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Home / Equine Research Bank / Stem Cell Rev Rep / Osteochondritis dissecans (OCD) in Horses – Molecular ...
Stem cell reviews and reports2019; 15(3); 374-390; doi: 10.1007/s12015-019-09875-6

Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy.

Abstract: Osteochondrosis (osteochondrosis dissecans; OCD) is a disease syndrome of growing cartilage related to different clinical entities such as epiphysitis, subchondral cysts and angular carpal deformities, which occurs in growing animals of all species, including horses. Nowadays, these disorders are affecting increasing numbers of young horses worldwide. As a complex multifactorial disease, OCD is initiated when failure in cartilage canals because of existing ischemia, chondrocyte biogenesis impairment as well as biochemical and genetic disruptions occur. Recently, particular attention have been accorded to the definition of possible relations between OCD and some metabolic disorders; in this way, implication of mitochondrial dysfunctions, endoplasmic reticulum disruptions, oxidative stress or endocrinological affections are among the most considered axes for future researches. As one of the most frequent cause of impaired orthopaedic potential, which may result in a sharp decrease in athletic performances of the affected animals, and lead to the occurrence of complications such as joint fragility and laminitis, OCD remains as one of the primary causes of considerable economic losses in all sections of the equine industry. It would therefore be important to provide more information on the exact pathophysiological mechanism(s) underlying early OC(D) lesions, in order to implement innovative strategies involving the use of progenitor stem cells, which are considered nowadays as a promising approach to regenerative medicine, with the potential to treat numerous orthopaedic disorders, including osteo-degenerative diseases, for prevention and reduction of incidence of the disease, not only in horses, but also in human medicine, as the equine model is already widely accepted by the scientific community and approved by the FDA, for the research and application of cellular therapies in the treatment of human conditions.
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Publication Date: 2019-02-24 PubMed ID: 30796679PubMed Central: PMC6534522DOI: 10.1007/s12015-019-09875-6Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Osteochondrosis (OCD) is a growing problem in young horses that can produce serious health complications and economic loss in the equine industry. The study looks at the factors behind the disease and explores the promising potential of progenitor stem cell treatment to manage and reduce its incidence.

Introduction

  • The abstract discusses a disease syndrome known as Osteochondrosis (Osteochondritis dissecans, OCD) that impacts growing animals of all species, particularly affecting horses.
  • The authors highlight that this disease is multifactorial, meaning it is initiated by multiple elements like ischemia in cartilage canals, impairment of chondrocyte biogenesis, and biochemical and genetic disturbances.
  • As an impactful disease, OCD hampers the orthopaedic potential of horses, reduces their performance, can cause complications like joint fragility and laminitis, and subsequently leads to hefty economic losses in the equine industry.

Relation of OCD and Metabolic Disorders

  • The researchers mention an increasing focus on the interconnections between OCD and certain metabolic disorders.
  • Dysfunctions in mitochondria, disruptions in the endoplasmic reticulum, oxidative stress, and endocrine disorders have all been considered key research areas for understanding the development of OCD in horses.

Understanding and Addressing OCD

  • For strategic disease management, there is a substantial need to gain a comprehensive understanding of the pathophysiological mechanism(s) propelling early OC(D) lesions.
  • Novel strategies involving progenitor stem cells, considered a hopeful approach to regenerative medicine, might be valuable in treating various disorders, including osteo-degenerative diseases.

Implications Beyond Veterinary Sector

  • Unlocking the potentials of progenitor stem cells in managing OCD has implications going beyond equine health as these findings may also be applicable in human medicine.
  • The equine model, approved by the FDA and accepted by the scientific community, is a potent tool for researching and applying cellular therapies in treating human diseases. Therefore, the fight against OCD extends to benefitting human health, too.

Cite This Article

APA
Bourebaba L, Röcken M, Marycz K. (2019). Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy. Stem Cell Rev Rep, 15(3), 374-390. https://doi.org/10.1007/s12015-019-09875-6

Publication

Stem cell reviews and reports
ISSN: 2629-3277
NlmUniqueID: 101752767
Country: United States
Language: English
Volume: 15
Issue: 3
Pages: 374-390

Researcher Affiliations

Bourebaba, Lynda
  • Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland.
Röcken, Michael
  • Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392, Gießen, Germany.
Marycz, Krzysztof
  • Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland. krzysztof.marycz@upwr.edu.pl.
  • Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392, Gießen, Germany. krzysztof.marycz@upwr.edu.pl.

MeSH Terms

  • Animals
  • Horse Diseases / genetics
  • Horse Diseases / metabolism
  • Horse Diseases / therapy
  • Horses
  • Osteochondritis Dissecans / genetics
  • Osteochondritis Dissecans / metabolism
  • Osteochondritis Dissecans / therapy
  • Osteochondritis Dissecans / veterinary
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / trends

Conflict of Interest Statement

There is no conflict of interest.

