Multiple peripheral nerve sheath tumors in the small intestine of a horse.
Abstract: Multiple neurofibromas, schwannomas, and hyperplastic enteric plexuses were observed in the distal jejunum and ileum of a 6-year-old pinto gelding. The animal was presented because of an acute episode of colic. Three meters of distal small intestine, partially incarcerated in the epiploic foramen, were surgically removed. Numerous tumor nodules up to 10 mm in diameter were found adjacent to a Meckel's diverticulum, predominantly located in the subserosa of a hypertrophic segment. Histologically, tumors were well demarcated and composed of interlacing fascicles formed by spindloid cells. Adjacent enteric plexuses were hyperplastic. Immunohistochemically, all tumors were positive for vimentin and S-100. Desmin immunoreactivity was only observed in larger tumors (> 500 microns). Glial fibrillary acid protein was demonstrated nearly exclusively in smaller ones. Immunostaining for neurofilament was restricted to entrapped ganglion cells. Based on conventional light microscopic examination and immunohistochemical evaluation, the lesion was diagnosed as multiple benign peripheral nerve sheath tumors in the small intestine.
Publication Date: 1996-11-01 PubMed ID: 8952038DOI: 10.1177/030098589603300618Google Scholar: Lookup
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Summary
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The research investigates the occurrence of multiple nerve sheath tumors in the small intestine of a six-year-old horse. These tumors consisted of neurofibromas, schwannomas, and hyperplastic enteric plexuses, which led to an acute episode of colic.
Study Background
- The research is based on a case study of a 6-year-old Pinto gelding horse, who suffered an acute episode of colic. This was found to be caused by multiple nerve sheath tumors in its small intestine.
- A portion of the horse’s small intestine was surgically removed due to partial incarceration in the epiploic foramen. This revealed the presence of numerous tumor nodules.
Tumor Characteristics
- The tumors, found in close proximity to a Meckel’s diverticulum, were primarily located in the subserosa of a hypertrophic segment. They varied in size, with some reaching up to 10mm in diameter.
- Under histological examination, the tumors were well-demarcated and found to be composed of interlacing fascicles formed by spindle cells. The enteric plexuses adjacent to the tumors were hyperplastic, meaning they contained an excessive number of cells.
Immunohistochemical Investigation
- Immunohistochemical testing was used to further study the tumors. All of them tested positive for vimentin and S-100 proteins.
- Desmin immunoreactivity, a specific type of staining utilized to visualize certain types of cells, was observed only in the larger tumors, those above 500 microns in size.
- On the other hand, glial fibrillary acid protein was largely demonstrated in the smaller tumors.
- Lastly, immunostaining for a protein called neurofilament, which forms part of the cytoskeleton in neurons, was restricted to trapped ganglion cells. Ganglion cells are responsible for processing and transmitting information in the nervous system.
Conclusion
- Based on the findings from the light microscopic examination and immunohistochemical evaluation, it was diagnosed that the horse had multiple benign peripheral nerve sheath tumors in its small intestine.
- The study does not delve deeper into potential treatment methods or the prognosis for the horse, highlighting the need for further research.
Cite This Article
APA
Kirchhof N, Scheidemann W, Baumgärtner W.
(1996).
Multiple peripheral nerve sheath tumors in the small intestine of a horse.
Vet Pathol, 33(6), 727-730.
https://doi.org/10.1177/030098589603300618 Publication
Researcher Affiliations
- Institut für Veterinär-Pathologie, Giessen, Germany. nicole.kirchhof@vetmed.uni-giessen.de
MeSH Terms
- Animals
- Desmin / analysis
- Desmin / metabolism
- Glial Fibrillary Acidic Protein / analysis
- Glial Fibrillary Acidic Protein / metabolism
- Horse Diseases / diagnosis
- Horse Diseases / metabolism
- Horse Diseases / pathology
- Horses
- Ileal Neoplasms / chemistry
- Ileal Neoplasms / diagnosis
- Ileal Neoplasms / veterinary
- Ileum / chemistry
- Ileum / innervation
- Ileum / pathology
- Immunohistochemistry
- Jejunal Neoplasms / chemistry
- Jejunal Neoplasms / diagnosis
- Jejunal Neoplasms / veterinary
- Jejunum / chemistry
- Jejunum / innervation
- Jejunum / pathology
- Male
- Nerve Sheath Neoplasms / chemistry
- Nerve Sheath Neoplasms / diagnosis
- Nerve Sheath Neoplasms / veterinary
- Neurofilament Proteins / analysis
- Neurofilament Proteins / metabolism
- Peripheral Nervous System Neoplasms / chemistry
- Peripheral Nervous System Neoplasms / diagnosis
- Peripheral Nervous System Neoplasms / veterinary
- S100 Proteins / analysis
- S100 Proteins / metabolism
- Vimentin / analysis
- Vimentin / metabolism
Citations
This article has been cited 3 times.- Rinnovati R, Xenos S, Beltrame A, Marigo A, Forni G, Morini M. Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse. J Equine Sci 2020 Oct;31(3):45-48.
- Ribas A, Miller R, Rasotto R. Small intestinal peripheral nerve sheath tumour in a cat. JFMS Open Rep 2017 Jan-Jun;3(1):2055116917710394.
- Resende TP, Pereira CE, Vannucci FA, Araujo FS, dos Santos JL, Cassali GD, Damasceno KA, Guedes RM. Malignant peripheral nerve sheath tumour in a sow. Acta Vet Scand 2015 Sep 25;57:56.
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