Serum and peritoneal fluid phosphate concentrations as predictors of major intestinal injury associated with equine colic.
Abstract: To determine the reliability with which inorganic phosphorus (phosphate) concentrations can be used to predict major intestinal injury associated with equine colic, phosphate concentrations were measured in serum, peritoneal fluid, or both from 9 clinically normal adult horses (group A), 37 horses successfully managed medically for signs of abdominal pain (group B), 26 horses with signs of abdominal pain and undergoing exploratory laparotomy without intestinal resection (group C), and 26 horses undergoing intestinal resection or euthanasia for extensive intestinal lesions (group D). Peritoneal fluid phosphate concentration was significantly greater in horses in group D (mean, 4.58 +/- 0.34 mg/dl) than in horses in group A (mean, 2.78 +/- 0.21 mg/dl), group B (mean, 2.92 +/- 0.27 mg/dl), and group C (mean, 2.98 +/- 0.28 mg/dl; P less than or equal to 0.01). Serum phosphate concentration was significantly greater in horses in group D (mean, 3.87 +/- 0.30 mg/dl) than in horses in group A (mean, 2.73 +/- 0.22 mg/dl), group B (mean, 2.80 +/- 0.21 mg/dl), and group C (mean, 2.78 +/- 0.22 mg/dl); P less than or equal to 0.05). There was significant (P less than or equal to 0.001) correlation between serum and peritoneal fluid phosphate concentrations within each group and when pairs from all groups were pooled. When peritoneal fluid phosphate concentrations exceeded 3.6 mg/dl, intestinal lesions requiring resection or euthanasia were predicted with sensitivity of 77% and specificity of 76%. When serum phosphate concentrations exceeded 3.3 mg/dl, such lesions were predicted with sensitivity of 60% and specificity of 73%.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1988-10-15 PubMed ID: 3192473
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- Journal Article
Summary
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The article presents a research on how serum and peritoneal fluid inorganic phosphorus concentrations can be used to predict severe intestinal injury in horses with colic. It deduces that higher concentrations, especially in peritoneal fluid, significantly correlate with the cause of serious intestinal conditions.
Study Setup
- The study examined four groups of horses with varying degrees of abdominal pain. There were 9 clinically normal horses (group A), 37 horses successfully treated with medication (group B), 26 horses that underwent exploratory surgery without intestinal resection (group C), and 26 horses that either had intestinal resection or were euthanized due to severe intestinal lesions (group D).
Results and Findings
- The results showed a significant increase in both serum and peritoneal fluid phosphate concentrations in horses of group D (those with severe intestinal lesions) compared to all other groups.
- For peritoneal fluid, the phosphate concentration in group D was about 4.58mg/dl on average, significantly higher than the concentrations in the other three groups (mean ranging from 2.78 to 2.98 mg/dl).
- For serum phosphate, the concentration was about 3.87mg/dl on average in group D horses, also significantly higher than the concentrations in the other three groups (mean approximately 2.73 to 2.80 mg/dl).
Correlations and Predictions
- A significant correlation (P less than or equal to 0.001) was found between serum and peritoneal fluid phosphate concentrations within each group and when all groups were combined.
- The research revealed that peritoneal fluid phosphate concentration exceeding 3.6 mg/dl predicted intestinal lesions requiring resection or euthanasia with a sensitivity of 77% and specificity of 76%
- When serum phosphate concentrations went beyond 3.3 mg/dl, the research was able to predict such lesions with a sensitivity of 60% and specificity of 73%.
Cite This Article
APA
Arden WA, Stick JA.
(1988).
Serum and peritoneal fluid phosphate concentrations as predictors of major intestinal injury associated with equine colic.
J Am Vet Med Assoc, 193(8), 927-931.
Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1101.
MeSH Terms
- Animals
- Ascitic Fluid / analysis
- Ascitic Fluid / veterinary
- Colic / blood
- Colic / diagnosis
- Colic / veterinary
- Horse Diseases / blood
- Horse Diseases / diagnosis
- Horses / metabolism
- Intestinal Diseases / blood
- Intestinal Diseases / diagnosis
- Intestinal Diseases / veterinary
- Phosphates / analysis
- Phosphates / blood
Citations
This article has been cited 4 times.- Barton AK, Richter IG, Ahrens T, Merle R, Alalwani A, Lilge S, Purschke K, Barnewitz D, Gehlen H. MMP-9 Concentration in Peritoneal Fluid Is a Valuable Biomarker Associated with Endotoxemia in Equine Colic.. Mediators Inflamm 2021;2021:9501478.
- Walker WT, Callan RJ, Hill AE, Tisher KB. Effects of oral powder electrolyte administration on packed cell volume, plasma chemistry parameters, and incidence of colic in horses participating in a 6-day 162-km trail ride.. Can Vet J 2014 Aug;55(8):765-71.
- Thoefner MB, Ersbøll BK, Jansson N, Hesselholt M. Diagnostic decision rule for support in clinical assessment of the need for surgical intervention in horses with acute abdominal pain.. Can J Vet Res 2003 Jan;67(1):20-9.
- Moore RM, Muir WW, Rush BR. Systemic and colonic venous plasma biochemical alterations in horses during low-flow ischemia and reperfusion of the large colon.. Can J Vet Res 1998 Jan;62(1):14-20.
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