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EFSA journal. European Food Safety Authority2022; 20(12); e07692; doi: 10.2903/j.efsa.2022.7692

Safety and efficacy of a feed additive consisting of a tincture derived from the roots of Angelica sinensis (Oliv.) Diels (dong quai tincture) for use in poultry, horses, dogs and cats (FEFANA asbl).

Abstract: Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a tincture from the roots of (Oliv.) Diels (dong quai tincture) when used as a sensory additive in feed for horses, dogs and cats and in water for drinking for poultry species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive is safe for horses and dogs at the maximum proposed use level of 123 and 481 mg/kg complete feed, respectively. For cats, the calculated safe concentration is 184 mg/kg complete feed. For the poultry species, the calculated safe concentration in water for drinking is 79 mg/kg for chickens for fattening, 117 mg/kg for laying hens and 106 mg/kg for turkeys for fattening. No safety concern would arise for the consumer from the use of dong quai tincture up to the highest safe levels in feed. The additive under assessment should be considered as irritant to skin and eyes, and as a dermal and respiratory sensitiser. The use of the dong quai tincture as a flavour in animal feed was not expected to pose a risk for the environment. Since the root of has flavouring properties and its function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.
© 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.
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Publication Date: 2022-12-15 PubMed ID: 36540776PubMed Central: PMC9751861DOI: 10.2903/j.efsa.2022.7692Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The European Food Safety Authority (EFSA) assessed a tincture derived from the roots of Angelica sinensis, commonly known as dong quai, and found it to be a safe and effective sensory additive for use in animal feed for pets such as horses, dogs, and cats, as well as in drinking water for livestock poultry. However, it is concluded that this additive could potentially cause irritation to the skin and eyes and could act as a dermal and respiratory sensitizer.

Objective of the Research

  • The research sought to evaluate the safety and efficacy of a feed additive made from a tincture derived from Angelica sinensis roots. This was prompted via a request from the European Commission, with the intention of allowing its use as a sensory additive in feed for horses, dogs, cats and in poultry drinking water.

Safe Dosage Levels

  • The study concludes that for dogs and horses, the feed additive is safe at maximum usage levels of 123 mg/kg and 481 mg/kg, respectively.
  • For cats, the safe concentration is calculated to be 184 mg/kg.
  • For poultry, the safe concentration in drinking water is posited at 79 mg/kg for chickens being fattened, 117 mg/kg for laying hens, and 106 mg/kg for turkeys being fattened.

Consumer Safety

  • The researchers found that there would be no safety concerns for consumers eating products from animals given the dong quai tincture at the highest safe levels.

Potential Irritant and Sensitizer

  • The dong quai tincture is considered to be a potential dermal and respiratory sensitizer and could cause irritation to skin and eyes. Sensitizers are substances that, upon first exposure, cause little to no reaction but upon repeated exposure may cause a marked immune response, often resulting in allergies.

Environmental Impact

  • The study found the usage of the dong quai tincture as a feed additive would not pose a risk to the environment

Efficacy and Use as a Flavour Additive

  • The use of this additive is justified by the natural flavoring properties of Angelica sinensis roots. Given that its function in animal feed would essentially be the same as in food, the researchers concluded that no further demonstration of efficacy was necessary.

Cite This Article

APA
Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. (2022). Safety and efficacy of a feed additive consisting of a tincture derived from the roots of Angelica sinensis (Oliv.) Diels (dong quai tincture) for use in poultry, horses, dogs and cats (FEFANA asbl). EFSA J, 20(12), e07692. https://doi.org/10.2903/j.efsa.2022.7692

Publication

EFSA journal. European Food Safety Authority
ISSN: 1831-4732
NlmUniqueID: 101642076
Country: United States
Language: English
Volume: 20
Issue: 12
Pages: e07692
PII: e07692

Researcher Affiliations

Bampidis, Vasileios
    Azimonti, Giovanna
      Bastos, Maria de Lourdes
        Christensen, Henrik
          Fašmon Durjava, Mojca
            Kouba, Maryline
              López-Alonso, Marta
                López Puente, Secundino
                  Marcon, Francesca
                    Mayo, Baltasar
                      Pechová, Alena
                        Petkova, Mariana
                          Ramos, Fernando
                            Sanz, Yolanda
                              Villa, Roberto Edoardo
                                Woutersen, Ruud
                                  Brantom, Paul
                                    Chesson, Andrew
                                      Westendorf, Johannes
                                        Manini, Paola
                                          Pizzo, Fabiola
                                            Dusemund, Birgit

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                                              Citations

                                              This article has been cited 2 times.
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                                                doi: 10.7759/cureus.41985pubmed: 37465088google scholar: lookup
                                              2. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Villa RE, Woutersen R, Aquilina G, Brantom P, Chesson A, Schlatter J, Westendorf J, Dirven Y, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil obtained from the fruit of Apium graveolens L. (celery seed oil) for all animal species (FEFANA asbl). EFSA J 2024 Jul;22(7):e8907.
                                                doi: 10.2903/j.efsa.2024.8907pubmed: 39055667google scholar: lookup
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