References

This article includes 123 references
  1. Jeffcott LB. Osteochondrosis - an international problem for the horse industry.. Journal of Equine Veterinary Science 1996;16(1):32–37.
  2. Carlson CS, Cullins LD, Meuten DJ. Osteochondrosis of the articular-epiphyseal cartilage complex in young horses: evidence for a defect in cartilage canal blood supply.. Vet Pathol 1995 Nov;32(6):641-7.
    pubmed: 8592799doi: 10.1177/030098589503200605google scholar: lookup
  3. Ekman S, Carlson CS. The pathophysiology of osteochondrosis.. Vet Clin North Am Small Anim Pract 1998 Jan;28(1):17-32.
    pubmed: 9463856doi: 10.1016/s0195-5616(98)50002-2google scholar: lookup
  4. Al-Hizab F, Clegg PD, Thompson CC, Carter SD. Microscopic localization of active gelatinases in equine osteochondritis dissecans (OCD) cartilage.. Osteoarthritis Cartilage 2002 Aug;10(8):653-61.
    pubmed: 12479388doi: 10.1053/joca.2002.0811google scholar: lookup
  5. Van Weeren PR, Olstad K. Pathogenesis of osteochondrosis dissecans: How does this translate to management of the clinical case?. Equine Veterinary Education 2016;28(3):155–166.
  6. Trotter GW, McIlwraith CW. Osteochondritis dissecans and subchondral cystic lesions and their relationship to osteochondrosis in the horse.. Journal of Equine Veterinary Science 1981;1(5):157–162.
  7. de Grauw JC, Brama PA, Wiemer P, Brommer H, van de Lest CH, van Weeren PR. Cartilage-derived biomarkers and lipid mediators of inflammation in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia.. Am J Vet Res 2006 Jul;67(7):1156-62.
    pubmed: 16817736doi: 10.2460/ajvr.67.7.1156google scholar: lookup
  8. Stromberg B. A review of the salient features of osteochondrosis in the horse.. Equine Vet J 1979 Oct;11(4):211-4.
    pubmed: 540628doi: 10.1111/j.2042-3306.1979.tb01346.xgoogle scholar: lookup
  9. Vos NJ. Incidence of osteochondrosis (dissecans) in Dutch warmblood horses presented for pre-purchase examination.. Ir Vet J 2008 Jan 1;61(1):33-7.
    pmc: PMC3113880pubmed: 21851701doi: 10.1186/2046-0481-61-1-33google scholar: lookup
  10. Ralston SL. Hyperglycemia/hyperinsulinemia after feeding a meal of grain to young horses with osteochondritis dissecans (OCD) lesions.. Pferdeheilkunde 1996;12(3):320–322.
  11. Stock KF, Hamann H, Distl O. Prevalence of osseous fragments in distal and proximal interphalangeal, metacarpo- and metatarsophalangeal and tarsocrural joints of Hanoverian Warmblood horses.. J Vet Med A Physiol Pathol Clin Med 2005 Oct;52(8):388-94.
    pubmed: 16176566doi: 10.1111/j.1439-0442.2005.00753.xgoogle scholar: lookup
  12. McIlwraith CW. Use of synovial fluid and serum biomarkers in equine bone and joint disease: a review.. Equine Vet J 2005 Sep;37(5):473-82.
    pubmed: 16163952doi: 10.2746/042516405774480102google scholar: lookup
  13. Branly T, Bertoni L, Contentin R, Rakic R, Gomez-Leduc T, Desancé M, Hervieu M, Legendre F, Jacquet S, Audigié F, Denoix JM, Demoor M, Galéra P. Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1.. Stem Cell Rev Rep 2017 Oct;13(5):611-630.
    pubmed: 28597211doi: 10.1007/s12015-017-9748-ygoogle scholar: lookup
  14. Jeffcott LB, Henson FM. Studies on growth cartilage in the horse and their application to aetiopathogenesis of dyschondroplasia (osteochondrosis).. Vet J 1998 Nov;156(3):177-92.
    pubmed: 9883086doi: 10.1016/s1090-0233(98)80121-4google scholar: lookup
  15. Campbell JR. Bone growth in foals and epiphyseal compression.. Equine Vet J 1977 Jul;9(3):116-21.
    pubmed: 891514doi: 10.1111/j.2042-3306.1977.tb04001.xgoogle scholar: lookup
  16. Semevolos SA. Osteochondritis Dissecans Development.. Vet Clin North Am Equine Pract 2017 Aug;33(2):367-378.
    pubmed: 28551287doi: 10.1016/j.cveq.2017.03.009google scholar: lookup
  17. Laverty S, Girard C. Pathogenesis of epiphyseal osteochondrosis.. Vet J 2013 Jul;197(1):3-12.
    pubmed: 23647656doi: 10.1016/j.tvjl.2013.03.035google scholar: lookup
  18. Sjaastad ØV, Hove K, Sand O. Physiology of domestic animals.. Scandinavian Veterinary Press 2003;58(244):239–241.
  19. Van Weeren PR. Aetiology, diagnosis and treatment of OC(D). Clinical Techniques in Equine Practice 2006;5:248–258.
  20. Shingleton WD, Mackie EJ, Cawston TE, Jeffcott LB. Cartilage canals in equine articular/epiphyseal growth cartilage and a possible association with dyschondroplasia.. Equine Vet J 1997 Sep;29(5):360-4.
    pubmed: 9306061doi: 10.1111/j.2042-3306.1997.tb03139.xgoogle scholar: lookup
  21. Carlson CS, Meuten DJ, Richardson DC. Ischemic necrosis of cartilage in spontaneous and experimental lesions of osteochondrosis.. J Orthop Res 1991 May;9(3):317-29.
    pubmed: 2010836doi: 10.1002/jor.1100090303google scholar: lookup
  22. van Linthoudt D, Revel M. Similar radiologic lesions of localized Scheuermann's disease of the lumbar spine in twin sisters.. Spine (Phila Pa 1976) 1994 Apr 15;19(8):987-9.
    pubmed: 8009360doi: 10.1097/00007632-199404150-00020google scholar: lookup
