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The Veterinary clinics of North America. Equine practice1999; 15(3); 725-746; doi: 10.1016/s0749-0739(17)30141-4

Pharmacologic considerations in the treatment of neonatal septicemia and its complications.

Abstract: This article focuses on the pharmacologic properties of drugs commonly used in the treatment of neonatal septicemia and its complications. Rational therapy demands an awareness of not only the pharmacology of individual drugs but also the interactions and anticipated fate of such drugs in the rapidly changing physiologic environment of the neonate. Further research in the area of equine neonatal pharmacology should greatly assist our understanding of the impact of the disease state on the unique physiology of the newborn and should allow us to better predict the ultimate fate of drugs commonly used for such purposes. Careful dosing and close monitoring of pharmacologic effects are critical for a successful outcome. In the future, newer therapeutic strategies that are safe and efficacious may provide a means to circumvent many of the problems currently encountered with treating the septicemic newborn foal.
Publication Date: 1999-12-10 PubMed ID: 10589476DOI: 10.1016/s0749-0739(17)30141-4Google Scholar: Lookup
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Summary

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The research investigates the properties and interactions of drugs used to treat septicemia in newborn foals, advocating for further research in equine neonatal pharmacology to improve effective dosing and monitoring for a successful outcome.

Pharmacology of drugs for neonatal septicemia

  • In this paper, the authors underscore the importance of understanding the pharmacologic properties of drugs used in the treatment of septicemia in newborn foals.
  • This involves not only the unique qualities of individual drugs, but also how these drugs interact with one another once administered to a patient. This can influence the overall effectiveness of a drug treatment plan.
  • Rational drug therapy requires an appreciation and understanding of these pharmacologic dynamics in order to optimize the efficacy and safety of treatment.

Importance of further research in equine neonatal pharmacology

  • According to the authors, there is a need for continued research in the field of equine neonatal pharmacology. This is due to the unique physiological state of neonates and how it can affect drug metabolism and response.
  • By gaining a deeper understanding of how a disease state influences the newborn foal’s unique physiology, medical professionals may be better equipped to anticipate the ultimate fate of commonly-used drugs and adjust their treatment strategies accordingly.

The need for careful drug dosing and monitoring

  • For successful treatment outcomes, the paper emphasizes the importance of careful dosing and close monitoring of pharmacologic effects. This is because rapid physiological changes in neonatal foals can alter drug interactions and effects.
  • Controlling the amount of drug administered and keeping a close eye on its impacts can help to adjust treatment plans in real time, ensuring better outcomes.

Future prospects in therapy for neonatal septicemia

  • The paper concludes with the authors expressing hope for the development of new therapeutic strategies that are both safe and effective. Such developments have the potential to circumvent many of the challenges currently associated with treating septicemia in newborn foals.
  • Such developments could likely revolutionize the treatment protocol for neonatal septicemia, offering a more predictable and thus more effective treatment regimen.

Cite This Article

APA
Wichtel ME, Buys E, DeLuca J, Stringel G. (1999). Pharmacologic considerations in the treatment of neonatal septicemia and its complications. Vet Clin North Am Equine Pract, 15(3), 725-746. https://doi.org/10.1016/s0749-0739(17)30141-4

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 15
Issue: 3
Pages: 725-746

Researcher Affiliations

Wichtel, M E
  • Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada. mwichtel@upei.ca
Buys, E
    DeLuca, J
      Stringel, G

        MeSH Terms

        • Animals
        • Animals, Newborn
        • Anti-Bacterial Agents / therapeutic use
        • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
        • Antidiarrheals / therapeutic use
        • Cephalosporins / therapeutic use
        • Histamine H2 Antagonists / therapeutic use
        • Horse Diseases / drug therapy
        • Horses
        • Hypnotics and Sedatives / therapeutic use
        • Sepsis / drug therapy
        • Sepsis / veterinary
        • Sulfonamides / therapeutic use

        Citations

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