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Animals : an open access journal from MDPI2021; 11(4); 1099; doi: 10.3390/ani11041099

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct.

Abstract: The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (, , ) and their receptors-, , , respectively, and (iv) the relative protein abundance of those receptors were assessed in cyclic mares' oviducts. The oviductal artery, arterioles and their ramifications, viewed by means of vascular injection-corrosion, differed in the infundibulum, ampulla and isthmus. The isthmus, immunostained with CD31, presented the largest vascular area and the highest number of vascular structures in the follicular phase. Transcripts (qPCR) and relative protein abundance (Western blot) of angiogenic factors fibroblast growth factor 1 ( and 2 ( and vascular endothelial growth factor (, and their respective receptors (, , ), were present in all oviduct portions throughout the estrous cycle. Upregulation of the transcripts of angiogenic receptors and in the ampulla and isthmus and of and in the isthmus were noted. Furthermore, in the isthmus, the relative protein abundance of FGFR1 and KDR was the highest. This study shows that the equine oviduct presents differences in microvascular density in its three portions. The angiogenic factors VEGF, FGF1, FGF2 and their respective receptors are expressed in all studied regions of the mare oviduct, in agreement with microvascular patterns.
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Publication Date: 2021-04-12 PubMed ID: 33921416PubMed Central: PMC8070128DOI: 10.3390/ani11041099Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper explores the distribution of blood vessels, as well as the genetic and protein expression of certain growth factors, in different sections of the mare oviduct throughout the estrous cycle. These growth factors stimulate blood vessel formation, a process important for fertilization and embryo development.

Research Methodology

The team focused its research on cyclic mares’ oviducts. The researchers utilized techniques like vascular injection-corrosion to visualize the layout and distribution of blood vessels, especially the oviductal artery, arterioles, and their branches, in different parts of the oviduct such as the infundibulum, ampulla, and isthmus. They used immunostaining with CD31 to quantify the vascular area and the number of vascular structures present in these sections.

  • RNA transcripts (qPCR) and relative protein abundance (Western blot) of angiogenic factors and their receptors were also measured in these regions.
  • The specific factors studied were fibroblast growth factor 1 (FGF1), fibroblast growth factor 2 (FGF2), and vascular endothelial growth factor (VEGF), along with their respective receptors FGFR1, KDR, and FGFR2.

Research Findings

The findings of the study showed distinct differences in microvascular density among the three sections of the oviduct. It was revealed that the isthmus presented the largest vascular area and the highest number of vascular structures in the follicular phase, which is part of the estrous cycle.

  • The angiogenic factors and their receptors were found to be present in all parts of the oviduct, throughout the estrous cycle, which ties in with the observed microvascular patterns.
  • Increases in the transcription of certain angiogenic receptors, such as FGFR1 and KDR, were noted in the ampulla and isthmus sections, and of FGFR2 and KDR in the isthmus area.
  • In terms of protein abundance, FGFR1 and KDR were notably high in the isthmus section.

Conclusion

The research concludes that there are differences in microvascular density across the three portions of the equine oviduct, and that angiogenic factors VEGF, FGF1, FGF2 and their receptors FGFR1, KDR, and FGFR2 are expressed throughout the mare oviduct in agreement with these microvascular patterns. These findings suggest that these factors might play a significant role in horse reproduction, particularly during fertilisation and early embryonic development.

Cite This Article

APA
Pinto-Bravo P, Rebordão MR, Amaral A, Fernandes C, Galvão A, Silva E, Pessa-Santos P, Alexandre-Pires G, Roberto da Costa RP, Skarzynski DJ, Ferreira-Dias G. (2021). Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct. Animals (Basel), 11(4), 1099. https://doi.org/10.3390/ani11041099

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 4
PII: 1099

Researcher Affiliations

Pinto-Bravo, Pedro
  • CERNAS (Research Center for Natural Resources, Environment and Society), Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal.
  • Coimbra College of Agriculture, Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal.
Rebordão, Maria Rosa
  • Coimbra College of Agriculture, Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal.
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Amaral, Ana
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Fernandes, Carina
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Galvão, António
  • Institute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.
Silva, Elisabete
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Pessa-Santos, Pedro
  • Hospitals of the University of Coimbra, 3004-561 Coimbra, Portugal.
Alexandre-Pires, Graça
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Roberto da Costa, Rosário P
  • CERNAS (Research Center for Natural Resources, Environment and Society), Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal.
  • Coimbra College of Agriculture, Polytechnic Institute of Coimbra, 3045-601 Coimbra, Portugal.
Skarzynski, Dariusz J
  • Institute of Animal Reproduction and Food Research, Polish Academy of Science, 10-748 Olsztyn, Poland.
Ferreira-Dias, Graça
  • CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.

