Results of a survey of equine practitioners on the use and perceived efficacy of polysulfated glycosaminoglycan.
Abstract: To determine the patterns of use and perceived efficacy of polysulfated glycosaminoglycan (PSGAG) for the treatment of degenerative joint disease in horses. Methods: Cross-sectional mail survey. Methods: 1,522 equine practitioners. Methods: Information was obtained on frequency and route of administration of PSGAG for the treatment of each of 4 forms of degenerative joint disease, the efficacy of PSGAG, and its efficacy compared with that of sodium hyaluronate. Data were analyzed by nonparametric and multivariate regression methods. Results: Response rate was 40.5%. Of practitioners responding, 26% were classified as having a special interest in lameness and 74% as general practitioners. Use of PSGAG was reported by 90.5% of all practitioners, but lameness practitioners used PSGAG more frequently than general practitioners. Use of PSGAG also was significantly more common among practitioners involved predominately with racing. Thoroughbreds, Standardbreds, or show horses. Use of PSGAG was reported to be moderately effective in the treatment of the 4 joint disease conditions. Practitioners treating Thoroughbred racehorses gave highest efficacy scores, and pleasure horse practitioners gave lowest efficacy scores. Use of PSGAG was considered more effective than sodium hyaluronate for the treatment of subacute degenerative joint disease and less effective for idiopathic joint effusion and acute synovitis. Conclusions: Use of PSGAG is regarded as moderately effective overall and is considered most useful in the treatment of subacute degenerative joint disease. The efficacy of PSGAG for incipient and chronic forms of degenerative disease is considered comparable to that of sodium hyaluronate.
Publication Date: 1996-11-01 PubMed ID: 8899019
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Clinical Study
- Degenerative Joint Disease
- Disease Treatment
- Equine Diseases
- Equine Health
- Equine Science
- Glycosaminoglycan
- Horse Racing
- Horses
- Lameness
- Polysaccharide Storage Myopathy
- Regression Analysis
- Sodium Hyaluronate
- Standardbred Horses
- Survey Study
- Thoroughbreds
- Veterinary Care
- Veterinary Medicine
- Veterinary Practice
Summary
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This research investigates equine practitioners’ usage and perceived effectiveness of polysulfated glycosaminoglycan (PSGAG) to treat degenerative joint disease in horses.
Methodology
- The researchers conducted a cross-sectional mail survey, targeting 1,522 equine practitioners.
- They obtained information regarding the frequency and method of administering PSGAG for treating four types of degenerative joint diseases.
- They also asked about the perceived efficacy of PSGAG and how it compares to sodium hyaluronate, another treatment option.
- The results were analyzed using nonparametric and multivariate regression methods.
Results
- A 40.5% response rate was achieved for this survey.
- Of the responders, 26% had a special interest in lameness while the remaining 74% were general practitioners.
- Approximately 90.5% of all practitioners reported using PSGAG in their practice. Moreover, practitioners specializing in lameness used PSGAG more frequently than others.
- It was also noted that the use of PSGAG was more prevalent among practitioners who mainly treated racing horses, such as Thoroughbreds, Standardbreds or show horses.
- Overall, practitioners regarded PSGAG as moderately effective in treating the four joint disease conditions.
- In terms of effectiveness, practitioners working with Thoroughbred racehorses gave PSGAG the highest scores, while those treating pleasure horses gave it the lowest efficacy scores.
Comparison With Sodium Hyaluronate
- Compared to sodium hyaluronate, PSGAG was considered more effective for treating subacute degenerative joint disease, but less effective for idiopathic joint effusion and acute synovitis.
Conclusions
- In conclusion, PSGAG is seen as a moderately effective treatment overall.
- It is particularly useful for treating subacute degenerative joint disease.
- For incipient and chronic forms of degenerative disease, the effectiveness of PSGAG is regarded as comparable to that of sodium hyaluronate.
Cite This Article
APA
Caron JP, Kaneene JB, Miller R.
(1996).
Results of a survey of equine practitioners on the use and perceived efficacy of polysulfated glycosaminoglycan.
J Am Vet Med Assoc, 209(9), 1564-1568.
Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
MeSH Terms
- Animals
- Breeding
- Cross-Sectional Studies
- Glycosaminoglycans / administration & dosage
- Glycosaminoglycans / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Injections, Intra-Articular / veterinary
- Injections, Intramuscular / veterinary
- Joint Diseases / drug therapy
- Joint Diseases / veterinary
- Linear Models
- Multivariate Analysis
- Surveys and Questionnaires
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