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Home / Equine Research Bank / Animals (Basel) / Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicit...
Animals : an open access journal from MDPI2022; 12(21); doi: 10.3390/ani12212939

Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses.

Abstract: Effective pain management in horses can be a challenge despite the understanding that appropriate analgesia improves animal welfare and increases treatment success. The administration of NSAID drugs, particularly phenylbutazone and flunixin, are common practice in equine veterinary patients. Known for their analgesic and anti-inflammatory properties, NSAIDs are used for the treatment of a variety of conditions in horses, from gastrointestinal to orthopedic pain. Despite extensive usage, NSAIDs have a narrow margin of safety and the body of literature documenting the efficacy and side effects of different NSAIDs is broad. The three main side effects associated with excessive or prolonged NSAID usage in horses include gastroduodenal ulceration, right dorsal colitis (RDC) and renal papillary necrosis. The use of cyclooxygenase-2 selective NSAIDS, such as firocoxib, are theoretically safer. The aim of this paper is to review the current literature on the use and efficacy of different NSAIDs, summarise the associated side effects of NSAID usage and evaluate the current state of knowledge for the diagnosis and treatment of such toxicities.
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Publication Date: 2022-10-26 PubMed ID: 36359062PubMed Central: PMC9655344DOI: 10.3390/ani12212939Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research deals with the use, effectiveness, and potential toxic side-effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in horses. It focuses on the common use of these drugs in veterinary practice and evaluates the literature on the impacts and possible remedies for associated toxicities.

Objective of the Research

  • This research provides a comprehensive examination of the use, efficacy, and potential side-effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in horse treatment.
  • The paper intends to summarise the known side-effects of NSAID use in horses and evaluate existing knowledge on the diagnosing and treating said adverse effects.

NSAIDs and Their Use in Horses

  • NSAIDs, particularly phenylbutazone and flunixin, are commonly administered to horses in veterinary practice.
  • These drugs are known for their pain-relieving (analgesic) and inflammation-reducing (anti-inflammatory) properties.
  • NSAIDs are utilized in horses’ treatment for various conditions ranging from gastrointestinal to orthopedic pain.

Known Side Effects of NSAIDs

  • Despite their widespread use and beneficial properties, NSAIDs have a narrow safety margin, which leads to possible side effects.
  • The most prevalent adverse effects linked with excessive or prolonged use of NSAIDs in horses include gastroduodenal ulceration, right dorsal colitis (RDC), and renal papillary necrosis.

Evaluating Safer NSAID Alternatives

  • The paper also discusses the prospective use of cyclooxygenase-2 selective NSAIDs like firocoxib, which are theoretically safer.
  • The objective is to potentially find safer alternatives to the commonly used NSAIDs in equine medicine, reducing the risk of adverse effects.

Cite This Article

APA
Flood J, Stewart AJ. (2022). Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses. Animals (Basel), 12(21). https://doi.org/10.3390/ani12212939

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 21

Researcher Affiliations

Flood, Jordan
  • School of Veterinary Science, University of Queensland Gatton, 5391 Warrego Highway, Gatton, QLD 4343, Australia.
Stewart, Allison J
  • School of Veterinary Science, University of Queensland Gatton, 5391 Warrego Highway, Gatton, QLD 4343, Australia.

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

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