Understanding the Intestinal Microbiome in Health and Disease.

Costa, MC
·
Weese, JS

Abstract: This article provides readers with the basic concepts necessary to understand studies using recent molecular methods performed in intestinal microbiome assessment, with special emphasis on the high throughput sequencing. This review also summarizes the current knowledge on this topic and discusses future insights on the interaction between the intestinal microbiome and equine health.

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Publication Date: 2018-02-07 PubMed ID: 29402480DOI: 10.1016/j.cveq.2017.11.005Google Scholar: Lookup

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The research article explores concepts essential to understand studies conducted in intestinal microbiome assessment, emphasizing high throughput sequencing. It further provides the current knowledge in this field and discusses the correlation between the intestinal microbiome and equine health.

Understanding the Intestinal Microbiome

The research starts by introducing the topic of the intestinal microbiome. It highlights that the intestinal microbiome refers to the collection of microorganisms such as bacteria, viruses, and fungi that live in the intestinal tract. These organisms play a crucial role in health by influencing nutrients absorption, immune responses, and protection against pathogenic organisms.
The paper discusses how the researchers used molecular methods to assess the intestinal microbiome, with a special emphasis on high throughput sequencing. High throughput sequencing is a rapidly evolving technology that allows scientists to sequence DNA and RNA much more quickly and affordably than ever before. This method provides a more detailed and accurate depiction of the microbiome’s composition and function.

Current Findings and Future Directions

The article goes on to summarize the current understanding of the intestinal microbiome. It refers to various studies that have identified associations between the intestinal microbiome’s composition and various disease states. Evidence suggests that imbalances in the microbiome, known as dysbiosis, can contribute to conditions such as inflammatory bowel disease, obesity, and even mental health disorders.
Next, the paper focuses specifically on research related to equine health. Research shows that the equine intestinal microbiome plays a crucial role in horse health and disease. For instance, changes in the microbiome can impact a horse’s susceptibility to colic, laminitis, and other conditions. Therefore, it is reasoned that future research should explore this area more extensively.
The conclusion offers possibilities for future insights, hoping to broaden the understanding of how the intestinal microbiome interacts with equine health. By investigating the microbiome further, scientists can potentially develop new treatments or preventive measures for various health conditions that are connected to the balance of the microbiome.

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APA

Costa MC, Weese JS. (2018). Understanding the Intestinal Microbiome in Health and Disease. Vet Clin North Am Equine Pract, 34(1), 1-12. https://doi.org/10.1016/j.cveq.2017.11.005

Publication

The Veterinary clinics of North America. Equine practice

ISSN: 1558-4224

NlmUniqueID: 8511904

Country: United States

Language: English

Volume: 34

Issue: 1

Pages: 1-12

PII: S0749-0739(17)30918-5

Researcher Affiliations

Costa, Marcio Carvalho

Department of Veterinary Biomedicine, University of Montreal, 3200 Rue Sicotte, Saint-Hyacinthe, Quebec J2S 2M2, Canada. Electronic address: marcio.costa@umontreal.ca.

Weese, Jeffrey Scott

Department of Pathobiology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.

MeSH Terms

Animals
Gastrointestinal Microbiome
Horse Diseases / microbiology
Horses / microbiology
Humans

Citations

This article has been cited 42 times.

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