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Home / Equine Research Bank / Animals (Basel) / Pressure Algometry for the Detection of Mechanical Nocicepti...
Animals : an open access journal from MDPI2020; 10(12); doi: 10.3390/ani10122195

Pressure Algometry for the Detection of Mechanical Nociceptive Thresholds in Horses.

Abstract: The clinical assessment of pain is subjective; therefore, variations exist between practitioners in their ability to identify and localize pain. Due to differing interpretations of the signs or severity of pain equine practitioners may assign varying levels of clinical significance and treatment options. There is a critical need to develop better tools to qualify and quantify pain in horses. Palpation is the most common method to detect local tenderness or sensitivity. To quantify this applied pressure, pressure algometry has been used to gradually apply pressure over specified landmarks until an avoidance response is noted, which is defined as the mechanical nociceptive threshold (MNT). Numerous studies have used pressure algometry in different applications to measure MNTs in horses. There is an acute need to establish normative values within different body regions and to develop standardized methods of testing MNTs to better guide practitioners in the diagnosis and treatment of pain. The aim of this systematic review was to summarize the evidence for the use of pressure algometry in horses. There is good evidence that pressure algometry is a repeatable, semi-objective method that can be used in a wide array of clinical and research applications to assess MNTs in horses.
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Publication Date: 2020-11-24 PubMed ID: 33255216PubMed Central: PMC7760268DOI: 10.3390/ani10122195Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper aims to analyze and gather information on the usage of pressure algometry as a tool for measuring pain thresholds in horses. The paper highlights its importance in veterinary practice to improve the subjectivity of pain diagnosis and treatment in equine healthcare.

Pressure Algometry in Pain Assessment

  • The paper begins by addressing the subjective nature of clinical pain assessment. The recognition and localization of pain might vary from one practitioner to another because of individual interpretations. This subjectivity can lead to differences in the severity assessment of pain and thus, the treatment options offered for equine pain management.
  • The researchers stress the need to devise better tools for accurately identifying and measuring pain in horses. It mentions the use of palpation, a manual pressure application technique, used widely to detect areas of pain or sensitivity in animals.

The Concept of Mechanical Nociceptive Thresholds

  • The study introduces the concept of mechanical nociceptive threshold (MNT), defined as the point at which an animal exhibits avoidance behavior due to the pressure applied. The technique used to determine this threshold is called pressure algometry.
  • However, the use of this tool requires establishing valid norms for different body regions and standardizing testing methods. It would indeed improve diagnosis and treatment, providing equine practitioners with a more robust, objective approach.

Systematic Review of Pressure Algometry Studies

  • The research paper is a systematic review, i.e., a comprehensive analysis of various studies that have used pressure algometry to measure MNTs in horses. It aims to collate evidence supporting the use of pressure algometry as a tool in horse healthcare.
  • The review concludes that there is good evidence to support the use of pressure algometry. The technique is found to be repeatable and semi-objective, meaning it provides consistent results and is less prone to individual interpretation. Thus, it could be beneficial in a wide array of clinical and research purposes involving the assessment of MNTs in horses.

Cite This Article

APA
Haussler KK. (2020). Pressure Algometry for the Detection of Mechanical Nociceptive Thresholds in Horses. Animals (Basel), 10(12). https://doi.org/10.3390/ani10122195

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 12

Researcher Affiliations

Haussler, Kevin K
  • Equine Orthopaedic Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

Conflict of Interest Statement

The author declares no conflict of interest.

