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Home / Equine Research Bank / BMC Microbiol / Multiresistant extended-spectrum β-lactamase-producing...
BMC microbiology2014; 14; 187; doi: 10.1186/1471-2180-14-187

Multiresistant extended-spectrum β-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany.

Abstract: Multiresistant Gram-negative bacteria producing extended-spectrum β-lactamases (ESBLs) are an emerging problem in human and veterinary medicine. This study focused on comparative molecular characterization of β-lactamase and ESBL-producing Enterobacteriaceae isolates from central Hesse in Germany. Isolates originated from humans, companion animals (dogs and cats) and horses. Results: In this study 153 (83.6%) of the human isolates (n = 183) and 163 (91.6%) of the animal isolates (n = 178) were confirmed as ESBL producers by PCR and subsequent sequencing of the PCR amplicons. Predominant ESBL subtypes in human and animal samples were CTX-M-15 (49.3%) and CTX-M-1 (25.8%) respectively. Subtype blaCTX-M-2 was found almost exclusively in equine and was absent from human isolates. The carbapenemase OXA-48 was detected in 19 ertapenem-resistant companion animal isolates in this study. The Plasmid-encoded quinolone resistance (PMQR) gene aac('6)-Ib-cr was the most frequently detected antibiotic- resistance gene present in 27.9% of the human and 36.9% of the animal ciprofloxacin-resistant isolates. Combinations of two or up to six different resistance genes (penicillinases, ESBLs and PMQR) were detected in 70% of all isolates investigated. The most frequent species in this study was Escherichia coli (74%), followed by Klebsiella pneumoniae (17.5%), and Enterobacter cloacae (4.2%). Investigation of Escherichia coli phylogenetic groups revealed underrepresentation of group B2 within the animal isolates. Conclusions: Isolates from human, companion animals and horses shared several characteristics regarding presence of ESBL, PMQR and combination of different resistance genes. The results indicate active transmission and dissemination of multi-resistant Enterobacteriaceae among human and animal populations.
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Publication Date: 2014-07-12 PubMed ID: 25014994PubMed Central: PMC4105247DOI: 10.1186/1471-2180-14-187Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research points to a widespread problem of bacteria resistant to antibiotics, with 83.6% of human samples and 91.6% of animal samples tested in central Hesse, Germany producing enzymes that break down antibiotics. The study also found high rates of antibiotic-resistant genes, indicative of active transmission of these highly-resistant bacteria among humans and animals.

Study Background

  • This study probes the molecular characteristics of β-lactamase and ESBL-producing Enterobacteriaceae isolates in central Hesse in Germany. This comes in the backdrop of increasingly common Gram-negative bacteria that produce ESBLs – enzymes that dismantle antibiotics and render them ineffective.
  • These isolates came from a diverse sample population comprising humans, pets (dogs and cats), and horses.

Findings

  • Out of the test samples, 83.6% of human isolates and 91.6% of animal isolates were confirmed as ESBL producers using PCR and subsequent sequencing of the PCR amplicons.
  • ESBL subtypes in samples revealed CTX-M-15 was dominant in human samples at 49.3%, while CTX-M-1 appeared in 25.8% of the animal samples.
  • blaCTX-M-2, another ESBL subtype, surfaced almost exclusively in horses, and was not present in human samples.
  • The carbapenemase OXA-48 was detected in 19 ertapenem-resistant isolates from pets. This enzyme can deactivate carbapenems, a group of antibiotics usually reserved for treating severe or high-risk bacterial infections.
  • The Plasmid-encoded quinolone resistance (PMQR) gene, aac(‘6)-Ib-cr, which leads to antibiotic resistance, was the most prevalent. It was found in 27.9% of human and 36.9% of animal isolates resistant to the antibiotic ciprofloxacin.
  • 70% of all isolates showed combinations of between two and six different resistance genes (including penicillinases, ESBLs, and PMQRs).
  • Escherichia coli was the most common species encountered at 74%, followed by Klebsiella pneumoniae at 17.5%, and Enterobacter cloacae at 4.2%.

Implications & Conclusion

  • The study discovered that human, pet, and horse isolates exhibited several common characteristics regarding the presence of ESBLs, PMQRs, and the combination of varying resistance genes.
  • The results suggest ongoing transmission and spread of multi-resistant Enterobacteriaceae among both human and animal populations. This raises significant concerns about the increasing prevalence of antibiotic resistance and the difficulties faced in its containment and treatment.

Cite This Article

APA
Schmiedel J, Falgenhauer L, Domann E, Bauerfeind R, Prenger-Berninghoff E, Imirzalioglu C, Chakraborty T. (2014). Multiresistant extended-spectrum β-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany. BMC Microbiol, 14, 187. https://doi.org/10.1186/1471-2180-14-187

Publication

BMC microbiology
ISSN: 1471-2180
NlmUniqueID: 100966981
Country: England
Language: English
Volume: 14
Pages: 187

Researcher Affiliations

Schmiedel, Judith
    Falgenhauer, Linda
      Domann, Eugen
        Bauerfeind, Rolf
          Prenger-Berninghoff, Ellen
            Imirzalioglu, Can
            • Institute of Medical Microbiology, Justus Liebig University Giessen and German Center for Infection Research (DZIF), Partner site Giessen-Marburg-Langen, Schubertstrasse 81, 35392 Giessen, Germany. Can.imirzalioglu@mikrobio.med.uni-giessen.de.
            Chakraborty, Trinad

              MeSH Terms

              • Animals
              • DNA, Bacterial / chemistry
              • DNA, Bacterial / genetics
              • Drug Resistance, Multiple, Bacterial
              • Enterobacteriaceae / drug effects
              • Enterobacteriaceae / enzymology
              • Enterobacteriaceae / isolation & purification
              • Genotype
              • Germany
              • Horses
              • Humans
              • Pets
              • Polymerase Chain Reaction
              • Sequence Analysis, DNA
              • beta-Lactamases / genetics

