Response of pony peritoneum to four peritoneal lavage solutions.
Abstract: Peritoneal lavage was performed on ponies to determine the effect on peritoneal surfaces. Lavage solution (20 L) was introduced into each pony's peritoneal cavity through catheters placed in the paralumbar fossa, and the solution was removed by drainage from the ventral portion of the abdomen. Six ponies each were lavaged with sterile saline (0.9% NaCl) solution, sterile saline solution containing 5 X 10(6) U of potassium penicillin and 3 g of neomycin or povidone-iodine diluted to 3% by volume with sterile saline solution, and 3 ponies were lavaged with povidone-iodine diluted to 10% with sterile saline solution. Peritoneal lavage catheters were inserted in 3 control ponies, but lavage fluids were not administered. Peritoneal fluid specimens were collected at 6, 24, 48, and 96 hours after lavage. Nucleated cell counts, RBC counts, total protein determinations, and cytologic analysis were performed. The ponies were euthanatized at 96 hours, and representative sections of the peritoneum were examined. Lavage with saline solution and saline solution with antibiotics induced a mild, transient inflammatory response in the peritoneal fluid, with minimal or no changes observed at necropsy. Solutions containing povidone-iodine induced chemical peritonitis, which was severe in ponies lavaged with 10% povidone-iodine solution. Peritoneal lavage with povidone-iodine solutions as dilute as 3% cannot be accomplished without causing inflammation of peritoneal surfaces.
Publication Date: 1988-06-01 PubMed ID: 3400925
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- Journal Article
Summary
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This study investigated the impact of four different peritoneal lavage solutions on the peritoneum (inside lining of the belly) in ponies. The findings show that solutions containing povidone-iodine caused severe inflammation, while saline solutions caused only a mild and short-lived inflammatory response.
Study Methodology
- A peritoneal lavage which is washing of the peritoneum cavity, was conducted on a group of ponies.
- A total of 20 liters of lavage solution was inserted into each pony’s abdomen via catheters positioned in the paralumbar fossa, a hollow area at the lower back of the animal.
- The lavage solution was later drained from the lower part of the pony’s abdomen.
- Different lavage solutions were tried: regular sterile saline solution, saline solution with potassium penicillin and neomycin, povidone-iodine diluted with saline by 3%, and povidone-iodine diluted by 10%.
- Three control ponies had the catheters inserted but no lavage fluid administered.
Data Collection and Analysis
- Specimens of peritoneal fluid were collected at multiple intervals – 6, 24, 48, and 96 hours after the lavage procedure.
- Several tests were conducted on these specimens like nucleated cell counts, red blood cell counts, total protein determinations, and cytologic analysis (a microscopic examination of cells).
- All ponies were euthanatized 96 hours after the procedure, and samples of their peritoneum were examined.
Study Findings
- Ponies that were lavaged with either pure saline solution or saline solution with antibiotics exhibited a mild and temporary inflammatory response in the peritoneal fluid, with insignificant or no observable changes during the post-mortem examination.
- Solutions containing povidone-iodine caused a chemical-inflammation in the peritoneum, which was severe in ponies lavaged with a 10% povidone-iodine solution.
- The study found that even peritoneal lavage with povidone-iodine solutions as dilute as 3% induced inflammation of the inside lining of the abdomen.
Cite This Article
APA
Schneider RK, Meyer DJ, Embertson RM, Gentile DG, Buergelt CD.
(1988).
Response of pony peritoneum to four peritoneal lavage solutions.
Am J Vet Res, 49(6), 889-894.
Publication
Researcher Affiliations
- Department of Surgical, University of Florida, Gainesville 32610.
MeSH Terms
- Animals
- Ascitic Fluid / pathology
- Cell Count
- Horses / surgery
- Neomycin / pharmacology
- Penicillins / pharmacology
- Peritoneal Cavity / pathology
- Peritoneal Lavage / veterinary
- Peritoneum / drug effects
- Peritoneum / pathology
- Povidone-Iodine / pharmacology
- Random Allocation
- Sodium Chloride / pharmacology
Citations
This article has been cited 1 times.- Rockow M, Griffenhagen G, Landolt G, Hendrickson D, Pezzanite L. Current Antimicrobial Use in Horses Undergoing Exploratory Celiotomy: A Survey of Board-Certified Equine Specialists. Animals (Basel) 2023 Apr 22;13(9).
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