References

This article includes 75 references
  1. Hammarberg M, Egenvall A, Pfau T, Rhodin M R. Rater agreement of visual lameness assessment in horses during lungeing. Equine Vet. J. 2016;48:78–82.
    doi: 10.1111/evj.12385pmc: PMC4964936pubmed: 25399722google scholar: lookup
  2. Keegan K G, Dent E V, Wilson D A, Janicek J, Kramer J, Lacarrubba A, Walsh D M, Cassells M W, Esther T M, Schiltz P. Repeatability of subjective evaluation of lameness in horses. Equine Vet. J. 2010;42:92–97.
    doi: 10.2746/042516409X479568pubmed: 20156242google scholar: lookup
  3. Dyson S, Berger J, Ellis A D, Mullard J. Development of an ethogram for a pain scoring system in ridden horses and its application to determine the presence of musculoskeletal pain. J. Vet. Behav. 2018;23:47–57.
    doi: 10.1016/j.jveb.2017.10.008google scholar: lookup
  4. Luna S P, Lopes C, Rosa A C, Oliveira F A, Crosignani N, Taylor P M, Pantoja J C. Validation of mechanical, electrical and thermal nociceptive stimulation methods in horses. Equine Vet. J. 2015;47:609–614.
    doi: 10.1111/evj.12332pubmed: 25130475google scholar: lookup
  5. Vanderweeën L, Oostendorp R A, Vaes P, Duquet W. Pressure algometry in manual therapy. Man. Ther. 1996;1:258–265.
    doi: 10.1054/math.1996.0276pubmed: 11440515google scholar: lookup
  6. Keating L, Lubke C, Powell V, Young T, Souvlis T, Jull G. Mid-thoracic tenderness: A comparison of pressure pain threshold between spinal regions, in asymptomatic subjects. Man. Ther. 2001;6:34–39.
    doi: 10.1054/math.2000.0377pubmed: 11243907google scholar: lookup
  7. Palmer J L, Bertone A L. Experimentally-induced synovitis as a model for acute synovitis in the horse. Equine Vet. J. 1994;26:492–495.
    doi: 10.1111/j.2042-3306.1994.tb04056.xpubmed: 7889925google scholar: lookup
  8. Kamerling S G, Dequick D J, Weckman T J, Sprinkle F P, Tobin T. Differential effects of phenylbutazone and local anesthetics on nociception in the equine. Eur. J. Pharm. 1984;107:35–41.
    doi: 10.1016/0014-2999(84)90088-8pubmed: 6526070google scholar: lookup
  9. Brunson D B, Collier M A, Scott E A, Majors L J. Dental dolorimetry for the evaluation of an analgesic agent in the horse. Am. J. Vet. Res. 1987;48:1082–1086.
    pubmed: 3631690
  10. Jöchle W, Hamm D. Sedation and analgesia with Domosedan (detomidine hydrochloride) in horses: Dose response studies on efficacy and its duration. Acta. Vet. Scand. Suppl. 1986;82:69–84.
    pubmed: 3464184
  11. Szabuniewics M, Szabuniewics J M. Use of the hoof tester in diagnosing lameness in horses. Vet. Med. Small Anim. Clin. 1975;70:205–212.
    pubmed: 1037773
  12. Skarda R T, Muir W W. Comparison of electroacupuncture and butorphanol on respiratory and cardiovascular effects and rectal pain threshold after controlled rectal distention in mares. Am. J. Vet. Res. 2003;64:137–144.
    doi: 10.2460/ajvr.2003.64.137pubmed: 12602580google scholar: lookup
  13. Mackenzie S A, Thiboutot E. Stimulus reactivity tests for the domestic horse (Equus caballus). Equine Pr. 1997;19:21–22.
  14. Fischer A A. Pressure algometry over normal muscles: Standard values, validity and reproducibility of pressure threshold. Pain. 1987;30:115–126.
