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Veterinary parasitology2022; 307-308; 109741; doi: 10.1016/j.vetpar.2022.109741

Reflections and future directions for continued development and refinement of guidelines for anthelmintic efficacy studies.

Abstract: This reflection paper complements the WAAVP (World Association for the Advancement of Veterinary Parasitology) general anthelmintic efficacy guideline, which outlines the general principles of anthelmintic efficacy evaluation across all animal host species. It provides background to the recommendations made in the WAAVP general anthelmintic efficacy guideline, with insights into the discussions leading to specific recommendations in the general guideline or the absence thereof. Furthermore, this paper discusses recent technological advancements with potential value to the evaluation of anthelmintic efficacy that may be considered for future versions of the general or species-specific guidelines if supported by sufficient levels of evidence. Finally, it also identifies potential research questions, such as the statistical approach for comparing worm counts between groups of animals.
Publication Date: 2022-06-01 PubMed ID: 35667202DOI: 10.1016/j.vetpar.2022.109741Google Scholar: Lookup
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Summary

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The research article is a reflective piece that provides insight into the processes behind the establishment of the World Association for the Advancement of Veterinary Parasitology’s (WAAVP) general guidelines for anthelmintic efficacy studies. It also discusses advancements in technology that could impact future versions of these guidelines and identifies new areas of research.

Background and Discussion on WAAVP Guidelines

  • The article starts by reflecting on the WAAVP guidelines that instruct on how to evaluate the efficacy of anthelmintic, or de-worming, drugs across all animal species. These guidelines underpin many of the practices in the veterinary field concerned with combating parasitical issues in animals.
  • The authors provide insight into the context of the discussions that led to the formation of specific recommendations within these guidelines, and also why certain recommendations were left out. This discussion provides valuable information on the thought processes behind these crucial veterinary guidelines.

Technological Advancements in Anthelmintic Efficacy Evaluation

  • The article then delves into the recent advances in technology that could significantly contribute to the assessment of the effectiveness of anti-worming medications. The authors propose that these technological developments should be considered for incorporation into future editions of the aforementioned guidelines.
  • The inclusion of these modern advancements could potentially improve the guidelines by making them more robust, effective and in tune with the latest technology, thereby enhancing their overall utility in the veterinary field.

Future Research Directions

  • The authors conclude the paper by identifying possible areas for future research. An example of this is the exploration of different statistical approaches that could be used to compare worm counts between groups of animals. This could lead to improved methods of assessing anthelmintic efficacy and further improvement of the guidelines.
  • By identifying these potential research questions, the authors are not only providing direction for future work in this field, but also promoting the continuous refinement and development of the WAAVP guidelines.

Cite This Article

APA
Geurden T, Smith ER, Vercruysse J, Yazwinski T, Rehbein S, Nielsen MK. (2022). Reflections and future directions for continued development and refinement of guidelines for anthelmintic efficacy studies. Vet Parasitol, 307-308, 109741. https://doi.org/10.1016/j.vetpar.2022.109741

Publication

ISSN: 1873-2550
NlmUniqueID: 7602745
Country: Netherlands
Language: English
Volume: 307-308
Pages: 109741
PII: S0304-4017(22)00095-4

Researcher Affiliations

Geurden, Thomas
  • Zoetis, Mercuriusstraat 20, 1930 Zaventem, Belgium. Electronic address: Thomas.geurden@zoetis.com.
Smith, Emily R
  • Center for Veterinary Medicine, USA Food and Drug Administration, Rockville, USA.
Vercruysse, Jozef
  • Faculty of Veterinary Medicine, University of Gent, Salisburylaan 133, B-9820 Merelbeke, Belgium.
Yazwinski, Tom
  • Department of Animal Science, University of Arkansas, Fayetteville, AR, USA.
Rehbein, Steffen
  • Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Rohrdorf, Germany.
Nielsen, Martin K
  • M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Anthelmintics / therapeutic use

Citations

This article has been cited 1 times.
  1. Oladosu OJ, Hennies M, Stehr M, Metges CC, Gauly M, Daş G. Pattern and repeatability of ascarid-specific antigen excretion through chicken faeces, and the diagnostic accuracy of coproantigen measurements as compared with McMaster egg counts and plasma and egg yolk antibody measurements in laying hens. Parasit Vectors 2023 Jun 1;16(1):175.
    doi: 10.1186/s13071-023-05782-5pubmed: 37264440google scholar: lookup