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Home / Equine Research Bank / J Appl Physiol (1985) / Probiotic supplementation in trained trotter horses: effect ...
Journal of applied physiology (Bethesda, Md. : 1985)2018; 125(2); 654-660; doi: 10.1152/japplphysiol.01131.2017

Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field.

Abstract: The attention of sports community toward probiotic supplementation as a way to promote exercise and training performance, together with good health, has increased in recent years. This has applied also to horses, with promising results. Here, for the first time, we tested a probiotic mix of several strains of live bacteria typically employed for humans to improve the training performance of Standardbred horses in athletic activity. To evaluate its effects on the horse performance, we measured lactate concentration in blood, a translational outcome largely employed for the purpose, combined with the study of hematological and biochemical parameters, together with urine from a metabolomics perspective. The results showed that the probiotic supplementation significantly reduced postexercise blood lactate concentration. The hematological and biochemical parameters, together with urine molecular profile, suggested that a likely mechanism underlying this positive effect was connected to a switch of energy source in muscle from carbohydrates to short-chain fatty acids. Three sulfur-containing molecules differently concentrated in urines in connection to probiotics administration suggested that such switch was linked to sulfur metabolism. NEW & NOTEWORTHY Probiotic supplementation could reduce postexercise blood lactate concentration in Standardbred horses in athletic activity. Blood parameters, together with urine molecular profile, suggest the mechanism underlying this positive effect is connected to a switch of energy source in muscle from carbohydrates to short-chain fatty acids. Sulfur-containing molecules found in urines in connection to probiotics administration suggested that such switch was linked to sulfur metabolism.
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Publication Date: 2018-04-19 PubMed ID: 29672225PubMed Central: PMC6139516DOI: 10.1152/japplphysiol.01131.2017Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study examines how probiotic supplementation affects the performance of professionally trained trotter horses, revealing that such supplementation can significantly reduce post-workout blood lactate concentration, suggesting that it might be switching the horses’ energy source in muscle from carbs to short-chain fatty acids.

Overview of Research

  • The research focuses on the usage of probiotics as dietary supplements for professional trotter horses. These horses are under high physical stress due to the intense nature of their activity, and the researchers sought to understand whether probiotics could directly impact the performance and health of these animals.
  • The researchers administered a mix of different strains of probiotics typically used for humans to the trial horses, and then monitored their health and performance parameters.

Methodology and Measurements

  • One of the key measures was the concentration of lactate in the blood – a standard metric for determining the efficiency of physical activity in many mammals. High levels of blood lactate show that the body is under stress from intense activity.
  • Along with this, hematological and biochemical measures were taken, and the urine of the horses was studied from a metabolomics perspective. Metabolomics allows researchers to understand the different substances found in urine, which in turn helps them track overall metabolism and physiological health.

Findings

  • The study found that the probiotics reduced the post-exercise lactate concentration within the blood, indicating improved endurance and lower physical stress levels after exercise. This suggests a positive impact of probiotic supplementation on physical performance in horses.
  • Hematological and biochemical parameters, as well as urine profiles, hint towards a possible shift in energy sources of muscles from carbohydrates to short-chain fatty acids, triggered potentially by the introduction of probiotics.
  • Interesting findings related to sulfur metabolism were made; three sulfur-containing molecules were found in variable concentrations in the horses’ urine in relation to the probiotics, indicating a possible link between sulfur metabolism and the energy source switch.

Significance

  • This study highlights the potential benefits of using probiotics in equine training and health programmes, especially for intensive activities where performance, endurance and recovery are critical.
  • Overall, it points towards an interesting link between probiotic supplementation, lactate concentration, energy source utilization, and sulfur metabolism in horses and perhaps by extension, in other mammals as well.

Cite This Article

APA
(2018). Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field. J Appl Physiol (1985), 125(2), 654-660. https://doi.org/10.1152/japplphysiol.01131.2017

Publication

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
NlmUniqueID: 8502536
Country: United States
Language: English
Volume: 125
Issue: 2
Pages: 654-660

Researcher Affiliations

MeSH Terms

  • Animals
  • Cross-Over Studies
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Horses / blood
  • Horses / metabolism
  • Horses / urine
  • Lactates / metabolism
  • Male
  • Metabolome / drug effects
  • Metabolomics / methods
  • Muscle, Skeletal / metabolism
  • Pathology, Clinical / methods
  • Physical Conditioning, Animal / physiology
  • Probiotics / administration & dosage
  • Sports / physiology
  • Urine / chemistry

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