Grant Funding

  • PTDC/CVT-REP/4202/2014 / Fundau00e7u00e3o para a Ciu00eancia e a Tecnologia
  • UIDB/00276/2020 / Fundau00e7u00e3o para a Ciu00eancia e a Tecnologia
  • No. PPN/BIL/2018/1/00250/U/0001 / Narodowa Agencja Wymiany Akademickiej

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 62 references
  1. Gadella BM, Rathi R, Brouwers JF, Stout TA, Colenbrander B. Capacitation and the acrosome reaction in equine sperm.. Anim Reprod Sci 2001 Dec 3;68(3-4):249-65.
    doi: 10.1016/S0378-4320(01)00161-0pubmed: 11744269google scholar: lookup
  2. Goudet G. Fertilisation in the horse and paracrine signalling in the oviduct.. Reprod Fertil Dev 2011;23(8):941-51.
    doi: 10.1071/RD10285pubmed: 22127000google scholar: lookup
  3. Leemans B, Gadella BM, Stout TA, De Schauwer C, Nelis H, Hoogewijs M, Van Soom A. Why doesn't conventional IVF work in the horse? The equine oviduct as a microenvironment for capacitation/fertilization.. Reproduction 2016 Dec;152(6):R233-R245.
    doi: 10.1530/REP-16-0420pubmed: 27651517google scholar: lookup
  4. Pérez-Cerezales S, Ramos-Ibeas P, Acuña OS, Avilés M, Coy P, Rizos D, Gutiérrez-Adán A. The oviduct: from sperm selection to the epigenetic landscape of the embryo.. Biol Reprod 2018 Mar 1;98(3):262-276.
    doi: 10.1093/biolre/iox173pubmed: 29228115google scholar: lookup
  5. Saint-Dizier M, Schoen J, Chen S, Banliat C, Mermillod P. Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions.. Int J Mol Sci 2019 Dec 28;21(1).
    doi: 10.3390/ijms21010223pmc: PMC6982147pubmed: 31905654google scholar: lookup
  6. Nelis H, Vanden Bussche J, Wojciechowicz B, Franczak A, Vanhaecke L, Leemans B, Cornillie P, Peelman L, Van Soom A, Smits K. Steroids in the equine oviduct: synthesis, local concentrations and receptor expression.. Reprod Fertil Dev 2015 Mar 10;.
    doi: 10.1071/RD14483pubmed: 25751414google scholar: lookup
  7. Reynolds LP, Killilea SD, Redmer DA. Angiogenesis in the female reproductive system.. FASEB J 1992 Feb 1;6(3):886-92.
    doi: 10.1096/fasebj.6.3.1371260pubmed: 1371260google scholar: lookup
  8. Redmer DA, Reynolds LP. Angiogenesis in the ovary.. Rev Reprod 1996 Sep;1(3):182-92.
    doi: 10.1530/ror.0.0010182pubmed: 9414456google scholar: lookup
  9. Yao C, Narumiya S. Prostaglandin-cytokine crosstalk in chronic inflammation.. Br J Pharmacol 2019 Feb;176(3):337-354.
    doi: 10.1111/bph.14530pmc: PMC6329627pubmed: 30381825google scholar: lookup
  10. López Albors O, Olsson F, Llinares AB, Gutiérrez H, Latorre R, Candanosa E, Guillén-Martínez A, Izquierdo-Rico MJ. Expression of the vascular endothelial growth factor system (VEGF) in the porcine oviduct during the estrous cycle.. Theriogenology 2017 Apr 15;93:46-54.
    doi: 10.1016/j.theriogenology.2017.01.028pubmed: 28257866google scholar: lookup
  11. Vailhé B, Feige JJ. Thrombospondins as anti-angiogenic therapeutic agents.. Curr Pharm Des 2003;9(7):583-8.
    doi: 10.2174/1381612033391342pubmed: 12570805google scholar: lookup
  12. Albini A, Brigati C, Ventura A, Lorusso G, Pinter M, Morini M, Mancino A, Sica A, Noonan DM. Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target.. J Transl Med 2009 Jan 14;7:5.
    doi: 10.1186/1479-5876-7-5pmc: PMC2630934pubmed: 19144161google scholar: lookup
  13. Garside SA, Harlow CR, Hillier SG, Fraser HM, Thomas FH. Thrombospondin-1 inhibits angiogenesis and promotes follicular atresia in a novel in vitro angiogenesis assay.. Endocrinology 2010 Mar;151(3):1280-9.
    doi: 10.1210/en.2009-0686pubmed: 20080874google scholar: lookup
  14. Lam PM, Briton-Jones C, Cheung CK, Lok IH, Yuen PM, Cheung LP, Haines C. Vascular endothelial growth factor in the human oviduct: localization and regulation of messenger RNA expression in vivo.. Biol Reprod 2003 May;68(5):1870-6.
    doi: 10.1095/biolreprod.102.012674pubmed: 12606391google scholar: lookup
  15. Wollenhaupt K, Welter H, Einspanier R, Manabe N, Brüssow KP. Expression of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation.. J Reprod Dev 2004 Jun;50(3):269-78.
