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Home / Equine Research Bank / Equine Vet J / Serum amyloid A in equine health and disease.
Equine veterinary journal2019; 51(3); 293-298; doi: 10.1111/evj.13062

Serum amyloid A in equine health and disease.

Abstract: Serum amyloid A (SAA) is the major acute phase protein in horses. It is produced during the acute phase response (APR), a nonspecific systemic reaction to any type of tissue injury. In the blood of healthy horses, SAA concentration is very low, but it increases dramatically with inflammation. Due to the short half-life of SAA, changes in its concentration in blood closely reflect the onset of inflammation and, therefore, measurement of SAA useful in the diagnosis and monitoring of disease and response to treatment. Increases in SAA concentration have been described in equine digestive, reproductive and respiratory diseases and following surgical procedures. Moreover, SAA has proven useful for detection of some subclinical pathologies that can disturb training and competing in equine athletes. Increasing availability of diagnostic tests for both laboratory and field use adds to SAA's applicability as a reliable indicator of horses' health status. This review article presents the current information on changes in SAA concentrations in the blood of healthy and diseased horses, focussing on clinical application of this biomarker.
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Publication Date: 2019-02-06 PubMed ID: 30565319PubMed Central: PMC7163734DOI: 10.1111/evj.13062Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Serum Amyloid A (SAA) is a key protein in horses that reacts to tissue injury and its measurement can help in diagnosing and monitoring diseases and treatment responses in horses. Detailed studies have shown that it can also detect subclinical issues that might affect a horse’s athletic performance and its applicability has been increased by the availability of diagnostic tests.

Role of Serum amyloid A in horses

  • Serum Amyloid A (SAA) is a major acute phase protein found in horses.
  • It is produced during the acute phase response (APR), which is a nonspecific response to any type of tissue injury.

Serum Amyloid A and inflammation

  • Under normal circumstances, the blood of healthy horses has a very low concentration of SAA.
  • However, the concentration of SAA increases dramatically when there is inflammation in the body.
  • This is because SAA has a short half-life, meaning that any changes in its concentration in the blood will reflect inflammation quite closely.

Serum Amyloid A in disease diagnosis and monitoring

  • The change in SAA concentration can also be used to diagnose and monitor diseases in horses.
  • SAA concentration increases have been observed in equine digestive, reproductive, and respiratory diseases and also after surgical procedures.

Use of Serum Amyloid A in identifying subclinical pathologies

  • Measurement of SAA can be useful in detecting some subclinical pathologies which could potentially interfere with training and competing in equine athletes.

Increased applicability of Serum Amyloid A

  • With the availability of diagnostic tests for both laboratory and field use, SAA’s applicability as a reliable indicator of a horse’s health status has increased.

Overall Focus

  • This research article focuses on the analyses and clinical application of changes in SAA concentrations in the blood of both healthy and diseased horses, giving it a prominent place as a biomarker in equine health.

Cite This Article

APA
Witkowska-Piłaszewicz OD, Żmigrodzka M, Winnicka A, Miśkiewicz A, Strzelec K, Cywińska A. (2019). Serum amyloid A in equine health and disease. Equine Vet J, 51(3), 293-298. https://doi.org/10.1111/evj.13062

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 51
Issue: 3
Pages: 293-298

Researcher Affiliations

Witkowska-Piłaszewicz, O D
  • Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, WarsawUniversity of Life Sciences - SGGW, Warsaw, Poland.
Żmigrodzka, M
  • Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, WarsawUniversity of Life Sciences - SGGW, Warsaw, Poland.
Winnicka, A
  • Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, WarsawUniversity of Life Sciences - SGGW, Warsaw, Poland.
Miśkiewicz, A
  • Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, WarsawUniversity of Life Sciences - SGGW, Warsaw, Poland.
Strzelec, K
  • Department of Horse Breeding and Use, University of Life Sciences in Lublin, Lublin, Poland.
Cywińska, A
  • Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, WarsawUniversity of Life Sciences - SGGW, Warsaw, Poland.

MeSH Terms

  • Animals
  • Biomarkers / blood
  • Horse Diseases / blood
  • Horse Diseases / metabolism
  • Horses
  • Inflammation / metabolism
  • Inflammation / veterinary
  • Serum Amyloid A Protein / metabolism

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