  23. Wittwer C, Dierks C, Hamann H, Distl O. Associations between candidate gene markers at a quantitative trait locus on equine chromosome 4 responsible for osteochondrosis dissecans in fetlock joints of South German Coldblood horses.. J Hered 2008 Mar-Apr;99(2):125-9.
    pubmed: 18227080doi: 10.1093/jhered/esm106google scholar: lookup
  24. Lewczuk D, Korwin-Kossakowska A. Genetic background of osteochondrosis in the horse – A review.. Animal Science Papers and Reports 2012;30(3):205–218.
  25. Hilla D, Distl O. Review: Genetic aspects of osteochondrosis (dissecans), palmar/plantar osteochondral fragments, radiographic changes in the navicular bone and degenerative joint diseases in horses.. Prakt. Tierarzt 2013;13:128–140.
  26. Lykkjen S, Olsen HF, Dolvik NI, Grøndahl AM, Røed KH, Klemetsdal G. Heritability estimates of tarsocrural osteochondrosis and palmar/plantar first phalanx osteochondral fragments in Standardbred trotters.. Equine Vet J 2014 Jan;46(1):32-7.
    pubmed: 23448227doi: 10.1111/evj.12058google scholar: lookup
  27. Naccache F, Metzger J, Distl O. Genetic risk factors for osteochondrosis in various horse breeds.. Equine Vet J 2018 Sep;50(5):556-563.
    pubmed: 29498750doi: 10.1111/evj.12824google scholar: lookup
  28. Austbø L, Røed KH, Dolvik NI, Skretting G. Identification of differentially expressed genes associated with osteochondrosis in standardbred horses using RNA arbitrarily primed PCR.. Anim Biotechnol 2010 Apr;21(2):135-9.
    pubmed: 20379890doi: 10.1080/10495391003608316google scholar: lookup
  29. Serteyn D, Piquemal D, Vanderheyden L, Lejeune JP, Verwilghen D, Sandersen C. Gene expression profiling from leukocytes of horses affected by osteochondrosis.. J Orthop Res 2010 Jul;28(7):965-70.
    pubmed: 20108324doi: 10.1002/jor.21089google scholar: lookup
  30. Desjardin C, Vaiman A, Mata X, Legendre R, Laubier J, Kennedy SP, Laloe D, Barrey E, Jacques C, Cribiu EP, Schibler L. Next-generation sequencing identifies equine cartilage and subchondral bone miRNAs and suggests their involvement in osteochondrosis physiopathology.. BMC Genomics 2014 Sep 17;15(1):798.
    pmc: PMC4190437pubmed: 25227120doi: 10.1186/1471-2164-15-798google scholar: lookup
  31. Gibson G, Asahara H. microRNAs and cartilage.. J Orthop Res 2013 Sep;31(9):1333-44.
    pubmed: 23754477doi: 10.1002/jor.22397google scholar: lookup
  32. Martinez-Sanchez A, Dudek KA, Murphy CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).. J Biol Chem 2012 Jan 6;287(2):916-24.
    pmc: PMC3256897pubmed: 22102413doi: 10.1074/jbc.m111.302430google scholar: lookup
  33. Barrey E, Rivière J, Morgenthaler C, Rossignol F, Mespoulhès-Rivière C, Robert C. P3004 differential expression of micrornas in synovial fluid as biomarkers of osteochondrosis in equine hock joints.. Journal of Animal Science 2016;94:52–53.
  34. Fernandes TL, Shimomura K, Asperti A, Pinheiro CCG, Caetano HVA, Oliveira CRGCM, Nakamura N, Hernandez AJ, Bueno DF. Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment.. Stem Cell Rev Rep 2018 Oct;14(5):734-743.
    pmc: PMC6132738pubmed: 29728886doi: 10.1007/s12015-018-9820-2google scholar: lookup
  35. Huang Z, Godkin O, Schulze-Tanzil G. The Challenge in Using Mesenchymal Stromal Cells for Recellularization of Decellularized Cartilage.. Stem Cell Rev Rep 2017 Feb;13(1):50-67.
    pubmed: 27826794doi: 10.1007/s12015-016-9699-8google scholar: lookup
  36. Nasrabadi D, Rezaeiani S, Eslaminejad MB, Shabani A. Improved Protocol for Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells -Effect of PTHrP and FGF-2 on TGFβ1/BMP2-Induced Chondrocytes Hypertrophy.. Stem Cell Rev Rep 2018 Oct;14(5):755-766.
    pubmed: 29691795doi: 10.1007/s12015-018-9816-ygoogle scholar: lookup
  37. Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis.. Cell Stem Cell 2009 Apr 3;4(4):324-35.
    pubmed: 19341622doi: 10.1016/j.stem.2009.01.015google scholar: lookup
  38. Marycz K, Kornicka K, Marędziak M, Golonka P, Nicpoń J. Equine metabolic syndrome impairs adipose stem cells osteogenic differentiation by predominance of autophagy over selective mitophagy.. J Cell Mol Med 2016 Dec;20(12):2384-2404.
    pmc: PMC5134411pubmed: 27629697doi: 10.1111/jcmm.12932google scholar: lookup
  39. Redman SN, Oldfield SF, Archer CW. Current strategies for articular cartilage repair.. Eur Cell Mater 2005 Apr 14;9:23-32; discussion 23-32.
    pubmed: 15830323doi: 10.22203/ecm.v009a04google scholar: lookup
  40. Johnstone B, Alini M, Cucchiarini M, Dodge GR, Eglin D, Guilak F, Madry H, Mata A, Mauck RL, Semino CE, Stoddart MJ. Tissue engineering for articular cartilage repair--the state of the art.. Eur Cell Mater 2013 May 2;25:248-67.
    pubmed: 23636950doi: 10.22203/ecm.v025a18google scholar: lookup
  41. Barbero A, Ploegert S, Heberer M, Martin I. Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes.. Arthritis Rheum 2003 May;48(5):1315-25.
    pubmed: 12746904doi: 10.1002/art.10950google scholar: lookup
  42. Alsalameh S, Amin R, Gemba T, Lotz M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage.. Arthritis Rheum 2004 May;50(5):1522-32.
    pubmed: 15146422doi: 10.1002/art.20269google scholar: lookup
