Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses.
Abstract: Thoroughbred racehorses are commonly affected by subchondral bone injury, but the exact prevalence and the distribution of palmar/plantar osteochondral disease (POD) lesions are unknown. The relationship between pathologies has not been elucidated, although it is widely accepted that POD is a manifestation of traumatic overload arthrosis. Objective: There is an association between grade of POD and other pathologies affecting the third metacarpal and metatarsal (MC/MTIII) condyles (wear lines, cartilage loss, marginal remodelling, dorsal impact injuries and linear fissures). Objective: To evaluate the pathology found affecting the distal MC/MTIII condyles of Thoroughbred racehorses at post mortem examination, to describe the prevalence and distribution of POD lesions within a population of racing Thoroughbreds and to determine relationships between pathologies of the distal condyles of the third metacarpal and metatarsal bones. Methods: The metacarpo/metatarsophalangeal joints of 64 Thoroughbred racehorses were examined at routine post mortem examination and graded for third metacarpal and metatarsal condylar pathology. Associations between pathologies were determined. Results: POD had a within horse prevalence of 67%. There was a significant linear relationship between grade of POD and grades of wear lines, cartilage ulceration and dorsal impact injuries. There was a significant relationship, but this was not linear, between grade of POD and grade of linear fissures. Using ordinal logistic regression, compared to condyles with grade 0 or grade 2 linear fissures, condyles with grade 1 linear fissures were found to be more likely to have a lower POD grade. Conclusions: POD can be considered to be a manifestation of traumatic overload arthrosis, but the role of subchondral bone adaptation is complex and warrants further investigation.
Publication Date: 2009-07-01 PubMed ID: 19562898DOI: 10.2746/042516409x368372Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research is about investigating the prevalence, distribution, and relation to other pathologies of palmar/plantar osteochondral disease (POD) lesions in Thoroughbred racehorses. By examining these horses after death, the study finds out that these POD lesions are related to traumatic overload arthrosis, although the role of subchondral bone adaptation needs more understanding.
Research Objectives
The study aimed to achieve several objectives:
- Examine the pathology impacting the distal metacarpal and metatarsal (MC/MTIII) condyles of Thoroughbred racehorses after death.
- Document the occurrence and distribution of POD lesions among a population of racing Thoroughbreds.
- Identify the relationships between various illnesses of the distal condyles of the third metacarpal and metatarsal bones.
Methodology
- The researchers conducted routine post mortem examinations on the metacarpo/metatarsophalangeal joints of 64 Thoroughbred racehorses.
- They determined and recorded the grade of the pathology for the third metacarpal and metatarsal condylar.
- The researchers also identified any correlations between the different forms of pathology.
Results
- The investigation found a 67% prevalence of POD in the examined horses.
- A significant linear relationship was discovered between the grade of POD and the grades of wear lines, cartilage ulceration, and dorsal impact injuries.
- The researchers found a significant but non-linear relationship between the grade of POD and the grade of linear fissures.
- According to an ordinal logistic regression analysis, the study found that condyles with grade 1 linear fissures are more likely to have a lower grade of POD compared to condyles with grade 0 or grade 2 linear fissures.
Conclusion
The study concludes that POD appears to be a manifestation of traumatic overload arthrosis, implicating the heavy strain racing imposes on the horses. However, the study also highlights the complex nature of subchondral bone adaptation, indicating that more research is needed to understand its role fully.
Cite This Article
APA
Barr ED, Pinchbeck GL, Clegg PD, Boyde A, Riggs CM.
(2009).
Post mortem evaluation of palmar osteochondral disease (traumatic osteochondrosis) of the metacarpo/metatarsophalangeal joint in Thoroughbred racehorses.
Equine Vet J, 41(4), 366-371.
https://doi.org/10.2746/042516409x368372 Publication
Researcher Affiliations
- Division of Veterinary Clinical Science, University of Liverpool, Leahurst, Neston, Cheshire, UK.
MeSH Terms
- Animals
- Foot Injuries / pathology
- Foot Injuries / veterinary
- Horse Diseases / pathology
- Horses
- Male
- Osteochondrosis / pathology
- Osteochondrosis / veterinary
Grant Funding
- Biotechnology and Biological Sciences Research Council
Citations
This article has been cited 20 times.- Daniel CR, Taylor SE, McPhee S, Wolfram U, Schwarz T, Sommer S, Kershaw LE. Relationship between CT-Derived Bone Mineral Density and UTE-MR-Derived Porosity Index in Equine Third Metacarpal and Metatarsal Bones. Animals (Basel) 2023 Aug 31;13(17).