    doi: 10.1016/0304-3959(87)90089-3pubmed: 3614975google scholar: lookup
  15. Taylor P M, Crosignani N, Lopes C, Rosa A C, Luna S P, Puoli Filho J N. Mechanical nociceptive thresholds using four probe configurations in horses. Vet. Anaesth. Analg. 2016;43:99–108.
    doi: 10.1111/vaa.12274pubmed: 25997162google scholar: lookup
  16. Hill R Z, Bautista D M. Getting in touch with mechanical pain mechanisms. Trends Neurosci. 2020;43:311–325.
    doi: 10.1016/j.tins.2020.03.004pubmed: 32353335google scholar: lookup
  17. Basbaum A I, Bautista D M, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–284.
    doi: 10.1016/j.cell.2009.09.028pmc: PMC2852643pubmed: 19837031google scholar: lookup
  18. Varcoe-Cocks K, Sagar K N, Jeffcott L B, McGowan C M. Pressure algometry to quantify muscle pain in racehorses with suspected sacroiliac dysfunction. Equine Vet. J. 2006;38:558–562.
    doi: 10.2746/042516406X154804pubmed: 17124847google scholar: lookup
  19. Haussler K K, Behre T H, Hill A E. Mechanical nociceptive thresholds within the pastern region of Tennessee Walking Horses. Equine Vet. J. 2008;40:455–459.
    doi: 10.2746/042516408X278166pubmed: 18321808google scholar: lookup
  20. Gerber M I, Swinker A M, Staniar W B, Werner J R, Jedrzejewski E A, Marcrina A L. Health factors associated with microchip insertion in horses. J. Equine Vet. Sci. 2012;32:177–182.
    doi: 10.1016/j.jevs.2011.08.016google scholar: lookup
  21. Long K, McGowan C M, Hyytiäinen H K. Effect of caudal traction on mechanical nociceptive thresholds of epaxial and pelvic musculature on a group of horses with signs of back pain. J. Equine Vet. Sci. 2020;93:e103197.
    doi: 10.1016/j.jevs.2020.103197pubmed: 32972678google scholar: lookup
  22. Malacarne B D, Cota L O, Neto A C P, Paz C F R, Dias L A, Correa M G, Carvalho A M, Faleiros R R, Xavier A B S. Mechanical nociceptive assessment of the equine hoof following distal interphalangeal joint intra-articular anesthesia. PeerJ. 2020;8:e9469.
    doi: 10.7717/peerj.9469pmc: PMC7427544pubmed: 32864201google scholar: lookup
  23. Pongratz U, Licka T. Algometry to measure pain threshold in the horse’s back-An in vivo and in vitro study. BMC Vet. Res. 2017;13:e80.
    doi: 10.1186/s12917-017-1002-ypmc: PMC5372265pubmed: 28356118google scholar: lookup
  24. Haussler K K, Erb H N. Mechanical nociceptive thresholds in the axial skeleton of horses. Equine Vet. J. 2006;38:70–75.
    doi: 10.2746/042516406775374315pubmed: 16411590google scholar: lookup
  25. Menke E S, Blom G, van Loon J P A M, Back W. Pressure algometry in Icelandic Horses: Interexaminer and intraexaminer reliability. J. Equine Vet. Sci. 2016;36:26–31.
    doi: 10.1016/j.jevs.2015.10.007google scholar: lookup
  26. Merrifield-Jones M, Tabor G, Williams J. Inter- and intra-rater reliability of soft tissue palpation scoring in the equine thoracic epaxial region. J. Equine Vet. Sci. 2019;83:e102812.
    doi: 10.1016/j.jevs.2019.102812pubmed: 31791525google scholar: lookup
  27. De Heus P, Van Oossanen G, Van D’ierendonck M C, Back W. A pressure algometer is a useful tool to objectively monitor the effect of diagnostic palpation by a physiotherapist in Warmblood horses. J. Equine Vet. Sci. 2010;30:310–321.