    doi: 10.1262/jrd.50.269pubmed: 15226591google scholar: lookup
  16. Roberto da Costa RP, Ferreira-Dias G, Mateus L, Korzekwa A, Andronowska A, Platek R, Skarzynski DJ. Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrous cycle.. Domest Anim Endocrinol 2007 May;32(4):287-302.
    doi: 10.1016/j.domaniend.2006.03.007pubmed: 16647832google scholar: lookup
  17. Roberto da Costa RP, Costa AS, Korzekwa AJ, Platek R, Siemieniuch M, Galvão A, Redmer DA, Silva JR, Skarzynski DJ, Ferreira-Dias G. Actions of a nitric oxide donor on prostaglandin production and angiogenic activity in the equine endometrium.. Reprod Fertil Dev 2008;20(6):674-83.
    doi: 10.1071/RD08015pubmed: 18671915google scholar: lookup
  18. Wang XQ, Zhou WJ, Luo XZ, Tao Y, Li DJ. Synergistic effect of regulatory T cells and proinflammatory cytokines in angiogenesis in the endometriotic milieu.. Hum Reprod 2017 Jun 1;32(6):1304-1317.
    doi: 10.1093/humrep/dex067pubmed: 28383711google scholar: lookup
  19. Adair T.H., Montani J.P.. Angiogenesis. .
  20. García-Martínez S, Sánchez Hurtado MA, Gutiérrez H, Sánchez Margallo FM, Romar R, Latorre R, Coy P, López Albors O. Mimicking physiological O2 tension in the female reproductive tract improves assisted reproduction outcomes in pig.. Mol Hum Reprod 2018 May 1;24(5):260-270.
    doi: 10.1093/molehr/gay008pubmed: 29490063google scholar: lookup
  21. Fagiani E, Christofori G. Angiopoietins in angiogenesis.. Cancer Lett 2013 Jan 1;328(1):18-26.
    doi: 10.1016/j.canlet.2012.08.018pubmed: 22922303google scholar: lookup
  22. Godin P, Tsoi M, Paquet M, Boerboom D. YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct.. Reproduction 2020 Aug;160(2):307-318.
    doi: 10.1530/REP-20-0202pubmed: 32520726google scholar: lookup
  23. Hooglugt A, van der Stoel MM, Boon RA, Huveneers S. Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature.. Front Oncol 2020;10:612802.
    doi: 10.3389/fonc.2020.612802pmc: PMC7890025pubmed: 33614496google scholar: lookup
  24. Folkman J, Klagsbrun M. Angiogenic factors.. Science 1987 Jan 23;235(4787):442-7.
    doi: 10.1126/science.2432664pubmed: 2432664google scholar: lookup
  25. Turner N, Lambros MB, Horlings HM, Pearson A, Sharpe R, Natrajan R, Geyer FC, van Kouwenhove M, Kreike B, Mackay A, Ashworth A, van de Vijver MJ, Reis-Filho JS. Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.. Oncogene 2010 Apr 8;29(14):2013-23.
    doi: 10.1038/onc.2009.489pmc: PMC2852518pubmed: 20101236google scholar: lookup
  26. Galvão A, Henriques S, Pestka D, Lukasik K, Skarzynski D, Mateus LM, Ferreira-Dias GM. Equine luteal function regulation may depend on the interaction between cytokines and vascular endothelial growth factor: an in vitro study.. Biol Reprod 2012 Jun;86(6):187.
    doi: 10.1095/biolreprod.111.097147pubmed: 22492973google scholar: lookup
  27. Galvão AM, Ferreira-Dias G, Skarzynski DJ. Cytokines and angiogenesis in the corpus luteum.. Mediators Inflamm 2013;2013:420186.
    doi: 10.1155/2013/420186pmc: PMC3693155pubmed: 23840095google scholar: lookup
  28. Galvão AM, Skarzynski D, Ferreira-Dias G. Luteolysis and the Auto-, Paracrine Role of Cytokines From Tumor Necrosis Factor α and Transforming Growth Factor β Superfamilies.. Vitam Horm 2018;107:287-315.
    doi: 10.1016/bs.vh.2018.01.001pubmed: 29544635google scholar: lookup
  29. Hess AP, Talbi S, Hamilton AE, Baston-Buest DM, Nyegaard M, Irwin JC, Barragan F, Kruessel JS, Germeyer A, Giudice LC. The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit.. Reprod Biomed Online 2013 Oct;27(4):423-35.
    doi: 10.1016/j.rbmo.2013.06.013pmc: PMC3950339pubmed: 23953067google scholar: lookup
  30. Stuttfeld E, Ballmer-Hofer K. Structure and function of VEGF receptors.. IUBMB Life 2009 Sep;61(9):915-22.
    doi: 10.1002/iub.234pubmed: 19658168google scholar: lookup
  31. Wijayagunawardane MP, Kodithuwakku SP, Yamamoto D, Miyamoto A. Vascular endothelial growth factor system in the cow oviduct: a possible involvement in the regulation of oviductal motility and embryo transport.. Mol Reprod Dev 2005 Dec;72(4):511-20.