              References

              This article includes 63 references
              1. Liebana E, Carattoli A, Coque TM, Hasman H, Magiorakos AP, Mevius D, Peixe L, Poirel L, Schuepbach-Regula G, Torneke K, Torren-Edo J, Torres C, Threlfall J. Public health risks of enterobacterial isolates producing extended-spectrum β-lactamases or AmpC β-lactamases in food and food-producing animals: an EU perspective of epidemiology, analytical methods, risk factors, and control options.. Clin Infect Dis 2013 Apr;56(7):1030-7.
                pubmed: 23243183doi: 10.1093/cid/cis1043google scholar: lookup
              2. Dolejska M, Villa L, Hasman H, Hansen L, Carattoli A. Characterization of IncN plasmids carrying bla CTX-M-1 and qnr genes in Escherichia coli and Salmonella from animals, the environment and humans.. J Antimicrob Chemother 2013 Feb;68(2):333-9.
                pubmed: 23060365doi: 10.1093/jac/dks387google scholar: lookup
              3. Ewers C, Bethe A, Semmler T, Guenther S, Wieler LH. Extended-spectrum β-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective.. Clin Microbiol Infect 2012 Jul;18(7):646-55.
                pubmed: 22519858doi: 10.1111/j.1469-0691.2012.03850.xgoogle scholar: lookup
              4. Wu G, Day MJ, Mafura MT, Nunez-Garcia J, Fenner JJ, Sharma M, van Essen-Zandbergen A, Rodríguez I, Dierikx C, Kadlec K, Schink AK, Chattaway M, Wain J, Helmuth R, Guerra B, Schwarz S, Threlfall J, Woodward MJ, Woodford N, Coldham N, Mevius D. Comparative analysis of ESBL-positive Escherichia coli isolates from animals and humans from the UK, The Netherlands and Germany.. PLoS One 2013;8(9):e75392.
                pmc: PMC3784421pubmed: 24086522doi: 10.1371/journal.pone.0075392google scholar: lookup
              5. Ewers C, Grobbel M, Stamm I, Kopp PA, Diehl I, Semmler T, Fruth A, Beutlich J, Guerra B, Wieler LH, Guenther S. Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lactamase-producing Escherichia coli among companion animals.. J Antimicrob Chemother 2010 Apr;65(4):651-60.
                pubmed: 20118165doi: 10.1093/jac/dkq004google scholar: lookup
              6. Ewers C, Bethe A, Stamm I, Grobbel M, Kopp PA, Guerra B, Stubbe M, Doi Y, Zong Z, Kola A, Schaufler K, Semmler T, Fruth A, Wieler LH, Guenther S. CTX-M-15-D-ST648 Escherichia coli from companion animals and horses: another pandemic clone combining multiresistance and extraintestinal virulence?. J Antimicrob Chemother 2014 May;69(5):1224-30.
                pubmed: 24398338doi: 10.1093/jac/dkt516google scholar: lookup
              7. Friese A, Schulz J, Laube H, von Salviati C, Hartung J, Roesler U. Faecal occurrence and emissions of livestock-associated methicillin-resistant Staphylococcus aureus (laMRSA) and ESbl/AmpC-producing E. coli from animal farms in Germany.. Berl Munch Tierarztl Wochenschr 2013 Mar-Apr;126(3-4):175-80.
                pubmed: 23540202
              8. Meyer E, Gastmeier P, Kola A, Schwab F. Pet animals and foreign travel are risk factors for colonisation with extended-spectrum β-lactamase-producing Escherichia coli.. Infection 2012 Dec;40(6):685-7.
                pubmed: 22971936doi: 10.1007/s15010-012-0324-8google scholar: lookup
              9. EUCAST. 2012 EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. .
              10. Mshana SE, Imirzalioglu C, Hossain H, Hain T, Domann E, Chakraborty T. Conjugative IncFI plasmids carrying CTX-M-15 among Escherichia coli ESBL producing isolates at a University hospital in Germany.. BMC Infect Dis 2009 Jun 17;9:97.
                pmc: PMC2708165pubmed: 19534775doi: 10.1186/1471-2334-9-97google scholar: lookup
              11. Gröbner S, Linke D, Schütz W, Fladerer C, Madlung J, Autenrieth IB, Witte W, Pfeifer Y. Emergence of carbapenem-non-susceptible extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates at the university hospital of Tübingen, Germany.. J Med Microbiol 2009 Jul;58(Pt 7):912-922.
                pubmed: 19502377doi: 10.1099/jmm.0.005850-0google scholar: lookup
              12. Kiratisin P, Apisarnthanarak A, Laesripa C, Saifon P. Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic.. Antimicrob Agents Chemother 2008 Aug;52(8):2818-24.
                pmc: PMC2493136pubmed: 18505851doi: 10.1128/aac.00171-08google scholar: lookup
              13. Ruiz del Castillo B, Vinué L, Román EJ, Guerra B, Carattoli A, Torres C, Martínez-Martínez L. Molecular characterization of multiresistant Escherichia coli producing or not extended-spectrum β-lactamases.. BMC Microbiol 2013 Apr 16;13:84.
                pmc: PMC3637601pubmed: 23586437doi: 10.1186/1471-2180-13-84google scholar: lookup
              14. Chen X, Zhang W, Pan W, Yin J, Pan Z, Gao S, Jiao X. Prevalence of qnr, aac(6')-Ib-cr, qepA, and oqxAB in Escherichia coli isolates from humans, animals, and the environment.. Antimicrob Agents Chemother 2012 Jun;56(6):3423-7.
                pmc: PMC3370760pubmed: 22391545doi: 10.1128/aac.06191-11google scholar: lookup
              15. Cattoir V, Poirel L, Nordmann P. Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France.. Antimicrob Agents Chemother 2008 Oct;52(10):3801-4.
                pmc: PMC2565908pubmed: 18644958doi: 10.1128/aac.00638-08google scholar: lookup
              16. Cattoir V, Poirel L, Rotimi V, Soussy CJ, Nordmann P. Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates.. J Antimicrob Chemother 2007 Aug;60(2):394-7.
                pubmed: 17561500doi: 10.1093/jac/dkm204google scholar: lookup
              17. Wang M, Guo Q, Xu X, Wang X, Ye X, Wu S, Hooper DC, Wang M. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.. Antimicrob Agents Chemother 2009 May;53(5):1892-7.
                pmc: PMC2681562pubmed: 19258263doi: 10.1128/aac.01400-08google scholar: lookup
              18. Cavaco LM, Hasman H, Xia S, Aarestrup FM. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin.. Antimicrob Agents Chemother 2009 Feb;53(2):603-8.
                pmc: PMC2630628pubmed: 19029321doi: 10.1128/aac.00997-08google scholar: lookup
              19. Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC. Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme.. Antimicrob Agents Chemother 2006 Nov;50(11):3953-5.
                pmc: PMC1635235pubmed: 16954321doi: 10.1128/aac.00915-06google scholar: lookup
              20. Jones GL, Warren RE, Skidmore SJ, Davies VA, Gibreel T, Upton M. Prevalence and distribution of plasmid-mediated quinolone resistance genes in clinical isolates of Escherichia coli lacking extended-spectrum beta-lactamases.. J Antimicrob Chemother 2008 Dec;62(6):1245-51.