- Morrice-West AV, Hitchens PL, Walmsley EA, Tasker K, Lim SL, Smith AD, Whitton RC. Relationship between Thoroughbred workloads in racing and the fatigue life of equine subchondral bone. Sci Rep 2022 Jul 7;12(1):11528.
- Johnston GCA, Ahern BJ, Palmieri C, Young AC. Imaging and Gross Pathological Appearance of Changes in the Parasagittal Grooves of Thoroughbred Racehorses. Animals (Basel) 2021 Nov 24;11(12).
- Boyde A. The Bone Cartilage Interface and Osteoarthritis. Calcif Tissue Int 2021 Sep;109(3):303-328.
- Bellone RR, Ocampo NR, Hughes SS, Le V, Arthur R, Finno CJ, Penedo MCT. Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. Equine Vet J 2020 May;52(3):411-414.
- Martig S, Hitchens PL, Stevenson MA, Whitton RC. Subchondral bone morphology in the metacarpus of racehorses in training changes with distance from the articular surface but not with age. J Anat 2018 Jun;232(6):919-930.
- Maeda Y, Hanada M, Oikawa MA. Epidemiology of racing injuries in Thoroughbred racehorses with special reference to bone fractures: Japanese experience from the 1980s to 2000s. J Equine Sci 2016;27(3):81-97.
- Noble P, Singer ER, Jeffery NS. Does subchondral bone of the equine proximal phalanx adapt to race training?. J Anat 2016 Jul;229(1):104-13.
- Martins EA, Michelacci YM, Baccarin RY, Cogliati B, Silva LC. Evaluation of chitosan-GP hydrogel biocompatibility in osteochondral defects: an experimental approach. BMC Vet Res 2014 Aug 27;10:197.
- Dubois MS, Morello S, Rayment K, Markel MD, Vanderby R Jr, Kalscheur VL, Hao Z, McCabe RP, Marquis P, Muir P. Computed tomographic imaging of subchondral fatigue cracks in the distal end of the third metacarpal bone in the thoroughbred racehorse can predict crack micromotion in an ex-vivo model. PLoS One 2014;9(7):e101230.
- Turley SM, Thambyah A, Riggs CM, Firth EC, Broom ND. Microstructural changes in cartilage and bone related to repetitive overloading in an equine athlete model. J Anat 2014 Jun;224(6):647-58.
- Pinchbeck GL, Clegg PD, Boyde A, Barr ED, Riggs CM. Horse-, training- and race-level risk factors for palmar/plantar osteochondral disease in the racing Thoroughbred. Equine Vet J 2013 Sep;45(5):582-6.
- Mansfield JC, Winlove CP. A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage. J Anat 2012 Apr;220(4):405-16.
- Malekipour F, Whitton RC, Muir P, Lee PV. Standing CT-based finite element models efficiently identify regions of high mechanical strain in equine metacarpal subchondral bone. Sci Rep 2025 Dec 11;16(1):1166.
- De Zani D, Rabbogliatti V, Rabba S, Auletta L, Longo M, Zani DD. Subchondral and Osteochondral Unit Bone Damage in the Fetlock Region of Sport Horses Using Low-Field MRI: Case Series. Animals (Basel) 2025 Dec 2;15(23).
- Irandoust S, Whitton C, Henak C, Muir P. Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses. R Soc Open Sci 2025 May;12(5):241935.
- Anderson JR, Phelan MM, Caamaño-Gutiérrez E, Clegg PD, Rubio-Martinez LM, Peffers MJ. Metabolomic and proteomic stratification of equine osteoarthritis. Equine Vet J 2025 Sep;57(5):1204-1218.
- Malekipour F, Whitton RC, Lee PV. Advancements in Subchondral Bone Biomechanics: Insights from Computed Tomography and Micro-Computed Tomography Imaging in Equine Models. Curr Osteoporos Rep 2024 Dec;22(6):544-552.
- Irandoust S, O'Neil LM, Stevenson CM, Franseen FM, Ramzan PHL, Powell SE, Brounts SH, Loeber SJ, Ergun DL, Whitton RC, Henak CR, Muir P. Comparison of radiography and computed tomography for identification of third metacarpal structural change and associated assessment of condylar stress fracture risk in Thoroughbred racehorses. Equine Vet J 2025 May;57(3):723-736.
- Bergstrom TC, Spriet M, Carpenter RS, Jacques KL, Stover SM. Condylar fracture location is correlated to exercise history in Thoroughbred racehorses. Equine Vet J 2025 Jan;57(1):76-86.
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