Analyze Diet
Veterinary sciences2024; 11(8); doi: 10.3390/vetsci11080385

Platelet-Rich Plasma and Related Orthobiologics for the Treatment of Equine Musculoskeletal Disorders-A Bibliometric Analysis from 2000 to 2024.

Abstract: (1) Background: There is increasing interest in the use of platelet-rich plasma and related orthobiologics for the treatment of chronic musculoskeletal disorders in horses; however, there is no information on the bibliometric impact of the literature published in this area. (2) Methods: A bibliometric analysis was performed using the bibliometrix R package by analyzing the documents registered in the WOS and Scopus databases from 2000 to 2024. The included registers were evaluated according to the menu of results from the biblioshiny web app (overview, sources, authors, documents, words, trending topics, clustering, conceptual structure, and social structure). (3) Conclusions: The documents produced were mainly published in Frontiers in Veterinary Science, Journal of Equine Veterinary Science, BMC Veterinary Research, and the American Journal of Veterinary Research). The most productive institutions were Universidad de Caldas, Colorado State University, University of California-Davis, and University of Leipzig, and the most productive countries were the USA, Brazil, and Colombia. Horse, platelet-rich plasma, equine, osteoarthritis, and autologous conditioned serum were the most frequently used keywords. The trending topics in this area are platelet lysates and orthobiologics. The collaboration network of authors, institutions, and countries shows an isolated development of individual author networks with modest collaboration between institutions and countries.
Publication Date: 2024-08-21 PubMed ID: 39195839PubMed Central: PMC11359792DOI: 10.3390/vetsci11080385Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents a bibliometric analysis of scientific studies related to the use of platelet-rich plasma and other orthobiologics in treating musculoskeletal disorders in horses from the year 2000 to 2024.

Methodology

  • The authors performed a bibliometric analysis, a research method that uses statistical analysis of written publications, such as books and articles.
  • The analysis used the ‘bibliometrix R package’, a tool used to quantify the impact of a certain field’s literature.
  • The authors analyzed documents registered in WOS (Web of Science) and Scopus databases from 2000 to 2024.
  • The included registers were evaluated according to various factors using the ‘biblioshiny’ web app – these factors included source, author, documents, and words, among others.

Findings

  • The research found that the most productive institutions researching this field were Universidad de Caldas, Colorado State University, University of California-Davis, and University of Leipzig.
  • The most productive countries were the USA, Brazil, and Colombia.
  • The most frequently used keywords in these documents were ‘horse’, ‘platelet-rich plasma’, ‘equine’, ‘osteoarthritis’, and ‘autologous conditioned serum’.
  • It also identified ‘platelet lysates’ and orthobiologics’ as trending topics in this area.

Collaboration and Impact

  • Despite the prolific research in this area, the authors found that there was isolated (or limited) collaboration between different author networks, institutions, and countries.
  • This suggests that there may be opportunities for improvement in cross-institutional and international collaboration in this field.

Implications

  • The outcomes of this bibliometric analysis reveal the central research interests and contributors in the field of equine orthobiologics, thus providing a roadmap for current researchers and future work.
  • Identifying the most productive institutions and countries can help researchers understand which entities are leading the research in this niche field.
  • Understanding the most frequently used keywords can provide insight into the prevailing research themes and areas of concern for the scientific community in this field.

Cite This Article

APA
Carmona JU, Carmona-Ramírez LH, López C. (2024). Platelet-Rich Plasma and Related Orthobiologics for the Treatment of Equine Musculoskeletal Disorders-A Bibliometric Analysis from 2000 to 2024. Vet Sci, 11(8). https://doi.org/10.3390/vetsci11080385

Publication

ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 11
Issue: 8

Researcher Affiliations

Carmona, Jorge U
  • Grupo de Investigación Terapia Regenerativa, Departamento de Salud Animal, Universidad de Caldas, Manizales 170004, Colombia.
Carmona-Ramírez, Luis H
  • Grupo de Investigación EFE, Facultad de Educación, Universidad Católica de Manizales, Manizales 170004, Colombia.
López, Catalina
  • Grupo de Investigación Patología Clínica Veterinaria, Departamento de Salud Animal, Universidad de Caldas, Manizales 170004, Colombia.

