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Home / Equine Research Bank / Viruses / Papillomavirus-like Particles in Equine Medicine.
Viruses2023; 15(2); 345; doi: 10.3390/v15020345

Papillomavirus-like Particles in Equine Medicine.

Abstract: Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.
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Publication Date: 2023-01-25 PubMed ID: 36851559PubMed Central: PMC9966523DOI: 10.3390/v15020345Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article covers the phenomenon of Papillomaviruses (PVs) causing benign lesions or cancer in vertebrates, with a particular focus on horses and other equids. The paper also discusses the development of vaccines that use virus-like particles (VLPs), derived from PV capside-proteins, for the efficient protection against PV infections.

Papillomaviruses and Their Effect on Equids

  • The focus of this research paper is on a specific family of small DNA tumor viruses known as Papillomaviruses (PVs). These viruses are known for their ability to induce benign lesions or cancer in vertebrates, including horses and other equids.
  • These PV-induced tumors are a consequential matter in equine species, as the research sheds light on this specific issue.

Transmission Routes of PV in Equid Species

  • Apart from discussing the effect of PVs on equids, the paper also explores possible routes through which these viruses might be transmitted among equid species.
  • This understanding is crucial in preventive procedures and in curbing the spread of these viruses within the equid population.

Virus-Like Particles (VLPs) based Vaccine

  • The most notable feature of PVs that the study highlights is their method of defense against the capsid-proteins of PVs, which spontaneously self-assemble to form empty, highly immunogenic virus-like particles (VLPs).
  • These VLPs have led to the creation of effective vaccines that can protect human beings from specific PV infections and their associated diseases.
  • The paper discusses recent developments concerning the adaptation of this PV VLP-based vaccine technology for use within equine medicine.

Cite This Article

APA
Hainisch EK, Jindra C, Kirnbauer R, Brandt S. (2023). Papillomavirus-like Particles in Equine Medicine. Viruses, 15(2), 345. https://doi.org/10.3390/v15020345

Publication

Viruses
ISSN: 1999-4915
NlmUniqueID: 101509722
Country: Switzerland
Language: English
Volume: 15
Issue: 2
PII: 345

Researcher Affiliations

Hainisch, Edmund K
  • Research Group Oncology (RGO), Clinical Unit of Equine Surgery, Department for Companion Animals and Horses, Veterinary University, 1210 Vienna, Austria.
Jindra, Christoph
  • Research Group Oncology (RGO), Clinical Unit of Equine Surgery, Department for Companion Animals and Horses, Veterinary University, 1210 Vienna, Austria.
  • Division of Molecular Oncology and Haematology, Karl Landsteiner University of Health Sciences, 3500 Krems an der Donau, Austria.
Kirnbauer, Reinhard
  • Laboratory of Viral Oncology (LVO), Department of Dermatology, Medical University, 1090 Vienna, Austria.
Brandt, Sabine
  • Research Group Oncology (RGO), Clinical Unit of Equine Surgery, Department for Companion Animals and Horses, Veterinary University, 1210 Vienna, Austria.

MeSH Terms

  • Animals
  • Capsid
  • Capsid Proteins / genetics
  • Capsid Proteins / immunology
  • Horses
  • Papillomaviridae / genetics
  • Vaccines, Virus-Like Particle
  • Papillomavirus Infections / prevention & control
  • Papillomavirus Infections / transmission
  • Horse Diseases / prevention & control
  • Horse Diseases / transmission
  • Horse Diseases / virology

Grant Funding

  • P50 CA098252 / NCI NIH HHS

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 3 times.
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