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The Veterinary record2016; 178(19); 473; doi: 10.1136/vr.103576

Meticillin-resistant Staphylococcus aureus colonisation and infection in Thoroughbred racehorses and veterinarians in Japan.

Abstract: Meticillin-resistant Staphylococcus aureus (MRSA) infections have been confirmed in hospitalised Thoroughbred racehorses at the hospitals of two training centres in Japan since 2009. To investigate the source of infection, the authors examined the rate of nasal MRSA colonisation in 600 healthy Thoroughbred racehorses, 53 veterinarians and 16 office staff at the racehorse hospitals of the two training centres. MRSA was not isolated from healthy Thoroughbred racehorses or hospital office staff. However, MRSA was isolated from 16 veterinarians (30.1 per cent), and the colonisation rate was significantly higher in veterinarians than in the office staff of the same hospitals. Also, 10 of the 16 MRSA strains (62.5 per cent) isolated from veterinarians were classified as type II by staphylococcal cassette chromosome mec (SCCmec) typing and ST5 by multilocus sequence typing. Pulsed-field gel electrophoresis analysis demonstrated that these 10 MRSA strains of SCCmec type II and ST5 were genetically identical or very similar to 9 MRSA strains isolated from infected horses hospitalised at these hospitals between 2009 and 2013. These results indicate that SCCmec type II and ST5 MRSA strains were probably transmitted between veterinarians and infected horses.
British Veterinary Association.
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Publication Date: 2016-04-25 PubMed ID: 27114407DOI: 10.1136/vr.103576Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigated the risk of methicillin-resistant Staphylococcus aureus (MRSA) colonisation among Thoroughbred racehorses and veterinarians in Japan. The research found that while MRSA was not detected in healthy horses or office staff, about 30% of veterinarians tested were colonized with MRSA. Interestingly, the MRSA strains identified in the veterinarians showed a high genetic similarity to strains previously found in infected horses, suggesting a probable transmission between the veterinarians and the horses.

Research Objectives and Context

  • The study aimed to investigate the sources of MRSA infections that have been confirmed in hospitalized Thoroughbred racehorses at two training centers in Japan since 2009.
  • To do this, the researchers examined the rate of nasal MRSA colonisation in a population that included healthy Thoroughbred racehorses, veterinarians, and office staff at the racehorse hospitals of the two training centres.

Methods

  • Samples were collected from 600 Thoroughbred racehorses, 53 veterinarians, and 16 office staff for MRSA detection.
  • The MRSA strains were categorized using staphylococcal cassette chromosome mec (SCCmec) typing, a method used to classify different strains of MRSA, and multilocus sequence typing.
  • Pulsed-field gel electrophoresis analysis, a technique used for the separation of large DNA molecules by applying a variable electrical field, was further used to evaluate the genetic relatedness of these MRSA strains.

Results

  • No MRSA strains were isolated from healthy Thoroughbred racehorses or office staff.
  • However, MRSA was detected in 16 veterinarians, which constituted approximately 30% of the sampled population.
  • Furthermore, the MRSA strains isolated from veterinarians were genetically identical or very similar to the MRSA strains identified in infected horses from the same hospitals between 2009 and 2013.

Implications

  • This study contributes important information to the understanding of MRSA transmission in veterinary health settings.
  • The researchers provided evidence for probable transmission of MRSA between racehorses and veterinarians in these hospital settings.
  • The results underscore the need for implementing biosecurity measures and infection control practices to mitigate the risk of MRSA transmission in veterinary hospitals.

Cite This Article

APA
Kuroda T, Kinoshita Y, Niwa H, Shinzaki Y, Tamura N, Hobo S, Kuwano A. (2016). Meticillin-resistant Staphylococcus aureus colonisation and infection in Thoroughbred racehorses and veterinarians in Japan. Vet Rec, 178(19), 473. https://doi.org/10.1136/vr.103576

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 178
Issue: 19
Pages: 473

Researcher Affiliations

Kuroda, T
  • Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association, Tokami-Cho 321-4, Utsunomiya, Tochigi 320-0856, Japan.
Kinoshita, Y
  • Microbiology Division, Epizootic Research Center, Equine Research Institute, Japan Racing Association, Shiba 1400-4, Shimotsuke, Tochigi 329-0412, Japan.
Niwa, H
  • Microbiology Division, Epizootic Research Center, Equine Research Institute, Japan Racing Association, Shiba 1400-4, Shimotsuke, Tochigi 329-0412, Japan.
Shinzaki, Y
  • Racehorse Clinic, Ritto Training Center, Japan Racing Association, Misono 1028, Ritto, Shiga 520-3085, Japan.
Tamura, N
  • Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association, Tokami-Cho 321-4, Utsunomiya, Tochigi 320-0856, Japan.
Hobo, S
  • Department of Domestic Animal Internal Medicine, Clinical Veterinary Science, Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, Kagoshima 890-0065, Japan.
Kuwano, A
  • Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association, Tokami-Cho 321-4, Utsunomiya, Tochigi 320-0856, Japan.

MeSH Terms

  • Animals
  • Cross Infection
  • Female
  • Horse Diseases / microbiology
  • Horses / microbiology
  • Hospitals, Animal
  • Humans
  • Infectious Disease Transmission, Patient-to-Professional
  • Infectious Disease Transmission, Professional-to-Patient
  • Japan
  • Male
  • Methicillin-Resistant Staphylococcus aureus / genetics
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Nasal Mucosa / microbiology
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / transmission
  • Staphylococcal Infections / veterinary
  • Veterinarians

Citations

This article has been cited 14 times.
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