    doi: 10.1016/j.jevs.2010.04.010google scholar: lookup
  28. Olsen L, Bremer H, Olofsson K, Brojer J, Bondesson U, Bergh A, Nostell K, Brostrom H, Bengtsson B, Ingvast-Larsson C. Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin. Res. Vet. Sci. 2013;95:212–218.
    doi: 10.1016/j.rvsc.2013.01.019pubmed: 23419937google scholar: lookup
  29. Haussler K K, Erb H N. Pressure algometry for the detection of induced back pain in horses: A preliminary study. Equine Vet. J. 2006;38:76–81.
    doi: 10.2746/042516406775374225pubmed: 16411591google scholar: lookup
  30. Haussler K K, Hill A E, Frisbie D D, McIlwraith C W. Determination and use of mechanical nociceptive thresholds of the thoracic limb to assess pain associated with induced osteoarthritis of the middle carpal joint in horses. Am. J. Vet. Res. 2007;68:1167–1176.
    doi: 10.2460/ajvr.68.11.1167pubmed: 17975970google scholar: lookup
  31. Visser E M, Menke E S, van Loon J P. Pressure algometry for assessment of abdominal wall sensitivity in horses after ventral midline coeliotomy. Vet. Anaesth. Analg. 2019;46:820–828.
    doi: 10.1016/j.vaa.2019.03.008pubmed: 31570274google scholar: lookup
  32. Van Loon J P, Menke E S, L’Ami J J, Jonckheer-Sheehy V S, Back W, Rene van Weeren P. Analgesic and anti-hyperalgesic effects of epidural morphine in an equine LPS-induced acute synovitis model. Vet. J. 2012;193:464–470.
    doi: 10.1016/j.tvjl.2012.01.015pubmed: 22342215google scholar: lookup
  33. Van Loon J P, Menke E S, Doornenbal A, Back W, Hellebrekers L J. Antinociceptive effects of low dose lumbosacral epidural ropivacaine in healthy ponies. Vet. J. 2012;193:240–245.
    doi: 10.1016/j.tvjl.2011.11.004pubmed: 22398129google scholar: lookup
  34. Schambourg M, Taylor P M. Mechanical nociceptive thresholds in endurance horses. Vet. Rec. 2020;186:e124.
    doi: 10.1136/vr.105499pubmed: 31563891google scholar: lookup
  35. Jordana M, Martens A, Duchateau L, Vanderperren K, Saunders J, Oosterlinck M, Pille F. Distal limb desensitisation following analgesia of the digital flexor tendon sheath in horses using four different techniques. Equine Vet. J. 2014;46:488–493.
    doi: 10.1111/evj.12186pubmed: 24033590google scholar: lookup
  36. Paz C F R, Magalhães J F, Mendes H M F, Rocha Junior S, Belknap J K, Alves G E S, Faleiros R R. Mechanical nociceptive thresholds of dorsal laminae in horses after local anaesthesia of the palmar digital nerves or dorsal branches of the digital nerve. Vet. J. 2016;214:102–108.
    doi: 10.1016/j.tvjl.2016.05.005pubmed: 27387735google scholar: lookup
  37. Haussler K K, Erb H N. Pressure algometry: Objective assessment of back pain and effects of chiropractic treatment. Proc. 49th Annu. Conv. Am. Assoc. Equine Pract. 2003;49:66–70.
  38. Haussler K K, Manchon P T, Donnell J R, Frisbie D D. Effects of low-level laser therapy and chiropractic care on back pain in Quarter Horses. J. Equine Vet. Sci. 2020;86:e102891.
    doi: 10.1016/j.jevs.2019.102891pubmed: 32067657google scholar: lookup
  39. Sullivan K A, Hill A E, Haussler K K. The effects of chiropractic, massage and phenylbutazone on spinal mechanical nociceptive thresholds in horses without clinical signs. Equine Vet. J. 2008;40:14–20.
