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Home / Equine Research Bank / Osteoarthritis Cartilage / Preclinical animal models in single site cartilage defect te...
Osteoarthritis and cartilage2008; 17(6); 705-713; doi: 10.1016/j.joca.2008.11.008

Preclinical animal models in single site cartilage defect testing: a systematic review.

Abstract: Review the literature for single site cartilage defect research and evaluate the respective strengths and weaknesses of different preclinical animal models. Methods: A literature search for animal models evaluating single site cartilage defects was performed. Variables tabulated and analyzed included animal species, age and number, defect depth and diameter and study duration. Cluster analyses were then used to separate animals with only distal femoral defects into similar groups based on defect dimensions. Representative human studies were included allowing comparison of common clinical lesions to animal models. The suitability of each species for single site cartilage defect research and its relevance to clinical human practice is then discussed. Results: One hundred thirteen studies relating to single site cartilage defects were reviewed. Cluster analysis included 101 studies and placed the murine, laprine, ovine, canine, porcine and caprine models in group 1. Group 2 contained ovine, canine, porcine, caprine and equine models. Group 3 contained only equine models and humans. Species in each group are similar with regard to defect dimensions. Some species occur in multiple groups reflecting utilization of a variety defect sizes. We report and discuss factors to be considered when selecting a preclinical animal model for single site cartilage defect research. Conclusions: Standardization of study design and outcome parameters would help to compare different studies evaluating various novel therapeutic concepts. Comparison to the human clinical counterpart during study design may help increase the predictive value of preclinical research using animal models and improve the process of developing efficacious therapies.
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Publication Date: 2008-11-21 PubMed ID: 19101179DOI: 10.1016/j.joca.2008.11.008Google Scholar: Lookup
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  • Journal Article
  • Review
  • Systematic Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article looks into the effectiveness and limitations of various preclinical animal models used in investigating single site cartilage defects, using a systematic review of existing literature.

Methodology

  • The researchers began by conducting a literature review of studies that employed animal models to understand single site cartilage defects.
  • Various variables were identified and analyzed, which included the species of the animal, its age and number, as well as the diameter and depth of the defect and the duration of the study.
  • A cluster analysis was also carried out to categorize animals with only distal femoral defects into groups based on the dimensions of the defect.
  • A few human studies were also incorporated into the research to compare common clinical lesions to those observed in animal models.
  • The researchers then examined the appropriateness of each species for single site cartilage defect research and its relevance to clinical practice involving humans.

Results

  • The researchers examined a total of 113 studies focusing on single site cartilage defects.
  • Out of these, 101 studies were included in the cluster analysis, which arranged murine, laprine, ovine, canine, porcine, and caprine models into group 1.
  • Group 2 consisted of ovine, canine, porcine, caprine, and equine models, whereas group 3 only included equine models and humans.
  • The species in each group were found to be similar in terms of defect dimensions. Some species appeared in multiple groups, which reflects the employment of various defect sizes.
  • The researchers also discussed factors that need to be considered when selecting a preclinical animal model for single site cartilage defect research.

Conclusions

  • The researchers concluded that standardizing the study design and outcome parameters would make comparing studies on different novel therapeutic concepts easier.
  • By comparing the outcomes of animal model studies to the human clinical counterpart during the study design phase, the predictability of preclinical research using animal models could be improved. This would subsequently enhance the development of efficient therapies.

Cite This Article

APA
Ahern BJ, Parvizi J, Boston R, Schaer TP. (2008). Preclinical animal models in single site cartilage defect testing: a systematic review. Osteoarthritis Cartilage, 17(6), 705-713. https://doi.org/10.1016/j.joca.2008.11.008

Publication

Osteoarthritis and cartilage
ISSN: 1522-9653
NlmUniqueID: 9305697
Country: England
Language: English
Volume: 17
Issue: 6
Pages: 705-713

Researcher Affiliations

Ahern, B J
  • Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA.
Parvizi, J
    Boston, R
      Schaer, T P

        MeSH Terms

        • Animals
        • Animals, Domestic
        • Biomechanical Phenomena
        • Cartilage, Articular / injuries
        • Cartilage, Articular / physiopathology
        • Cluster Analysis
        • Fracture Healing / physiology
        • Humans
        • Mice
        • Models, Animal
        • Species Specificity

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