    doi: 10.1002/mrd.20379pubmed: 16155957google scholar: lookup
  32. Małysz-Cymborska I, Andronowska A. Expression of the vascular endothelial growth factor receptor system in porcine oviducts after induction of ovulation and superovulation.. Domest Anim Endocrinol 2014 Oct;49:86-95.
    doi: 10.1016/j.domaniend.2014.06.003pubmed: 25124278google scholar: lookup
  33. Javerzat S, Auguste P, Bikfalvi A. The role of fibroblast growth factors in vascular development.. Trends Mol Med 2002 Oct;8(10):483-9.
    doi: 10.1016/S1471-4914(02)02394-8pubmed: 12383771google scholar: lookup
  34. Cross MJ, Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition.. Trends Pharmacol Sci 2001 Apr;22(4):201-7.
    doi: 10.1016/S0165-6147(00)01676-Xpubmed: 11282421google scholar: lookup
  35. Berisha B, Sinowatz F, Schams D. Expression and localization of fibroblast growth factor (FGF) family members during the final growth of bovine ovarian follicles.. Mol Reprod Dev 2004 Feb;67(2):162-71.
    doi: 10.1002/mrd.10386pubmed: 14694431google scholar: lookup
  36. Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.. Cytokine Growth Factor Rev 2005 Apr;16(2):159-78.
    doi: 10.1016/j.cytogfr.2005.01.004pubmed: 15863032google scholar: lookup
  37. Ferreira-Dias GM, Serrão PM, Durão JF, Silva JR. Microvascular development and growth of uterine tissue during the estrous cycle in mares.. Am J Vet Res 2001 Apr;62(4):526-30.
    doi: 10.2460/ajvr.2001.62.526pubmed: 11327459google scholar: lookup
  38. Ferreira-Dias G, Bravo PP, Mateus L, Redmer DA, Medeiros JA. Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle.. Domest Anim Endocrinol 2006 May;30(4):247-59.
    doi: 10.1016/j.domaniend.2005.07.007pubmed: 16140491google scholar: lookup
  39. Rebordão MR, Amaral A, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão A, Skarzynski DJ, Ferreira-Dias G. Impairment of the antifibrotic prostaglandin E(2) pathway may influence neutrophil extracellular traps-induced fibrosis in the mare endometrium.. Domest Anim Endocrinol 2019 Apr;67:1-10.
    doi: 10.1016/j.domaniend.2018.10.004pubmed: 30522057google scholar: lookup
  40. Alexandre-Pires G.. Vascularization of rabbit term placenta (Oryctolagus cuniculus). Braz. J. Morphol. Sci. 1998;15:95–106.
  41. Pinto-Bravo P, Galvão A, Rebordão MR, Amaral A, Ramilo D, Silva E, Szóstek-Mioduchowska A, Alexandre-Pires G, Roberto da Costa R, Skarzynski DJ, Ferreira-Dias G. Ovarian steroids, oxytocin, and tumor necrosis factor modulate equine oviduct function.. Domest Anim Endocrinol 2017 Oct;61:84-99.
    doi: 10.1016/j.domaniend.2017.06.005pubmed: 28753494google scholar: lookup
  42. Rebordão MR, Amaral A, Lukasik K, Szóstek-Mioduchowska A, Pinto-Bravo P, Galvão A, Skarzynski DJ, Ferreira-Dias G. Constituents of neutrophil extracellular traps induce in vitro collagen formation in mare endometrium.. Theriogenology 2018 Jun;113:8-18.
    doi: 10.1016/j.theriogenology.2018.02.001pubmed: 29452855google scholar: lookup
  43. Dheda K, Huggett JF, Bustin SA, Johnson MA, Rook G, Zumla A. Validation of housekeeping genes for normalizing RNA expression in real-time PCR.. Biotechniques 2004 Jul;37(1):112-4, 116, 118-9.
    doi: 10.2144/04371RR03pubmed: 15283208google scholar: lookup
  44. Zhao S, Fernald RD. Comprehensive algorithm for quantitative real-time polymerase chain reaction.. J Comput Biol 2005 Oct;12(8):1047-64.
    doi: 10.1089/cmb.2005.12.1047pmc: PMC2716216pubmed: 16241897google scholar: lookup
  45. Verco CJ, Gannon BJ, Jones WR. Variations in rabbit oviduct microvascular architecture after ovulation induced by hCG.. J Reprod Fertil 1984 Sep;72(1):15-9.
    doi: 10.1530/jrf.0.0720015pubmed: 6471044google scholar: lookup
  46. Verco CJ, Gannon BJ, Jones WR. Microvascular architecture of the pregnant rabbit oviduct.. Acta Anat (Basel) 1984;118(3):167-70.
    doi: 10.1159/000145839pubmed: 6464642google scholar: lookup
  47. Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch.. Dev Cell 2009 Feb;16(2):196-208.