    doi: 10.2746/042516407X240456pubmed: 18083655google scholar: lookup
  40. Edner A, Lindberg L G, Brostrom H, Bergh A. Does a magnetic blanket induce changes in muscular blood flow, skin temperature and muscular tension in horses?. Equine Vet. J. 2015;47:302–307.
    doi: 10.1111/evj.12291pubmed: 24779912google scholar: lookup
  41. Biermann N M, Rindler N, Buchner H H F. The effect of pulsed electromagnetic fields on back pain in polo ponies evaluated by pressure algometry and flexion testing: A randomized, double-blind, placebo-controlled trial. J. Equine Vet. Sci. 2014;34:500–507.
    doi: 10.1016/j.jevs.2013.10.177google scholar: lookup
  42. Trager L R, Funk R A, Clapp K S, Dahlgren L A, Werre S R, Hodgson D R, Pleasant R S. Extracorporeal shockwave therapy raises mechanical nociceptive threshold in horses with thoracolumbar pain. Equine Vet. J. 2020;52:250–257.
    doi: 10.1111/evj.13159pubmed: 31393628google scholar: lookup
  43. L’Ami J J, Vermunt L E, van Loon J P, Sloet van Oldruitenborgh-Oosterbaan M M. Sublingual administration of detomidine in horses: Sedative effect, analgesia and detection time. Vet. J. 2013;196:253–259.
    doi: 10.1016/j.tvjl.2012.08.016pubmed: 23062724google scholar: lookup
  44. Starling M, McLean A, McGreevy P. The Contribution of Equitation Science to Minimising Horse-Related Risks to Humans. Animals. 2016;6:15.
    doi: 10.3390/ani6030015pmc: PMC4810043pubmed: 26907354google scholar: lookup
  45. Love E J, Taylor P M, Murrell J, Whay H R. Effects of acepromazine, butorphanol and buprenorphine on thermal and mechanical nociceptive thresholds in horses. Equine Vet. J. 2012;44:221–225.
    doi: 10.1111/j.2042-3306.2011.00412.xpubmed: 21696438google scholar: lookup
  46. Chambers J P, Waterman A E, Livingston A. Further development of equipment to measure nociceptive thresholds in large animals. J. Vet. Anaesth. 1994;21:66–72.
    doi: 10.1111/j.1467-2995.1994.tb00489.xgoogle scholar: lookup
  47. Nalon E, Maes D, Piepers S, van Riet M M J, Janssens G P J, Millet S, Tuyttens F A M. Mechanical nociception thresholds in lame sows: Evidence of hyperalgesia as measured by two different methods. Vet. J. 2013;198:386–390.
    doi: 10.1016/j.tvjl.2013.08.016pubmed: 24055221google scholar: lookup
  48. Duan G, Xiang G, Zhang X, Guo S, Zhang Y. An improvement of mechanical pain sensitivity measurement method: The smaller sized probes may detect heterogeneous sensory threshold in healthy male subjects. Pain Med. 2014;15:272–280.
    doi: 10.1111/pme.12245pubmed: 24118900google scholar: lookup
  49. Grint N J, Beths T, Yvorchuk K, Taylor P M, Dixon M, Whay H R, Murrell J C. The influence of various confounding factors on mechanical nociceptive thresholds in the donkey. Vet. Anaesth. Analg. 2014;41:421–429.
    doi: 10.1111/vaa.12132pubmed: 24576142google scholar: lookup
  50. Polson S, Taylor P M, Yates D. Effects of age and reproductive status on postoperative pain after routine ovariohysterectomy in cats. J. Feline. Med. Surg. 2014;16:170–176.
    doi: 10.1177/1098612X13503651pmc: PMC11383135pubmed: 24043720google scholar: lookup
