Plasma glucose and insulin concentrations and feeding behavior in ponies.
Abstract: The hypothesis that changes in blood glucose concentrations and(or) utilization rate affect feeding behavior in ponies was tested. Ponies (n = 4) were fasted for 4 h, then given iv injections of 50% glucose [.2 g glucose/BW.75 kg (low dose, LD) or 1.0 g glucose/BW.75 kg (high dose, HD)] or an equal volume of normal saline (HDS; LDS) 5 min before being allowed access to pelleted feed. Blood samples were drawn at regular intervals pre- and post-treatment and analyzed for plasma glucose (PG), immunoreactive insulin (IRI) and glucagon concentrations. All glucose-treated animals immediately ate meals of size (HD = .67 +/- .23 kg, LD = .62 +/- .30 kg) and duration (HD = 54 +/- 19 min; LD = 49 +/- 16 min) comparable to those observed after saline injections (HDS = .58 +/- .29 kg in 48 +/- 16 min. LDS = .58 +/- .10 g in 50 +/- 15 min). There was a tendency, however, to prolong the interval between the first and second meal (first intermeal interval) after glucose injections (LD = 62 +/- 16 min, P less than .10; HD = 65 +/- 12 min, P less than .05) relative to saline treatment (LDS = 44 +/- 15 min; HDS = 35 +/- 8 min). Glucose-treated ponies PG was elevated (P less than .01) at the time of refeeding (LD = 122 +/- 14 mg/100 ml; HD = 259 +/- 69 mg/100 ml) relative to controls (84 +/- 2 mg/100 ml) as was 11.2 ng/ml; control = 2.67 +/- 2.20 ng/ml). The concentration of glucagon did not change significantly with either feeding of glucose treatment. The animal's PG and IRI dropped to within or below control ranges by 35 (LD) or 65 min (HD) post-treatment. The results indicated that, in ponies, intravenous glucose loads can prolong the duration of satiety experienced after a meal. Exogenously-induced hyperglycemia and resultant hyperinsulinemia do not, however, affect the first meal size or duration of ponies after a 4 h fast.
Publication Date: 1982-06-01 PubMed ID: 7050066DOI: 10.2527/jas1982.5461132xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research studied ponies to explore the impact of changes in blood glucose concentration and its rate of utilization on feeding behavior. The results indicate that intravenous glucose loads can extend the length of satiety after a meal. However, the first meal size or duration is not influenced by externally induced high blood sugar and corresponding high insulin levels.
Investigation Method
- The study subjects were four ponies. To set a controlled environment, the ponies were put on a 4-hour fast.
- Post the fast, ponies were intravenously injected with a solution of 50% glucose. Two quantities were administered – a low dose and a high dose. Normal saline injections were also given as a part of the control group.
- Five minutes post injections, the ponies were given pelleted feed.
- Blood samples were drawn at regular intervals before and after the treatment, which were then analyzed for plasma glucose, insulin, and glucagon concentrations.
Observations and Findings
- The study observed that all glucose-treated ponies immediately consumed meals of size and duration comparable to those observed after saline injections.
- However, there was a tendency to extend the interval between the first and second meal following a glucose injection.
- At the time of refeeding, glucose-treated ponies showed elevated Plasma Glucose (PG) and Insulin levels relative to controls. The concentration of glucagon, however, did not change significantly with feeding or glucose treatment.
- The PG and insulin levels dropped to within or below control ranges about 35 (Low Dose) or 65 min (High Dose) post-treatment.
Conclusion
- The research concluded that, in ponies, intravenous glucose loads can prolong the duration of satiety experienced after a meal.
- However, the first meal size or the duration to finish it was not affected by externally induced high blood glucose levels and corresponding high insulin levels.
- These findings indicate a complex interplay between glucose and insulin concentrations with feeding behavior in ponies.
Cite This Article
APA
Ralston SL, Baile CA.
(1982).
Plasma glucose and insulin concentrations and feeding behavior in ponies.
J Anim Sci, 54(6), 1132-1137.
https://doi.org/10.2527/jas1982.5461132x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Blood Glucose / metabolism
- Feeding Behavior
- Glucagon / blood
- Horses / physiology
- Insulin / blood
- Male
Grant Funding
- GM-02051 / NIGMS NIH HHS
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
