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Home / Equine Research Bank / Front Vet Sci / Radio-Telemetric Assessment of Cardiac Variables and Locomot...
Frontiers in veterinary science2019; 6; 414; doi: 10.3389/fvets.2019.00414

Radio-Telemetric Assessment of Cardiac Variables and Locomotion With Experimentally Induced Hypermagnesemia in Horses Using Chronically Implanted Catheters.

Abstract: The objective of this study was to characterize the pharmacokinetics and pharmacodynamics of intravenous administration of magnesium sulfate to horses using a novel radio-telemetry system for physiologic signal capture. Five Horses were surgically implanted with a radio-telemetric carotid catheter. Implants were paired with a non-invasive telemetric unit which acquired a six lead ECG and 3-axis acceleration to assess activity acquired wirelessly in real-time for future analysis. Horses were exposed to a new stall environment before (baseline) and after 60 mg/kg (30 mL) of magnesium sulfate (MgSO), or the same volume of 0.9% saline, administered intravenously in a blinded, random crossover design. Blood for pharmacokinetics, telemetric data, and body temperature were recorded serially for 24 h. Data were analyzed across time and between treatments. Significance was set at < 0.05. Ionized magnesium concentration (Mg) increased and the Ca to Mg ratio decreased and persisted for 5 h after MgSO administration. Heart rate (HR) increased and mean arterial blood pressure (MAP) decreased for at least 6 h. Electrocardiogram (ECG) intervals (RR) decreased and (PR and QTc) increased in duration compared to controls indicating an increase in heart rate, and slower myocardial conduction in the MgSO group. Acceleration in all planes was less in the MgSO group compared to controls indicating decreased locomotion. This novel method permitted collection of physiologic signals without interference by handlers or animal restraint. An intravenous bolus of MgSO produced cardiac variable changes associated with the reduction of locomotion in these horses, and in a direction that may be causal. Locomotion was decreased when horses were first introduced into a new environment which reflects the calming effect desired in sport horses. Telemetric monitoring can be used as a model to elucidate the behavior and physiologic effects of other drugs. The administration of MgSO may be detected for regulatory purposes with the monitoring of Mg and Ca concentrations and their ratio.
Copyright © 2019 Schumacher, Toribio, Lakritz and Bertone.
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Publication Date: 2019-11-21 PubMed ID: 31850378PubMed Central: PMC6881382DOI: 10.3389/fvets.2019.00414Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents a study assessing the impact of magnesium sulfate administration on horse heart rate and movement, using a newly developed radio-telemetry system for live, non-invasive monitoring. The study shows that magnesium sulfate injection alters cardiac functions and reduces horse locomotion, reflecting potential calming effects sought in sports horses.

Introduction

  • The research aimed to investigate the effects of intravenous magnesium sulfate administration in horses, using a novel radio-telemetry system to understand heart rate and movement in real time.
  • Radio-telemetry allows for remote, continuous, real-time physiological data collection, reducing direct human-horse interaction and possible bias due to handler-induced stress.

Method

  • Five horses were implanted with a catheter and linked to a non-invasive telemetric recording unit to monitor cardiac variables and locomotion wirelessly.
  • The horses were exposed to a new environment and were given 60 mg/kg of magnesium sulfate intravenously, or an equivalent amount of saline, in a random, blinded test.
  • Data collected included ionized magnesium concentration, heart rate, arterial blood pressure, Electrocardiogram (ECG) intervals, and movement levels.

Results & Findings

  • Results showed that after magnesium sulfate administration, the ionized magnesium concentration increased, while the ratio of calcium to magnesium decreased, suggesting an alteration in mineral balance within the body.
  • Cardiac measurements showed an increased heart rate and a decrease in arterial blood pressure for at least 6 hours. Additional ECG measurements also suggested a slowing of myocardial conduction.
  • The horses exhibited less motion in all directions, suggesting a decrease in locomotion following the magnesium sulfate administration.

Implications & Conclusion

  • This study demonstrated that the administration of magnesium sulfate can alter cardiac variables and reduce horse locomotion, highlighting potential calming effects sought in sports horses.
  • Also, the study showcases how real-time telemetric monitoring can provide comprehensive insights into drug-induced behavioral and physiological changes in animals.
  • Lastly, by monitoring magnesium and calcium concentrations and their ratio, the administration of magnesium sulfate can be tracked for regulatory purposes.

Cite This Article

APA
Schumacher SA, Toribio RE, Lakritz J, Bertone AL. (2019). Radio-Telemetric Assessment of Cardiac Variables and Locomotion With Experimentally Induced Hypermagnesemia in Horses Using Chronically Implanted Catheters. Front Vet Sci, 6, 414. https://doi.org/10.3389/fvets.2019.00414

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 6
Pages: 414
PII: 414

Researcher Affiliations

Schumacher, Stephen A
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.
  • The United States Equestrian Federation, Equine Drugs and Medications Program, Columbus, OH, United States.
Toribio, Ramiro E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.
Lakritz, Jeffrey
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.
Bertone, Alicia L
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.

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Citations

This article has been cited 1 times.
  1. Schumacher SA, Kamr AM, Lakritz J, Burns TA, Bertone AL, Toribio RE. Effects of intravenous magnesium sulfate on serum calcium-regulating hormones and plasma and urinary electrolytes in healthy horses. PLoS One 2021;16(6):e0247542.
    doi: 10.1371/journal.pone.0247542pubmed: 34181644google scholar: lookup
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