  51. Grint N J, Beths T, Yvorchuk-St Jean K, Whay H R, Murrell J C. Analysis of behaviors observed during mechanical nociceptive threshold testing in donkeys and horses. J. Equine Vet. Sci. 2017;50:102–109.
    doi: 10.1016/j.jevs.2016.11.001google scholar: lookup
  52. Koo T K, Guo J Y, Brown C M. Test-retest reliability, repeatability, and sensitivity of an automated deformation-controlled indentation on pressure pain threshold measurement. J. Manip. Physiol. 2013;36:84–90.
    doi: 10.1016/j.jmpt.2013.01.001pubmed: 23499143google scholar: lookup
  53. Linde L D, Kumbhare D A, Joshi M, Srbely J Z. The relationship between rate of algometer application and pain pressure threshold in the assessment of myofascial trigger point sensitivity. Pain Pr. 2018;18:224–229.
    doi: 10.1111/papr.12597pubmed: 28440895google scholar: lookup
  54. Kinser A M, Sands W A, Stone M H. Reliability and validity of a pressure algometer. J. Strength Cond. Res. 2009;23:312–314.
    doi: 10.1519/JSC.0b013e31818f051cpubmed: 19130648google scholar: lookup
  55. Vaughan B, McLaughlin P, Gosling C. Validity of an electronic pressure algometer. Int. J. Osteopath. Med. 2007;10:24–28.
    doi: 10.1016/j.ijosm.2006.12.003google scholar: lookup
  56. Spadavecchia C, Arendt-Nielsen L, Andersen O K, Spadavecchia L, Doherr M, Schatzmann U. Comparison of nociceptive withdrawal reflexes and recruitment curves between the forelimbs and hind limbs in conscious horses. Am. J. Vet. Res. 2003;64:700–707.
    doi: 10.2460/ajvr.2003.64.700pubmed: 12828255google scholar: lookup
  57. Colbath A C, Wittenburg L A, Gold J R, McIlwraith C W, Moorman V J. The effects of mepivacaine hydrochloride on antimicrobial activity and mechanical nociceptive threshold during amikacin sulfate regional limb perfusion in the horse. Vet. Surg. 2016;45:798–803.
    doi: 10.1111/vsu.12515pubmed: 27416788google scholar: lookup
  58. Lizarraga I, Beths T. A comparative study of xylazine-induced mechanical hypoalgesia in donkeys and horses. Vet. Anaesth. Analg. 2012;39:533–538.
    doi: 10.1111/j.1467-2995.2012.00725.xpubmed: 22574779google scholar: lookup
  59. Hinnigan G, Milner P, Talbot A, Singer E. Is anaesthesia of the deep branch of the lateral plantar nerve specific for the diagnosis of proximal metatarsal pain in the horse?. Vet. Comp. Orthop. Traumatol. 2014;27:351–357.
    doi: 10.3415/VCOT-13-12-0146pubmed: 25213031google scholar: lookup
  60. List T, Helkimo M, Karlsson R. Influence of pressure rates on the reliability of a pressure threshold meter. J. Craniomandib. Disord. 1991;5:173–178.
    pubmed: 1812145
  61. Treede R D, Rolke R, Andrews K, Magerl W. Pain elicited by blunt pressure: Neurobiological basis and clinical relevance. Pain. 2002;98:235–240.
    doi: 10.1016/S0304-3959(02)00203-8pubmed: 12127024google scholar: lookup
  62. Gozalo-Marcilla M, de Oliveira A R, Fonseca M W, Possebon F S, Pelligand L, Taylor P M, Luna S P L. Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses. Equine Vet. J. 2019;51:530–536.
    doi: 10.1111/evj.13054pubmed: 30485499google scholar: lookup