  43. Jiang Y, Tuan RS. Origin and function of cartilage stem/progenitor cells in osteoarthritis.. Nat Rev Rheumatol 2015 Apr;11(4):206-12.
    pmc: PMC5413931pubmed: 25536487doi: 10.1038/nrrheum.2014.200google scholar: lookup
  44. Simon TM, Jackson DW. Articular cartilage: injury pathways and treatment options.. Sports Med Arthrosc Rev 2006 Sep;14(3):146-54.
    pubmed: 17135961doi: 10.1097/00132585-200609000-00006google scholar: lookup
  45. Seol D, McCabe DJ, Choe H, Zheng H, Yu Y, Jang K, Walter MW, Lehman AD, Ding L, Buckwalter JA, Martin JA. Chondrogenic progenitor cells respond to cartilage injury.. Arthritis Rheum 2012 Nov;64(11):3626-3637.
    pmc: PMC4950521pubmed: 22777600doi: 10.1002/art.34613google scholar: lookup
  46. Williams R, Khan IM, Richardson K, Nelson L, McCarthy HE, Analbelsi T, Singhrao SK, Dowthwaite GP, Jones RE, Baird DM, Lewis H, Roberts S, Shaw HM, Dudhia J, Fairclough J, Briggs T, Archer CW. Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage.. PLoS One 2010 Oct 14;5(10):e13246.
    pmc: PMC2954799pubmed: 20976230doi: 10.1371/journal.pone.0013246google scholar: lookup
  47. Huang YZ, Xie HQ, Silini A, Parolini O, Zhang Y, Deng L, Huang YC. Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives.. Stem Cell Rev Rep 2017 Oct;13(5):575-586.
    pubmed: 28721683doi: 10.1007/s12015-017-9753-1google scholar: lookup
  48. Jiang Y, Cai Y, Zhang W, Yin Z, Hu C, Tong T, Lu P, Zhang S, Neculai D, Tuan RS, Ouyang HW. Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration.. Stem Cells Transl Med 2016 Jun;5(6):733-44.
    pmc: PMC4878331pubmed: 27130221doi: 10.5966/sctm.2015-0192google scholar: lookup
  49. Čamernik K, Barlič A, Drobnič M, Marc J, Jeras M, Zupan J. Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?. Stem Cell Rev Rep 2018 Jun;14(3):346-369.
    pubmed: 29556896doi: 10.1007/s12015-018-9800-6google scholar: lookup
  50. Punwar S, Khan WS. Mesenchymal stem cells and articular cartilage repair: clinical studies and future direction.. Open Orthop J 2011;5 Suppl 2:296-301.
    pmc: PMC3149861pubmed: 21886696doi: 10.2174/1874325001105010296google scholar: lookup
  51. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.. Osteoarthritis Cartilage 2002 Jun;10(6):432-63.
    pubmed: 12056848doi: 10.1053/joca.2002.0801google scholar: lookup
  52. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators.. J Cell Biochem 2006 Aug 1;98(5):1076-84.
    pubmed: 16619257doi: 10.1002/jcb.20886google scholar: lookup
  53. Castro-Viñuelas R, Sanjurjo-Rodríguez C, Piñeiro-Ramil M, Hermida-Gómez T, Fuentes-Boquete IM, de Toro-Santos FJ, Blanco-García FJ, Díaz-Prado SM. Induced pluripotent stem cells for cartilage repair: current status and future perspectives.. Eur Cell Mater 2018 Sep 11;36:96-109.
    pubmed: 30204229doi: 10.22203/ecm.v036a08google scholar: lookup
  54. Wang M, Yuan Z, Ma N, Hao C, Guo W, Zou G, Zhang Y, Chen M, Gao S, Peng J, Wang A, Wang Y, Sui X, Xu W, Lu S, Liu S, Guo Q. Advances and Prospects in Stem Cells for Cartilage Regeneration.. Stem Cells Int 2017;2017:4130607.
    pmc: PMC5299204pubmed: 28246531doi: 10.1155/2017/4130607google scholar: lookup
  55. Guzzo RM, Scanlon V, Sanjay A, Xu RH, Drissi H. Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential.. Stem Cell Rev Rep 2014 Dec;10(6):820-9.
    pubmed: 24958240doi: 10.1007/s12015-014-9538-8google scholar: lookup
  56. Oellerich D, Miosg N. Chondrogenic progenitor cells and cartilage repair.. Cartilage 59–72.
  57. Anasiz Y, Ozgul RK, Uckan-Cetinkaya D. A New Chapter for Mesenchymal Stem Cells: Decellularized Extracellular Matrices.. Stem Cell Rev Rep 2017 Oct;13(5):587-597.
    pubmed: 28766102doi: 10.1007/s12015-017-9757-xgoogle scholar: lookup
  58. Wolker RRE. Osteochondrosis in the horse.. Large Animal Veterinary Rounds 2007;7(1):1–6.
  59. Mirams M, Ayodele BA, Tatarczuch L, Henson FM, Pagel CN, Mackie EJ. Identification of novel osteochondrosis--Associated genes.. J Orthop Res 2016 Mar;34(3):404-11.
    pubmed: 26296056doi: 10.1002/jor.23033google scholar: lookup
  60. Bruns J, Werner M, Habermann C. Osteochondritis Dissecans: Etiology, Pathology, and Imaging with a Special Focus on the Knee Joint.. Cartilage 2018 Oct;9(4):346-362.
    pmc: PMC6139592pubmed: 28639852doi: 10.1177/1947603517715736google scholar: lookup
  61. Jeffcott LB. Osteochondrosis in the horse--searching for the key to pathogenesis.. Equine Vet J 1991 Sep;23(5):331-8.
    pubmed: 1959522doi: 10.1111/j.2042-3306.1991.tb03733.xgoogle scholar: lookup
  62. Ytrehus B, Carlson CS, Ekman S. Etiology and pathogenesis of osteochondrosis.. Vet Pathol 2007 Jul;44(4):429-48.
    pubmed: 17606505doi: 10.1354/vp.44-4-429google scholar: lookup
  63. Olstad K, Ekman S, Carlson CS. An Update on the Pathogenesis of Osteochondrosis.. Vet Pathol 2015 Sep;52(5):785-802.
    pubmed: 26080832doi: 10.1177/0300985815588778google scholar: lookup
  64. Olstad K, Hendrickson EH, Carlson CS, Ekman S, Dolvik NI. Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans.. Osteoarthritis Cartilage 2013 May;21(5):730-8.
    pubmed: 23428601doi: 10.1016/j.joca.2013.02.005google scholar: lookup
