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Home / Equine Research Bank / Can J Vet Res / Serum copper and ceruloplasmin activity at the early growing...
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire1998; 62(2); 122-126;

Serum copper and ceruloplasmin activity at the early growing stage in foals.

Abstract: Serum concentrations of copper (Cu), zinc (Zn), manganese (Mn), calcium (Ca) and inorganic phosphorus (P), as well as antigenic ceruloplasmin (Cp) and oxidase activity as a functional index for copper metabolism, were measured in 10 foals (5 males and 5 females) and their dams. Samples were harvested from the foals within 1 wk after birth and monthly from 1 to 17 mo of age. Samples were collected from their dams in the perinatal period (monthly from 2 mo before delivery to 5 mo postpartum). Serum oxidase activity, antigenic Cp and Cu in foals were extremely low at 1 wk. Serum Cp had the lowest value of 17.0 +/- 8.0 (mean +/- SD) mg/dL within the 1st wk, then increased rapidly up to 43.7 +/- 5.8 mg/dL at 1 mo, and maintained this level until the 17th mo. Serum Zn in foals had the highest value of 73.2 +/- 13.1 micrograms/dL within 1 wk, then decreased to 38.3 +/- 5.9 micrograms/dL by 17 mo. Serum Mn, Ca and P in mares were almost stable and within established reference ranges for our laboratory in the perinatal period, and these values in foals were also in the normal range. Even on appropriate feeding, serum Cu, Cp and oxidase activity were quite low a few weeks after birth, while a higher proportion of Cp-binding copper was found in the foals. This might be caused by the limited synthesis of ceruloplasmin in this period. These data suggest that newborn foals are in a critical situation of marginal copper status in the early stage of growth.
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Publication Date: 1998-04-29 PubMed ID: 9553711PubMed Central: PMC1189458
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the changes in the concentrations of various substances such as copper and ceruloplasmin in the bodies of newborn foals during early growth stages. The study suggests that newborn foals might experience a marginal copper status in their early growth stages, despite feeding appropriately.

Study Design and Methodology

  • The study monitored and measured the concentration levels of substances like copper (Cu), zinc (Zn), manganese (Mn), calcium (Ca) and inorganic phosphorus (P) in the serum of 10 foals – 5 males and 5 females – and their mothers.
  • They also accounted for antigenic ceruloplasmin (Cp) and oxidase activity as functional indices for copper metabolism.
  • Samples were collected from the foals immediately after birth and then monthly from the first to the seventeenth month.
  • Their mothers’ samples were collected monthly from two months before delivery to five months postpartum.

Results and Observations

  • Serum oxidase activity, antigenic Cp, and Cu in foals were found to be incredibly low within the first week.
  • Serum Cp had its lowest value within the first week and then increased rapidly by the first month and maintained that level until the seventeenth month.
  • Serum Zn had its highest value within the first week, then decreased by the seventeenth month.
  • Serum Mn, Ca, and P in mares were stable and within established reference ranges for the laboratory in the perinatal period, and these values in foals were also normal.

Conclusions

  • The results indicate that despite appropriate feeding routines, serum Cu, Cp, and oxidase activity were quite low a few weeks after birth.
  • There was a higher proportion of Cp-binding copper found in the foals, which could be because of limited ceruloplasmin synthesis in this period.
  • The research suggests that newborn foals may be in a precarious situation of borderline copper status in the early stages of growth, which might have implications for their health and development.

Cite This Article

APA
Okumura M, Asano M, Tagami M, Tsukiyama K, Fujinaga T. (1998). Serum copper and ceruloplasmin activity at the early growing stage in foals. Can J Vet Res, 62(2), 122-126.

Publication

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 0830-9000
NlmUniqueID: 8607793
Country: Canada
Language: English
Volume: 62
Issue: 2
Pages: 122-126

Researcher Affiliations

Okumura, M
  • Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Asano, M
    Tagami, M
      Tsukiyama, K
        Fujinaga, T

          MeSH Terms

          • Aging / blood
          • Animals
          • Calcium / blood
          • Ceruloplasmin / analysis
          • Ceruloplasmin / metabolism
          • Copper / blood
          • Embryonic and Fetal Development
          • Female
          • Fetal Blood / physiology
          • Horses / blood
          • Horses / growth & development
          • Male
          • Manganese / blood
          • Oxidoreductases / blood
          • Phosphates / blood
          • Zinc / blood

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          Citations

          This article has been cited 2 times.
          1. Stahl LT, Müller A, Krohn J, Büttner K, Wehrend A. Serum concentrations of selenium, copper, and zinc in neonatal foals: Influence of failure of passive transfer and age-related changes. Can Vet J 2024 May;65(5):481-487.
            pubmed: 38694739
          2. Shawaf T, Almathen F, Meligy A, El-Deeb W, Al-Bulushi S. Biochemical analysis of some serum trace elements in donkeys and horses in Eastern region of Kingdom of Saudi Arabia. Vet World 2017 Oct;10(10):1269-1274.
            doi: 10.14202/vetworld.2017.1269-1274pubmed: 29184375google scholar: lookup
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