  63. Love E J, Pelligand L, Taylor P M, Murrell J C, Sear J W. Pharmacokinetic-pharmacodynamic modelling of intravenous buprenorphine in conscious horses. Vet. Anaesth. Analg. 2015;42:17–29.
    doi: 10.1111/vaa.12165pubmed: 24735059google scholar: lookup
  64. Nussbaum E L, Downes L. Reliability of clinical pressure-pain algometric measurements obtained on consecutive days. Phys. Ther. 1998;78:160–169.
    doi: 10.1093/ptj/78.2.160pubmed: 9474108google scholar: lookup
  65. Kosek E, Ekholm J, Nordemar R. A comparison of pressure pain thresholds in different tissues and body regions. Long-term reliability of pressure algometry in healthy volunteers. Scand. J. Rehabil. Med. 1993;25:117–124.
    pubmed: 8248762
  66. Pauli P, Wiedemann G, Nickola M. Pressure pain thresholds asymmetry in left- and right-handers: Associations with behavioural measures of cerebral laterality. Eur. J. Pain. 1999;3:151–156.
    doi: 10.1053/eujp.1999.0108pubmed: 10700344google scholar: lookup
  67. Rédua M A, Valadão C A A, Duque J C, Balestrero L T. The pre-emptive effect of epidural ketamine on wound sensitivity in horses tested by using von Frey filaments. Vet. Anaesth. Analg. 2002;29:200–206.
    doi: 10.1046/j.1467-2995.2002.00083.xpubmed: 28404363google scholar: lookup
  68. . The Effect of Weight Carried and Time Ridden on Back Pain in Horses Ridden During Horse Shows as Determined by Pressure Algometry. .
  69. Hamra J G, Kamerling S G, Wolfsheimer K J, Bagwell C A. Diurnal variation in plasma ir-beta-endorphin levels and experimental pain thresholds in the horse. Life Sci. 1993;53:121–129.
    doi: 10.1016/0024-3205(93)90659-Qpubmed: 8515686google scholar: lookup
  70. Ohrbach R, Gale E N. Pressure pain thresholds in normal muscles: Reliability, measurement effects, and topographic differences. Pain. 1989;37:257–263.
    doi: 10.1016/0304-3959(89)90189-9pubmed: 2755707google scholar: lookup
  71. Crabtree N E, Mochal-King C A, Sloan P B, Eddy A L, Wills R W, Meredith A N, Fontenot R L. Synovial butorphanol concentrations and mechanical nociceptive thresholds after intravenous regional limb perfusion in standing sedated horses. Vet. Surg. 2019;48:1473–1482.
    doi: 10.1111/vsu.13309pubmed: 31513300google scholar: lookup
  72. Kosek E, Ekholm J, Hansson P. Pressure pain thresholds in different tissues in one body region. The influence of skin sensitivity in pressure algometry. Scand. J. Rehabil. Med. 1999;31:89–93.
    pubmed: 10380724
  73. Jordana M, Martens A, Duchateau L, Haspeslagh M, Vanderperren K, Oosterlinck M, Pille F. Diffusion of mepivacaine to adjacent synovial structures after intrasynovial analgesia of the digital flexor tendon sheath. Equine Vet. J. 2016;48:326–330.
    doi: 10.1111/evj.12447pubmed: 25827158google scholar: lookup
  74. Contino E K, King M R, Valdes-Martinez A, McIlwraith C W. In vivo diffusion characteristics following perineural injection of the deep branch of the lateral plantar nerve with mepivacaine or iohexol in horses. Equine Vet. J. 2015;47:230–234.
    doi: 10.1111/evj.12261pubmed: 24612216google scholar: lookup
  75. Muir W W. Pain: Mechanisms and management in horses. Vet. Clin. Equine Pr. 2010;26:467–480.
    doi: 10.1016/j.cveq.2010.07.008pubmed: 21056294google scholar: lookup

