[New drugs for horses and production animals in 2019].
Abstract: In 2019, one novel pharmaceutical agent for horses or food-producing animals was released on the German market: An injection suspension for horses containing chondrogenic-induced equine allogeneic peripheral blood-derived mesenchymal stem cells as the active ingredient (ArtiCell Forte) is now available. Two established veterinary active pharmaceutical ingredients became accessible for additional species: a salicylanilide anthelmintic oxyclozanide (Distocur) for the treatment and control of fascioliasis in sheep as well as a type-I synthetic pyrethroid permethrin (Z-Itch), which now has additionally been authorized for donkeys. Additionally, one veterinary drug with a new combination of active ingredients (toltrazuril + gleptoferron), 2 drugs (permethrin, omeprazole) in a new pharmaceutical formulation, one drug (lidocaine) with a novel route of administration, one drug (amprolium) with a higher content of the active ingredient, as well as one active substance (butylscopolaminium bromide) in mono-preparation have been launched on the market for horses and food-producing animals. Im Jahr 2019 kam für Pferde und landwirtschaftliche Nutztiere ein neuer Wirkstoff auf den deutschen Tierarzneimittelmarkt. So steht erstmalig für Pferde eine Injektionssuspension mit chondrogen induzierten allogenen peripheren mesenchymalen Stammzellen aus dem Blut vom Pferd zur Verfügung (ArtiCell Forte). Zwei Wirkstoffe erhielten eine Tierartenerweiterung. So wurde das Fasziolizid Oxyclozanid (Distocur) aus der Gruppe der Salicylsäureanilide auch für Schafe und das synthetische Typ-I-Pyrethroid Permethrin (Z-Itch) auch für Esel zugelassen. Außerdem kamen eine neue Wirkstoffkombination (Toltrazuril + Gleptoferron), 2 Wirkstoffe (Permethrin, Omeprazol) in einer neuen Darreichungsform, ein Wirkstoff (Lidocain) in einer neuen Anwendungsart, ein Wirkstoff (Amprolium) mit einem höheren Wirkstoffgehalt und ein Wirkstoff (Butylscopolaminiumbromid) in Monozubereitung für Pferde und landwirtschaftliche Nutztiere auf den Markt.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication Date: 2020-04-23 PubMed ID: 32325500DOI: 10.1055/a-1122-7849Google Scholar: Lookup
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Summary
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The research presents the new pharmaceutical products available on the German market for horses and food-producing animals in 2019. Among the innovations are an injection for horses containing stem cells, added uses for two existing drugs, and some modifications to existing medications.
New Injection for Horses
- The fresh addition to the market is an injection suspension for horses named ArtiCell Forte. It’s composed of chondrogenic-induced equine allogeneic peripheral blood-derived mesenchymal stem cells. Meant to promote healing, this innovative solution leverages the power of stem cells – versatile cells capable of differentiation into many other types of cells.
Expanded Usage of Existing Drugs
- Two well-established veterinary drugs are now available for new species. Specifically, the anthelmintic oxyclozanide, formerly used to deal with parasitic worms in cattle, has received authorization for treating fascioliasis (liver fluke disease) in sheep.
- In the second case, a synthetic pyrethroid insecticide called permethrin has been authorized for use in donkeys. Previously, this substance was used only to control pests in a variety of settings, including pets.
Updated Formulations and Applications
- The research also notes the arrival of several drugs with either new combinations of active ingredients or reformulations. Notably, there’s a new compound combining toltrazuril, an antiprotozoal agent, and gleptoferron, an iron formulation. These two agents are used for prevention of coccidiosis, a parasitic disease in pigs, and for the prevention of iron deficiency in piglets, respectively.
- Two medications, permethrin and omeprazole, a substance used for reducing stomach acid in humans and animals, have been released in new pharmaceutical forms.
- The local anesthetic lidocaine is now available in a new route of administration. Additionally, amprolium, a thiamine (Vitamin B1) analogue that fights coccidiosis, is now offered with a higher content of active compound.
- Lastly, butylscopolaminium bromide is now available as a mono-preparation. Known for its antispasmodic properties, this medication relieves pain and discomfort caused by cramps in the gut.
Cite This Article
APA
Emmerich IU.
(2020).
[New drugs for horses and production animals in 2019].
Tierarztl Prax Ausg G Grosstiere Nutztiere, 48(2), 118-123.
https://doi.org/10.1055/a-1122-7849 Publication
Researcher Affiliations
- Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinische Fakultät der Universität Leipzig.
MeSH Terms
- Animals
- Cattle
- Drug Combinations
- Horses
- Mesenchymal Stem Cells / chemistry
- Sheep
- Swine
- Veterinary Drugs / administration & dosage
- Veterinary Drugs / pharmacology
- Veterinary Drugs / therapeutic use
Conflict of Interest Statement
Die Autorin bestätigt, dass kein Interessenkonflikt besteht.
Citations
This article has been cited 1 times.- Stage HJ, Trappe S, Söllig K, Trachsel DS, Kirsch K, Zieger C, Merle R, Aschenbach JR, Gehlen H. Multilineage Differentiation Potential of Equine Adipose-Derived Stromal/Stem Cells from Different Sources. Animals (Basel) 2023 Apr 15;13(8).
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