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 63 references
  1. Pérez Fraile A, González-Cubero E, Martínez-Flórez S, Olivera E.R, Villar-Suárez V. Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review. Vet. Sci. 2023;10:666.
    doi: 10.3390/vetsci10120666pmc: PMC10748126pubmed: 38133217google scholar: lookup
  2. Reis I.L, Lopes B, Sousa P, Sousa A.C, Caseiro A.R, Mendonça C.M, Santos J.M, Atayde L.M, Alvites R.D, Maurício A.C. Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives-A Review. Vet. Sci. 2024;11:190.
    doi: 10.3390/vetsci11050190pmc: PMC11126110pubmed: 38787162google scholar: lookup
  3. Kim D.S, Bae S. Impact and challenges of enactment for advanced regenerative medicine in South Korea. Front. Bioeng. Biotechnol. 2022;10:972865.
    pmc: PMC9597240pubmed: 36312539
  4. Lu C, Le Q. Advances in Organoid Technology: A Focus on Corneal Limbal Organoids. Stem Cell Rev. Rep. 2024;20:1227–1235.
    pubmed: 38558362
  5. Boone L, Peroni J. Introduction to Equine Biologic and Regenerative Therapies. Vet. Clin. N. Am. Equine Pract. 2023;39:419–427.
    pubmed: 37558508
  6. Wilfong J.M, Badley E.M, Perruccio A.V. Old before their time? The impact of osteoarthritis on younger adults. Arthritis Care Res. 2024.
    doi: 10.1002/acr.25374pubmed: 38751094google scholar: lookup
  7. Carmont M.R, Gunnarsson B, Brorsson A, Nilsson-Helander K. Musculotendinous ruptures of the achilles tendon had greater heel-rise height index compared with mid-substance rupture with non-operative management: A retrospective cohort study. J. ISAKOS. 2024;9:148–152.
    pubmed: 38154754
  8. Wang N, Wang H, Shen L, Liu X, Ma Y, Wang C. Aging-Related Rotator Cuff Tears: Molecular Mechanisms and Implications for Clinical Management. Adv. Biol. 2024;8:e2300331.
    pubmed: 38295015
  9. M’Cloud W.R.C, Guzmán K.E, Panek C.L, Colbath A.C. Stem cells and platelet-rich plasma for the treatment of naturally occurring equine tendon and ligament injuries: A systematic review and meta-analysis. J. Am. Vet. Med. Assoc. 2024;262((Suppl. S1)):S50–S60.
    pubmed: 38471305
  10. Carlier S, Depuydt E, Van Hecke L, Martens A, Saunders J, Spaas J.H. Safety assessment of equine allogeneic tenogenic primed mesenchymal stem cells in horses with naturally occurring tendon and ligament injuries. Front. Vet. Sci. 2024;11:1282697.
    pmc: PMC10925754pubmed: 38468694
  11. McGowan T.W, Pinchbeck G, Phillips C.J, Perkins N, Hodgson D.R, McGowan C.M. A survey of aged horses in Queensland, Australia. Part 2: Clinical signs and owners’ perceptions of health and welfare. Aust. Vet. J. 2010;88:465–471.
    pubmed: 21091457
  12. McGowan C.M, Ireland J.L. Welfare, Quality of Life, and Euthanasia of Aged Horses. Vet. Clin. N. Am. Equine Pract. 2016;32:355–367.
    pubmed: 27449393
  13. Peng C, Yang L, Labens R, Gao Y, Zhu Y, Li J. A systematic review and meta-analysis of the efficacy of platelet-rich plasma products for treatment of equine joint disease. Equine Vet. J. 2024;56:858–869.
    pubmed: 38185481
  14. Mayet A, Zablotski Y, Roth S.P, Brehm W, Troillet A. Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. Front. Vet. Sci. 2023;10:1125695.
    pmc: PMC9997849pubmed: 36908512
  15. McCarrel T.M. Equine Platelet-Rich Plasma. Vet. Clin. N. Am. Equine Pract. 2023;39:429–442.
    pubmed: 37550126
  16. Maleas G, Mageed M. Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy. Front. Vet. Sci. 2021;8:678453.
