Pharmacologic treatment of priapism in two horses.
Abstract: Benztropine mesylate was used successfully to treat priapism that developed during anesthesia in 2 horses. After IV injection, there was a rapid resolution of signs in both horses, and no side effects were observed. The choice of an effective method to treat priapism is challenging because precise causes in most patients have not been well-defined. Benztropine mesylate is a synthetic compound resulting from the combination of the active portions of atropine and diphenhydramine, and is believed effective because of its central acetyl-choline-antagonizing properties.
Publication Date: 1991-11-01 PubMed ID: 1752772
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Summary
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The research article presents a successful use of drug Benztropine mesylate in treating abnormal erection, known as priapism, in two anaesthetised horses without any negative side effects.
Introduction and Method
- The study was conducted on two horses that developed priapism during anesthesia.
- The researchers administered Benztropine mesylate, a synthetic compound derived from the active portions of two drugs – atropine and diphenhydramine, intravenously.
Results
- After the intravenous injection of Benztropine mesylate, both the horses showed a quick resolution of signs indicating priapism.
- Moreover, no side effects were observed in both the subjects.
Significance and Conclusion
- The study acknowledges the difficulty in choosing an effective treatment for priapism due to its usually undefined precise causes.
- The successful outcomes from this research might be attributed to the central acetyl-choline-antagonizing properties of Benztropine mesylate.
- The results indicate that Benztropine mesylate could be a potential choice for treating priapism in horses.
- However, further studies with more subjects could be needed to definitively establish its efficacy and scope of use.
Cite This Article
APA
Wilson DV, Nickels FA, Williams MA.
(1991).
Pharmacologic treatment of priapism in two horses.
J Am Vet Med Assoc, 199(9), 1183-1184.
Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
MeSH Terms
- Anesthesia, General / adverse effects
- Anesthesia, General / veterinary
- Animals
- Arthroscopy / veterinary
- Benztropine / analogs & derivatives
- Benztropine / therapeutic use
- Horse Diseases / drug therapy
- Horse Diseases / etiology
- Horses
- Male
- Parasympatholytics / therapeutic use
- Priapism / drug therapy
- Priapism / etiology
- Priapism / veterinary
- Urinary Bladder Calculi / surgery
- Urinary Bladder Calculi / veterinary
- Urinary Catheterization / veterinary
Citations
This article has been cited 2 times.- Roux FA, Le Breuil F, Branchereau J, Deschamps JY. Stuttering Priapism in a Dog-First Report. Vet Sci 2022 Sep 23;9(10).
- Dodd AL, Patel S, Fipps DC. Loxapine-Induced Priapism: A Case Report and Review of the Literature on Antipsychotic-Induced Priapism. Case Rep Psychiatry 2021;2021:5589967.
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