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Home / Equine Research Bank / Vet Surg / Percutaneous doxycycline sclerotherapy in a horse with a man...
Veterinary surgery : VS2022; 51(8); 1265-1272; doi: 10.1111/vsu.13844

Percutaneous doxycycline sclerotherapy in a horse with a mandibular aneurysmal bone cyst.

Abstract: To describe the use and outcome of sclerotherapy with intralesional doxycycline foam in a horse with a mandibular aneurysmal bone cyst. Methods: Case report. Methods: Client-owned 1 year old Standardbred filly. Methods: The horse presented for progressive mandibular swelling. A 10 mg/mL doxycycline foam was prepared for intralesional injection. Three doses were injected into the lesion under computed tomographic guidance at 6 and 15 weeks after initial treatment. Volume reduction was monitored after each treatment with 3D volumetric rendering and region of interest segmentation using commercially available software. Results: The volume of the lesion decreased from 458.7455 cm before treatment, to 363.3101 cm at 6 weeks, 273.5855 cm at 15 weeks, and 247.2316 cm 6 months later, resulting in a total reduction of 54% of the initial volume. Bone formation was noted in the lesion. No adverse effects related to doxycycline foam injections were noted. The mandibular swelling was resolved after treatment. Conclusions: Intralesional doxycycline sclerotherapy was shown to be efficacious in reducing the volume of the aneurysmal bone cyst in the horse presented in this report. There was complete resolution of mandibular swelling with no side effects related to the intralesional injections.
© 2022 American College of Veterinary Surgeons.
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Publication Date: 2022-06-22 PubMed ID: 35730789DOI: 10.1111/vsu.13844Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a treatment method using doxycycline sclerotherapy for a horse with a mandibular aneurysmal bone cyst. The treatment was found effective reducing the volume of the cyst and causing no adverse effects.

Patient and Presentation

  • The subject of the study was a one-year-old Standardbred filly, which had an aneurysmal bone cyst in its mandible. The horse was presented with progressive mandibular swelling, an indication of the presence of the bone cyst.

Methodology

  • The researchers prepared a 10 mg/mL intralesional injection of doxycycline foam for treating the cyst.
  • Three doses of this foam were administered to the horse under the guidance of computed tomography. The timing of the doses was at the initial treatment, 6 weeks after the initial treatment, and 15 weeks after the initial treatment.
  • Post each treatment, the researchers monitored the cyst’s volume using 3D volumetric rendering and region of interest segmentation provided by commercially available software.

Results

  • The cyst’s volume witnessed a significant reduction post the treatments. Initially, the volume was 458.7455 cm, which reduced to 363.3101 cm at 6 weeks, 273.5855 cm at 15 weeks and finally, to 247.2316 cm after 6 months of the initial treatment.
  • In total, there was a 54% reduction in the volume of the cyst from before the initial treatment to 6 months post the initial treatment.
  • Notably, bone formation was observed within the lesion attributable to the treatments.
  • No adverse outcomes or side effects resulting from the injections of doxycycline foam were reported.
  • The issue of mandibular swelling in the horse was completely resolved after the treatment course.

Conclusion

  • This study demonstrates the effectiveness of using intralesional doxycycline sclerotherapy in treating an aneurysmal bone cyst in a horse.
  • The treatment not only led to significant cyst volume reduction but also prompted bone formation within the lesion and resolved the swelling issue, all without causing any noticeable side effects.

Cite This Article

APA
Perez JA, Weber KL, Bender SJ, Wulster KB, Parente EJ. (2022). Percutaneous doxycycline sclerotherapy in a horse with a mandibular aneurysmal bone cyst. Vet Surg, 51(8), 1265-1272. https://doi.org/10.1111/vsu.13844

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 51
Issue: 8
Pages: 1265-1272

Researcher Affiliations

Perez, Jairo A
  • Department of Clinical Sciences, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Weber, Kristy L
  • Cancer Center and Division of Orthopedics at Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Bender, Susan J
  • Department of Clinical Sciences, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Wulster, Kathryn B
  • Department of Clinical Sciences, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Parente, Eric J
  • Department of Clinical Sciences, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

MeSH Terms

  • Horses
  • Female
  • Animals
  • Sclerotherapy / veterinary
  • Sclerotherapy / adverse effects
  • Sclerotherapy / methods
  • Bone Cysts, Aneurysmal / drug therapy
  • Bone Cysts, Aneurysmal / etiology
  • Bone Cysts, Aneurysmal / veterinary
  • Doxycycline / therapeutic use
  • Treatment Outcome
  • Injections, Intralesional / veterinary
  • Horse Diseases / etiology

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This article includes 24 references
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