                pubmed: 18827034doi: 10.1093/jac/dkn406google scholar: lookup
              21. Clermont O, Bonacorsi S, Bingen E. Rapid and simple determination of the Escherichia coli phylogenetic group.. Appl Environ Microbiol 2000 Oct;66(10):4555-8.
                pmc: PMC92342pubmed: 11010916doi: 10.1128/aem.66.10.4555-4558.2000google scholar: lookup
              22. GENE-E. [ http://www.broadinstitute.org/cancer/software/GENE-E/]
              23. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.. Clin Microbiol Infect 2012 Mar;18(3):268-81.
                pubmed: 21793988doi: 10.1111/j.1469-0691.2011.03570.xgoogle scholar: lookup
              24. Wieler LH, Ewers C, Guenther S, Walther B, Lübke-Becker A. Methicillin-resistant staphylococci (MRS) and extended-spectrum beta-lactamases (ESBL)-producing Enterobacteriaceae in companion animals: nosocomial infections as one reason for the rising prevalence of these potential zoonotic pathogens in clinical samples.. Int J Med Microbiol 2011 Dec;301(8):635-41.
                pubmed: 22000738doi: 10.1016/j.ijmm.2011.09.009google scholar: lookup
              25. Rodríguez I, Barownick W, Helmuth R, Mendoza MC, Rodicio MR, Schroeter A, Guerra B. Extended-spectrum {beta}-lactamases and AmpC {beta}-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003-07.. J Antimicrob Chemother 2009 Aug;64(2):301-9.
                pubmed: 19474065doi: 10.1093/jac/dkp195google scholar: lookup
              26. Stolle I, Prenger-Berninghoff E, Stamm I, Scheufen S, Hassdenteufel E, Guenther S, Bethe A, Pfeifer Y, Ewers C. Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs.. J Antimicrob Chemother 2013 Dec;68(12):2802-8.
                pubmed: 23833179doi: 10.1093/jac/dkt259google scholar: lookup
              27. Woodford N, Wareham DW, Guerra B, Teale C. Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making?. J Antimicrob Chemother 2014 Feb;69(2):287-91.
                pubmed: 24092657doi: 10.1093/jac/dkt392google scholar: lookup
              28. Fischer J, Rodríguez I, Schmoger S, Friese A, Roesler U, Helmuth R, Guerra B. Salmonella enterica subsp. enterica producing VIM-1 carbapenemase isolated from livestock farms.. J Antimicrob Chemother 2013 Feb;68(2):478-80.
                pubmed: 23034713doi: 10.1093/jac/dks393google scholar: lookup
              29. Shi W, Li K, Ji Y, Jiang Q, Wang Y, Shi M, Mi Z. Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production.. Braz J Microbiol 2013;44(2):435-42.
                pmc: PMC3833140pubmed: 24294234doi: 10.1590/s1517-83822013000200015google scholar: lookup
              30. Livermore DM, Hawkey PM. CTX-M: changing the face of ESBLs in the UK.. J Antimicrob Chemother 2005 Sep;56(3):451-4.
                pubmed: 16006451doi: 10.1093/jac/dki239google scholar: lookup
              31. Geser N, Stephan R, Hächler H. Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk.. BMC Vet Res 2012 Mar 7;8:21.
                pmc: PMC3319423pubmed: 22397509doi: 10.1186/1746-6148-8-21google scholar: lookup
              32. Overdevest I, Willemsen I, Rijnsburger M, Eustace A, Xu L, Hawkey P, Heck M, Savelkoul P, Vandenbroucke-Grauls C, van der Zwaluw K, Huijsdens X, Kluytmans J. Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands.. Emerg Infect Dis 2011 Jul;17(7):1216-22.
                pmc: PMC3381403pubmed: 21762575doi: 10.3201/eid1707.110209google scholar: lookup
              33. Hordijk J, Schoormans A, Kwakernaak M, Duim B, Broens E, Dierikx C, Mevius D, Wagenaar JA. High prevalence of fecal carriage of extended spectrum β-lactamase/AmpC-producing Enterobacteriaceae in cats and dogs.. Front Microbiol 2013;4:242.
                pmc: PMC3745002pubmed: 23966992doi: 10.3389/fmicb.2013.00242google scholar: lookup
              34. Poirel L, Nordmann P, Ducroz S, Boulouis HJ, Arné P, Millemann Y. Extended-spectrum β-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals.. Antimicrob Agents Chemother 2013 May;57(5):2372-5.
                pmc: PMC3632922pubmed: 23422912doi: 10.1128/aac.02622-12google scholar: lookup
              35. Johns I, Verheyen K, Good L, Rycroft A. Antimicrobial resistance in faecal Escherichia coli isolates from horses treated with antimicrobials: a longitudinal study in hospitalised and non-hospitalised horses.. Vet Microbiol 2012 Oct 12;159(3-4):381-9.
                pubmed: 22565010doi: 10.1016/j.vetmic.2012.04.010google scholar: lookup
              36. Dierikx CM, van Duijkeren E, Schoormans AH, van Essen-Zandbergen A, Veldman K, Kant A, Huijsdens XW, van der Zwaluw K, Wagenaar JA, Mevius DJ. Occurrence and characteristics of extended-spectrum-β-lactamase- and AmpC-producing clinical isolates derived from companion animals and horses.. J Antimicrob Chemother 2012 Jun;67(6):1368-74.
                pubmed: 22382469doi: 10.1093/jac/dks049google scholar: lookup
              37. Smet A, Boyen F, Flahou B, Doublet B, Praud K, Martens A, Butaye P, Cloeckaert A, Haesebrouck F. Emergence of CTX-M-2-producing Escherichia coli in diseased horses: evidence of genetic exchanges of bla(CTX-M-2) linked to ISCR1.. J Antimicrob Chemother 2012 May;67(5):1289-91.
                pubmed: 22328640doi: 10.1093/jac/dks016google scholar: lookup
              38. Ferreira JC, Penha Filho RA, Andrade LN, Berchieri A Jr, Darini AL. Detection of chromosomal bla(CTX-M-2) in diverse Escherichia coli isolates from healthy broiler chickens.. Clin Microbiol Infect 2014 Oct;20(10):O623-6.
                pubmed: 24438126doi: 10.1111/1469-0691.12531google scholar: lookup
              39. Berman H, Barberino MG, Moreira ED Jr, Riley L, Reis JN. Distribution of strain type and antimicrobial susceptibility of Escherichia coli isolates causing meningitis in a large urban setting in Brazil.. J Clin Microbiol 2014 May;52(5):1418-22.
                pmc: PMC3993653pubmed: 24523478doi: 10.1128/jcm.03104-13google scholar: lookup
              40. Burke L, Hopkins KL, Meunier D, de Pinna E, Fitzgerald-Hughes D, Humphreys H, Woodford N. Resistance to third-generation cephalosporins in human non-typhoidal Salmonella enterica isolates from England and Wales, 2010-12.. J Antimicrob Chemother 2014 Apr;69(4):977-81.
                pubmed: 24288030doi: 10.1093/jac/dkt469google scholar: lookup
              41. Yang T, Zeng Z, Rao L, Chen X, He D, Lv L, Wang J, Zeng L, Feng M, Liu JH. The association between occurrence of plasmid-mediated quinolone resistance and ciprofloxacin resistance in Escherichia coli isolates of different origins.. Vet Microbiol 2014 May 14;170(1-2):89-96.
