Obtention and preliminary clinical evaluation of an equine albumin for intravenous administration in adult Colombian Creole Horses (Equus ferus caballus).
Abstract: Albumin is one of the most abundant and physiologically important blood protein in horses due to its ability to regulate vascular volume and transport blood metabolites or drugs. Despite the importance of this protein, in Colombia there is no previous reference of the use of equine albumin in horses as a pharmacological therapy and there is no available any pharmaceutical preparation of this protein to be administrated in horses. This study aims to evaluate for first time the preliminary clinical response of healthy adult Colombian Creole horses after the intravenous administration of an equine albumin preparation, manufactured in Colombia. Equine albumin was prepared from the plasma of healthy horses and obtained through the modified Salting Out technique. The Standard Quality Characterization was carried out following World Health Organization standards which included physicochemical, sterility and hemotropics tests before being administered to the horses. Albumin was administered at a concentration of 5,334 mg per animal to 3 healthy horses that were clinically evaluated before, during and after albumin administration, recording different paraclinical and clinical parameters. After manufacturing, the equine albumin obtained fulfilled the quality characteristics to be administered intravenously. After the administration, the product did not generate any adverse reactions or adverse clinical alteration at the concentration used. During the clinical evaluation we were able to observe a plasma volume expansion. Results indicates the ability to obtain a high quality product that can potentially be used as a pharmacological therapy in horses.
Copyright: © 2026 Cifuentes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publication Date: 2026-02-20 PubMed ID: 41719219PubMed Central: PMC12922972DOI: 10.1371/journal.pone.0341577Google Scholar: Lookup
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Cite This Article
APA
Cifuentes V, Zuluaga-Cabrera AM, Vargas-Muñoz LJ, Estrada-Gómez S.
(2026).
Obtention and preliminary clinical evaluation of an equine albumin for intravenous administration in adult Colombian Creole Horses (Equus ferus caballus).
PLoS One, 21(2), e0341577.
https://doi.org/10.1371/journal.pone.0341577 Publication
Researcher Affiliations
- Grupo de Toxinologia y Alternativas Terapeuticas Alimentarias, Universidad de Antioquia UdeA, Medellin, Antioquia, Colombia.
- Tech Life Saving (TLS), a tech innovation group company, Medellin, Antioquia, Colombia.
- Tech Life Saving (TLS), a tech innovation group company, Medellin, Antioquia, Colombia.
- Tech Life Saving (TLS), a tech innovation group company, Medellin, Antioquia, Colombia.
- Grupo de Toxinologia y Alternativas Terapeuticas Alimentarias, Universidad de Antioquia UdeA, Medellin, Antioquia, Colombia.
- Tech Life Saving (TLS), a tech innovation group company, Medellin, Antioquia, Colombia.
MeSH Terms
- Animals
- Horses
- Colombia
- Administration, Intravenous
- Albumins / administration & dosage
- Male
- Female
Conflict of Interest Statement
The authors have declared that no competing interests exist. Tech Life Saving (TLS) is a Spin-Off from the University of Antioquia where different professors and researchers from the University of Antioquia participate. TLS is the owner (by licensing of the University of Antioquia) of the manufacturing and quality control process and is covered by an intellectual property protection agreement. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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