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Microbial events in the hindgut during carbohydrate-induced equine laminitis.
Abstract: Equine laminitis is the most serious foot disease of the horse, often resulting in death or euthanasia. Laminitis has long been recognized as an affliction of horses, as has the association of this condition with the ingestion of carbohydrates. Research into the pathophysiology of this condition has been facilitated by the development of reliable models for experimentally inducing laminitis, and DNA-based techniques for profiling complex microbiomes have dramatically increased the knowledge of the microbiology of this disease. Recent studies have provided substantial evidence showing equine hindgut streptococcal species to be the most likely causative agent. Although these studies are not definitive, they provide the foundations for future work to determine the source of laminitis trigger factors and their mechanisms of action.
Copyright 2010 Elsevier Inc. All rights reserved.
Publication Date: 2010-04-13 PubMed ID: 20381737DOI: 10.1016/j.cveq.2010.01.007Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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Summary
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The research article discusses the role of microbial events in the hindgut during carbohydrate-induced laminitis in horses, a serious foot ailment predominantly linked with high carbohydrate intake. It investigates how certain bacterial species in the horse’s gut might be the main cause of this condition, and the findings are set to shape future research in identifying the true source of laminitis triggers and their effects.
Understanding Equine Laminitis
- Equine laminitis is a debilitating foot disease that often affects horses, leading to grave consequences such as death or euthanasia. The condition is chiefly related to the consumption of carbohydrates.
- This disease has been known to be a major issue in equine health for a long time, causing significant distress and discomfort to the animals. Much of the research has been dedicated to understanding the pathology of this disease and finding effective treatments.
Research Tools and Techniques
- Advancements in experimental methods for inducing laminitis, along with DNA-based techniques for profiling complex microbiomes, have paved the way for in-depth research into this disease’s microbiology. These developments have enabled researchers to delve into the probable causes and mechanisms at a microbial level.
- These techniques have opened up a new field of research into the microbiome of horses’ guts and how it may contribute to the development of conditions like laminitis.
Role of Hindgut Streptococcal Species in Laminitis
- Recent efforts have revealed significant evidence pointing towards streptococcal species in the horse’s hindgut as the potential underlying cause of laminitis. These bacterial species are believed to play a significant part in triggering the disease, especially when the diet is high in carbohydrates.
- Though these studies are not the final say on the matter, they set the groundwork for future research into identifying the exact triggers of laminitis and their modes of action within the horse’s gut. This understanding is crucial for developing accurate diagnostic tools and effective treatments for this debilitating disease.
Cite This Article
APA
Milinovich GJ, Klieve AV, Pollitt CC, Trott DJ.
(2010).
Microbial events in the hindgut during carbohydrate-induced equine laminitis.
Vet Clin North Am Equine Pract, 26(1), 79-94.
https://doi.org/10.1016/j.cveq.2010.01.007 Publication
Researcher Affiliations
- Australian Equine Laminitis Research Unit, School of Veterinary Science, The University of Queensland, St Lucia, Queensland 4072, Australia. g.milinovich@gmail.com
MeSH Terms
- Animal Nutritional Physiological Phenomena / physiology
- Animals
- Dietary Carbohydrates / administration & dosage
- Dietary Carbohydrates / adverse effects
- Dietary Carbohydrates / metabolism
- Disease Models, Animal
- Fatty Acids, Volatile / analysis
- Fatty Acids, Volatile / metabolism
- Foot Diseases / microbiology
- Foot Diseases / veterinary
- Gastrointestinal Tract / microbiology
- Hoof and Claw / pathology
- Horse Diseases / microbiology
- Horses
- Inflammation / microbiology
- Inflammation / veterinary
- Oligosaccharides / administration & dosage
- Oligosaccharides / adverse effects
- Oligosaccharides / metabolism
- Streptococcus / metabolism
Citations
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