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Risk factors for epistaxis on British racecourses: evidence for locomotory impact-induced trauma contributing to the aetiology of exercise-induced pulmonary haemorrhage.

Abstract: The proposed biological mechanisms for exercise-induced pulmonary haemorrhage (EIPH) are many and varied. Better knowledge of risk factors should lead to achievable measures to reduce the incidence. Objective: To identify risk factors associated with epistaxis following racing in UK Thoroughbreds, to gain possible insights into the pathogenesis of the condition and to investigate the association between epistaxis and race finishing position. Methods: The association of epistaxis occurring on UK racecourses between 1996 and 1998 with a wide range of race-, horse- and start-level variables was examined in multivariable mixed effect logistic regression analyses. Four multivariable analyses were conducted, one for all race types considered collectively and one each for flat, hurdle and steeplechase race types considered separately. Results: Risk of epistaxis was significantly increased for hurdle and steeplechase race types compared to both flat and National Hunt flat races. In 3 of the 4 final models, there was a significant biological trend for increasing risk of epistaxis with increasing ground hardness ('going') and accumulated years spent racing. However, in flat races epistaxis was such a rare outcome (0.33 cases per 1000 starts) that this subset analysis had insufficient power to measure the detectable effect of 'going' as statistically significant. Horses with epistaxis were significantly more likely to have a poorer finishing position than those without blood at the nostrils. Conclusions: Findings were consistent with the theory that locomotory impact-induced trauma contributes to exercise-induced epistaxis. Further validation of this hypothesis through application of similar methods to endoscopically visible EIPH and through biomechanical studies is warranted. Conclusions: Knowledge of significant risk factors should allow formulation of practical measures, such as track watering, to reduce the risks of EIPH and epistaxis in racehorses.
Publication Date: PubMed ID: 16163941
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Summary

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This research studied risk factors associated with a condition called Epistaxis in UK Thoroughbreds after races. It concluded that the risk of Epistaxis was significantly higher for hurdle and steeplechase races compared to flat races, with the risk increasing with the hardness of the ground and the accumulated years of a horse’s racing career. The findings also indicated potential measures to reduce the incidence of the condition, such as watering the tracks.

Understanding the Research

  • The research is focused on understanding the factors contributing to Epistaxis, a condition characterized by bleeding from the nostrils, in Thoroughbred racehorses in the UK. This condition is considered a potential symptom of a more serious issue known as Exercise-Induced Pulmonary Haemorrhage (EIPH), where intense exercise causes bleeding in the lungs.
  • The research employs multivariable mixed effect logistic regression analyses on data from UK racecourses between 1996 and 1998. The analysis included various race-, horse- and start-level variables.

Main Findings

  • The research revealed that the risk of Epistaxis was notably higher for hurdle and steeplechase race types compared to both flat and National Hunt flat races.
  • The level of ground hardness (‘going’) and the accumulated years a horse has spent racing were observed to increase the risk of Epistaxis. However, in flat races, Epistaxis was a rare outcome that didn’t yield statistically significant results in relation to ground hardness.
  • Horses suffering from Epistaxis were significantly more likely to have poor finishing positions in races than those without the symptom.

Significance and Further Studies

  • The findings align with the theory that the physical impact on horses’ locomotory system during races may contribute to the occurrence of Epistaxis. This theory requires further validation using similar methods to visually observe EIPH, as well as through biomechanical studies.
  • The understanding of these significant risk factors can aid in devising practical measures to mitigate the risk of Epistaxis and EIPH in racehorses. One suggested measure based on the findings is to water the race tracks, reducing ground hardness and potentially risk of these conditions.

Cite This Article

APA
(). Risk factors for epistaxis on British racecourses: evidence for locomotory impact-induced trauma contributing to the aetiology of exercise-induced pulmonary haemorrhage. .

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Citations

This article has been cited 5 times.
  1. Bayly WM, Leguillette R, Sides RH, Massie S, Guigand C, Jones KB, Warlick LM, Thueson EL, Troudt TA, Slocombe RF, Jones JH. Equine exercise-induced pulmonary hemorrhage: the role of high left-heart pressures secondary to exercise-induced hypervolemia, and high inspiratory pressures. J Appl Physiol (1985) 2024 Nov 1;137(5):1359-1373.
  2. Sugiyama F, Takahashi Y, Nomura M, Ebisuda Y, Mukai K, Yoshida T. Risk Factors for Epistaxis in Thoroughbred Flat Races in Japan (2001-2020). Animals (Basel) 2023 Apr 14;13(8).
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  3. Lo Feudo CM, Stucchi L, Stancari G, Alberti E, Conturba B, Zucca E, Ferrucci F. Associations between Exercise-Induced Pulmonary Hemorrhage (EIPH) and Fitness Parameters Measured by Incremental Treadmill Test in Standardbred Racehorses. Animals (Basel) 2022 Feb 12;12(4).
    doi: 10.3390/ani12040449pubmed: 35203157google scholar: lookup
  4. Poole DC, Erickson HH. Exercise-induced pulmonary hemorrhage: where are we now?. Vet Med (Auckl) 2016;7:133-148.
    doi: 10.2147/VMRR.S120421pubmed: 30050846google scholar: lookup
  5. Hinchcliff KW, Couetil LL, Knight PK, Morley PS, Robinson NE, Sweeney CR, van Erck E. Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement. J Vet Intern Med 2015 May-Jun;29(3):743-58.
    doi: 10.1111/jvim.12593pubmed: 25996660google scholar: lookup