microb Drug Resist 2008;14:307–310.
                    doi: 10.1089/mdr.2008.0845pubmed: 19025385google scholar: lookup
                  26. Van den Eede A, Hermans K, Van den Abeele A, Floré K, Dewulf J, Vanderhaeghen W, Crombé F, Butaye P, Gasthuys F, Haesebrouck F, Martens A. Methicillin-resistant Staphylococcus aureus (MRSA) on the skin of long-term hospitalised horses.. Vet J in press.
                    pubmed: 22264643
                  27. Hanselman BA, Kruth SA, Rousseau J, Low DE, Willey BM, McGeer A, Weese JS. Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel.. Emerg Infect Dis 2006;12:1933–1938.
                    doi: 10.3201/eid1212.060231pmc: PMC3291342pubmed: 17326947google scholar: lookup
                  28. Anderson ME, Lefebvre SL, Weese JS. Evaluation of prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in veterinary personnel attending an international equine veterinary conference.. Vet Microbiol 2008;129:410–417.
                    doi: 10.1016/j.vetmic.2007.11.031pubmed: 18187274google scholar: lookup
                  29. Moodley A, Nightingale EC, Stegger M, Nielsen SS, Skov RL, Guardabassi L. High risk for nasal carriage of methicillin-resistant Staphylococcus aureus among danish veterinary practitioners.. Scand J Work Env Hea 2008;34:151–157.
                    doi: 10.5271/sjweh.1219pubmed: 18470441google scholar: lookup
                  30. Wulf MWH, Sorum M, van Nes A, Skov R, Melchers WJG, Klaassen CHW, Voss A. Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study.. Clin Microbiol Infec 2008;14:29–34.
                    doi: 10.1111/j.1469-0691.2007.01873.xpubmed: 17986212google scholar: lookup
                  31. Denis O, Suetens C, Hallin M, Catry B, Ramboer I, Dispas M, Willems G, Gordts B, Butaye P, Struelens MJ. Methicillin-resistant Staphylococcus aureus ST398 in swine farm personnel, Belgium.. Emerg Infect Dis 2009;15:1098–1101.
                    doi: 10.3201/eid1507.080652pmc: PMC2744256pubmed: 19624929google scholar: lookup
                  32. Crombé F, Willems G, Dispas M, Hallin M, Denis O, Suetens K, Gordts B, Struelens M, Butaye P. Prevalence and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus among pigs in Belgium.. Microb Drug Resist 2011;18:125–131.
                    pubmed: 22088147
                  33. Kramer A, Schwebke I, Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review.. BMC Infect Dis 2006;6:130.
                    doi: 10.1186/1471-2334-6-130pmc: PMC1564025pubmed: 16914034google scholar: lookup
                  34. Dewaele I, De Man I, Stael A, Heyndrickx M, Herman L, Rasschaert G, Delputte P, Butaye P, Vlaemynck G. Methicillin-resistant Staphylococcus aureus (MRSA) on pig farms: analysis of pigs, pig farmers and farm environment.. 2007. Proceedings 2nd Symposium ARAE 2007. 17-19 December, Tours-France, Abstract 36.
                  35. Anonymous. Scientific opinion of the panel on biological hazards on a request from the European commission on assessment of the public health significance of meticillin resistant Staphylococcus aureus (MRSA) in animals and foods.. The EFSA Journal 2009;7:1–73.
                  36. Garcia-Graells C, Antoine J, Larsen J, Catry B, Skov R, Denis O. Livestock veterinarians at high risk of acquiring methicillin-resistant Staphylococcus aureus ST398.. Epidemiol Infect 2012;140:383–389.
                    doi: 10.1017/S0950268811002263pubmed: 22082716google scholar: lookup
                  37. de Neeling AJ, van den Broek MJM, Spalburg EC, van Santen-Verheuvel MG, Dam-Deisz WDC, Boshuizen HC, van de Giessen AW, van Duijkeren E, Huijsdens XW. High prevalence of methicillin resistant Staphylococcus aureus in pigs.. Vet Microbiol 2007;122:366–372.
                    doi: 10.1016/j.vetmic.2007.01.027pubmed: 17367960google scholar: lookup
                  38. van Duijkeren E, Ikawaty R, Broekhuizen-Stins MJ, Jansen MD, Spalburg EC, de Neeling AJ, Allaart JG, van Nes A, Wagenaar JA, Fluit AC. Transmission of methicillin-resistant Staphylococcus aureus strains between different kinds of pig farms.. Vet Microbiol 2008;126:383–389.
                    doi: 10.1016/j.vetmic.2007.07.021pubmed: 17765409google scholar: lookup
                  39. Mulders MN, Haenen APJ, Geenen PL, Vesseur PC, Poldervaart ES, Bosch T, Huijsdens XW, Hengeveld PD, Dam-Deisz WDC, Graat EAM, Mevius D, Voss A, Van De Giessen AW. Prevalence of livestock-associated MRSA in broiler flocks and risk factors for slaughterhouse personnel in The Netherlands.. Epidemiol Infect 2010;138:743–755.