  65. Henson FM, Davies ME, Jeffcott LB. Equine dyschondroplasia (osteochondrosis)--histological findings and type VI collagen localization.. Vet J 1997 Jul;154(1):53-62.
    pubmed: 9265853doi: 10.1016/s1090-0233(05)80008-5google scholar: lookup
  66. Bridges CH, Harris ED. Experimentally induced cartilaginous fractures (osteochondritis dissecans) in foals fed low-copper diets.. J Am Vet Med Assoc 1988 Jul 15;193(2):215-21.
    pubmed: 3403350
  67. Hurtig M, Green S, Dobson H, Mikuni-Takagaki Y, Choi J. Clinical and biochemical correlates of defective cartilage and bone growth in copper-deficient foals.. Equine Veterinary Journal S16.
  68. van de Lest CH, Brama PA, van El B, DeGroot J, van Weeren PR. Extracellular matrix changes in early osteochondrotic defects in foals: a key role for collagen?. Biochim Biophys Acta 2004 Sep 6;1690(1):54-62.
    pubmed: 15337170doi: 10.1016/j.bbadis.2004.05.002google scholar: lookup
  69. Hernández-Vidal G, Jeffcott LB, Davies ME. Immunolocalization of cathepsin B in equine dyschondroplastic articular cartilage.. Vet J 1998 Nov;156(3):193-201.
    pubmed: 9883087doi: 10.1016/s1090-0233(98)80122-6google scholar: lookup
  70. Lecocq M, Girard CA, Fogarty U, Beauchamp G, Richard H, Laverty S. Cartilage matrix changes in the developing epiphysis: early events on the pathway to equine osteochondrosis?. Equine Vet J 2008 Jul;40(5):442-54.
    pubmed: 18487100doi: 10.2746/042516408x297453google scholar: lookup
  71. Bank RA, Soudry M, Maroudas A, Mizrahi J, TeKoppele JM. The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.. Arthritis Rheum 2000 Oct;43(10):2202-10.
    pubmed: 11037879doi: 10.1002/1529-0131(200010)43:10<2202::aid-anr7>3.0.co;2-egoogle scholar: lookup
  72. Gründer W. MRI assessment of cartilage ultrastructure.. NMR Biomed 2006 Nov;19(7):855-76.
    pubmed: 17075962doi: 10.1002/nbm.1092google scholar: lookup
  73. Ekman S, Rodriguez-Martinez H, Plöen L. Morphology of normal and osteochondrotic porcine articular-epiphyseal cartilage. A study in the domestic pig and minipig of wild hog ancestry.. Acta Anat (Basel) 1990;139(3):239-53.
    pubmed: 2077805
  74. Lillich JD, Bertone AL, Malemud CJ, Weisbrode SE, Ruggles AJ, Stevenson S. Biochemical, histochemical, and immunohistochemical characterization of distal tibial osteochondrosis in horses.. Am J Vet Res 1997 Jan;58(1):89-98.
    pubmed: 8989503
  75. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA. Matrix metalloproteinases: a review.. Crit Rev Oral Biol Med 1993;4(2):197-250.
    pubmed: 8435466doi: 10.1177/10454411930040020401google scholar: lookup
  76. Kinoh H, Sato H, Tsunezuka Y, Takino T, Kawashima A, Okada Y, Seiki M. MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.. J Cell Sci 1996 May;109 ( Pt 5):953-9.
    pubmed: 8743942doi: 10.1242/jcs.109.5.953google scholar: lookup
  77. d'Ortho MP, Will H, Atkinson S, Butler G, Messent A, Gavrilovic J, Smith B, Timpl R, Zardi L, Murphy G. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.. Eur J Biochem 1997 Dec 15;250(3):751-7.
    pubmed: 9461298doi: 10.1111/j.1432-1033.1997.00751.xgoogle scholar: lookup
  78. Partsch G, Matucci-Cerinic M, Marabini S, Jantsch S, Pignone A, Cagnoni M. Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.. Scand J Rheumatol 1991;20(2):98-103.
    pubmed: 1709520doi: 10.3109/03009749109165283google scholar: lookup
  79. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling.. FASEB J 1991 May;5(8):2145-54.
    pubmed: 1850705
  80. Ishiguro N, Ito T, Obata K, Fujimoto N, Iwata H. Determination of stromelysin-1, 72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis.. J Rheumatol 1996 Sep;23(9):1599-604.
    pubmed: 8877931
  81. Posthumus MD, Limburg PC, Westra J, Cats HA, Stewart RE, van Leeuwen MA, van Rijswijk MH. Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis.. Rheumatology (Oxford) 1999 Nov;38(11):1081-7.
    pubmed: 10556259doi: 10.1093/rheumatology/38.11.1081google scholar: lookup
  82. Mehraban F, Lark MW, Ahmed FN, Xu F, Moskowitz RW. Increased secretion and activity of matrix metalloproteinase-3 in synovial tissues and chondrocytes from experimental osteoarthritis.. Osteoarthritis Cartilage 1998 Jul;6(4):286-94.
    pubmed: 9876398doi: 10.1053/joca.1998.0122google scholar: lookup
  83. Jouglin M, Robert C, Valette JP, Gavard F, Quintin-Colonna F, Denoix JM. Metalloproteinases and tumor necrosis factor-alpha activities in synovial fluids of horses: correlation with articular cartilage alterations.. Vet Res 2000 Sep-Oct;31(5):507-15.
    pubmed: 11050746doi: 10.1051/vetres:2000136google scholar: lookup
  84. Clegg PD, Burke RM, Coughlan AR, Riggs CM, Carter SD. Characterisation of equine matrix metalloproteinase 2 and 9; and identification of the cellular sources of these enzymes in joints.. Equine Vet J 1997 Sep;29(5):335-42.
    pubmed: 9306058doi: 10.1111/j.2042-3306.1997.tb03136.xgoogle scholar: lookup
  85. Clegg PD, Coughlan AR, Carter SD. Equine TIMP-1 and TIMP-2: identification, activity and cellular sources.. Equine Vet J 1998 Sep;30(5):416-23.