    pmc: PMC8253571pubmed: 34222402
  17. Chu C.R, Fortier L.A, Williams A, Payne K.A, McCarrel T.M, Bowers M.E, Jaramillo D. Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model. J. Bone Joint Surg. Am. 2018;100:138–146.
    pmc: PMC6819026pubmed: 29342064
  18. Russell J.W, Russell T.M, Vasey J.R, Hall M.S. Autologous bone marrow aspirate for treatment of superficial digital flexor tendonitis in 105 racehorses. Vet. Rec. 2016;179:69.
    pubmed: 27206445
  19. Burk J, Wittenberg-Voges L, Schubert S, Horstmeier C, Brehm W, Geburek F. Treatment of Naturally Occurring Tendon Disease with Allogeneic Multipotent Mesenchymal Stromal Cells: A Randomized, Controlled, Triple-Blinded Pilot Study in Horses. Cells 2023;12:2513.
    doi: 10.3390/cells12212513pmc: PMC10650642pubmed: 37947591google scholar: lookup
  20. Carvalho Ade M, Badial P.R, Álvarez L.E.C, Yamada A.L, Borges A.S, Deffune E, Hussni C.A, Alves A.L.G. Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: A randomized controlled trial. Stem Cell Res. Ther. 2013;4:85.
    pmc: PMC3854756pubmed: 23876512
  21. Renzi S, Riccò S, Dotti S, Sesso L, Grolli S, Cornali M, Carlin S, Patruno M, Cinotti S, Ferrari M. Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report. Res. Vet. Sci. 2013;95:272–277.
    pubmed: 23419936
  22. Geburek F, Roggel F, van Schie H.T.M, Beineke A, Estrada R, Weber K, Hellige M, Rohn K, Jagodzinski M, Welke B. Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: A controlled experimental trial. Stem Cell Res. Ther. 2017;8:129.
    pmc: PMC5460527pubmed: 28583184
  23. Geburek F, Gaus M, van Schie H.T, Rohn K, Stadler P.M. Effect of intralesional platelet-rich plasma (PRP) treatment on clinical and ultrasonographic parameters in equine naturally occurring superficial digital flexor tendinopathies—A randomized prospective controlled clinical trial. BMC Vet. Res. 2016;12:191.
    pmc: PMC5015224pubmed: 27604193
  24. Garrett K.S, Bramlage L.R, Spike-Pierce D.L, Cohen N.D. Injection of platelet- and leukocyte-rich plasma at the junction of the proximal sesamoid bone and the suspensory ligament branch for treatment of yearling Thoroughbreds with proximal sesamoid bone inflammation and associated suspensory ligament branch desmitis. J. Am. Vet. Med. Assoc. 2013;243:120–125.
    pubmed: 23786200
  25. Tyrnenopoulou P, Diakakis N, Karayannopoulou M, Savvas I, Koliakos G. Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint. Vet. Q. 2016;36:56–62.
    pubmed: 26828234
  26. Fukuda K, Kuroda T, Tamura N, Mita H, Miyata H, Kasashima Y. Platelet Lysate Enhances Equine Skeletal Muscle Regeneration in A Bupivacaine-Induced Muscle Injury Model(☆). J. Equine Vet. Sci. 2022;112:103892.
    pubmed: 35124154
  27. Brown K.A, Gregorio E.N, Barot D, Usimaki A, Linardi R.L, Missanelli J.R, You Y, Robinson M.A, Ortved K.F. Single-dose nonsteroidal anti-inflammatory drugs in horses have no impact on concentrations of cytokines or growth factors in autologous protein solution and platelet-rich plasma. Am. J. Vet. Res. 2024;85.
    doi: 10.2460/ajvr.23.11.0258pubmed: 38346393google scholar: lookup
  28. Ortved K.F. Equine Autologous Conditioned Serum and Autologous Protein Solution. Vet. Clin. N. Am. Equine Pract. 2023;39:443–451.
    pubmed: 37625916
  29. Toner S, Crosby C. Pro-stride and extracorporeal shockwave therapy as treatment of lateral collateral desmopathy of the proximal interphalangeal joint in a Dutch Warmblood gelding. Can. Vet. J. 2023;64:268–274.
