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Role of neutrophils in equine asthma.
Abstract: Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are key actors in host defense, migrating toward sites of inflammation and infection, where they act as early responder cells toward external insults. However, neutrophils can also mediate tissue damage in various non-infectious inflammatory processes. Within the airways, these cells likely contribute to bronchoconstriction, mucus hypersecretion, and pulmonary remodeling by releasing pro-inflammatory mediators, including the cytokines interleukin (IL)-8 and IL-17, neutrophil elastase, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs). The mechanisms that regulate neutrophil functions in the tissues are complex and incompletely understood. Therefore, the inflammatory activity of neutrophils must be regulated with exquisite precision and timing, a task achieved through a complex network of mechanisms that regulates neutrophil survival. The discovery and development of compounds that can help regulate ROS, NET formation, cytokine release, and clearance would be highly beneficial in the design of therapies for this disease in horses. In this review, neutrophil functions during inflammation will be discussed followed by a discussion of their contribution to airway tissue injury in equine asthma.
Publication Date: 2018-05-24 PubMed ID: 29792391DOI: 10.1017/S146625231800004XGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study investigates the role of neutrophils, a type of white blood cell, in causing inflammation and tissue damage in horses with asthma. The researchers discuss the need for treatments that can regulate these cells’ activity to prevent the harmful effects they can have in asthmatic horses.
Understanding Neutrophils
- Neutrophils are important for defence against inflammation and infection, acting as early responders when the body is attacked.
- Despite this, they can also be harmful and cause tissue damage when involved in non-infectious inflammatory processes, such as asthma.
- The researchers note that the ways in which neutrophils function within tissues are complicated and not fully understood yet.
Neutrophils in Asthma
- In asthma-affected horses, neutrophils are a major factor in bronchiolitis, an inflammation of the smallest air passages in the lungs.
- Within the airways, they can contribute to various problems including bronchoconstriction (narrowing of the airways), excessive production of mucus, and pulmonary remodeling (changes to the structure of the lungs).
- These problems are caused by pro-inflammatory mediators that the neutrophils release, such as the cytokines IL-8 and IL-17, neutrophil elastase, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs).
Regulating Neutrophils
- Regulating the inflammatory activity of neutrophils is a complex task, achieved through a network of mechanisms that manage neutrophil survival.
- The investigators suggest that compounds which can help regulate ROS, NET formation, cytokine release, and clearance would be valuable for designing therapies for horse asthma.
Conclusion
- This study provides a comprehensive review of the functions of neutrophils during inflammation and their role in causing tissue injury in equine asthma.
- The researchers suggest regulation of the activity of these cells can provide a pathway to new treatments to manage this disease in horses.
Cite This Article
APA
Uberti B, Morán G.
(2018).
Role of neutrophils in equine asthma.
Anim Health Res Rev, 19(1), 65-73.
https://doi.org/10.1017/S146625231800004X Publication
Researcher Affiliations
- Department of Clinical Veterinary Sciences,Faculty of Veterinary Sciences,Universidad Austral de Chile,Valdivia,Chile.
- Department of Pharmacology,Faculty of Veterinary Sciences, Universidad Austral de Chile,Valdivia,Chile.
MeSH Terms
- Animals
- Asthma / immunology
- Asthma / pathology
- Asthma / veterinary
- Cytokines / genetics
- Cytokines / metabolism
- Extracellular Traps
- Horse Diseases / immunology
- Horse Diseases / pathology
- Horses
- Neutrophils / physiology
Citations
This article has been cited 16 times.- Salinas C, Barriga K, Albornoz A, Alarcon P, Quiroga J, Uberti B, Sarmiento J, Henriquez C, Ehrenfeld P, Burgos RA, Moran G. Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses. Front Vet Sci 2022;9:1025249.
- Rutledge JJ, Paegelow J, Ritchey J, Singh A, Rizzi T, Murray C, Gilliam L, Crisman E, Williams NJ, Holbrook TC. Nebulized glycosylated caffeic acid phenylether ester attenuation of environmental particulate-induced airway inflammation in horses. Front Vet Sci 2022;9:958567.
- Janssen P, Tosi I, Hego A, Maréchal P, Marichal T, Radermecker C. Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity. Front Immunol 2022;13:921077.
- Bayless RL, Sheats MK, Jones SL. Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis. Front Vet Sci 2022;9:900453.
- Morán G, Uberti B, Quiroga J. Role of Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases. Front Immunol 2022;13:850416.
- Simões J, Batista M, Tilley P. The Immune Mechanisms of Severe Equine Asthma-Current Understanding and What Is Missing. Animals (Basel) 2022 Mar 16;12(6).
- Couetil L, Cardwell JM, Leguillette R, Mazan M, Richard E, Bienzle D, Bullone M, Gerber V, Ivester K, Lavoie JP, Martin J, Moran G, Niedźwiedź A, Pusterla N, Swiderski C. Equine Asthma: Current Understanding and Future Directions. Front Vet Sci 2020;7:450.
- Albornoz A, Morales N, Uberti B, Henriquez C, Burgos RA, Alarcon P, Moran G. Tamoxifen and its metabolites induce mitochondrial membrane depolarization and caspase-3 activation in equine neutrophils. Vet Med Sci 2020 Nov;6(4):673-678.
- Sheats MK, Davis KU, Poole JA. Comparative Review of Asthma in Farmers and Horses. Curr Allergy Asthma Rep 2019 Oct 10;19(11):50.
- Sheats MK. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci 2019;6:69.
- Morales N, Henriquez C, Sarmiento J, Uberti B, Moran G. Tamoxifen inhibits chemokinesis in equine neutrophils. Ir Vet J 2018;71:22.
- Cooper BL, Hobbs KJ, Bayless R, Stinson-Miller A, Gruber E, Hepworth-Warren K, Lavoie JP, Sheats MK. A Portable Fluorometer Detects Significantly Elevated Cell-Free DNA in Tracheal Wash and Bronchoalveolar Lavage Fluid in Horses with Severe Asthma. Animals (Basel) 2025 Dec 3;15(23).
- Albornoz A, Morales B, Fernandez VB, Henriquez C, Quiroga J, Alarcón P, Moran G, Burgos RA. Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma. Animals (Basel) 2025 Jul 7;15(13).
- Kowalik S, O'reilly M, Niedźwiedź A, Kędzierski W. Equine Asthma Does Not Affect Circulating Myostatin Concentrations in Horses. Animals (Basel) 2024 Mar 4;14(5).
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- Simões J, Tilley P. Decision Making in Severe Equine Asthma-Diagnosis and Monitoring. Animals (Basel) 2023 Dec 16;13(24).
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