                    doi: 10.1017/S0950268810000075pubmed: 20109255google scholar: lookup
                  40. Graveland H, Wagenaar JA, Heesterbeek H, Mevius D, van Duijkeren E, Heederik D. Methicillin resistant Staphylococcus aureus ST398 in veal calf farming: human MRSA carriage related with animal antimicrobial usage and farm hygiene.. PLoS One 2010;5:e10990.
                    doi: 10.1371/journal.pone.0010990pmc: PMC2882326pubmed: 20544020google scholar: lookup
                  41. Weese JS, Rousseau J. Attempted eradication of methicillin-resistant Staphylococcus aureus colonisation in horses on two farms.. Equine Vet J 2005;37:510–514.
                    pubmed: 16295927
                  42. Mehrotra M, Wang G, Johnson WM. Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative toxins, toxic shock syndrome toxin 1 and methicillin resistance.. J Clin Microbiol 2000;38:1032–1035.
                    pmc: PMC86330pubmed: 10698991
                  43. Harmsen D, Claus H, Witte W, Rothganger J, Claus H, Turnwald D, Vogel U. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management.. J Clin Microbiol 2003;41:5442–5448.
                    doi: 10.1128/JCM.41.12.5442-5448.2003pmc: PMC309029pubmed: 14662923google scholar: lookup
                  44. Oliveira DC, de Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus.. Antimicrob Agents Ch 2002;46:2155–2161.
                    doi: 10.1128/AAC.46.7.2155-2161.2002pmc: PMC127318pubmed: 12069968google scholar: lookup
                  45. Zhang KY, McClure JA, Elsayed S, Louie T, Conly JM. Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus.. J Clin Microbiol 2005;43:5026–5033.
                    doi: 10.1128/JCM.43.10.5026-5033.2005pmc: PMC1248471pubmed: 16207957google scholar: lookup

                  Citations

                  This article has been cited 9 times.
                  1. Bullone M, Bellato A, Robino P, Nebbia P, Morello S, Marchis D, Tarducci A, Ru G. Prevalence and risk factors associated with nasal carriage of methicillin-resistant staphylococci in horses and their caregivers. Vet Res 2024 Sep 9;55(1):108.
                    doi: 10.1186/s13567-024-01364-0pubmed: 39252070google scholar: lookup
                  2. Khairullah AR, Sudjarwo SA, Effendi MH, Ramandinianto SC, Widodo A, Riwu KHP. A review of horses as a source of spreading livestock-associated methicillin-resistant Staphylococcus aureus to human health. Vet World 2022 Aug;15(8):1906-1915.
                    doi: 10.14202/vetworld.2022.1906-1915pubmed: 36313842google scholar: lookup
                  3. Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Padalino B, Pasquali P, Roberts HC, Spoolder H, Ståhl K, Velarde A, Viltrop A, Winckler C, Baldinelli F, Broglia A, Kohnle L, Alvarez J. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Staphylococcus aureus in cattle and horses. EFSA J 2022 May;20(5):e07312.
                    doi: 10.2903/j.efsa.2022.7312pubmed: 35582361google scholar: lookup
                  4. Kaspar U, von Lützau K, Schlattmann A, Rösler U, Köck R, Becker K. Zoonotic multidrug-resistant microorganisms among non-hospitalized horses from Germany. One Health 2019 Jun;7:100091.
                    doi: 10.1016/j.onehlt.2019.100091pubmed: 31016221google scholar: lookup
                  5. Lakhundi S, Zhang K. Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology. Clin Microbiol Rev 2018 Oct;31(4).
                    doi: 10.1128/CMR.00020-18pubmed: 30209034google scholar: lookup
                  6. Oguttu JW, Qekwana DN, Odoi A. An Exploratory Descriptive Study of Antimicrobial Resistance Patterns of Staphylococcus Spp. Isolated from Horses Presented at a Veterinary Teaching Hospital. BMC Vet Res 2017 Aug 22;13(1):269.
                    doi: 10.1186/s12917-017-1196-zpubmed: 28830437google scholar: lookup
                  7. Boyle AG, Rankin SC, Duffee LA, Morris D. Prevalence of Methicillin-Resistant Staphylococcus aureus from Equine Nasopharyngeal and Guttural Pouch Wash Samples. J Vet Intern Med 2017 Sep;31(5):1551-1555.
                    doi: 10.1111/jvim.14783pubmed: 28661019google scholar: lookup
                  8. Islam MZ, Espinosa-Gongora C, Damborg P, Sieber RN, Munk R, Husted L, Moodley A, Skov R, Larsen J, Guardabassi L. Horses in Denmark Are a Reservoir of Diverse Clones of Methicillin-Resistant and -Susceptible Staphylococcus aureus. Front Microbiol 2017;8:543.
                    doi: 10.3389/fmicb.2017.00543pubmed: 28421046google scholar: lookup
                  9. Crombé F, Argudín MA, Vanderhaeghen W, Hermans K, Haesebrouck F, Butaye P. Transmission Dynamics of Methicillin-Resistant Staphylococcus aureus in Pigs. Front Microbiol 2013;4:57.
                    doi: 10.3389/fmicb.2013.00057pubmed: 23518663google scholar: lookup
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