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The Veterinary clinics of North America. Equine practice1989; 5(3); 539-550; doi: 10.1016/s0749-0739(17)30573-4

Second-intention healing.

Abstract: Second-intention healing (contraction and epithelization) is most appropriate for heavily traumatized, contaminated wounds that may have a prolonged debridement phase. Therapy during healing can promote rapid debridement and faster healing. Healing of lower limb wounds by second intention may be protracted, owing to poorer wound contraction and excessive granulation tissue production as compared with body wounds.
Publication Date: 1989-12-01 PubMed ID: 2691029DOI: 10.1016/s0749-0739(17)30573-4Google Scholar: Lookup
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Summary

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The article researches the impacts and processes of second-intention healing, a method best suited for severely traumatized and contaminated wounds, where therapy can advocate quicker recovery. The healing of lower limb wounds may be longer due to issues with wound contraction and excessive granulation tissue production.

Second-Intention Healing

  • The research article focuses on second-intention healing, also known as secondary healing. This is a healing process typically adopted for wounds that are heavily traumatized or contaminated. These wounds require more attention and care due to the level of damage caused.
  • The technique involves the wound being left open to heal naturally, without the need for suturing or stitching. It works through the processes of contraction (the wound edges physically coming closer together) and epithelization (the creation of an epithelial layer to close the wound).
  • Second-intention healing may need an extended debridement phase. Debridement is the removal of damaged, infected, or dead tissue to enhance the healing potential of the healthy surrounding tissue.
  • Providing therapy during the healing process can expedite the debridement period and thus, promote faster overall healing.

Challenges in Lower Limb Wounds

  • The healing of lower limb wounds through second-intention healing can be a challenge due to poor wound contraction and excess granulation tissue production. Wound contraction is the process that physically brings the wound edges closer together to promote healing. Lower limb wounds may have limited contractility due to the type of tissues or the location of the wounds, slowing the healing process.
  • Excessive granulation tissue production may also hinder the healing process. Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process. However, an overproduction can lead to complications such as delayed healing or wound infection.
  • This suggests that while second-intention healing is overall a viable technique, it may be more effective for certain types of wounds or locations on the body than others, requiring a tailored approach in wound management and care.

Cite This Article

APA
Bertone AL. (1989). Second-intention healing. Vet Clin North Am Equine Pract, 5(3), 539-550. https://doi.org/10.1016/s0749-0739(17)30573-4

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 5
Issue: 3
Pages: 539-550

Researcher Affiliations

Bertone, A L
  • Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge.

MeSH Terms

  • Animals
  • Granulation Tissue / growth & development
  • Horses / injuries
  • Skin / injuries
  • Skin Physiological Phenomena
  • Wound Healing

References

This article includes 29 references

Citations

This article has been cited 3 times.
  1. Zambroni ME, Bertone PA, Cabral AL, Boatti AS, Romanini SV, Martínez SR, Gómez ML. Easy-to-Apply Hydrogel Patch for Field Treatment and Monitoring of Equine Wounds. Gels 2025 Apr 27;11(5).
    doi: 10.3390/gels11050328pubmed: 40422348google scholar: lookup
  2. Vicente-da-Silva JV, Pereira JODSL, do Carmo FA, Patricio BFC. Skin and Wound Healing: Conventional Dosage versus Nanobased Emulsions Forms. ACS Omega 2025 Apr 8;10(13):12837-12855.
    doi: 10.1021/acsomega.5c00455pubmed: 40224422google scholar: lookup
  3. Tracey AK, Alcott CJ, Schleining JA, Safayi S, Zaback PC, Hostetter JM, Reinertson EL. The effects of topical oxygen therapy on equine distal limb dermal wound healing. Can Vet J 2014 Dec;55(12):1146-52.
    pubmed: 25477541