    pubmed: 9758100doi: 10.1111/j.2042-3306.1998.tb04512.xgoogle scholar: lookup
  86. Suárez A, Ángela C, Stanek C, Edinger J, Buchner H. Measurement of Metalloproteinase-3 levels in synovial fluid from horses as biomarker of joint disease.. Revista Electrónica De Veterinaria 2017;18(10):1–11.
  87. Brink P, Smith RK, Tverdal A, Dolvik NI. Changes in synovial fluid biomarker concentrations following arthroscopic surgery in horses with osteochondritis dissecans of the distal intermediate ridge of the tibia.. Am J Vet Res 2015 Jul;76(7):599-607.
    pubmed: 26111089doi: 10.2460/ajvr.76.7.599google scholar: lookup
  88. Hedbom E, Antonsson P, Hjerpe A, Aeschlimann D, Paulsson M, Rosa-Pimentel E, Sommarin Y, Wendel M, Oldberg A, Heinegård D. Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.. J Biol Chem 1992 Mar 25;267(9):6132-6.
    pubmed: 1556121
  89. Misumi K, Vilim V, Clegg PD, Thompson CC, Carter SD. Measurement of cartilage oligomeric matrix protein (COMP) in normal and diseased equine synovial fluids.. Osteoarthritis Cartilage 2001 Feb;9(2):119-27.
    pubmed: 11237659doi: 10.1053/joca.2000.0367google scholar: lookup
  90. Taylor SE, Weaver MP, Pitsillides AA, Wheeler BT, Wheeler-Jones CP, Shaw DJ, Smith RK. Cartilage oligomeric matrix protein and hyaluronan levels in synovial fluid from horses with osteoarthritis of the tarsometatarsal joint compared to a control population.. Equine Vet J 2006 Nov;38(6):502-7.
    pubmed: 17124839doi: 10.2746/042516406x156073google scholar: lookup
  91. Skiöldebrand E, Heinegård D, Eloranta ML, Nilsson G, Dudhia J, Sandgren B, Ekman S. Enhanced concentration of COMP (cartilage oligomeric matrix protein) in osteochondral fractures from racing Thoroughbreds.. J Orthop Res 2005 Jan;23(1):156-63.
    pubmed: 15607888doi: 10.1016/j.orthres.2004.05.013google scholar: lookup
  92. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity.. Genes Dev 2010 Jul 15;24(14):1507-18.
    pmc: PMC2904941pubmed: 20634317doi: 10.1101/gad.1924910google scholar: lookup
  93. Xu M, Stattin EL, Shaw G, Heinegård D, Sullivan G, Wilmut I, Colman A, Önnerfjord P, Khabut A, Aspberg A, Dockery P, Hardingham T, Murphy M, Barry F. Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.. Stem Cells Transl Med 2016 Sep;5(9):1171-81.
    pmc: PMC4996445pubmed: 27388238doi: 10.5966/sctm.2015-0384google scholar: lookup
  94. Verwilghen DR, Enzerink E, Martens A, Franck T, Balligand M, Henrotin Y, Detilleux J, Serteyn D. Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.. Osteoarthritis Cartilage 2011 Nov;19(11):1323-9.
    pubmed: 21884810doi: 10.1016/j.joca.2011.08.002google scholar: lookup
  95. Deberg M, Labasse A, Christgau S, Cloos P, Bang Henriksen D, Chapelle JP, Zegels B, Reginster JY, Henrotin Y. New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.. Osteoarthritis Cartilage 2005 Mar;13(3):258-65.
    pubmed: 15727893doi: 10.1016/j.joca.2004.12.002google scholar: lookup
  96. Ameye LG, Deberg M, Oliveira M, Labasse A, Aeschlimann JM, Henrotin Y. The chemical biomarkers C2C, Coll2-1, and Coll2-1NO2 provide complementary information on type II collagen catabolism in healthy and osteoarthritic mice.. Arthritis Rheum 2007 Oct;56(10):3336-46.
    pubmed: 17907187doi: 10.1002/art.22875google scholar: lookup
  97. Verwilghen DR, Martens A, Busschers E, Franck T, Deberg M, Henrotin Y, Vanderheyden L, Serteyn D. Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis.. Vet Res Commun 2011 Oct;35(7):401-8.
    pubmed: 21681550doi: 10.1007/s11259-011-9487-5google scholar: lookup
  98. Lepage OM, Marcoux M, Tremblay A, Dumas G. Sex does not influence serum osteocalcin levels in standardbred horses of different ages.. Can J Vet Res 1992 Oct;56(4):379-81.
    pmc: PMC1263574pubmed: 1477808
  99. Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW. Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals.. Am J Vet Res 2004 Feb;65(2):143-50.
    pubmed: 14974569doi: 10.2460/ajvr.2004.65.143google scholar: lookup
  100. Frisbie DD, Al-Sobayil F, Billinghurst RC, Kawcak CE, McIlwraith CW. Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses.. Osteoarthritis Cartilage 2008 Oct;16(10):1196-204.
    pubmed: 18442931doi: 10.1016/j.joca.2008.03.008google scholar: lookup
  101. Dimock AN, Siciliano PD, McIlwraith CW. Evidence supporting an increased presence of reactive oxygen species in the diseased equine joint.. Equine Vet J 2000 Sep;32(5):439-43.
    pubmed: 11037267doi: 10.2746/042516400777591129google scholar: lookup
  102. Kehrer JP. Free radicals as mediators of tissue injury and disease.. Crit Rev Toxicol 1993;23(1):21-48.
    pubmed: 8471159doi: 10.3109/10408449309104073google scholar: lookup
  103. Auer DE. An hypothesis on the etio-pathogenesis of equine inflammatory joint disease.. Vet Clin Pathol 1989;18(1):21-6.
    pubmed: 15156523doi: 10.1111/j.1939-165x.1989.tb00508.xgoogle scholar: lookup
  104. Gutteridge JM. Free radicals in disease processes: a compilation of cause and consequence.. Free Radic Res Commun 1993;19(3):141-58.
