Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency.
Abstract: Theileria equi immune plasma was infused into young horses (foals) with severe combined immunodeficiency. Although all foals became infected following intravenous challenge with homologous T. equi merozoite stabilate, delayed time to peak parasitemia occurred. Protective effects were associated with a predominance of passively transferred merozoite-specific IgG3.
Publication Date: 2011-10-28 PubMed ID: 22038847PubMed Central: PMC3255952DOI: 10.1128/CVI.05301-11Google Scholar: Lookup
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- Journal Article
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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The study explores the impact of passively transmitted merozoite-specific antibodies in protecting horses with severe combined immunodeficiency against Theileria equi. The research discovered that the transfer of these specific antibodies could delay the peak of parasitemia.
Understanding the Study
- The research looked into the effects of passively injecting specific antibodies into young horses afflicted with severe combined immunodeficiency or SCID. These foals were then exposed to Theileria equi merozoite, a protozoan parasite that causes equine piroplasmosis leading to fever, anemia, jaundice, and sometimes death in horses.
- The passively transferred antibodies were merozoite-specific antibodies found in the immune plasma of adult horses that were previously infected and recovered from T. equi infection. This passive transfer made use of the body’s natural defense mechanism, which creates specific antibodies in response to an infection.
Key Findings
- Despite all foals becoming infected upon exposure to the parasite, the researchers noted a delay in the time to peak parasitemia, suggesting a kind of protective effect from the passively transferred antibodies.
- The study infers that passively transferred merozoite-specific IgG3 antibodies were primarily associated with this protective effect. The IgG3 antibodies were identified as a specific type of immunoglobulin (a kind of protein produced by the immune system to neutralize harmful pathogens) that targets the merozoites of Theileria equi.
Implications of the Study
- The study’s outcomes highlight the potential role of passively transferred merozoite-specific antibodies in the fight against T. equi, particularly in cases where the host’s immune system is compromised such as in SCID-afflicted horses.
- The findings could enhance understanding and potentially influence future research on effective therapeutic methods for T. equi infection and similar infectious diseases.
Cite This Article
APA
Mealey RH, Kappmeyer LS, Ueti MW, Wagner B, Knowles DP.
(2011).
Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency.
Clin Vaccine Immunol, 19(1), 100-104.
https://doi.org/10.1128/CVI.05301-11 Publication
Researcher Affiliations
- Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA. rhm@vetmed.wsu.edu
MeSH Terms
- Animals
- Antibodies, Protozoan / administration & dosage
- Antibodies, Protozoan / immunology
- Horse Diseases / prevention & control
- Horse Diseases / therapy
- Horses
- Immunization, Passive / methods
- Immunoglobulin G / administration & dosage
- Immunoglobulin G / immunology
- Immunologic Factors / administration & dosage
- Immunologic Factors / immunology
- Merozoites / immunology
- Parasitemia / prevention & control
- Severe Combined Immunodeficiency / veterinary
- Theileria / immunology
- Theileriasis / prevention & control
- Time Factors
References
This article includes 25 references
- nCordes T. Seroprevalence of equine piroplasmosis in the United States. Info sheet #569.1009 2009.
- Cunha CW, McGuire TC, Kappmeyer LS, Hines SA, Lopez AM, Dellagostin OA, Knowles DP. Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection.. Clin Vaccine Immunol 2006 Feb;13(2):297-300.
- Goehring LS, Wagner B, Bigbie R, Hussey SB, Rao S, Morley PS, Lunn DP. Control of EHV-1 viremia and nasal shedding by commercial vaccines.. Vaccine 2010 Jul 19;28(32):5203-11.
- Knowles DP Jr, Kappmeyer LS, Perryman LE. Specific immune responses are required to control parasitemia in Babesia equi infection.. Infect Immun 1994 May;62(5):1909-13.
- Knowles DP Jr, Perryman LE, Goff WL, Miller CD, Harrington RD, Gorham JR. A monoclonal antibody defines a geographically conserved surface protein epitope of Babesia equi merozoites.. Infect Immun 1991 Jul;59(7):2412-7.
