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Home / Equine Research Bank / Animals (Basel) / Lung Function Variation during the Estrus Cycle of Mares Aff...
Animals : an open access journal from MDPI2022; 12(4); 494; doi: 10.3390/ani12040494

Lung Function Variation during the Estrus Cycle of Mares Affected by Severe Asthma.

Abstract: While the prevalence of asthma is higher in boys than in girls during childhood, this tendency reverses at puberty, suggesting an effect of sex hormones on the disease pathophysiology. Fluctuations of asthma severity concurring with the estrus cycle are reported in women, but this phenomenon has never been investigated in mares to date. The objective of this exploratory study was to determine whether the estrus cycle modulates airway obstruction in severe equine asthma (SEA). Five mares with SEA during exacerbation of the disease were studied. The whole breath, expiratory and inspiratory resistance, and reactance were compared during the follicular and luteal phases of the estrus cycle. The reproductive tract was evaluated by rectal palpation, ultrasound, and serum progesterone levels. The inspiratory resistance and reactance improved during the luteal phase of the estrus cycle, and variation in progesterone levels and the dominant follicle size correlated with several lung function parameters. The fluctuation of airway dysfunction during the estrus cycle is noteworthy as deterioration of the disease could perhaps be expected and prevented by horse owners and veterinarians. Further studies are required to determine if the equine species could be a suitable model to evaluate the effects of sex hormones on asthma.
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Publication Date: 2022-02-17 PubMed ID: 35203202PubMed Central: PMC8868231DOI: 10.3390/ani12040494Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on investigating the potential influence of the estrus cycle on severe equine asthma (SEA) in mares. The study observes changes in lung function according to different phases of the estrus cycle and also suggests the possible use of the equine species as a model to evaluate the effects of sex hormones on asthma.

Objective of the Study

  • The primary aim of this exploratory research was to determine if the estrus cycle influences airway obstruction in mares affected by severe equine asthma (SEA).

Methodology

  • The study was conducted on five mares diagnosed with SEA during an exacerbation phase of the disease.
  • The key parameters of lung function studied included the whole breath, expiratory and inspiratory resistance, and reactance. These factors were compared during both the follicular and luteal phases of the estrus cycle.
  • The assessment of the reproductive tract was carried out using rectal palpation, ultrasound, and evaluating serum progesterone levels.

Findings

  • The study revealed that the inspiratory resistance and reactance improved during the luteal phase of the estrus cycle.
  • It also found a correlation between variations in progesterone levels and the size of the dominant follicle with several lung function parameters.

Significance and Future Directions

  • The discovery of airway dysfunction fluctuation during the estrus cycle is significant because it suggests that disease deterioration could potentially be anticipated and prevented by horse owners and veterinarians.
  • The study calls for further research to ascertain whether the equine species can be used as a suitable model for evaluating the effects of sex hormones on asthma in general.

Cite This Article

APA
Mainguy-Seers S, Diaw M, Lavoie JP. (2022). Lung Function Variation during the Estrus Cycle of Mares Affected by Severe Asthma. Animals (Basel), 12(4), 494. https://doi.org/10.3390/ani12040494

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 4
PII: 494

Researcher Affiliations

Mainguy-Seers, Sophie
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Diaw, Mouhamadou
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Lavoie, Jean-Pierre
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.

Grant Funding

  • PJT-148807 / CIHR
  • Doctoral student grant (272483) / Fonds de Recherche du Quu00e9bec - Santu00e9

Conflict of Interest Statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Citations

This article has been cited 5 times.
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