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  5. Doherty O, Conway R, McGreevy P. Using an Equine Cadaver Head to Investigate Associations Between Sub-Noseband Space, Noseband Tension, and Sub-Noseband Pressure at Three Locations. Animals (Basel) 2025 Jul 19;15(14).
    doi: 10.3390/ani15142141pubmed: 40723604google scholar: lookup
  6. Portier K, Schiesari C, Gauthier L, Yeng LT, Tabacchi Fantoni D, Formenton MR. Comparison of the Prevalence and Location of Trigger Points in Dressage and Show-Jumping Horses. Animals (Basel) 2025 May 27;15(11).
    doi: 10.3390/ani15111558pubmed: 40509024google scholar: lookup
  7. MacKechnie-Guire R, Clayton H, Williams J, Marlin D, Fisher M, Fisher D, Walker V, Murray RC. Comparison of Rein Forces and Pressure Beneath the Noseband and Headpiece of a Snaffle Bridle and a Double Bridle. Animals (Basel) 2025 Apr 5;15(7).
    doi: 10.3390/ani15071058pubmed: 40218450google scholar: lookup
  8. Kschonek J, Twele L, Deters K, Miller M, Reinmold J, Emmerich I, Hennig-Pauka I, Kemper N, Kreienbrock L, Wendt M, Kästner S, Grosse Beilage E. Part I: understanding pain in pigs-basic knowledge about pain assessment, measures and therapy. Porcine Health Manag 2025 Mar 11;11(1):12.
    doi: 10.1186/s40813-025-00421-0pubmed: 40069905google scholar: lookup
  9. Cai Y, Li Q, Banga AK, Wesselmann U, Zhao C. Tetrodotoxin Delivery Pen Safely Uses Potent Natural Neurotoxin to Manage Severe Cutaneous Pain. Adv Healthc Mater 2025 Apr;14(9):e2401549.
    doi: 10.1002/adhm.202401549pubmed: 39981822google scholar: lookup
  10. Clayton HM, Murray R, Williams JM, Walker V, Fisher M, Fisher D, Nixon J, Mackechnie-Guire R. Facial pressure beneath a cavesson noseband adjusted to different tightness levels during standing and chewing. Equine Vet J 2025 Jul;57(4):1127-1137.
    doi: 10.1111/evj.14451pubmed: 39710981google scholar: lookup
  11. Blum S, Gisler J, Dalla Costa E, Montavon S, Spadavecchia C. Investigating conditioned pain modulation in horses: can the lip-twitch be used as a conditioning stimulus?. Front Pain Res (Lausanne) 2024;5:1463688.
    doi: 10.3389/fpain.2024.1463688pubmed: 39512387google scholar: lookup
  12. Petrucci M, Spadavecchia C, Rieben R, Casoni D. Mechanical and thermal thresholds before and after application of a conditioning stimulus in healthy Göttingen Minipigs. PLoS One 2024;19(8):e0309604.
    doi: 10.1371/journal.pone.0309604pubmed: 39208203google scholar: lookup
  13. Gisler J, Chiavaccini L, Blum S, Montavon S, Spadavecchia C. Pressure pain mapping of equine distal joints: feasibility and reliability. Front Pain Res (Lausanne) 2024;5:1342954.
    doi: 10.3389/fpain.2024.1342954pubmed: 38726353google scholar: lookup
  14. De Castilho T, Rosa GDS, Stievani FC, Apolônio EVP, Pfeifer JPH, Altheman VG, Palialogo V, Santos NJD, Fonseca-Alves CE, Alves ALG. Biocompatibility of hydrogel derived from equine tendon extracellular matrix in horses subcutaneous tissue. Front Bioeng Biotechnol 2023;11:1296743.
    doi: 10.3389/fbioe.2023.1296743pubmed: 38260745google scholar: lookup
  15. McAndrews A, Zarucco L, Hopster K, Stefanovski D, Foster D, Driessen B. Evaluation of Three Methods of Sensory Function Testing for the Assessment of Successful Maxillary Nerve Blockade in Horses. J Vet Dent 2025 Jan;42(1):48-54.
    doi: 10.1177/08987564231164769pubmed: 37013274google scholar: lookup
  16. Armitage AJ, Miller JM, Sparks TH, Georgiou AE, Reid J. Efficacy of autologous mesenchymal stromal cell treatment for chronic degenerative musculoskeletal conditions in dogs: A retrospective study. Front Vet Sci 2022;9:1014687.
    doi: 10.3389/fvets.2022.1014687pubmed: 36713862google scholar: lookup
  17. Cota LO, Malacarne BD, Dias LA, Neto ACP, Kneipp MLA, Cavalcante MA, Cunha MSLD, Paz CFR, Carvalho AM, Faleiros RR, Xavier ABDS. Mechanical nociceptive assessment of the equine hoof after navicular bursa anesthetic infiltration validated by bursography. PLoS One 2022;17(6):e0269532.
    doi: 10.1371/journal.pone.0269532pubmed: 35671268google scholar: lookup
  18. Haussler KK, Hesbach AL, Romano L, Goff L, Bergh A. A Systematic Review of Musculoskeletal Mobilization and Manipulation Techniques Used in Veterinary Medicine. Animals (Basel) 2021 Sep 24;11(10).
    doi: 10.3390/ani11102787pubmed: 34679808google scholar: lookup
  19. Troya-Portillo L, López-Sanromán J, Villalba-Orero M, Santiago-Llorente I. Cardiorespiratory, Sedative and Antinociceptive Effects of a Medetomidine Constant Rate Infusion with Morphine, Ketamine or Both. Animals (Basel) 2021 Jul 13;11(7).
    doi: 10.3390/ani11072081pubmed: 34359209google scholar: lookup
  20. Viscardi AV, Reppert EJ, Kleinhenz MD, Wise P, Lin Z, Montgomery S, Daniell H, Curtis A, Martin M, Coetzee JF. Analgesic Comparison of Flunixin Meglumine or Meloxicam for Soft-Tissue Surgery in Sheep: A Pilot Study. Animals (Basel) 2021 Feb 6;11(2).
    doi: 10.3390/ani11020423pubmed: 33562143google scholar: lookup
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