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Veterinary surgery : VS2007; 36(6); 563-567; doi: 10.1111/j.1532-950X.2007.00305.x

Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses.

Abstract: To determine the relationship between plasma lactate concentration and colonic viability and survival in horses with >or=360 degrees volvulus of the ascending colon. Methods: Retrospective study. Methods: Horses (n=73) with >or=360 degrees volvulus of the ascending colon. Methods: Medical records (January 2000-November 2005) of all horses examined for colic at Michigan State University Veterinary Teaching Hospital were reviewed. Horses were included only if plasma lactate concentration was measured preoperatively and a diagnosis of >or=360 degrees volvulus of the ascending colon was confirmed by surgery or necropsy. Non-survivors were only included if the ascending colon was evaluated histopathologically. Logistic regression analysis was used to model the relationship between lactate, colonic viability, and survival. Results: Of 73 horses, 61 were discharged. Mean (+/-SD) plasma lactate concentration was significantly lower in survivors (2.98+/-2.53 mmol/L) compared with non-survivors (9.48+/-5.22 mmol/L; odds ratio [OR]=1.628, 95% confidence limit [CI]=1.259-2.105). Plasma lactate concentration was significantly lower in horses with a viable colon (3.30+/-2.85 mmol/L) compared with horses with a non-viable colon (9.1+/-6.09 mmol/L; OR=1.472, 95% CI=1.173-1.846). Plasma lactate concentration or=360 degrees volvulus of the ascending colon. Conclusions: Plasma lactate concentration may help predict colonic viability and horse survival after ascending colon volvulus in horses.
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Publication Date: 2007-08-10 PubMed ID: 17686130DOI: 10.1111/j.1532-950X.2007.00305.xGoogle Scholar: Lookup
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  • Journal Article

Summary

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This study investigates the association between plasma lactate levels and the survival rate and colonic viability in horses suffering from extensive volvulus in the ascending colon. The researchers find a significant correlation, suggesting plasma lactate concentration can serve as a predictive tool for horse survival and colon health after a severe volvulus event.

Research Methodology

  • The study was conducted retrospectively, analyzing medical records for horses suffering from extensive twists (or, in medical terms, volvulus) of 360 degrees or more in the ascending colon.
  • The analysis was based on medical records spanning from January 2000 to November 2005. All records were sourced from Michigan State University Veterinary Teaching Hospital.
  • The study included only those cases where plasma lactate concentration was measured preoperatively and the diagnosis of extensive volvulus in the ascending colon was confirmed through surgery or post-mortem examination.
  • Non-surviving horses were included in the study only if the condition of the ascending colon was evaluated using histological techniques.
  • A statistical method, logistic regression analysis, was employed to understand the correlation between plasma lactate levels, colonic viability, and survival probability.

Key Findings

  • A total of 73 horses were incorporated in the study, out of which, 61 survived and were discharged.
  • The average plasma lactate concentration in surviving horses was significantly lower (2.98±2.53 mmol/L) as compared to non-survivors (9.48±5.22 mmol/L). The odds ratio calculated was 1.628, with a 95% confidence interval of 1.259-2.105.
  • Horses with a viable colon showed a significantly lower plasma lactate concentration (3.30±2.85 mmol/L) in comparison to those with a non-viable colon (9.1±6.09 mmol/L). The odds ratio was measured as 1.472, with a 95% confidence interval of 1.173-1.846.
  • A plasma lactate concentration lower than 6.0 mmol/L predicted survival with an 84% sensitivity and 83% specificity.

Conclusions

  • The researchers concluded that there was a strong association between plasma lactate concentration at the time of hospital admission and the outcome in horses with extensive volvulus of the ascending colon.
  • Plasma lactate concentration can serve as a predictive parameter for assessing colonic viability and survival after a severe volvulus event in horses.

