Prevalence of benzimidazole-resistance in equine cyathostome populations in south east England.
Abstract: In order to study the prevalence of benzimidazole-resistance in equine cyathostomes, 30 stables in south east England were selected according to strict criteria but with minimum bias to provide three matched groups of 100 horses. One group was treated with fenbendazole, one with pyrantel embonate and the third was left untreated. The overall efficacies of fenbendazole and pyrantel embonate, as judged by the faecal egg-count reduction test, were 56.3 and 95.8 per cent, respectively. The numbers of horses at individual stables were too small to draw conclusions at each stable, but whereas efficacies greater than 85 per cent were recorded for pyrantel at 26 of 27 stables, the corresponding figure for fenbendazole was five of 27. Cyathostomes accounted for more than 90 per cent of the larvae cultured from faeces before and after treatment. Trichostrongylus axei was detected on 20 sites, but Strongylus species were present on only five. In the area of the survey, benzimidazole-resistance was very widespread in stables which used benzimidazole anthelmintics regularly and had more than nine horses per stable, but the benzimidazole-resistant cyathostome strains were adequately controlled with the non-benzimidazole anthelmintic pyrantel embonate.
Publication Date: 1992-04-11 PubMed ID: 1595158DOI: 10.1136/vr.130.15.315Google Scholar: Lookup
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- Journal Article
Summary
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The research focuses on studying the prevalence of resistance to a certain type of deworming medication (benzimidazole) in equine parasites, cyathostomes, found in south east England and suggests pyrantel embonate as a more effective treatment.
Research Overview
- The experiment was conducted on 30 stables that were strategically chosen based on certain criteria in south east England.
- Every stable had three groups of 100 horses each, treated with varying substances – fenbendazole, an anthelmintics from benzimidazole family, pyrantel embonate, a non-benzimidazole anthelmintic, and a group left untreated to act as control.
Achieved Results
- The effectiveness of fenbendazole and pyrantel embonate in removing the parasites was measured by the faecal egg-count reduction method.
- The overall effectiveness percentages were determined to be 56.3% and 95.8% for fenbendazole and pyrantel embonate respectively.
- Going into further details, while pyrantel’s effectiveness exceeded 85% in 26 out of 27 stables, fenbendazole’s effectiveness was above this threshold only in 5 out of 27 stables.
Evaluation of Parasite Populations
- Cyathostomes were the primary target of the study since they constituted more than 90% of the larvae cultured from horse faeces before and after the given treatments.
- Another parasite, Trichostrongylus axei, was detected in 20 locations, and parasites from the Strongylus species were located only in five.
Prevalence and Control of Benzimidazole-Resistance in Cyathostomes
- The data clearly indicates a widespread prevalence of benzimidazole-resistance in cyathostomes, especially at stables which regularly used benzimidazole anthelmintics and housed more than nine horses.
- However, it was found that these benzimidazole-resistant strains of cyathostomes could effectively be controlled with pyrantel embonate, a non-benzimidazole anthelmintic.
Cite This Article
APA
Fisher MA, Jacobs DE, Grimshaw WT, Gibbons LM.
(1992).
Prevalence of benzimidazole-resistance in equine cyathostome populations in south east England.
Vet Rec, 130(15), 315-318.
https://doi.org/10.1136/vr.130.15.315 Publication
Researcher Affiliations
- Department of Veterinary Pathology, Royal Veterinary College (University of London), Herts.
MeSH Terms
- Animals
- Body Weight
- Drug Resistance
- England
- Feces / parasitology
- Female
- Fenbendazole / pharmacology
- Fenbendazole / therapeutic use
- Horses
- Male
- Parasite Egg Count / veterinary
- Pyrantel Pamoate / pharmacology
- Pyrantel Pamoate / therapeutic use
- Strongyle Infections, Equine / drug therapy
- Strongyle Infections, Equine / parasitology
- Strongyloidea / drug effects
Citations
This article has been cited 3 times.- Traversa D, von Samson-Himmelstjerna G, Demeler J, Milillo P, Schürmann S, Barnes H, Otranto D, Perrucci S, di Regalbono AF, Beraldo P, Boeckh A, Cobb R. Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S2.
- Corning S. Equine cyathostomins: a review of biology, clinical significance and therapy. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S1.
- Ihler CF. A field survey on anthelmintic resistance in equine small strongyles in Norway. Acta Vet Scand 1995;36(1):135-43.
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