Recent developments in the epidemiology of virus diseases and BSE.
Abstract: There is a continuous change in viral epidemics with respect to clinical symptoms, their duration or disappearance and the emergence of new diseases. This can be observed both in human and animal diseases. This evolution of virus diseases is mainly related to three factors: etiological agent, host and environment. As far as genetic alterations of the virus are concerned, two major mechanisms are involved: 1) mutations such as recombination and reassortment; 2) selection for resistance or susceptibility. The epidemiology of newly emerged virus diseases in man and animals, such as AIDS and hemorrhagic fevers, and bovine spongiform encephalopathy (BSE), canine hemorrhagic gastroenteritis or respiratory syndrome in horses will be discussed.
Publication Date: 2000-07-08 PubMed ID: 10885827DOI: 10.1007/BF02561670Google Scholar: Lookup
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Summary
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The article discusses the continuous evolution of viral epidemics, focusing on the impact of genetic mutations and host resistance in the emergence of new diseases like AIDS, hemorrhagic fevers and bovine spongiform encephalopathy (BSE) in both humans and animals.
Continuous Evolution of Viral Diseases
- The research talks about constant changes taking place in the sphere of viral epidemics, affecting both humans and animals. These changes include variation in clinical symptoms of diseases, their time span or even complete disappearance, and emergence of new diseases.
- Three primary factors are attributed to this continuous evolution: the etiological agent (the cause or manner of causation of diseases), the host in which the virus propagates, and the environmental conditions.
Role of Genetic Alterations
- Two major mechanisms through which genetic alterations of the virus contribute to disease evolution are discussed: recombination and reassortment mutations.
- Recombination is the process where genetic material from two parent molecules is brought together within one molecule. On the other hand, reassortment is the mixing of the genetic material of a species into new combinations in different individuals.
- These genetic alterations can cause the emergence of new disease strains or influence the progression of existing diseases.
Selection for Resistance or Susceptibility
- The research acknowledges the role of selection for resistance or susceptibility in affecting disease the course and outcome of disease developments.
- Resistance refers to the ability of an organism to defend against a disease agent, whereas susceptibility implies the opposite – the lack of resistance to a disease.
- This interplay between resistance and susceptibility can influence the prevalence and severity of a disease in a particular population.
Newly Emerged Diseases: AIDS, Hemorrhagic Fevers, and BSE
- The article then discusses the epidemiology – the study of disease occurrence and its control in a population – of newly emerged diseases in detail, presenting examples of both human and animal diseases. These examples include Acquired Immunodeficiency Syndrome (AIDS), hemorrhagic fevers, and bovine spongiform encephalopathy (BSE), also known as mad cow disease.
- Other disease examples provided are canine hemorrhagic gastroenteritis (a severe illness in dogs causing vomiting and bloody diarrhea) and respiratory syndrome in horses.
Cite This Article
APA
Kaaden OR, Truyen U.
(2000).
Recent developments in the epidemiology of virus diseases and BSE.
Infection, 27 Suppl 2, S39-S41.
https://doi.org/10.1007/BF02561670 Publication
Researcher Affiliations
- Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin, Ludwig-Maximilians-Universität München and WHO Collaborating Centre for Collection and Evaluation of Data on Comparative Virology, Germany.
MeSH Terms
- Africa / epidemiology
- Animals
- Cats
- Cattle
- Developing Countries
- Disease Outbreaks
- Dogs
- Encephalopathy, Bovine Spongiform / epidemiology
- Encephalopathy, Bovine Spongiform / transmission
- Encephalopathy, Bovine Spongiform / virology
- Horses
- Humans
- Incidence
- RNA Virus Infections / epidemiology
- RNA Viruses / isolation & purification
- Risk Factors
- Virus Diseases / epidemiology
- Virus Diseases / transmission
- Virus Diseases / virology
- Zoonoses
References
This article includes 9 references
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