Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses.
Abstract: To determine the relationship between plasma lactate concentration and colonic viability and survival in horses with >or=360 degrees volvulus of the ascending colon. Methods: Retrospective study. Methods: Horses (n=73) with >or=360 degrees volvulus of the ascending colon. Methods: Medical records (January 2000-November 2005) of all horses examined for colic at Michigan State University Veterinary Teaching Hospital were reviewed. Horses were included only if plasma lactate concentration was measured preoperatively and a diagnosis of >or=360 degrees volvulus of the ascending colon was confirmed by surgery or necropsy. Non-survivors were only included if the ascending colon was evaluated histopathologically. Logistic regression analysis was used to model the relationship between lactate, colonic viability, and survival. Results: Of 73 horses, 61 were discharged. Mean (+/-SD) plasma lactate concentration was significantly lower in survivors (2.98+/-2.53 mmol/L) compared with non-survivors (9.48+/-5.22 mmol/L; odds ratio [OR]=1.628, 95% confidence limit [CI]=1.259-2.105). Plasma lactate concentration was significantly lower in horses with a viable colon (3.30+/-2.85 mmol/L) compared with horses with a non-viable colon (9.1+/-6.09 mmol/L; OR=1.472, 95% CI=1.173-1.846). Plasma lactate concentration or=360 degrees volvulus of the ascending colon. Conclusions: Plasma lactate concentration may help predict colonic viability and horse survival after ascending colon volvulus in horses.
Publication Date: 2007-08-10 PubMed ID: 17686130DOI: 10.1111/j.1532-950X.2007.00305.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This study investigates the association between plasma lactate levels and the survival rate and colonic viability in horses suffering from extensive volvulus in the ascending colon. The researchers find a significant correlation, suggesting plasma lactate concentration can serve as a predictive tool for horse survival and colon health after a severe volvulus event.
Research Methodology
- The study was conducted retrospectively, analyzing medical records for horses suffering from extensive twists (or, in medical terms, volvulus) of 360 degrees or more in the ascending colon.
- The analysis was based on medical records spanning from January 2000 to November 2005. All records were sourced from Michigan State University Veterinary Teaching Hospital.
- The study included only those cases where plasma lactate concentration was measured preoperatively and the diagnosis of extensive volvulus in the ascending colon was confirmed through surgery or post-mortem examination.
- Non-surviving horses were included in the study only if the condition of the ascending colon was evaluated using histological techniques.
- A statistical method, logistic regression analysis, was employed to understand the correlation between plasma lactate levels, colonic viability, and survival probability.
Key Findings
- A total of 73 horses were incorporated in the study, out of which, 61 survived and were discharged.
- The average plasma lactate concentration in surviving horses was significantly lower (2.98±2.53 mmol/L) as compared to non-survivors (9.48±5.22 mmol/L). The odds ratio calculated was 1.628, with a 95% confidence interval of 1.259-2.105.
- Horses with a viable colon showed a significantly lower plasma lactate concentration (3.30±2.85 mmol/L) in comparison to those with a non-viable colon (9.1±6.09 mmol/L). The odds ratio was measured as 1.472, with a 95% confidence interval of 1.173-1.846.
- A plasma lactate concentration lower than 6.0 mmol/L predicted survival with an 84% sensitivity and 83% specificity.
Conclusions
- The researchers concluded that there was a strong association between plasma lactate concentration at the time of hospital admission and the outcome in horses with extensive volvulus of the ascending colon.
- Plasma lactate concentration can serve as a predictive parameter for assessing colonic viability and survival after a severe volvulus event in horses.
Cite This Article
APA
Johnston K, Holcombe SJ, Hauptman JG.
(2007).
Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses.
Vet Surg, 36(6), 563-567.
https://doi.org/10.1111/j.1532-950X.2007.00305.x Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, Michigan State University, College of Veterinary Medicine, East Lansing, MI 48824, USA.
MeSH Terms
- Animals
- Biomarkers / blood
- Colonic Diseases / blood
- Colonic Diseases / mortality
- Colonic Diseases / surgery
- Colonic Diseases / veterinary
- Female
- Horse Diseases / blood
- Horse Diseases / mortality
- Horse Diseases / surgery
- Horses
- Intestinal Volvulus / blood
- Intestinal Volvulus / mortality
- Intestinal Volvulus / surgery
- Intestinal Volvulus / veterinary
- Lactic Acid / blood
- Male
- Necrosis
- Predictive Value of Tests
- Prognosis
- Retrospective Studies
- Sensitivity and Specificity
- Survival Analysis
- Treatment Outcome
Citations
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- Kretsch CM, Chigerwe M. Assessment of preoperative and postoperative l-lactatemia and clinical outcomes in goats undergoing tube cystostomy: A retrospective study of 34 cases (2015-2020).. J Vet Intern Med 2021 Nov;35(6):2926-2932.
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- Gehlen H, Faust MD, Grzeskowiak RM, Trachsel DS. Association Between Disease Severity, Heart Rate Variability (HRV) and Serum Cortisol Concentrations in Horses with Acute Abdominal Pain.. Animals (Basel) 2020 Sep 2;10(9).
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- Johnson LM, Holcombe SJ, Shearer TR, Watson V, Gandy J, Southwood LL, Lynch TM, Schroeder EL, Fogle CA, Sordillo LM. Multicenter Placebo-Controlled Randomized Study of Ethyl Pyruvate in Horses Following Surgical Treatment for ≥ 360° Large Colon Volvulus.. Front Vet Sci 2020;7:204.
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