                pubmed: 24553411doi: 10.1016/j.vetmic.2014.01.019google scholar: lookup
              42. Poirel L, Cattoir V, Nordmann P. Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies.. Front Microbiol 2012;3:24.
                pmc: PMC3270319pubmed: 22347217doi: 10.3389/fmicb.2012.00024google scholar: lookup
              43. Chaves J, Ladona MG, Segura C, Coira A, Reig R, Ampurdanés C. SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.. Antimicrob Agents Chemother 2001 Oct;45(10):2856-61.
                pmc: PMC90742pubmed: 11557480doi: 10.1128/aac.45.10.2856-2861.2001google scholar: lookup
              44. Mshana SE, Hain T, Domann E, Lyamuya EF, Chakraborty T, Imirzalioglu C. Predominance of Klebsiella pneumoniae ST14 carrying CTX-M-15 causing neonatal sepsis in Tanzania.. BMC Infect Dis 2013 Oct 7;13:466.
                pmc: PMC3851032pubmed: 24099282doi: 10.1186/1471-2334-13-466google scholar: lookup
              45. Leistner R, Sakellariou C, Gürntke S, Kola A, Steinmetz I, Kohler C, Pfeifer Y, Eller C, Gastmeier P, Schwab F. Mortality and molecular epidemiology associated with extended-spectrum β-lactamase production in Escherichia coli from bloodstream infection.. Infect Drug Resist 2014;7:57-62.
                pmc: PMC3958498pubmed: 24648746doi: 10.2147/idr.s56984google scholar: lookup
              46. Shahid M, Singh A, Sobia F, Rashid M, Malik A, Shukla I, Khan HM. bla(CTX-M), bla(TEM), and bla(SHV) in Enterobacteriaceae from North-Indian tertiary hospital: high occurrence of combination genes.. Asian Pac J Trop Med 2011 Feb;4(2):101-5.
                pubmed: 21771430doi: 10.1016/s1995-7645(11)60046-1google scholar: lookup
              47. Munday CJ, Whitehead GM, Todd NJ, Campbell M, Hawkey PM. Predominance and genetic diversity of community- and hospital-acquired CTX-M extended-spectrum beta-lactamases in York, UK.. J Antimicrob Chemother 2004 Sep;54(3):628-33.
                pubmed: 15294889doi: 10.1093/jac/dkh397google scholar: lookup
              48. Cantón R, Coque TM. The CTX-M beta-lactamase pandemic.. Curr Opin Microbiol 2006 Oct;9(5):466-75.
                pubmed: 16942899doi: 10.1016/j.mib.2006.08.011google scholar: lookup
              49. Sabtcheva S, Kaku M, Saga T, Ishii Y, Kantardjiev T. High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria.. Antimicrob Agents Chemother 2009 Jan;53(1):335-6.
                pmc: PMC2612178pubmed: 19001110doi: 10.1128/aac.00584-08google scholar: lookup
              50. Shibl AM, Al-Agamy MH, Khubnani H, Senok AC, Tawfik AF, Livermore DM. High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.. Diagn Microbiol Infect Dis 2012 Aug;73(4):350-3.
                pubmed: 22633335doi: 10.1016/j.diagmicrobio.2012.04.005google scholar: lookup
              51. European center for disease prevention and control. Antibiotic resistance surveillance in Europe 2012. .
              52. Zhang L, Foxman B, Marrs C. Both urinary and rectal Escherichia coli isolates are dominated by strains of phylogenetic group B2.. J Clin Microbiol 2002 Nov;40(11):3951-5.
                pmc: PMC139655pubmed: 12409357doi: 10.1128/jcm.40.11.3951-3955.2002google scholar: lookup
              53. Picard B, Garcia JS, Gouriou S, Duriez P, Brahimi N, Bingen E, Elion J, Denamur E. The link between phylogeny and virulence in Escherichia coli extraintestinal infection.. Infect Immun 1999 Feb;67(2):546-53.
                pmc: PMC96353pubmed: 9916057doi: 10.1128/iai.67.2.546-553.1999google scholar: lookup
              54. Karisik E, Ellington MJ, Livermore DM, Woodford N. Virulence factors in Escherichia coli with CTX-M-15 and other extended-spectrum beta-lactamases in the UK.. J Antimicrob Chemother 2008 Jan;61(1):54-8.
                pubmed: 17981835doi: 10.1093/jac/dkm401google scholar: lookup
              55. Valat C, Auvray F, Forest K, Métayer V, Gay E, Peytavin de Garam C, Madec JY, Haenni M. Phylogenetic grouping and virulence potential of extended-spectrum-β-lactamase-producing Escherichia coli strains in cattle.. Appl Environ Microbiol 2012 Jul;78(13):4677-82.
                pmc: PMC3370483pubmed: 22522692doi: 10.1128/aem.00351-12google scholar: lookup
              56. Yang YS, Ku CH, Lin JC, Shang ST, Chiu CH, Yeh KM, Lin CC, Chang FY. Impact of Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae on the outcome of community-onset bacteremic urinary tract infections.. J Microbiol Immunol Infect 2010 Jun;43(3):194-9.
                pubmed: 21291846doi: 10.1016/s1684-1182(10)60031-xgoogle scholar: lookup
              57. Martínez-Martínez L, Pascual A, Jacoby GA. Quinolone resistance from a transferable plasmid.. Lancet 1998 Mar 14;351(9105):797-9.
                pubmed: 9519952doi: 10.1016/s0140-6736(97)07322-4google scholar: lookup
              58. Hartmann A, Locatelli A, Amoureux L, Depret G, Jolivet C, Gueneau E, Neuwirth C. Occurrence of CTX-M Producing Escherichia coli in Soils, Cattle, and Farm Environment in France (Burgundy Region).. Front Microbiol 2012;3:83.
                pmc: PMC3297819pubmed: 22408639doi: 10.3389/fmicb.2012.00083google scholar: lookup
              59. Guenther S, Ewers C, Wieler LH. Extended-Spectrum Beta-Lactamases Producing E. coli in Wildlife, yet Another Form of Environmental Pollution?. Front Microbiol 2011;2:246.
                pmc: PMC3244693pubmed: 22203818doi: 10.3389/fmicb.2011.00246google scholar: lookup
              60. Huber H, Zweifel C, Wittenbrink MM, Stephan R. ESBL-producing uropathogenic Escherichia coli isolated from dogs and cats in Switzerland.. Vet Microbiol 2013 Mar 23;162(2-4):992-996.
                pubmed: 23177909doi: 10.1016/j.vetmic.2012.10.029google scholar: lookup
              61. Dahmen S, Haenni M, Châtre P, Madec JY. Characterization of blaCTX-M IncFII plasmids and clones of Escherichia coli from pets in France.. J Antimicrob Chemother 2013 Dec;68(12):2797-801.
                pubmed: 23852541doi: 10.1093/jac/dkt291google scholar: lookup
              62. Dierikx C, van der Goot J, Fabri T, van Essen-Zandbergen A, Smith H, Mevius D. Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers.. J Antimicrob Chemother 2013 Jan;68(1):60-7.
                pubmed: 22949623doi: 10.1093/jac/dks349google scholar: lookup
              63. Calistri P, Iannetti S, Danzetta ML, Narcisi V, Cito F, Sabatino DD, Bruno R, Sauro F, Atzeni M, Carvelli A, Giovannini A. The components of 'One World - One Health' approach.. Transbound Emerg Dis 2013 Nov;60 Suppl 2:4-13.
                pubmed: 24589096doi: 10.1111/tbed.12145google scholar: lookup