    doi: 10.1016/j.devcel.2009.01.015pubmed: 19217422google scholar: lookup
  48. Rouwkema J, Khademhosseini A. Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks.. Trends Biotechnol 2016 Sep;34(9):733-745.
    doi: 10.1016/j.tibtech.2016.03.002pubmed: 27032730google scholar: lookup
  49. Gabler C, Einspanier A, Schams D, Einspanier R. Expression of vascular endothelial growth factor (VEGF) and its corresponding receptors (flt-1 and flk-1) in the bovine oviduct.. Mol Reprod Dev 1999 Aug;53(4):376-83.
    doi: 10.1002/(SICI)1098-2795(199908)53:4<376::AID-MRD2>3.0.CO;2-Zpubmed: 10398412google scholar: lookup
  50. Lam PM, Briton-Jones C, Cheung CK, Lok IH, Cheung LP, Haines C. In vivo regulation of mRNA expression of vascular endothelial growth factor receptors (KDR and flt-1) in the human oviduct.. Fertil Steril 2004 Feb;81(2):416-23.
    doi: 10.1016/j.fertnstert.2003.06.025pubmed: 14967383google scholar: lookup
  51. Guo X, Yi H, Li TC, Wang Y, Wang H, Chen X. Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications.. Biomolecules 2021 Feb 10;11(2).
    doi: 10.3390/biom11020253pmc: PMC7916576pubmed: 33578823google scholar: lookup
  52. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor.. Endocr Rev 1997 Feb;18(1):4-25.
    doi: 10.1210/edrv.18.1.0287pubmed: 9034784google scholar: lookup
  53. Baffert F, Le T, Sennino B, Thurston G, Kuo CJ, Hu-Lowe D, McDonald DM. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling.. Am J Physiol Heart Circ Physiol 2006 Feb;290(2):H547-59.
    doi: 10.1152/ajpheart.00616.2005pubmed: 16172161google scholar: lookup
  54. Sia D, Alsinet C, Newell P, Villanueva A. VEGF signaling in cancer treatment.. Curr Pharm Des 2014;20(17):2834-42.
    doi: 10.2174/13816128113199990590pubmed: 23944367google scholar: lookup
  55. Tasaki Y, Nishimura R, Shibaya M, Lee HY, Acosta TJ, Okuda K. Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells.. J Reprod Dev 2010 Apr;56(2):223-9.
    doi: 10.1262/jrd.09-139Spubmed: 20035107google scholar: lookup
  56. Thisse B, Thisse C. Functions and regulations of fibroblast growth factor signaling during embryonic development.. Dev Biol 2005 Nov 15;287(2):390-402.
    doi: 10.1016/j.ydbio.2005.09.011pubmed: 16216232google scholar: lookup
  57. Katsahambas S, Hearn MT. Localization of basic fibroblast growth factor mRNA (FGF-2 mRNA) in the uterus of mated and unmated gilts.. J Histochem Cytochem 1996 Nov;44(11):1289-301.
    doi: 10.1177/44.11.8918904pubmed: 8918904google scholar: lookup
  58. Gupta A, Bazer FW, Jaeger LA. Immunolocalization of acidic and basic fibroblast growth factors in porcine uterine and conceptus tissues.. Biol Reprod 1997 Jun;56(6):1527-36.
    doi: 10.1095/biolreprod56.6.1527pubmed: 9166706google scholar: lookup
  59. Grazul-Bilska AT, Redmer DA, Jablonka-Shariff A, Biondini ME, Reynolds LP. Proliferation and progesterone production of ovine luteal cells from several stages of the estrous cycle: effects of fibroblast growth factors and luteinizing hormone.. Can J Physiol Pharmacol 1995 Apr;73(4):491-500.
    doi: 10.1139/y95-062pubmed: 7545534google scholar: lookup
  60. Gabler C, Lauer B, Einspanier A, Schams D, Einspanier R. Detection of mRNA and immunoreactive proteins for acidic and basic fibroblast growth factor and expression of the fibroblast growth factor receptors in the bovine oviduct.. J Reprod Fertil 1997 Mar;109(2):213-21.
    doi: 10.1530/jrf.0.1090213pubmed: 9155730google scholar: lookup
  61. Saucedo L, Sobarzo C, Brukman NG, Guidobaldi HA, Lustig L, Giojalas LC, Buffone MG, Vazquez-Levin MH, Marín-Briggiler C. Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology.. Reproduction 2018 Aug;156(2):163-172.
    doi: 10.1530/REP-18-0133pubmed: 29866768google scholar: lookup
  62. Grazul-Bilska A.T., Redmer D.A., Reynolds L.P.. Growth factors during ovarian angiogenesis. In: Augustin H.G., Iruela-Arispe M.L., Roger P.A.W., Smith S.K., editors. Vascular Morphogenesis in the Female Reproductive System. Birkhauser; Boston, MA, USA: 2001. pp. 131–147.

