Sepsis in adults and foals.
Abstract: Sepsis develops in horses when the host response to the invading pathogens is not properly balanced according to the severity of the insult. Several clinical conditions frequently encountered in equine practice may be associated with the development of sepsis and have the potential to progress to more severe forms, such as severe sepsis, MODS, and septic shock. Consequently, it is important for equine practitioners to be aware of the manifestations,pathophysiology, and treatment of sepsis. Although enormous progress has been made in recent years in our understanding of the pathophysiology of sepsis. more work remains to be done in improving basic critical care guidelines and basic monitoring in equine intensive care units and in critically evaluating potential equine sepsis therapy. Fortunately, we can learn from the important advances made recently in the treatment of human sepsis patients;hence, rapid progress may be expected in a near future, especially as more and more veterinarians show interest in the discipline of equine critical care. With the completion of several genome projects and the availability of high-throughput genetic techniques, one hopes that we will further refine our understanding of the events underlying the development of severe sepsis and septic shock, which could lead to more appropriate therapeutic intervention targeted to each individual according to the state of the immune response in that horse.
Publication Date: 2004-04-06 PubMed ID: 15062458DOI: 10.1016/j.cveq.2003.12.005Google Scholar: Lookup
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Summary
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The research article discusses the complex condition of sepsis in horses, specifically in adult horses and foals. It explores the understanding of sepsis, the various issues accompanying the condition, and the potential areas where future research could enhance current understandings and treatment options.
Understanding Sepsis in Horses
- The paper starts by discussing the development of sepsis in horses. This condition occurs when the body’s response to invading pathogens is not in sync with the severity of the insult, leading to an ill-balanced reaction. Several diseases often found in equine practice can become associated with the development of sepsis, making it a critical issue to explore.
Consequences and Potential Progressions
- The potential progression from sepsis to severe sepsis, multiple organ dysfunction syndrome (MODS), and septic shock is also discussed. These are progressively more severe forms of the condition that can have serious, long-term impacts on the health of the horse.
Importance of Awareness in Equine Practitioners
- The research underscores the importance for equine practitioners to have substantial awareness of the signs, pathophysiology, and treatments of sepsis. This knowledge will not only aid in the treatment of the condition but can also contribute to preventing its development and progression.
Progress in Sepsis Understanding and Future Prospects
- The paper acknowledges the remarkable progress made in understanding the pathophysiology of sepsis. It notes, however, that there is still significant work to do to improve critical care guidelines and monitoring methods in equine intensive care units, as well as to evaluate potential therapy options for equine sepsis.
- Looking to the future, the paper states that further understanding of sepsis will likely derive from recent advances in human sepsis treatment. It also hopes for fast-paced progress, particularly as more veterinarians take an interest in equine critical care.
- The completion of various genome projects and the availability of high-throughput genetic techniques give hope for the future. Such advancements could further refine our understanding of sepsis development and shock, enabling more targeted and individual therapeutic intervention based on each horse’s immune response.
Cite This Article
APA
Roy MF.
(2004).
Sepsis in adults and foals.
Vet Clin North Am Equine Pract, 20(1), 41-61.
https://doi.org/10.1016/j.cveq.2003.12.005 Publication
Researcher Affiliations
- Center for the Study of Host Resistance, Montreal General Hospital Research Institute, McGill University Health Center, 1650 Cedar Avenue, Room L11-513, Montreal, Québec H3G 1A4, Canada. marie-france.roy@mail.mcgill.ca
MeSH Terms
- Animals
- Animals, Newborn
- Critical Care / methods
- Critical Illness
- Horse Diseases / physiopathology
- Horse Diseases / therapy
- Horses
- Hospitals, Animal
- Sepsis / physiopathology
- Sepsis / therapy
- Sepsis / veterinary
- Shock, Septic / physiopathology
- Shock, Septic / therapy
- Shock, Septic / veterinary
References
This article includes 85 references
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