Cite This Article

APA
Johnston K, Holcombe SJ, Hauptman JG. (2007). Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses. Vet Surg, 36(6), 563-567. https://doi.org/10.1111/j.1532-950X.2007.00305.x

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 36
Issue: 6
Pages: 563-567

Researcher Affiliations

Johnston, Kimberly
  • Department of Large Animal Clinical Sciences, Michigan State University, College of Veterinary Medicine, East Lansing, MI 48824, USA.
Holcombe, Susan J
    Hauptman, Joe G

      MeSH Terms

      • Animals
      • Biomarkers / blood
      • Colonic Diseases / blood
      • Colonic Diseases / mortality
      • Colonic Diseases / surgery
      • Colonic Diseases / veterinary
      • Female
      • Horse Diseases / blood
      • Horse Diseases / mortality
      • Horse Diseases / surgery
      • Horses
      • Intestinal Volvulus / blood
      • Intestinal Volvulus / mortality
      • Intestinal Volvulus / surgery
      • Intestinal Volvulus / veterinary
      • Lactic Acid / blood
      • Male
      • Necrosis
      • Predictive Value of Tests
      • Prognosis
      • Retrospective Studies
      • Sensitivity and Specificity
      • Survival Analysis
      • Treatment Outcome

      Citations

      This article has been cited 24 times.
      1. Spadari A, Gialletti R, Gandini M, Valle E, Cerullo A, Cavallini D, Bertoletti A, Rinnovati R, Forni G, Scilimati N, Giusto G. Short-Term Survival and Postoperative Complications Rates in Horses Undergoing Colic Surgery: A Multicentre Study. Animals (Basel) 2023 Mar 20;13(6).
        doi: 10.3390/ani13061107pubmed: 36978647google scholar: lookup
      2. Smanik LE, Moser DK, Rothers KP, Hackett ES. Serial venous lactate measurement following gastrointestinal surgery in horses. J Vet Sci 2022 Sep;23(5):e66.
        doi: 10.4142/jvs.22038pubmed: 36038187google scholar: lookup
      3. Bishop RC, Gutierrez-Nibeyro SD, Stewart MC, McCoy AM. Performance of predictive models of survival in horses undergoing emergency exploratory laparotomy for colic. Vet Surg 2022 Aug;51(6):891-902.
        doi: 10.1111/vsu.13839pubmed: 35674231google scholar: lookup
      4. Farrell A, Kersh K, Liepman R, Dembek KA. Development of a Colic Scoring System to Predict Outcome in Horses. Front Vet Sci 2021;8:697589.
        doi: 10.3389/fvets.2021.697589pubmed: 34692803google scholar: lookup
      5. Kretsch CM, Chigerwe M. Assessment of preoperative and postoperative l-lactatemia and clinical outcomes in goats undergoing tube cystostomy: A retrospective study of 34 cases (2015-2020). J Vet Intern Med 2021 Nov;35(6):2926-2932.
        doi: 10.1111/jvim.16271pubmed: 34617625google scholar: lookup
      6. Witkowska-Piłaszewicz O, Cywińska A, Michlik-Połczyńska K, Czopowicz M, Strzelec K, Biazik A, Parzeniecka-Jaworska M, Crisman M, Witkowski L. Variations in haematological and biochemical parameters in healthy ponies. BMC Vet Res 2021 Jan 19;17(1):38.
        doi: 10.1186/s12917-020-02741-5pubmed: 33468115google scholar: lookup
      7. Gehlen H, Faust MD, Grzeskowiak RM, Trachsel DS. Association Between Disease Severity, Heart Rate Variability (HRV) and Serum Cortisol Concentrations in Horses with Acute Abdominal Pain. Animals (Basel) 2020 Sep 2;10(9).
        doi: 10.3390/ani10091563pubmed: 32887514google scholar: lookup
      8. Di Lorenzo E, Rossi R, Ferrari F, Martini V, Comazzi S. Blood L-Lactate Concentration as an Indicator of Outcome in Roe Deer (Capreolus capreolus) Admitted to a Wildlife Rescue Center. Animals (Basel) 2020 Jun 20;10(6).
        doi: 10.3390/ani10061066pubmed: 32575686google scholar: lookup
      9. Johnson LM, Holcombe SJ, Shearer TR, Watson V, Gandy J, Southwood LL, Lynch TM, Schroeder EL, Fogle CA, Sordillo LM. Multicenter Placebo-Controlled Randomized Study of Ethyl Pyruvate in Horses Following Surgical Treatment for ≥ 360° Large Colon Volvulus. Front Vet Sci 2020;7:204.
