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Home / Equine Research Bank / Immunogenetics / Segregation distortion within the equine MHC; analogy to a m...
Immunogenetics1986; 24(4); 225-229; doi: 10.1007/BF00364526

Segregation distortion within the equine MHC; analogy to a mouse T/t-complex trait.

Abstract: Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Significant segregation distortion was not seen for mares or for unrelated stallions, regardless of the ELA markers they possessed. Since the effect was seen for this one sire family and not seen for other stallions with A10, it is unlikely that the gene for A10 is the cause of this phenomenon, but rather A10 is linked to another major histocompatibility complex (MHC) gene causing this trait. This trait appeared analogous to the segregation distortion observed for the T/t complex of the mouse. Since segregation distortion involving MHC genes has been seen in other species, genes for this trait may be a general feature of the MHC.
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Publication Date: 1986-01-01 PubMed ID: 3781570DOI: 10.1007/BF00364526Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a genetic phenomenon known as segregation distortion detected in a family of American Standardbred horses. It seems to be linked to the horse’s major histocompatibility complex or MHC, akin to a trait observed in mice.

Introduction

  • The research focuses on a genetically linked abnormality observed in an expansive family of American Standardbred horses, which stemmed from one stallion and spread through its 17 sons and grandsons.

Segregation Distortion

  • Segregation distortion is a non-Mendelian inheritance manner whereby specific alleles (versions of a gene) are passed onto progeny more frequently than expected under regular Mendelian genetics.
  • In this study, the genetic trait ELA-A10 (A10) showed significant segregation distortion within the stallion line, being passed on to 57.7% of the 638 offspring instead of the anticipated 50%.

Lack of Segregation Distortion among Mares and Unrelated Stallions

  • This study found that the segregation distortion observed was specific to this one sire line and was not seen in mares or unrelated stallions, regardless of the ELA markers they carried.
  • This specificity suggests that the A10 gene itself is not the cause of segregation distortion, but it is likely linked to another gene within the major histocompatibility complex (MHC).

Analogy to mouse T/t-complex Trait

  • The research further identifies that the observed trait in horses appears similar to the segregation distortion witnessed in the T/t complex in mice.
  • Such analogy suggests that the genes causing this trait may be a general feature found within the MHC, implying the phenomenon of segregation distortion involving MHC genes isn’t limited to a specific species.

Cite This Article

APA
Bailey E. (1986). Segregation distortion within the equine MHC; analogy to a mouse T/t-complex trait. Immunogenetics, 24(4), 225-229. https://doi.org/10.1007/BF00364526

Publication

Immunogenetics
ISSN: 0093-7711
NlmUniqueID: 0420404
Country: United States
Language: English
Volume: 24
Issue: 4
Pages: 225-229

Researcher Affiliations

Bailey, E

    MeSH Terms

    • Animals
    • Female
    • Haplotypes
    • Heterozygote
    • Histocompatibility Antigens / genetics
    • Horses / genetics
    • Horses / immunology
    • Major Histocompatibility Complex
    • Male

    Grant Funding

    • HD-14487 / NICHD NIH HHS

    References

    This article includes 16 references
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    Citations

    This article has been cited 4 times.
    1. Friocourt G, Perrin A, Saunders PA, Nikalayevich E, Voisset C, Coutton C, Martinez G, Morel F. Bypassing Mendel's First Law: Transmission Ratio Distortion in Mammals. Int J Mol Sci 2023 Jan 13;24(2).
      doi: 10.3390/ijms24021600pubmed: 36675116google scholar: lookup
    2. Melhem MF, Kunz HW, Gill TJ 3rd. A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1967-71.
      doi: 10.1073/pnas.90.5.1967pubmed: 8446616google scholar: lookup
    3. Langemeier JL, Bailey E, Henney PJ. Linkage studies between the Tcp-1, Tcp-10, and Mhc-Eqca-A loci in the horse. Immunogenetics 1993;38(5):359-62.
      doi: 10.1007/BF00210478pubmed: 8344722google scholar: lookup
    4. Willison K, Kelly A, Dudley K, Goodfellow P, Spurr N, Groves V, Gorman P, Sheer D, Trowsdale J. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. EMBO J 1987 Jul;6(7):1967-74.
      doi: 10.1002/j.1460-2075.1987.tb02459.xpubmed: 3653076google scholar: lookup
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