    pubmed: 8244084doi: 10.3109/10715769309111598google scholar: lookup
  105. De Franceschi L, Grigolo B, Roseti L, Marconi E, Facchini A, Buda R, Vannini F, Giannini S. Osteochondritis dissecans.. Histopathology 2007 Jul;51(1):133-5.
    pubmed: 17532772doi: 10.1111/j.1365-2559.2007.02711.xgoogle scholar: lookup
  106. Vincent F, Brun H, Clain E, Ronot X, Adolphe M. Effects of oxygen-free radicals on proliferation kinetics of cultured rabbit articular chondrocytes.. J Cell Physiol 1989 Nov;141(2):262-6.
    pubmed: 2808536doi: 10.1002/jcp.1041410205google scholar: lookup
  107. Rathakrishnan C, Tiku K, Raghavan A, Tiku ML. Release of oxygen radicals by articular chondrocytes: a study of luminol-dependent chemiluminescence and hydrogen peroxide secretion.. J Bone Miner Res 1992 Oct;7(10):1139-48.
    pubmed: 1280902doi: 10.1002/jbmr.5650071005google scholar: lookup
  108. Serteyn D, Piquemal D, Mendoza L, Caudron I, Noguier F, Bruno R, Sandersen C, Lejeune JP. Osteochondrosis-related gene expression in equine leukocytes differs among affected joints in foals.. Journal of Molecular Biomarkers & Diagnosis 2014;5(5):189.
  109. Kinsley MA, Semevolos SA, Duesterdieck-Zellmer KF. Wnt/β-catenin signaling of cartilage canal and osteochondral junction chondrocytes and full thickness cartilage in early equine osteochondrosis.. J Orthop Res 2015 Oct;33(10):1433-8.
    pubmed: 25676127doi: 10.1002/jor.22846google scholar: lookup
  110. Kaasik A, Safiulina D, Choubey V, Kuum M, Zharkovsky A, Veksler V. Mitochondrial swelling impairs the transport of organelles in cerebellar granule neurons.. J Biol Chem 2007 Nov 9;282(45):32821-6.
    pubmed: 17785462doi: 10.1074/jbc.m702295200google scholar: lookup
  111. Halestrap AP. The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism.. Biochim Biophys Acta 1989 Mar 23;973(3):355-82.
    pubmed: 2647140doi: 10.1016/s0005-2728(89)80378-0google scholar: lookup
  112. Desjardin C, Chat S, Gilles M, Legendre R, Riviere J, Mata X, Balliau T, Esquerré D, Cribiu EP, Betch JM, Schibler L. Involvement of mitochondrial dysfunction and ER-stress in the physiopathology of equine osteochondritis dissecans (OCD).. Exp Mol Pathol 2014 Jun;96(3):328-38.
    pubmed: 24657499doi: 10.1016/j.yexmp.2014.03.004google scholar: lookup
  113. Ruiz-Romero C, López-Armada MJ, Blanco FJ. Mitochondrial proteomic characterization of human normal articular chondrocytes.. Osteoarthritis Cartilage 2006 Jun;14(6):507-18.
    pubmed: 16520066doi: 10.1016/j.joca.2005.12.004google scholar: lookup
  114. Cameron TL, Bell KM, Tatarczuch L, Mackie EJ, Rajpar MH, McDermott BT, Boot-Handford RP, Bateman JF. Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.. PLoS One 2011;6(9):e24600.
    pmc: PMC3174197pubmed: 21935428doi: 10.1371/journal.pone.0024600google scholar: lookup
  115. Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.. Int Rev Cell Mol Biol 2013;301:215-90.
    pmc: PMC3666557pubmed: 23317820doi: 10.1016/b978-0-12-407704-1.00005-1google scholar: lookup
  116. Yammani RR. S100 proteins in cartilage: role in arthritis.. Biochim Biophys Acta 2012 Apr;1822(4):600-6.
    pmc: PMC3294013pubmed: 22266138doi: 10.1016/j.bbadis.2012.01.006google scholar: lookup
  117. Skagen PS, Horn T, Kruse HA, Staergaard B, Rapport MM, Nicolaisen T. Osteochondritis dissecans (OCD), an endoplasmic reticulum storage disease?: a morphological and molecular study of OCD fragments.. Scand J Med Sci Sports 2011 Dec;21(6):e17-33.
    pubmed: 20561273doi: 10.1111/j.1600-0838.2010.01128.xgoogle scholar: lookup
  118. McIlwraith CW. Management of Joint Disease in the Sport Horse.. In: Proceedings of the 2010 Kentucky Equine Research Nutrition Conference, Feeding and Veterinary Management Of The Sport Horse, Lexington, KY, April 26–27, pp. 61–81.
  119. McIlwraith CW. Surgical versus conservative management of osteochondrosis.. Vet J 2013 Jul;197(1):19-28.
    pubmed: 23746868doi: 10.1016/j.tvjl.2013.03.037google scholar: lookup
  120. Pearce SG, Firth EC, Grace ND, Fennessy PF. Effect of copper supplementation on the evidence of developmental orthopaedic disease in pasture-fed New Zealand Thoroughbreds.. Equine Vet J 1998 May;30(3):211-8.
    pubmed: 9622322doi: 10.1111/j.2042-3306.1998.tb04490.xgoogle scholar: lookup
  121. Sparks HD, Nixon AJ, Fortier LA, Mohammed HO. Arthroscopic reattachment of osteochondritis dissecans cartilage flaps of the femoropatellar joint: long-term results.. Equine Vet J 2011 Nov;43(6):650-9.
    pubmed: 21649712doi: 10.1111/j.2042-3306.2011.00362.xgoogle scholar: lookup
  122. Stack JD, Levingstone TJ, Lalor W, Sanders R, Kearney C, O'Brien FJ, David F. Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete.. J Tissue Eng Regen Med 2017 Oct;11(10):2785-2795.
    pubmed: 27198896doi: 10.1002/term.2173google scholar: lookup
  123. Corzani M, Meccariello L, Bisaccia M, Ferrara P, Rinonapoli G, Piscitelli L, Liberata Meccariello M, Caraffa A. A modern treatment of bilateral osteochondritis dissecans in knees: From a case report to literature’s review.. International Journal of Surgery and Medicine 2016;2(4):223–229.