              Citations

              This article has been cited 68 times.
              1. Morina JC, Franklin RB. Drivers of Antibiotic Resistance Gene Abundance in an Urban River.. Antibiotics (Basel) 2023 Aug 1;12(8).
                doi: 10.3390/antibiotics12081270pubmed: 37627690google scholar: lookup
              2. Ndlovu T, Kgosietsile L, Motshwarakgole P, Ndlovu SI. Evaluation of Potential Factors Influencing the Dissemination of Multidrug-Resistant Klebsiella pneumoniae and Alternative Treatment Strategies.. Trop Med Infect Dis 2023 Jul 26;8(8).
                doi: 10.3390/tropicalmed8080381pubmed: 37624319google scholar: lookup
              3. Fernández M, Garcias B, Duran I, Molina-López RA, Darwich L. Current Situation of Bacterial Infections and Antimicrobial Resistance Profiles in Pet Rabbits in Spain.. Vet Sci 2023 May 14;10(5).
                doi: 10.3390/vetsci10050352pubmed: 37235435google scholar: lookup
              4. Pimenta J, Pinto AR, Saavedra MJ, Cotovio M. Equine Gram-Negative Oral Microbiota: An Antimicrobial Resistances Watcher?. Antibiotics (Basel) 2023 Apr 21;12(4).
                doi: 10.3390/antibiotics12040792pubmed: 37107153google scholar: lookup
              5. Igbinosa EO, Beshiru A, Igbinosa IH, Cho GS, Franz CMAP. Multidrug-resistant extended spectrum β-lactamase (ESBL)-producing Escherichia coli from farm produce and agricultural environments in Edo State, Nigeria.. PLoS One 2023;18(3):e0282835.
                doi: 10.1371/journal.pone.0282835pubmed: 36897838google scholar: lookup
              6. Werhahn Beining M, Hartmann M, Luebke-Becker A, Guenther S, Schaufler K, Hille K, Kreienbrock L. Carriage of Extended Spectrum Beta Lactamase-Producing Escherichia coli: Prevalence and Factors Associated with Fecal Colonization of Dogs from a Pet Clinic in Lower Saxony, Germany.. Animals (Basel) 2023 Feb 7;13(4).
                doi: 10.3390/ani13040584pubmed: 36830371google scholar: lookup
              7. Primeau CA, Bharat A, Janecko N, Carson CA, Mulvey M, Reid-Smith R, McEwen S, McWhirter JE, Parmley EJ. Integrated surveillance of extended-spectrum beta-lactamase (ESBL)-producing Salmonella and Escherichia coli from humans and animal species raised for human consumption in Canada from 2012 to 2017.. Epidemiol Infect 2022 Dec 20;151:e14.
                doi: 10.1017/S0950268822001509pubmed: 36698196google scholar: lookup
              8. Rincón-Real AA, Suárez-Alfonso MC. Carbapenem resistance in critically important human pathogens isolated from companion animals: a systematic literature review.. Osong Public Health Res Perspect 2022 Dec;13(6):407-423.
                doi: 10.24171/j.phrp.2022.0033pubmed: 36617547google scholar: lookup
              9. Carelli M, Griggio F, Mingoia M, Garofalo C, Milanović V, Pozzato N, Leoni F, Veschetti L, Malerba G, Sandri A, Patuzzo C, Simoni S, Lleo MM, Vignaroli C. Detecting Carbapenemases in Animal and Food Samples by Droplet Digital PCR.. Antibiotics (Basel) 2022 Nov 25;11(12).
                doi: 10.3390/antibiotics11121696pubmed: 36551353google scholar: lookup
              10. Muñoz-Ibarra E, Molina-López RA, Durán I, Garcias B, Martín M, Darwich L. Antimicrobial Resistance in Bacteria Isolated from Exotic Pets: The Situation in the Iberian Peninsula.. Animals (Basel) 2022 Jul 27;12(15).
                doi: 10.3390/ani12151912pubmed: 35953901google scholar: lookup
              11. Boyd SE, Holmes A, Peck R, Livermore DM, Hope W. OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline.. Antimicrob Agents Chemother 2022 Aug 16;66(8):e0021622.
                doi: 10.1128/aac.00216-22pubmed: 35856662google scholar: lookup
              12. Perestrelo S, Correia Carreira G, Valentin L, Fischer J, Pfeifer Y, Werner G, Schmiedel J, Falgenhauer L, Imirzalioglu C, Chakraborty T, Käsbohrer A. Comparison of approaches for source attribution of ESBL-producing Escherichia coli in Germany.. PLoS One 2022;17(7):e0271317.
                doi: 10.1371/journal.pone.0271317pubmed: 35839265google scholar: lookup
              13. Menard J, Goggs R, Mitchell P, Yang Y, Robbins S, Franklin-Guild RJ, Thachil AJ, Altier C, Anderson R, Putzel GG, McQueary H, Goodman LB. Effect of antimicrobial administration on fecal microbiota of critically ill dogs: dynamics of antimicrobial resistance over time.. Anim Microbiome 2022 Jun 4;4(1):36.
                doi: 10.1186/s42523-022-00178-9pubmed: 35659110google scholar: lookup
              14. Silva JMD, Menezes J, Marques C, Pomba CF. Companion Animals-An Overlooked and Misdiagnosed Reservoir of Carbapenem Resistance.. Antibiotics (Basel) 2022 Apr 17;11(4).
                doi: 10.3390/antibiotics11040533pubmed: 35453284google scholar: lookup
              15. Ghenea AE, Zlatian OM, Cristea OM, Ungureanu A, Mititelu RR, Balasoiu AT, Vasile CM, Salan AI, Iliuta D, Popescu M, Udriștoiu AL, Balasoiu M. TEM,CTX-M,SHV Genes in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a County Clinical Emergency Hospital Romania-Predominance of CTX-M-15.. Antibiotics (Basel) 2022 Apr 10;11(4).
                doi: 10.3390/antibiotics11040503pubmed: 35453254google scholar: lookup
              16. Seman A, Mihret A, Sebre S, Awoke T, Yeshitela B, Yitayew B, Aseffa A, Asrat D, Abebe T. Prevalence and Molecular Characterization of Extended Spectrum β-Lactamase and Carbapenemase-Producing Enterobacteriaceae Isolates from Bloodstream Infection Suspected Patients in Addis Ababa, Ethiopia.. Infect Drug Resist 2022;15:1367-1382.
                doi: 10.2147/IDR.S349566pubmed: 35378892google scholar: lookup
              17. Wareth G, Linde J, Hammer P, Pletz MW, Neubauer H, Sprague LD. WGS-Based Phenotyping and Molecular Characterization of the Resistome, Virulome and Plasmid Replicons in Klebsiella pneumoniae Isolates from Powdered Milk Produced in Germany.. Microorganisms 2022 Mar 5;10(3).
