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Home / Equine Research Bank / BMC Vet Res / Searching for ivermectin resistance in a Strongylidae popula...
BMC veterinary research2017; 13(1); 210; doi: 10.1186/s12917-017-1133-1

Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland.

Abstract: There are no available studies describing the possible resistance of strongyles to ivermectin in horses in Poland. One hundred seventy three horses from nine stud farms from South-Western Poland were studied. The effectiveness of ivermectin was studied on the 14th day after ivermectin administration using the fecal egg count reduction test, and a long-term observation of the egg reappearance period was carried out. The fecal study was carried out using a modified McMaster method, which typically detects 20 eggs per gram of stool. The results were subjected to statistical analysis that enabled quantification of the eggs in the stool samples. Results: The study revealed high efficacy of ivermectin on the 14th day after administration without a shortening of the egg reappearance period. Conclusions: The results indicate that strongyles resistance to ivermectin in Poland is not a serious problem.
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Publication Date: 2017-07-03 PubMed ID: 28673347PubMed Central: PMC5496315DOI: 10.1186/s12917-017-1133-1Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research performed explores the effectiveness of the drug ivermectin in treating horses for strongyles, a type of parasitic worm, in Poland. The findings suggest that ivermectin still shows high efficacy, suggesting no serious resistance issue with strongyles.

Objective and Methodology

The primary goal of the research was to investigate potential resistance of strongyles, a common parasite in horses, to the anthelmintic drug, ivermectin, in Poland. This resistance hadn’t been adequately studied before in the local context. These parasites can cause severe health issues in horses, making the effectiveness of medication crucial.

  • The study involved 173 horses from 9 stud farms in South-Western Poland. These horses served as the sample for the study.
  • After administering ivermectin, the researchers observed its effectiveness on the 14th day using a fecal egg count reduction test. This test is a standard method to evaluate deworming efficiency.
  • They also conducted a long-term study to see the egg reappearance period in the horses’ stool.
  • The detection and count of parasite eggs in the horses’ stool were done using a modified McMaster method. This method typically identifies 20 eggs per gram of stool, providing a quantitative measurement of parasite load.

Results and Conclusion

The results of the study showed positive findings in the fight against parasitic worms in horses. The researchers found no significant problem regarding the resistance of strongyles to ivermectin.

  • Ivermectin proved to be highly effective on the 14th day after administration.
  • The study did not indicate any shortening of the egg reappearance period, thus showing that the drug had a lasting effect on the horses.
  • Therefore, based on their findings, the researchers concluded that there is no significant opposition to ivermectin in the strongyles population in Poland.

Cite This Article

APA
Zak A, Siwinska N, Slowikowska M, Borowicz H, Kubiak K, Hildebrand J, Popiolek M, Niedzwiedz A. (2017). Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland. BMC Vet Res, 13(1), 210. https://doi.org/10.1186/s12917-017-1133-1

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 13
Issue: 1
Pages: 210
PII: 210

Researcher Affiliations

Zak, A
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland. agnieszka.zak@up.wroc.pl.
Siwinska, N
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland.
Slowikowska, M
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland.
Borowicz, H
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland.
Kubiak, K
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland.
Hildebrand, J
  • Department of Parasitology, Institute of Genetics and Microbiology, University of Wroclaw, ul. S. Przybyszewskiego 63/77, 51-148, Wroclaw, Poland.
Popiolek, M
  • Department of Parasitology, Institute of Genetics and Microbiology, University of Wroclaw, ul. S. Przybyszewskiego 63/77, 51-148, Wroclaw, Poland.
Niedzwiedz, A
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366, Wroclaw, Poland.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Anthelmintics / therapeutic use
  • Drug Resistance
  • Feces / parasitology
  • Female
  • Horse Diseases
  • Horses
  • Ivermectin / pharmacology
  • Ivermectin / therapeutic use
  • Male
  • Parasite Egg Count / veterinary
  • Poland
  • Strongyle Infections, Equine / drug therapy
  • Strongyloidea / isolation & purification

Conflict of Interest Statement

ETHICS APPROVAL AND CONSENT TO PARTICIPATE: In accordance with the Experiments on Animals Act from January 15th 2015 (Journal of Laws of the Republic of Poland, 2015, item. 266), concerning the welfare of the animals used for research or teaching purposes, the provisions shall not apply to: 1. veterinary services as defined by the Act from December 18th 2003 concerning veterinary practices (Journal of Laws from 2004, No. 11, item 95 as amended in item 3), as well as agricultural activity, raising and breeding livestock according to the Animal Welfare Act, not designed to carry out medical procedures; 2. clinical veterinary studies carried out according to Article 37ah-37ak of the Act from September 6th 2001 – Pharmaceutical Law (Journal of Laws from 2008, No. 45, item 271 as amended in item 4); 3. activity aimed at identifying animals; 4. capturing wild animals for biometric and systematic assessment; 5. veterinary procedures which to not cause pain, suffering, distress or permanent health impairment equal to or more invasive than the insertion of a needle. Hence, the study entitled “Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland.” does not require the approval of the Ethics Committee. All procedures were performed during the study with the owner consent. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors state that there are no conflicts of interest. None of the aforementioned companies had any involvement, direct or indirect, in the development of the manuscript and the works reflects the opinions solely of the authors. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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