        doi: 10.3389/fvets.2020.00204pubmed: 32373640google scholar: lookup
      10. DeNotta SL, Divers TJ. Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver. Vet Clin North Am Equine Pract 2020 Apr;36(1):105-120.
        doi: 10.1016/j.cveq.2019.11.004pubmed: 31982231google scholar: lookup
      11. Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr, Fogle CA, Gonzalez LM. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg 2020 Apr;49(3):472-479.
        doi: 10.1111/vsu.13361pubmed: 31916608google scholar: lookup
      12. Marcato F, van den Brand H, Kemp B, van Reenen K. Evaluating Potential Biomarkers of Health and Performance in Veal Calves. Front Vet Sci 2018;5:133.
        doi: 10.3389/fvets.2018.00133pubmed: 29977895google scholar: lookup
      13. Cole GC, Tordiffe ASW, Steenkamp G. Assessment of a portable lactate meter for field use in the white rhinoceros (Ceratotherium simum). Onderstepoort J Vet Res 2017 Nov 10;84(1):e1-e10.
        doi: 10.4102/ojvr.v84i1.1399pubmed: 29227129google scholar: lookup
      14. Kucera CR, Stranahan LW, Hughes F, Blikslager AT, Gonzalez LM. Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus. Equine Vet J 2018 Jul;50(4):452-456.
        doi: 10.1111/evj.12767pubmed: 29032573google scholar: lookup
      15. Muir W. Effect of Intravenously Administered Crystalloid Solutions on Acid-Base Balance in Domestic Animals. J Vet Intern Med 2017 Sep;31(5):1371-1381.
        doi: 10.1111/jvim.14803pubmed: 28833697google scholar: lookup
      16. Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome. J Vet Intern Med 2017 Mar;31(2):582-592.
        doi: 10.1111/jvim.14670pubmed: 28207163google scholar: lookup
      17. Murakami T, Nakao S, Sato Y, Nakada S, Sato A, Mukai S, Kobayashi M, Yamada Y, Kawakami E. Blood lactate concentration as diagnostic predictors of uterine necrosis and its outcome in dairy cows with uterine torsion. J Vet Med Sci 2017 Mar 18;79(3):513-516.
        doi: 10.1292/jvms.16-0203pubmed: 28163266google scholar: lookup
      18. Mizen K, Woodman J, Boysen SR, Wagg C, Greco-Otto P, Léguillette R, Roy MF. Effect of Dexamethasone on Resting Blood Lactate Concentrations in Horses. J Vet Intern Med 2017 Jan;31(1):164-169.
        doi: 10.1111/jvim.14630pubmed: 28019037google scholar: lookup
      19. Gonzalez LM, Fogle CA, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013. Equine Vet J 2015 May;47(3):279-84.
        doi: 10.1111/evj.12273pubmed: 24735170google scholar: lookup
      20. Sasani F, Javanbakht J, Ghamsari M, Hassan MA. A report of left dorsal displacement of the large colon in a tropical horse. Asian Pac J Trop Biomed 2013 Apr;3(4):325-9.
        doi: 10.1016/S2221-1691(13)60072-6pubmed: 23620860google scholar: lookup
      21. Crosby CE, O'Connor A, Munsterman AS. Alactic base excess is not a sensitive or specific diagnostic tool for outcome in horses with colic. Front Vet Sci 2025;12:1618304.
        doi: 10.3389/fvets.2025.1618304pubmed: 40895787google scholar: lookup
      22. Hepworth-Warren KL, Love K. Survey of the approach to the diagnosis and management of bacterial pneumonia in adult horses by equine veterinarians. Front Vet Sci 2024;11:1484970.
        doi: 10.3389/fvets.2024.1484970pubmed: 39764370google scholar: lookup
      23. Bayless RL, Cooper BL, Sheats MK. Extracted Plasma Cell-Free DNA Concentrations Are Elevated in Colic Patients with Systemic Inflammation. Vet Sci 2024 Sep 12;11(9).
        doi: 10.3390/vetsci11090427pubmed: 39330806google scholar: lookup
      24. Rapezzano G, Marcatili M, Stephenson R, Pereira R, Hallowell G, Duz M. Evaluation of peritoneal l-lactate concentration in horses in the early post-partum period. Vet Med Sci 2024 May;10(3):e1352.
        doi: 10.1002/vms3.1352pubmed: 38634206google scholar: lookup
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