                doi: 10.3390/microorganisms10030564pubmed: 35336140google scholar: lookup
              18. Deku JG, Duedu KO, Ativi E, Kpene GE, Feglo PK. Burden of Fluoroquinolone Resistance in Clinical Isolates of Escherichia coli at the Ho Teaching Hospital, Ghana.. Ethiop J Health Sci 2022 Jan;32(1):93-102.
                doi: 10.4314/ejhs.v32i1.11pubmed: 35250221google scholar: lookup
              19. Garcia-Fierro R, Drapeau A, Dazas M, Saras E, Rodrigues C, Brisse S, Madec JY, Haenni M. Comparative phylogenomics of ESBL-, AmpC- and carbapenemase-producing Klebsiella pneumoniae originating from companion animals and humans.. J Antimicrob Chemother 2022 Apr 27;77(5):1263-1271.
                doi: 10.1093/jac/dkac041pubmed: 35224624google scholar: lookup
              20. Zhao Y, Zhu Y, Liu B, Mi J, Li N, Zhao W, Wu R, Holyoak GR, Li J, Liu D, Zeng S, Wang Y. Antimicrobial Susceptibility of Bacterial Isolates from Donkey Uterine Infections, 2018-2021.. Vet Sci 2022 Feb 5;9(2).
                doi: 10.3390/vetsci9020067pubmed: 35202320google scholar: lookup
              21. Thomson K, Eskola K, Eklund M, Suominen K, Määttä M, Junnila J, Nykäsenoja S, Niinistö K, Grönthal T, Rantala M. Characterisation of and risk factors for extended-spectrum β-lactamase producing Enterobacterales (ESBL-E) in an equine hospital with a special reference to an outbreak caused by Klebsiella pneumoniae ST307:CTX-M-1.. Acta Vet Scand 2022 Feb 9;64(1):4.
                doi: 10.1186/s13028-022-00621-6pubmed: 35139865google scholar: lookup
              22. Butaye P, Stegger M, Moodley A, Damborg P, Williams A, Halliday-Simmonds I, Guardabassi L. One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.. Antibiotics (Basel) 2021 Dec 30;11(1).
                doi: 10.3390/antibiotics11010042pubmed: 35052919google scholar: lookup
              23. Roscetto E, Varriale C, Galdiero U, Esposito C, Catania MR. Extended-Spectrum Beta-Lactamase-Producing and Carbapenem-Resistant Enterobacterales in Companion and Animal-Assisted Interventions Dogs.. Int J Environ Res Public Health 2021 Dec 8;18(24).
                doi: 10.3390/ijerph182412952pubmed: 34948564google scholar: lookup
              24. Nittayasut N, Yindee J, Boonkham P, Yata T, Suanpairintr N, Chanchaithong P. Multiple and High-Risk Clones of Extended-Spectrum Cephalosporin-Resistant and bla(NDM-5)-Harbouring Uropathogenic Escherichia coli from Cats and Dogs in Thailand.. Antibiotics (Basel) 2021 Nov 10;10(11).
                doi: 10.3390/antibiotics10111374pubmed: 34827312google scholar: lookup
              25. Carvalho I, Carvalho JA, Martínez-Álvarez S, Sadi M, Capita R, Alonso-Calleja C, Rabbi F, Dapkevicius MLNE, Igrejas G, Torres C, Poeta P. Characterization of ESBL-Producing Escherichia coli and Klebsiella pneumoniae Isolated from Clinical Samples in a Northern Portuguese Hospital: Predominance of CTX-M-15 and High Genetic Diversity.. Microorganisms 2021 Sep 9;9(9).
                doi: 10.3390/microorganisms9091914pubmed: 34576808google scholar: lookup
              26. Verma A, Carney K, Taylor M, Amsler K, Morgan J, Gruszynski K, Erol E, Carter C, Locke S, Callipare A, Shah DH. Occurrence of potentially zoonotic and cephalosporin resistant enteric bacteria among shelter dogs in the Central and South-Central Appalachia.. BMC Vet Res 2021 Sep 25;17(1):313.
                doi: 10.1186/s12917-021-03025-2pubmed: 34563197google scholar: lookup
              27. Salgado-Caxito M, Benavides JA, Adell AD, Paes AC, Moreno-Switt AI. Global prevalence and molecular characterization of extended-spectrum β-lactamase producing-Escherichia coli in dogs and cats - A scoping review and meta-analysis.. One Health 2021 Jun;12:100236.
                doi: 10.1016/j.onehlt.2021.100236pubmed: 33889706google scholar: lookup
              28. Shin SR, Noh SM, Jung WK, Shin S, Park YK, Moon DC, Lim SK, Park YH, Park KT. Characterization of Extended-Spectrum β-Lactamase-Producing and AmpC β-Lactamase-Producing Enterobacterales Isolated from Companion Animals in Korea.. Antibiotics (Basel) 2021 Mar 3;10(3).
                doi: 10.3390/antibiotics10030249pubmed: 33802246google scholar: lookup
              29. Courtice R, Sniatynski M, Rubin JE. Characterization of antimicrobial-resistant Escherichia coli causing urinary tract infections in dogs: Passive surveillance in Saskatchewan, Canada 2014 to 2018.. J Vet Intern Med 2021 May;35(3):1389-1396.
                doi: 10.1111/jvim.16103pubmed: 33751667google scholar: lookup
              30. Wareth G, Neubauer H. The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation.. Vet Res 2021 Feb 8;52(1):16.
                doi: 10.1186/s13567-020-00875-wpubmed: 33557913google scholar: lookup
              31. Pauly N, Hammerl JA, Grobbel M, Tenhagen BA, Käsbohrer A, Bisenius S, Fuchs J, Horlacher S, Lingstädt H, Mauermann U, Mitro S, Müller M, Rohrmann S, Schiffmann AP, Stührenberg B, Zimmermann P, Schwarz S, Meemken D, Irrgang A. ChromID(®) CARBA Agar Fails to Detect Carbapenem-Resistant Enterobacteriaceae With Slightly Reduced Susceptibility to Carbapenems.. Front Microbiol 2020;11:1678.
                doi: 10.3389/fmicb.2020.01678pubmed: 32849351google scholar: lookup
              32. Carvalho I, Tejedor-Junco MT, González-Martín M, Corbera JA, Silva V, Igrejas G, Torres C, Poeta P. Escherichia coli Producing Extended-Spectrum β-lactamases (ESBL) from Domestic Camels in the Canary Islands: A One Health Approach.. Animals (Basel) 2020 Jul 29;10(8).
                doi: 10.3390/ani10081295pubmed: 32751146google scholar: lookup
              33. Schwengers O, Barth P, Falgenhauer L, Hain T, Chakraborty T, Goesmann A. Platon: identification and characterization of bacterial plasmid contigs in short-read draft assemblies exploiting protein sequence-based replicon distribution scores.. Microb Genom 2020 Oct;6(10).
