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Home / Equine Research Bank / Metabolites / Metabolic Predictors of Equine Performance in Endurance Raci...
Metabolites2021; 11(2); doi: 10.3390/metabo11020082

Metabolic Predictors of Equine Performance in Endurance Racing.

Abstract: Equine performance in endurance racing depends on the interplay between physiological and metabolic processes. However, there is currently no parameter for estimating the readiness of animals for competition. Our objectives were to provide an in-depth characterization of metabolic consequences of endurance racing and to establish a metabolic performance profile for those animals. We monitored metabolite composition, using a broad non-targeted metabolomics approach, in blood plasma samples from 47 Arabian horses participating in endurance races. The samples were collected before and after the competition and a total of 792 metabolites were measured. We found significant alterations between before and after the race in 417 molecules involved in lipids and amino acid metabolism. Further, even before the race starts, we found metabolic differences between animals who completed the race and those who did not. We identified a set of six metabolite predictors (imidazole propionate, pipecolate, ethylmalonate, 2R-3R-dihydroxybutyrate, β-hydroxy-isovalerate and X-25455) of animal performance in endurance competition; the resulting model had an area under a receiver operating characteristic (AUC) of 0.92 (95% CI: 0.85-0.98). This study provides an in-depth characterization of metabolic alterations driven by endurance races in equines. Furthermore, we showed the feasibility of identifying potential metabolic signatures as predictors of animal performance in endurance competition.
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Publication Date: 2021-01-31 PubMed ID: 33572513PubMed Central: PMC7912089DOI: 10.3390/metabo11020082Google Scholar: Lookup
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  • Journal Article

Summary

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The research article explores the effects of endurance racing on the metabolic processes in Arabian horses and presents a set of six metabolic predictors that can estimate a horse’s performance in competition.

Objective of the Study

  • The research was aimed at understanding the physiological and metabolic factors that impact equine performance in endurance races.
  • The researchers sought to provide a thorough characterization of the metabolic changes in Arabian horses during endurance racing.
  • The study also aimed to establish a metabolic performance profile for Arabian horses taking part in endurance races, as there are currently no parameters for assessing readiness for competition.

Methodology

  • A comprehensive, non-targeted metabolomics approach was used to monitor the metabolite composition in blood plasma samples from 47 Arabian horses before and after they participated in endurance races.
  • The research team measured a total of 792 metabolites during the study.

Findings

  • The study found significant changes in 417 molecules involved in lipids and amino acid metabolism.
  • These changes were observed between the pre-race and post-race blood samples.
  • Interestingly, there were observable metabolic differences before the race even began, when comparing horses who successfully completed the race versus those who did not.

Predictors of Performance

  • The researchers identified a set of six metabolite predictors for performance in endurance racing, including imidazole propionate, pipecolate, ethylmalonate, 2R-3R-dihydroxybutyrate, β-hydroxy-isovalerate, and X-25455.
  • The resulting model, using these six metabolic predictors, had a high accuracy, with an area under a receiver operating characteristic (AUC) of 0.92 (95% CI: 0.85-0.98).

Conclusion

  • This study provides a comprehensive analysis of the metabolic fluidity induced by endurance races in Arabian horses.
  • It demonstrates that it is possible to identify metabolic markers as predictors of performance in endurance competition, offering potential tactics for preparing horses for competition and possibly limiting injury or early fatigue.

Cite This Article

APA
Halama A, Oliveira JM, Filho SA, Qasim M, Achkar IW, Johnson S, Suhre K, Vinardell T. (2021). Metabolic Predictors of Equine Performance in Endurance Racing. Metabolites, 11(2). https://doi.org/10.3390/metabo11020082

Publication

Metabolites
ISSN: 2218-1989
NlmUniqueID: 101578790
Country: Switzerland
Language: English
Volume: 11
Issue: 2

Researcher Affiliations

Halama, Anna
  • Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Oliveira, Joao M
  • Equine Veterinary Medical Center, Qatar Foundation, Doha 5825, Qatar.
Filho, Silvio A
  • Department of Endurance Racing, Al Shaqab, Doha 36623, Qatar.
Qasim, Muhammad
  • Equine Veterinary Medical Center, Qatar Foundation, Doha 5825, Qatar.
Achkar, Iman W
  • Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Johnson, Sarah
  • Equine Veterinary Medical Center, Qatar Foundation, Doha 5825, Qatar.
Suhre, Karsten
  • Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Vinardell, Tatiana
  • Equine Veterinary Medical Center, Qatar Foundation, Doha 5825, Qatar.
  • College of Health and Life Sciences, Hamad Bin Khalifa University, Member of Qatar Foundation, Doha 34110, Qatar.

Conflict of Interest Statement

The authors declare no conflict of interest.

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