    pmc: PMC9979729pubmed: 36874545
  30. Gaesser A.M, Underwood C, Linardi R.L, Even K.M, Reef V.B, Shetye S.S, Mauck R.L, King W.J, Engiles J.B, Ortved K.F. Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model. Front. Vet. Sci. 2021;8:697551.
    pmc: PMC8287003pubmed: 34291103
  31. Camargo Garbin L, Morris M.J. A Comparative Review of Autologous Conditioned Serum and Autologous Protein Solution for Treatment of Osteoarthritis in Horses. Front. Vet. Sci. 2021;8:602978.
    pmc: PMC7933025pubmed: 33681323
  32. Velloso Alvarez A, Boone L.H, Pondugula S.R, Caldwell F, Wooldridge A.A. Effects of Autologous Conditioned Serum, Autologous Protein Solution, and Triamcinolone on Inflammatory and Catabolic Gene Expression in Equine Cartilage and Synovial Explants Treated With IL-1β in Co-culture. Front. Vet. Sci. 2020;7:323.
    pmc: PMC7332692pubmed: 32671108
  33. Bertone A.L, Ishihara A, Zekas L.J, Wellman M.L, Lewis K.B, Schwarze R.A, Barnaba A.R, Schmall M.L, Kanter P.M, Genovese R.L. Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses. Am. J. Vet. Res. 2014;75:141–151.
    pubmed: 24471750
  34. McCoy A.M. Animal Models of Osteoarthritis: Comparisons and Key Considerations. Vet. Pathol. 2015;52:803–818.
    pubmed: 26063173
  35. Dias I.R, Viegas C.A, Carvalho P.P. Large Animal Models for Osteochondral Regeneration. Adv. Exp. Med. Biol. 2018;1059:441–501.
    pubmed: 29736586
  36. Knott L.E, Fonseca-Martinez B.A, O’Connor A.M, Goodrich L.R, McIlwraith C.W, Colbath A.C. Current use of biologic therapies for musculoskeletal disease: A survey of board-certified equine specialists. Vet. Surg. 2022;51:557–567.
    pmc: PMC9322007pubmed: 35383972
  37. Camargo Garbin L, Lopez C, Carmona J.U. A Critical Overview of the Use of Platelet-Rich Plasma in Equine Medicine over the Last Decade. Front. Vet. Sci. 2021;8:641818.
    pmc: PMC8044532pubmed: 33869321
  38. Wei N, Xu Y, Li Y, Shi J, Zhang X, You Y, Sun Q, Zhai H, Hu Y. A bibliometric analysis of T cell and atherosclerosis. Front. Immunol. 2022;13:948314.
    pmc: PMC9606647pubmed: 36311729
  39. Pranckutė R. Web of Science (WoS) and Scopus: The Titans of Bibliographic Information in Today’s Academic World. Publications 2021;9:12.
  40. Joshi A. Comparison between Scopus & ISI Web of science. J. Glob. Values. 2016;7:1–11.
  41. Aria M, Cuccurullo C. bibliometrix: An R-tool for comprehensive science mapping analysis. J. Informetr. 2017;11:959–975.
  42. Sutter W.W, Kaneps A.J, Bertone A.L. Comparison of hematologic values and transforming growth factor-beta and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am. J. Vet. Res. 2004;65:924–930.
    pubmed: 15281650
  43. Frisbie D.D, Kawcak C.E, Werpy N.M, Park R.D, McIlwraith C.W. Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am. J. Vet. Res. 2007;68:290–296.
    pubmed: 17331019
  44. Waselau M, Sutter W.W, Genovese R.L, Bertone A.L. Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses. J. Am. Vet. Med. Assoc. 2008;232:1515–1520.
    pubmed: 18479242
  45. Del Bue M, Riccò S, Ramoni R, Conti V, Gnudi G, Grolli S. Equine adipose-tissue derived mesenchymal stem cells and platelet concentrates: Their association in vitro and in vivo. Vet. Res. Commun. 2008;32((Suppl. 1)):S51–S55.
    pubmed: 18683070
  46. Argüelles D, Carmona J.U, Pastor J, Iborra A, Viñals L, Martínez P, Bach E, Prades M. Evaluation of single and double centrifugation tube methods for concentrating equine platelets. Res. Vet. Sci. 2006;81:237–245.
