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The Veterinary clinics of North America. Equine practice2017; 33(3); 551-562; doi: 10.1016/j.cveq.2017.08.004

Periocular Neoplasia in the Horse.

Abstract: Periocular neoplasia is common in horses. Treatment of the periocular skin and ocular adnexal structures can be technically challenging. Common neoplastic conditions, a treatment algorithm, surgical principles, and therapeutic modalities are reviewed. Regardless of the type of neoplasia found or the treatment that is applied, success is most likely when the neoplastic tumor is small.
Publication Date: 2017-11-07 PubMed ID: 29103561DOI: 10.1016/j.cveq.2017.08.004Google Scholar: Lookup
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Summary

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The research article focuses on the prevalence of periocular neoplasia in horses and looks into its treatments, which can be technically demanding due to the challenge presented by the ocular and periocular skin structures. It further discusses common neoplastic conditions, treatment approaches, surgical principles, and therapeutic measures. The paper highlights that the smaller the neoplastic tumor, the higher the chances of successful treatment.

Common Neoplastic Conditions

  • The paper starts by giving an overview of common neoplastic conditions that affect horses. These conditions are primarily characterized by abnormal growths that start in the ocular and periocular skin structures.
  • These neoplasms can range from benign to malignant and knowing the type can be key in informing the treatment and management methods used.

Treatment Algorithm

  • The research discusses the algorithm that can be used to treat periocular neoplasia in horses. An algorithm here refers to a step-by-step procedure that can be consistently followed in the management and treatment of this condition.
  • This could involve steps such as diagnosis, determining the severity and type of neoplasm, deciding the treatment method, and then following up on the treatment success.

Surgical Principles

  • The article emphasizes some of the surgical principles that need to be adhered to when treating periocular neoplasia. Due to the delicate nature of the ocular and periocular structures, it would be crucial to abide by these principles for successful surgery.
  • These principles could involve ensuring minimal invasive techniques are applied, cleanliness to prevent infections, and techniques to limit post-surgery complications.

Therapeutic Modalities

  • Various therapeutic modalities used in the management and treatment of periocular neoplasia in horses are discussed in the article. These therapeutic options could involve surgical procedures, chemotherapy, radiation therapy, or a combination of these, based on the type and severity of neoplasm.

Success of Treatment

  • Lastly, the paper points out that the success of the treatment is most likely when the neoplastic tumor is small. This may be because smaller growths can be more efficiently managed and eliminated, causing less damage to the ocular and periocular structures of the horse.
  • The researchers emphasize on the importance of early detection for the treatment to be successful.

Cite This Article

APA
Estell K. (2017). Periocular Neoplasia in the Horse. Vet Clin North Am Equine Pract, 33(3), 551-562. https://doi.org/10.1016/j.cveq.2017.08.004

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 33
Issue: 3
Pages: 551-562
PII: S0749-0739(17)30888-X

Researcher Affiliations

Estell, Krista
  • Department of Equine Internal Medicine, Marion duPont Scott Equine Medical Center, Virginia-Maryland College of Veterinary Medicine, 17690 Old Waterford Road, Leesburg, VA 20176, USA. Electronic address: Krista.estell@gmail.com.

MeSH Terms

  • Animals
  • Carcinoma, Squamous Cell / therapy
  • Carcinoma, Squamous Cell / veterinary
  • Eye Neoplasms / therapy
  • Eye Neoplasms / veterinary
  • Eyelid Neoplasms / therapy
  • Eyelid Neoplasms / veterinary
  • Head and Neck Neoplasms / therapy
  • Head and Neck Neoplasms / veterinary
  • Horse Diseases / therapy
  • Horses
  • Squamous Cell Carcinoma of Head and Neck

Citations

This article has been cited 6 times.
  1. Wotman KL, Chow L, Martabano B, Pezzanite LM, Dow S. Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia. Cancer Immunol Immunother 2023 May;72(5):1185-1198.
    doi: 10.1007/s00262-022-03321-2pubmed: 36367558google scholar: lookup
  2. De Ridder T, Ruppin M, Wheeless M, Williams S, Reddell P. Use of the Intratumoural Anticancer Drug Tigilanol Tiglate in Two Horses. Front Vet Sci 2020;7:639.
    doi: 10.3389/fvets.2020.00639pubmed: 33033726google scholar: lookup
  3. Giraldo A, Pinard CL, Plattner BL, Dubois MS. Periocular sarcoid with bone invasion in a Thoroughbred mare. Can Vet J 2020 Apr;61(4):415-419.
    pubmed: 32255829
  4. de Moura Alonso J, Apolonio EVP, Teng FS, Perandré PI, Amorim RL, Mazaro RD, Watanabe MJ, Alves ALG, Hussni CA. Periocular basal cell carcinoma in a donkey: case report. Vet Res Commun 2025 Feb 18;49(2):106.
    doi: 10.1007/s11259-025-10680-5pubmed: 39964623google scholar: lookup
  5. Blohm KO, Nell B. Adjunctive bevacizumab therapy in an equine corneal stromal invasive squamous cell carcinoma with a 53-months follow-up. Tierarztl Prax Ausg G Grosstiere Nutztiere 2024 Apr;52(2):108-114.
    doi: 10.1055/a-2253-8103pubmed: 38701802google scholar: lookup
  6. Chow L, Flaherty E, Pezzanite L, Williams M, Dow S, Wotman K. Impact of Equine Ocular Surface Squamous Neoplasia on Interactions between Ocular Transcriptome and Microbiome. Vet Sci 2024 Apr 7;11(4).
    doi: 10.3390/vetsci11040167pubmed: 38668434google scholar: lookup