- Kumar S, Malhotra DV, Dhar S, Nichani AK. Vaccination of donkeys against Babesia equi using killed merozoite immunogen.. Vet Parasitol 2002 May 30;106(1):19-33.
- Lewis MJ, Wagner B, Woof JM. The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.. Mol Immunol 2008 Feb;45(3):818-27.
- Magnuson NS, Perryman LE, Wyatt CR, Ishizaka T, Mason PH, Namen AE, Banks KL, Magnuson JA. Continuous cultivation of equine lymphocytes: evidence for occasional T cell-like maturation events in horses with hereditary severe combined immunodeficiency.. J Immunol 1984 Nov;133(5):2518-24.
- McGuire TC, Banks KL, Poppie MJ. Combined immunodeficiency in horses: characterization of the lymphocyte defect.. Clin Immunol Immunopathol 1975 Mar;3(4):555-66.
- McGuire TC, Van Hoosier GL Jr, Henson JB. The complement-fixation reaction in eguine infectious anemia: demonstration of inhibition by IgG (T).. J Immunol 1971 Dec;107(6):1738-44.
- Mealey RH, Fraser DG, Oaks JL, Cantor GH, McGuire TC. Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: lessons for control of lentiviruses.. Clin Immunol 2001 Nov;101(2):237-47.
- Mealey RH, Littke MH, Leib SR, Davis WC, McGuire TC. Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy.. Vet Immunol Immunopathol 2008 Jan 15;121(1-2):8-22.
- Perryman LE, McGuire TC, Crawford TB. Maintenance of foals with combined immunodeficiency: causes and control of secondary infections.. Am J Vet Res 1978 Jun;39(6):1043-7.
- Perryman LE, O'Rourke KI, McGuire TC. Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.. J Virol 1988 Aug;62(8):3073-6.
- Scoles GA, Hutcheson HJ, Schlater JL, Hennager SG, Pelzel AM, Knowles DP. Equine piroplasmosis associated with Amblyomma cajennense Ticks, Texas, USA.. Emerg Infect Dis 2011 Oct;17(10):1903-5.
- Shin EK, Perryman LE, Meek K. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.. J Immunol 1997 Apr 15;158(8):3565-9.
- Taylor SD, Leib SR, Carpenter S, Mealey RH. Selection of a rare neutralization-resistant variant following passive transfer of convalescent immune plasma in equine infectious anemia virus-challenged SCID horses.. J Virol 2010 Jul;84(13):6536-48.
- Ueti MW, Palmer GH, Kappmeyer LS, Scoles GA, Knowles DP. Expression of equi merozoite antigen 2 during development of Babesia equi in the midgut and salivary gland of the vector tick Boophilus microplus.. J Clin Microbiol 2003 Dec;41(12):5803-9.
- Ueti MW, Palmer GH, Scoles GA, Kappmeyer LS, Knowles DP. Persistently infected horses are reservoirs for intrastadial tick-borne transmission of the apicomplexan parasite Babesia equi.. Infect Immun 2008 Aug;76(8):3525-9.
- Reference deleted.
- Wagner B. Immunoglobulins and immunoglobulin genes of the horse.. Dev Comp Immunol 2006;30(1-2):155-64.
- Wagner B, Greiser-Wilke I, Wege AK, Radbruch A, Leibold W. Evolution of the six horse IGHG genes and corresponding immunoglobulin gamma heavy chains.. Immunogenetics 2002 Aug;54(5):353-64.
- Wagner B, Miller DC, Lear TL, Antczak DF. The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse.. J Immunol 2004 Sep 1;173(5):3230-42.
- Wagner B, Miller WH Jr, Erb HN, Lunn DP, Antczak DF. Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses.. Vet Immunol Immunopathol 2009 Nov 15;132(1):53-61.
- Wiler R, Leber R, Moore BB, VanDyk LF, Perryman LE, Meek K. Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.. Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11485-9.
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