                doi: 10.1099/mgen.0.000398pubmed: 32579097google scholar: lookup
              34. Léon A, Castagnet S, Maillard K, Paillot R, Giard JC. Evolution of In Vitro Antimicrobial Susceptibility of Equine Clinical Isolates in France between 2016 and 2019.. Animals (Basel) 2020 May 7;10(5).
                doi: 10.3390/ani10050812pubmed: 32392891google scholar: lookup
              35. Hong JS, Song W, Park HM, Oh JY, Chae JC, Jeong S, Jeong SH. Molecular Characterization of Fecal Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Escherichia coli From Healthy Companion Animals and Cohabiting Humans in South Korea.. Front Microbiol 2020;11:674.
                doi: 10.3389/fmicb.2020.00674pubmed: 32351490google scholar: lookup
              36. Iseppi R, Di Cerbo A, Messi P, Sabia C. Antibiotic Resistance and Virulence Traits in Vancomycin-Resistant Enterococci (VRE) and Extended-Spectrum β-Lactamase/AmpC-producing (ESBL/AmpC) Enterobacteriaceae from Humans and Pets.. Antibiotics (Basel) 2020 Mar 31;9(4).
                doi: 10.3390/antibiotics9040152pubmed: 32244399google scholar: lookup
              37. Sukmawinata E, Uemura R, Sato W, Thu Htun M, Sueyoshi M. Multidrug-Resistant ESBL/AmpC-Producing Klebsiella pneumoniae Isolated from Healthy Thoroughbred Racehorses in Japan.. Animals (Basel) 2020 Feb 25;10(3).
                doi: 10.3390/ani10030369pubmed: 32106501google scholar: lookup
              38. Loncaric I, Cabal Rosel A, Szostak MP, Licka T, Allerberger F, Ruppitsch W, Spergser J. Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria.. Animals (Basel) 2020 Feb 20;10(2).
                doi: 10.3390/ani10020332pubmed: 32093201google scholar: lookup
              39. Sukmawinata E, Uemura R, Sato W, Mitoma S, Kanda T, Sueyoshi M. IncI1 Plasmid Associated with bla(CTX-M-2) Transmission in ESBL-Producing Escherichia coli Isolated from Healthy Thoroughbred Racehorse, Japan.. Antibiotics (Basel) 2020 Feb 7;9(2).
                doi: 10.3390/antibiotics9020070pubmed: 32046117google scholar: lookup
              40. Hordijk J, Farmakioti E, Smit LAM, Duim B, Graveland H, Theelen MJP, Wagenaar JA. Fecal Carriage of Extended-Spectrum-β-Lactamase/AmpC-Producing Escherichia coli in Horses.. Appl Environ Microbiol 2020 Apr 1;86(8).
                doi: 10.1128/AEM.02590-19pubmed: 32033947google scholar: lookup
              41. Anderson REV, Boerlin P. Carbapenemase-producing Enterobacteriaceae in animals and methodologies for their detection.. Can J Vet Res 2020 Jan;84(1):3-17.
                pubmed: 31920216
              42. Sukmawinata E, Sato W, Mitoma S, Kanda T, Kusano K, Kambayashi Y, Sato T, Ishikawa Y, Goto Y, Uemura R, Sueyoshi M. Extended-spectrum β-lactamase-producing Escherichia coli isolated from healthy Thoroughbred racehorses in Japan.. J Equine Sci 2019 Sep;30(3):47-53.
                doi: 10.1294/jes.30.47pubmed: 31592106google scholar: lookup
              43. Trigo da Roza F, Couto N, Carneiro C, Cunha E, Rosa T, Magalhães M, Tavares L, Novais Â, Peixe L, Rossen JW, Lamas LP, Oliveira M. Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.. Front Microbiol 2019;10:1657.
                doi: 10.3389/fmicb.2019.01657pubmed: 31379799google scholar: lookup
              44. Hong JS, Song W, Park HM, Oh JY, Chae JC, Shin S, Jeong SH. Clonal Spread of Extended-Spectrum Cephalosporin-Resistant Enterobacteriaceae Between Companion Animals and Humans in South Korea.. Front Microbiol 2019;10:1371.
                doi: 10.3389/fmicb.2019.01371pubmed: 31275286google scholar: lookup
              45. Bortolami A, Zendri F, Maciuca EI, Wattret A, Ellis C, Schmidt V, Pinchbeck G, Timofte D. Diversity, Virulence, and Clinical Significance of Extended-Spectrum β-Lactamase- and pAmpC-Producing Escherichia coli From Companion Animals.. Front Microbiol 2019;10:1260.
                doi: 10.3389/fmicb.2019.01260pubmed: 31231344google scholar: lookup
              46. de Lagarde M, Larrieu C, Praud K, Schouler C, Doublet B, Sallé G, Fairbrother JM, Arsenault J. Prevalence, risk factors, and characterization of multidrug resistant and extended spectrum β-lactamase/AmpC β-lactamase producing Escherichia coli in healthy horses in France in 2015.. J Vet Intern Med 2019 Mar;33(2):902-911.
                doi: 10.1111/jvim.15415pubmed: 30648296google scholar: lookup
              47. Kaspar U, von Lützau A, Schlattmann A, Roesler U, Köck R, Becker K. Zoonotic multidrug-resistant microorganisms among small companion animals in Germany.. PLoS One 2018;13(12):e0208364.
                doi: 10.1371/journal.pone.0208364pubmed: 30532196google scholar: lookup
              48. Vázquez-López R, Solano-Gálvez S, León-Chávez BA, Thompson-Bonilla MR, Guerrero-González T, Gómez-Conde E, Martínez-Fong D, González-Barrios JA. Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City.. High Throughput 2018 Nov 23;7(4).
                doi: 10.3390/ht7040036pubmed: 30477153google scholar: lookup
              49. Boehmer T, Vogler AJ, Thomas A, Sauer S, Hergenroether M, Straubinger RK, Birdsell D, Keim P, Sahl JW, Williamson CHD, Riehm JM. Phenotypic characterization and whole genome analysis of extended-spectrum beta-lactamase-producing bacteria isolated from dogs in Germany.. PLoS One 2018;13(10):e0206252.
                doi: 10.1371/journal.pone.0206252pubmed: 30365516google scholar: lookup
              50. Zeynudin A, Pritsch M, Schubert S, Messerer M, Liegl G, Hoelscher M, Belachew T, Wieser A. Prevalence and antibiotic susceptibility pattern of CTX-M type extended-spectrum β-lactamases among clinical isolates of gram-negative bacilli in Jimma, Ethiopia.. BMC Infect Dis 2018 Oct 20;18(1):524.
                doi: 10.1186/s12879-018-3436-7pubmed: 30342476google scholar: lookup