    pubmed: 16969921
  47. Carmona J.U, Argüelles D, Climent F, Prades M. Autologous Platelet Concentrates as a Treatment of Horses with Osteoarthritis: A Preliminary Pilot Clinical Study. J. Equine Vet. Sci. 2007;27:167–170.
  48. Hraha T.H, Doremus K.M, McIlwraith C.W, Frisbie D.D. Autologous conditioned serum: The comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood. Equine Vet. J. 2011;43:516–521.
    pubmed: 21496084
  49. Textor J.A, Tablin F. Activation of equine platelet-rich plasma: Comparison of methods and characterization of equine autologous thrombin. Vet. Surg. 2012;41:784–794.
    pubmed: 22742830
  50. Argüelles D, Carmona J.U, Climent F, Muñoz E, Prades M. Autologous platelet concentrates as a treatment for musculoskeletal lesions in five horses. Vet. Rec. 2008;162:208–211.
    pubmed: 18281627
  51. Chen C, Song M. Visualizing a field of research: A methodology of systematic scientometric reviews. PLoS ONE 2019;14:e0223994.
    pmc: PMC6822756pubmed: 31671124
  52. Chen W, Yang Y, Tang G. Mapping knowledge structure and research trends of knee osteoarthritis with meniscus in two decades: A bibliometric analysis. Front. Surg. 2022;9:939003.
    pmc: PMC9649907pubmed: 36386528
  53. Xiao Z, Chen W, Wei Z, Zhang Q, Tang G. Global trends and hotspots in the application of platelet-rich plasma in knee osteoarthritis: A bibliometric analysis from 2008 to 2022. Medicine 2023;102:e35854.
    pmc: PMC10681507pubmed: 38013292
  54. Ren B, Lv X, Tu C, Li Z. Research trends of platelet-rich plasma application in orthopaedics from 2002 to 2020: A bibliometric analysis. Int. Orthop. 2021;45:2773–2790.
    pubmed: 34337692
  55. Xu J, Du W, Xue X, Chen M, Zhou W, Luo X. Global research trends on platelet-rich plasma for tendon and ligament injuries from the past two decades: A bibliometric and visualized study. Front. Surg. 2023;10:1113491.
    pmc: PMC9950278pubmed: 36843990
  56. Cui Y, Lin L, Wang Z, Wang K, Xiao L, Lin W, Zhang Y. Research trends of platelet-rich plasma therapy on knee osteoarthritis from 2011 to 2021: A review. Medicine 2023;102:e32434.
    pmc: PMC9839303pubmed: 36637944
  57. Cash C, Scott L, Walden R.L, Kuhn A, Bowman E. Bibliometric analysis of the top 50 highly cited articles on platelet-rich plasma in osteoarthritis and tendinopathy. Regen. Med. 2022;17:491–506.
    pubmed: 35578970
  58. Bradford S.C. Sources of information on specific subjects. Engineering 1934;137:85–86.
  59. Alvarado R.U. El crecimiento de la literatura sobre la ley de Bradford. Investig. Bibl. Arch. Bibl. E Inf. 2016;30:51–72.
  60. Lotka A.J. The frequency distribution of scientific productivity. J. Wash. Acad. Sci. 1926;16:317–323.
  61. Marycz K, Toker N.Y, Grzesiak J, Wrzeszcz K, Golonka P. The therapeutic effect of autogenic adipose derived stem cells combined with autogenic platelet rich plasma in tendons disorders in horses in vitro and in vivo research. J. Anim. Vet. Adv. 2012;11:4324–4331.
  62. Carmona J.U, López C, Prades M. Uso de concentrados autólogos de plaquetas obtenidos mediante el método del tubo como tratamiento de artropatías en caballos. Arch. De. Med. Vet. 2009;41:175–179.
  63. Fortier L.A, Smith R.K. Regenerative medicine for tendinous and ligamentous injuries of sport horses. Vet. Clin. N. Am. Equine Pract. 2008;24:191–201.
    pubmed: 18314043