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Home / Equine Research Bank / Front Vet Sci / Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associate...
Frontiers in veterinary science2020; 6; 503; doi: 10.3389/fvets.2019.00503

Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals.

Abstract: The most common pathologic manifestation of , a gram-positive, facultative intracellular bacterium, is pyogranulomatous pneumonia in foals and weanlings. Hematogenous spread of bacteria may subsequently occur, resulting in joint sepsis, osteomyelitis, or subcutaneous abscessation. Medical records from horses presenting to the Cornell University Equine Hospital from 1998 to 2018 were reviewed for cases diagnosed with joint and/or bone infection, and information about case progression and outcome were analyzed. We hypothesized that, despite advances in diagnostic imaging, antimicrobials and antimicrobial delivery methods, the prognosis for joint sepsis and osteomyelitis remains grave for athletic activity and poor for survival. The 12 cases that met the review criteria had a mortality rate of 84% (10/12), with one case lost to follow up after discharge and one case discharged with a grave prognosis for athleticism.
Copyright © 2020 Ruocco, Luedke, Fortier, Ducharme and Reesink.
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Publication Date: 2020-01-14 PubMed ID: 31993449PubMed Central: PMC6971166DOI: 10.3389/fvets.2019.00503Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study analyzes cases of Rhodococcus equi joint sepsis and osteomyelitis in foals and identifies an alarmingly high mortality rate and poor prognosis for survival and athleticism, despite improvements in diagnosis and treatment.

Introduction

  • Rhodococcus equi is a Gram-positive bacterium that often leads to pyogranulomatous pneumonia in young horses like foals and weanlings.
  • The bacteria can spread through the bloodstream to different parts of the body, causing joint sepsis, osteomyelitis (an infection in the bone), or subcutaneous abscessation (formation of abscesses under the skin).

Study Methodology

  • For this study, medical records from horses presented to the Cornell University Equine Hospital between the years 1998 to 2018 were reviewed.
  • The aim was to gather information on cases diagnosed with Rhodococcus equi joint sepsis and/or osteomyelitis, and analyze the progression and outcome of each case.
  • The initial hypothesis was that despite advancements in diagnostic imaging techniques, antimicrobials (drugs that kill or stop the growth of bacteria), and antimicrobial delivery methods, the prognosis for both conditions remains daunting, with a poor outlook for athletic activity and survival.

Findings

  • The review of records yielded 12 cases that met the review criteria.
  • Astonishingly, these cases had a mortality rate of 84% (10 out of 12 cases), emphasizing the severity of Rhodococcus equi infections.
  • One case was lost to follow up after the horse was discharged, and another one was discharged but with a grave prognosis for athletic performance.

Conclusion

  • The study results corroborated the initial hypothesis, highlighting the severe implications of Rhodococcus equi joint sepsis and osteomyelitis in foals.
  • Despite advancements in detection and treatment methods, prognosis remains poor.
  • This underlines the urgent need for further research and development in methods of prevention, detection, and treatment of these conditions.

Cite This Article

APA
Ruocco NA, Luedke LK, Fortier LA, Ducharme NG, Reesink HL. (2020). Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals. Front Vet Sci, 6, 503. https://doi.org/10.3389/fvets.2019.00503

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 6
Pages: 503
PII: 503

Researcher Affiliations

Ruocco, Nicholas A
  • Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.
Luedke, Lauren K
  • Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.
Fortier, Lisa A
  • Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.
Ducharme, Norm G
  • Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.
Reesink, Heidi L
  • Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

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Citations

This article has been cited 2 times.
  1. Sting R, Schwabe I, Kieferle M, Münch M, Rau J. Fatal Infection in an Alpaca (Vicugna pacos) Caused by Pathogenic Rhodococcus equi. Animals (Basel) 2022 May 19;12(10).
    doi: 10.3390/ani12101303pubmed: 35625149google scholar: lookup
  2. Zanilabdin M, Ilgekbayeva G, Otarbayev B, Nissanova R, Mussayeva G, Takai S, Suzuki Y, Kakuda T, Kurman S, Kassymov Y, Valiyeva B. Integrated molecular and serological survey of Rhodococcus equi in horses from three regions of Kazakhstan. Front Vet Sci 2025;12:1650186.
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