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Home / Equine Research Bank / Vet Surg / Meta-analysis of the effects of lidocaine on postoperative r...
Veterinary surgery : VS2019; 49(1); 44-52; doi: 10.1111/vsu.13286

Meta-analysis of the effects of lidocaine on postoperative reflux in the horse.

Abstract: To determine the efficacy of lidocaine at reducing incidence of postoperative reflux (POR) in horses by using quantitative statistical analysis. Methods: Systematic meta-analytical review. Methods: Studies on horses undergoing gastrointestinal surgery for small intestinal lesions, identified by systematic search between 2001 and 2017. Methods: A search with PubMed/MEDLINE, Web of Science, and Google Scholar was performed, followed by secondary searches of veterinary trade journals and bibliographies of relevant articles. The primary outcome measure for this study was the effect of lidocaine therapy on the odds of POR. Subgroup analysis assessed included the timing of lidocaine therapy, incidence of mortality, and incidence of repeat celiotomy. A meta-analysis was performed with a random effects model, with the effect size calculated as an odds ratio (OR) with 95% confidence intervals (CI). Statistical significance was set at P < .05. Results: Among 1933 peer reviewed publications that met the initial search criteria, 12 relevant studies were available for analysis. Lidocaine was associated with an increased incidence of diagnosis of POR (OR 6.3, 95% CI [1.4, 27.0], P = .01). Horses treated with lidocaine were more likely to survive to discharge (OR 6.8, 95% CI [3.9, 11.7], P < .01). Conclusions: Lidocaine was associated with an increased survival rate in horses undergoing exploratory celiotomy for small intestinal disease according to this meta-analysis of the recent literature. Conclusions: This body of published evidence provides support to administer lidocaine in horses to improve survival rather than preventing POR.
© 2019 The American College of Veterinary Surgeons.
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Publication Date: 2019-07-09 PubMed ID: 31290164DOI: 10.1111/vsu.13286Google Scholar: Lookup
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  • Journal Article
  • Meta-Analysis
  • Systematic Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article shows that lidocaine, while associated with an increased rate of postoperative reflux (POR) in horses, is also connected with a higher survival rate in horses undergoing exploratory surgery for small intestinal disease. The research was derived from a meta-analysis of studies conducted between 2001 and 2017.

Research Methodology

  • This study is a systematic meta-analytical review investigating the efficacy of lidocaine at reducing the instance of postoperative reflux (POR) in horses.
  • The researchers carried out a meticulous search for studies on horses that had undergone gastrointestinal surgery for small intestinal lesions from 2001 to 2017.
  • Multiple databases were utilized for this search, including PubMed/MEDLINE, Web of Science, and Google Scholar. Secondary searches were also conducted across veterinary trade journals and bibliographies of pertinent articles.
  • Two key outcome measures for this study included the effect of lidocaine therapy on POR odds and the incidence of mortality and repeated celiotomy.
  • A meta-analysis using a random effects model was employed. Here, the effect size was estimated as an odds ratio (OR) with a 95% confidence interval (CI). A P-value of less than 0.05 was deemed statistically significant.

Results

  • A total of 12 relevant studies were extracted from 1933 peer-reviewed publications that satisfied the initial search criteria.
  • The analysis revealed that lidocaine was linked to an increased diagnosis of POR. The odds ratio was 6.3, with a 95% confident interval between 1.4 and 27.0 and a P-value of 0.01.
  • Despite high POR rates, horses that received lidocaine treatment had a higher survival rate to discharge with OR of 6.8, 95% CI of 3.9 to 11.7, and P-value of less than 0.01.

Conclusions

  • While lidocaine was associated with an increased rate of POR, the survival rate for horses undergoing exploratory celiotomy for small intestinal disease significantly increased according to the accumulated literature.
  • These findings suggest that lidocaine can be administered to horses to enhance survival following intestinal surgery rather than to prevent POR.

Cite This Article

APA
Durket E, Gillen A, Kottwitz J, Munsterman A. (2019). Meta-analysis of the effects of lidocaine on postoperative reflux in the horse. Vet Surg, 49(1), 44-52. https://doi.org/10.1111/vsu.13286

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 49
Issue: 1
Pages: 44-52

Researcher Affiliations

Durket, Elyse
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa.
Gillen, Alexandra
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa.
Kottwitz, Jack
  • Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama.
Munsterman, Amelia
  • Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.

MeSH Terms

  • Administration, Intravenous / veterinary
  • Anesthetics, Local / administration & dosage
  • Animals
  • Digestive System Surgical Procedures / veterinary
  • Gastroesophageal Reflux / prevention & control
  • Gastroesophageal Reflux / veterinary
  • Horse Diseases / mortality
  • Horse Diseases / surgery
  • Horses
  • Intestinal Pseudo-Obstruction / surgery
  • Intestinal Pseudo-Obstruction / veterinary
  • Intestine, Small
  • Intraoperative Care / veterinary
  • Laparoscopy / adverse effects
  • Lidocaine / administration & dosage
  • Postoperative Complications / prevention & control
  • Postoperative Complications / veterinary
  • Survival Analysis

References

This article includes 25 references
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Citations

This article has been cited 2 times.
  1. Patton ME, Andrews FM, Bogers SH, Wong D, McKenzie HC 3rd, Werre SR, Byron CR. Effects of Bit Chewing on Gastric Emptying, Small Intestinal Transit, and Orocecal Transit Times in Clinically Normal Horses.. Animals (Basel) 2023 Aug 4;13(15).
    doi: 10.3390/ani13152518pubmed: 37570326google scholar: lookup
  2. Yau K, Halleran J, Boileau M, Foster D. Retrospective study on the use of lidocaine constant rate infusions for the treatment of ileus in ruminants and camelids.. J Vet Intern Med 2021 Nov;35(6):2933-2936.
    doi: 10.1111/jvim.16262pubmed: 34514646google scholar: lookup
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