Metabolic syndrome-From human organ disease to laminar failure in equids.
Abstract: Obesity, insulin resistance, hyperinsulinemia and hypertriglyceridemia are components of an equine metabolic syndrome phenotype associated with increased laminitis risk in horses. Links between these conditions and laminitis must still be elucidated, but human medicine provides candidate mechanisms for future study, including inflammation associated with obesity, vascular compromise induced by insulin resistance, and endothelial dysfunction. Just as metabolic syndrome has been linked to cardiovascular disease in humans, studies are now required to determine the exact mechanisms responsible for the increased predisposition to laminitis observed in horses with equine metabolic syndrome.
Publication Date: 2008-11-11 PubMed ID: 19110319DOI: 10.1016/j.vetimm.2008.11.012Google Scholar: Lookup
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Summary
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This research article investigates the connection between metabolic syndrome and the predisposition for laminar failure, specifically laminitis in horses. This study borrows concepts from human medicine, and recognizes inflammation related to obesity, vascular compromise due to insulin resistance, and endothelial dysfunction as possible mechanisms to guide future research.
Understanding the Research Context
- The focus of this study is on metabolic syndrome in horses, specifically looking at the relationship between the syndrome and an increased risk of laminitis. The research aims to provide more understanding based in human medicine that could guide future studies.
- Metabolic syndrome in horses involves obesity, insulin resistance, hyperinsulinemia, and hypertriglyceridemia. These conditions have been observed to have a strong association with an increased risk of laminitis, a serious and potentially debilitating hoof disease in horses.
Objective of the Research
- The research aims to identify the systemic links between these conditions and laminitis. It endeavours to shed light on how these conditions could be contributing to the onset of laminitis in horses.
- The objective furthermore is to apply the understanding of metabolic syndrome from human medicine to identify possible mechanisms leading to laminitis in horses.
Application of Human Medicine
- Using knowledge from human medicine, this study proposes key factors such as inflammation associated with obesity, vascular compromise induced by insulin resistance, and endothelial dysfunction as potential underlying mechanisms for laminitis.
- Just as human metabolic syndrome has been linked to cardiovascular disease, this study suggests that equine metabolic syndrome could be responsible for a higher susceptibility to laminitis in horses.
Future Research
- Regarding future research, more studies are needed to determine the exact mechanisms responsible for the heightened predisposition to laminitis observed in horses with the equine metabolic syndrome.
- The findings from these future studies would potentially lead to better prevention and treatment strategies for laminitis in horses, consequently improving their health and longevity.
Cite This Article
APA
Geor R, Frank N.
(2008).
Metabolic syndrome-From human organ disease to laminar failure in equids.
Vet Immunol Immunopathol, 129(3-4), 151-154.
https://doi.org/10.1016/j.vetimm.2008.11.012 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States. geor@cvm.msu.edu
MeSH Terms
- Animals
- Foot Diseases / etiology
- Foot Diseases / pathology
- Foot Diseases / veterinary
- Hoof and Claw
- Horse Diseases / etiology
- Horse Diseases / pathology
- Horses
- Humans
- Inflammation / etiology
- Inflammation / pathology
- Inflammation / veterinary
- Metabolic Syndrome / complications
- Metabolic Syndrome / pathology
- Metabolic Syndrome / veterinary
Citations
This article has been cited 5 times.- Storms N, Medina Torres C, Franck T, Sole Guitart A, de la Rebière G, Serteyn D. Presence of Myeloperoxidase in Lamellar Tissue of Horses Induced by an Euglycemic Hyperinsulinemic Clamp.. Front Vet Sci 2022;9:846835.
- Angelone M, Conti V, Biacca C, Battaglia B, Pecorari L, Piana F, Gnudi G, Leonardi F, Ramoni R, Basini G, Dotti S, Renzi S, Ferrari M, Grolli S. The Contribution of Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma to the Treatment of Chronic Equine Laminitis: A Proof of Concept.. Int J Mol Sci 2017 Oct 11;18(10).
- Peugnet P, Wimel L, Duchamp G, Sandersen C, Camous S, Guillaume D, Dahirel M, Dubois C, Jouneau L, Reigner F, Berthelot V, Chaffaux S, Tarrade A, Serteyn D, Chavatte-Palmer P. Enhanced or reduced fetal growth induced by embryo transfer into smaller or larger breeds alters post-natal growth and metabolism in pre-weaning horses.. PLoS One 2014;9(7):e102044.
- Lacombe VA. Expression and regulation of facilitative glucose transporters in equine insulin-sensitive tissue: from physiology to pathology.. ISRN Vet Sci 2014;2014:409547.
- Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer.. Equine Vet J 2010 Oct;42(7):658-70.
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