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Animals : an open access journal from MDPI2020; 10(8); doi: 10.3390/ani10081403

Luminal and Mucosal Microbiota of the Cecum and Large Colon of Healthy and Diarrheic Horses.

Abstract: The aim of this study was to compare the mucosal and luminal content microbiota of the cecum and colon of healthy and diarrheic horses. Marked differences in the richness and in the community composition between the mucosal and luminal microbiota of the cecum and large colon of horses with colitis were observed. Microbial dysbiosis occurs in horses with colitis at different levels of the intestinal tract, and microbiota composition is different between the mucosa and luminal content of diarrheic horses. The changes in some key taxa associated with dysbiosis in the equine intestinal microbiota, such as Escherichia, Fusobacterium and Lactobacillus, deserve further inquiry in order to determine their utility for disease diagnosis and treatment.
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Publication Date: 2020-08-12 PubMed ID: 32806591PubMed Central: PMC7460328DOI: 10.3390/ani10081403Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study researched the differences in gut bacteria in the cecum and colon of healthy horses as compared to horses suffering from diarrhea. The researchers observed significant differences in the variety and composition of bacteria between the healthy and diseased horses. They also noted differences between the bacteria found on the intestinal lining (mucosal) and in the intestinal contents (lumens) of the diarrheic horses. Further research is needed to confirm if any specific bacteria could be used to diagnose or treat the disease.

Study Objective and Design

  • The aim of the study was to analyze and compare the microbiota (bacterial populations) found both in the luminal content, and on the mucosal lining of the cecum and large colon in healthy horses and those suffering from diarrhea (colitis).
  • The study was designed to understand the link between gut bacteria and the incidence of colitis in horses, and investigate if any changes in certain key bacteria could serve as a pointer towards disease diagnosis and treatment.

Key Findings

  • Marked differences were observed in the richness (diversity and abundance) and community composition (types and proportions) of the mucosal and luminal bacteria in the cecum and large colon of the horses suffering from colitis as compared to the healthy ones.
  • The research identified that microbial dysbiosis (imbalance or maladaptation in the microbiota) happens at different levels of the intestinal tract in horses with colitis, and the composition of microbiota is different between the mucosa and luminal content of diarrheic horses.

Implications and Future Research

  • The changes in specific types of bacteria, that are usually associated with dysbiosis in the equine intestinal microbiota, were given specific mention. The researchers suggested these changes potentially hold the key to disease diagnosis and treatment.
  • However, the study concluded that more in-depth research is necessary to clearly establish the functions and usability of these bacteria for any future diagnostic or therapeutic procedures.

Cite This Article

APA
Arroyo LG, Rossi L, Santos BP, Gomez DE, Surette MG, Costa MC. (2020). Luminal and Mucosal Microbiota of the Cecum and Large Colon of Healthy and Diarrheic Horses. Animals (Basel), 10(8). https://doi.org/10.3390/ani10081403

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 8

Researcher Affiliations

Arroyo, Luis G
  • Departments of Clinical Studies, Ontario Veterinary College, University of Guelph, University of Guelph, Guelph, ON N1G 2W1, Canada.
Rossi, Laura
  • Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
Santos, Bruna P
  • Departments of Clinical Studies, Ontario Veterinary College, University of Guelph, University of Guelph, Guelph, ON N1G 2W1, Canada.
Gomez, Diego E
  • Departments of Clinical Studies, Ontario Veterinary College, University of Guelph, University of Guelph, Guelph, ON N1G 2W1, Canada.
Surette, Michael G
  • Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada.
Costa, Marcio C
  • Department of Biomedical Sciences, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 6Z7, Canada.

Grant Funding

  • 052825 / Equine Guelph

Conflict of Interest Statement

The authors declare no conflicts of interest.

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