Citations

This article has been cited 12 times.
  1. Schmökel H, Farrell A, Balisi MF. Subchondral defects resembling osteochondrosis dissecans in joint surfaces of the extinct saber-toothed cat Smilodon fatalis and dire wolf Aenocyon dirus. PLoS One 2023;18(7):e0287656.
    doi: 10.1371/journal.pone.0287656pubmed: 37436967google scholar: lookup
  2. Zhang J, Hu Y, Wang Z, Wu X, Yang C, Yang H. Hypoxia-inducible factor expression is related to apoptosis and cartilage degradation in temporomandibular joint osteoarthritis. BMC Musculoskelet Disord 2022 Jun 16;23(1):583.
    doi: 10.1186/s12891-022-05544-xpubmed: 35710352google scholar: lookup
  3. Kajabi AW, Zbýň Š, Johnson CP, Tompkins MA, Nelson BJ, Takahashi T, Shea KG, Marette S, Carlson CS, Ellermann JM. Longitudinal 3T MRI T(2) * mapping of Juvenile osteochondritis dissecans (JOCD) lesions differentiates operative from non-operative patients-Pilot study. J Orthop Res 2023 Jan;41(1):150-160.
    doi: 10.1002/jor.25343pubmed: 35430743google scholar: lookup
  4. Storch C, Fuhrmann H, Schoeniger A. HOX Gene Expressions in Cultured Articular and Nasal Equine Chondrocytes. Animals (Basel) 2021 Aug 30;11(9).
    doi: 10.3390/ani11092542pubmed: 34573508google scholar: lookup
  5. Golonka P, Kornicka-Garbowska K, Marycz K. SIRT1(+) Adipose Derived Mesenchymal Stromal Stem Cells (ASCs) Suspended in Alginate Hydrogel for the Treatment of Subchondral Bone Cyst in Medial Femoral Condyle in the Horse. Clinical Report. Stem Cell Rev Rep 2020 Dec;16(6):1328-1334.
    doi: 10.1007/s12015-020-10025-6pubmed: 32803696google scholar: lookup
  6. Büttgen L, Geibel J, Simianer H, Pook T. Simulation Study on the Integration of Health Traits in Horse Breeding Programs. Animals (Basel) 2020 Jul 7;10(7).
    doi: 10.3390/ani10071153pubmed: 32645982google scholar: lookup
  7. Kornicka-Garbowska K, Pędziwiatr R, Woźniak P, Kucharczyk K, Marycz K. Microvesicles isolated from 5-azacytidine-and-resveratrol-treated mesenchymal stem cells for the treatment of suspensory ligament injury in horse-a case report. Stem Cell Res Ther 2019 Dec 18;10(1):394.
    doi: 10.1186/s13287-019-1469-5pubmed: 31852535google scholar: lookup
  8. Chiaradia E, Pepe M, Orvietani PL, Renzone G, Magini A, Sforna M, Emiliani C, Di Meo A, Scaloni A. Proteome Alterations in Equine Osteochondrotic Chondrocytes. Int J Mol Sci 2019 Dec 7;20(24).
    doi: 10.3390/ijms20246179pubmed: 31817880google scholar: lookup
  9. Marycz K, Szłapka-Kosarzewska J, Geburek F, Kornicka-Garbowska K. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev Rep 2019 Dec;15(6):842-850.
    doi: 10.1007/s12015-019-09913-3pubmed: 31620992google scholar: lookup
  10. Martinez-Saez L, Marín-García PJ, Llobat ML. Osteochondrosis in horses: An overview of genetic and other factors. Equine Vet J 2026 Jan;58(1):6-19.
    doi: 10.1111/evj.14518pubmed: 40302410google scholar: lookup
  11. Theyse LFH, Mazur EM. Osteoarthritis, adipokines and the translational research potential in small animal patients. Front Vet Sci 2024;11:1193702.
    doi: 10.3389/fvets.2024.1193702pubmed: 38831954google scholar: lookup
  12. Canonici F, Cocumelli C, Cersini A, Marcoccia D, Zepparoni A, Altigeri A, Caciolo D, Roncoroni C, Monteleone V, Innocenzi E, Alimonti C, Ghisellini P, Rando C, Pechkova E, Eggenhöffner R, Scicluna MT, Barbaro K. Articular Cartilage Regeneration by Hyaline Chondrocytes: A Case Study in Equine Model and Outcomes. Biomedicines 2023 May 31;11(6).
    doi: 10.3390/biomedicines11061602pubmed: 37371697google scholar: lookup
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