              51. Borzi MM, Cardozo MV, Oliveira ES, Pollo AS, Guastalli EAL, Santos LFD, Ávila FA. Characterization of avian pathogenic Escherichia coli isolated from free-range helmeted guineafowl.. Braz J Microbiol 2018 Nov;49 Suppl 1(Suppl 1):107-112.
                doi: 10.1016/j.bjm.2018.04.011pubmed: 30170963google scholar: lookup
              52. Ye Q, Wu Q, Zhang S, Zhang J, Yang G, Wang J, Xue L, Chen M. Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae From Retail Food in China.. Front Microbiol 2018;9:1709.
                doi: 10.3389/fmicb.2018.01709pubmed: 30135680google scholar: lookup
              53. Alousi S, Salloum T, Arabaghian H, Matar GM, Araj GF, Tokajian ST. Genomic Characterization of MDR Escherichia coli Harboring bla(OXA-48) on the IncL/M-type Plasmid Isolated from Blood Stream Infection.. Biomed Res Int 2018;2018:3036143.
                doi: 10.1155/2018/3036143pubmed: 30050923google scholar: lookup
              54. Pulss S, Stolle I, Stamm I, Leidner U, Heydel C, Semmler T, Prenger-Berninghoff E, Ewers C. Multispecies and Clonal Dissemination of OXA-48 Carbapenemase in Enterobacteriaceae From Companion Animals in Germany, 2009-2016.. Front Microbiol 2018;9:1265.
                doi: 10.3389/fmicb.2018.01265pubmed: 29963026google scholar: lookup
              55. Mairi A, Pantel A, Sotto A, Lavigne JP, Touati A. OXA-48-like carbapenemases producing Enterobacteriaceae in different niches.. Eur J Clin Microbiol Infect Dis 2018 Apr;37(4):587-604.
                doi: 10.1007/s10096-017-3112-7pubmed: 28990132google scholar: lookup
              56. Harada K, Shimizu T, Mukai Y, Kuwajima K, Sato T, Kajino A, Usui M, Tamura Y, Kimura Y, Miyamoto T, Tsuyuki Y, Ohki A, Kataoka Y. Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan.. PLoS One 2017;12(3):e0174178.
                doi: 10.1371/journal.pone.0174178pubmed: 28328967google scholar: lookup
              57. Ye Q, Wu Q, Zhang S, Zhang J, Yang G, Wang H, Huang J, Chen M, Xue L, Wang J. Antibiotic-Resistant Extended Spectrum ß-Lactamase- and Plasmid-Mediated AmpC-Producing Enterobacteriaceae Isolated from Retail Food Products and the Pearl River in Guangzhou, China.. Front Microbiol 2017;8:96.
                doi: 10.3389/fmicb.2017.00096pubmed: 28217112google scholar: lookup
              58. Dalhoff A, Schubert S, Vente A. Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections.. Antimicrob Agents Chemother 2017 May;61(5).
                doi: 10.1128/AAC.02446-16pubmed: 28193648google scholar: lookup
              59. Adegoke AA, Faleye AC, Singh G, Stenström TA. Antibiotic Resistant Superbugs: Assessment of the Interrelationship of Occurrence in Clinical Settings and Environmental Niches.. Molecules 2016 Dec 27;22(1).
                doi: 10.3390/molecules22010029pubmed: 28035988google scholar: lookup
              60. Jafari RA, Motamedi H, Maleki E, Ghanbarpour R, Mayahi M. Phylogenetic typing and detection of extended-spectrum β-lactamases in Escherichia coli isolates from broiler chickens in Ahvaz, Iran.. Vet Res Forum 2016 Summer;7(3):227-233.
                pubmed: 27872719
              61. Projahn M, Daehre K, Roesler U, Friese A. Extended-Spectrum-Beta-Lactamase- and Plasmid-Encoded Cephamycinase-Producing Enterobacteria in the Broiler Hatchery as a Potential Mode of Pseudo-Vertical Transmission.. Appl Environ Microbiol 2017 Jan 1;83(1).
                doi: 10.1128/AEM.02364-16pubmed: 27795309google scholar: lookup
              62. Abraham S, O'Dea M, Trott DJ, Abraham RJ, Hughes D, Pang S, McKew G, Cheong EYL, Merlino J, Saputra S, Malik R, Gottlieb T. Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats.. Sci Rep 2016 Oct 21;6:35527.
                doi: 10.1038/srep35527pubmed: 27767038google scholar: lookup
              63. Liu X, Thungrat K, Boothe DM. Occurrence of OXA-48 Carbapenemase and Other β-Lactamase Genes in ESBL-Producing Multidrug Resistant Escherichia coli from Dogs and Cats in the United States, 2009-2013.. Front Microbiol 2016;7:1057.
                doi: 10.3389/fmicb.2016.01057pubmed: 27462301google scholar: lookup
              64. Timofte D, Maciuca IE, Williams NJ, Wattret A, Schmidt V. Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase-Producing Escherichia coli ST410 in the United Kingdom.. Microb Drug Resist 2016 Oct;22(7):609-615.
                doi: 10.1089/mdr.2016.0036pubmed: 27314838google scholar: lookup
              65. Prieto A, Urcola I, Blanco J, Dahbi G, Muniesa M, Quirós P, Falgenhauer L, Chakraborty T, Hüttener M, Juárez A. Tracking bacterial virulence: global modulators as indicators.. Sci Rep 2016 May 12;6:25973.
                doi: 10.1038/srep25973pubmed: 27169404google scholar: lookup
              66. Mshana SE, Falgenhauer L, Mirambo MM, Mushi MF, Moremi N, Julius R, Seni J, Imirzalioglu C, Matee M, Chakraborty T. Predictors of blaCTX-M-15 in varieties of Escherichia coli genotypes from humans in community settings in Mwanza, Tanzania.. BMC Infect Dis 2016 Apr 29;16:187.
                doi: 10.1186/s12879-016-1527-xpubmed: 27129719google scholar: lookup
              67. Agabou A, Lezzar N, Ouchenane Z, Khemissi S, Satta D, Sotto A, Lavigne JP, Pantel A. Clonal relationship between human and avian ciprofloxacin-resistant Escherichia coli isolates in North-Eastern Algeria.. Eur J Clin Microbiol Infect Dis 2016 Feb;35(2):227-34.
                doi: 10.1007/s10096-015-2534-3pubmed: 26634353google scholar: lookup
              68. Schauss T, Glaeser SP, Gütschow A, Dott W, Kämpfer P. Improved detection of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli in input and output samples of German biogas plants by a selective pre-enrichment procedure.. PLoS One 2015;10(3):e0119791.
                doi: 10.1371/journal.pone.0119791pubmed: 25799434google scholar: lookup
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