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    doi: 10.3389/fvets.2022.1016191pubmed: 36504863google scholar: lookup
  2. Neto da Silva AC, Costa AL, Teixeira A, Alpoim-Moreira J, Fernandes C, Fradinho MJ, Rebordão MR, Silva E, Ferreira da Silva J, Bliebernicht M, Alexandre-Pires G, Ferreira-Dias G. Collagen and Microvascularization in Placentas From Young and Older Mares. Front Vet Sci 2021;8:772658.
    doi: 10.3389/fvets.2021.772658pubmed: 35059454google scholar: lookup
  3. Ahmadi K, Reiisi S, Habibi Z. Comparison of the gene expression profiles of endometrial and trophoblastic cells in women with recurrent miscarriage: A bioinformatics approach. Int J Reprod Biomed 2024 Jun;22(6):495-506.
    doi: 10.18502/ijrm.v22i6.16800pubmed: 39205919google scholar: lookup
  4. Finding EJT, Faulkner A, Nash L, Wheeler-Jones CPD. Equine Endothelial Cells Show Pro-Angiogenic Behaviours in Response to Fibroblast Growth Factor 2 but Not Vascular Endothelial Growth Factor A. Int J Mol Sci 2024 May 30;25(11).
    doi: 10.3390/ijms25116017pubmed: 38892205google scholar: lookup
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