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Acta veterinaria Scandinavica1974; 15(4); 609-619; doi: 10.1186/BF03547230

Serum levels of the immunoglobulins IgG and IgG(T) in horses.

Abstract: Levels of the immunoglobulins IgG and IgG(T) in serum in Norwegian horses of the breeds “Døle” and “Fjord” were determined by the quantitative radial immunodiffusion test. No significant differences were apparent between the 2 Norwegian breeds. The immunoglobulin levels were approximately in the same range as previously reported for Shetland ponies. Immunoglobulins could not be detected in the newborn foal. As early as 24 hrs. after birth the mean immunoglobulin level was within the adult range. After a drop during the first month of life, the immunoglobulins increased. IgG(T) rose more rapidly and to a higher level than IgG. In 2 year old horses, IgG(T) was significantly higher than in adults, while IgG was significantly lower. IgG(T) seems to be a very important immunoglobulin in foals and young horses. Det ble foretatt bestemmelse av serumkonsentrasjoner av immunglobulinene IgG og IgG(T) hos voksne norske hester av rasene „dølehest“ og „fjording“ ved kvantitativ radial immundiffusjonstest. Av „dølehest“ ble det også gjort undersøkelse på hester 2 og 3 år garnie og på en gruppe føll på forskjellig alderstrinn etter fødsel. Signifikant forskj ell mellom de to norske hesteraser kunne ikke påvises. Immunglobulinkonsentrasjonene var omtrentlig pa samme nivå som tidligere er angitt for Shetland ponnier. Immunglobuliner kunne ikke påvises hos det nyfødte føll. Allerede 24 timer etter fødsel var middelkonsentrasjonene av immunglobuliner på høyde med det voksne dyrs. Etter et fall i løpet av første levemåned ble det en stigning i immunglobulinene. IgG(T) steg raskere og til et høyere nivå enn IgG. Hos 2 år garnie hester var IgG(T) signifikant høyere enn hos voksne hester, mens IgG var signifikant lavere. IgG(T) synes å være et meget viktig immunglobulin hos føll og unghester.
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Publication Date: 1974-01-01 PubMed ID: 4218064PubMed Central: PMC8407179DOI: 10.1186/BF03547230Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the levels of two types of immunoglobulins (IgG and IgG(T)) present in the serum of Norwegian horses. It was found that newborn foals initially lack these immunoglobulins, but acquire them within 24 hours after birth, with IgG(T) notably increasing more rapidly and to higher levels than IgG.

Objectives and Methodology

  • The research aimed at understanding the immunoglobulin serum levels in two breeds of Norwegian horses – “Døle” and “Fjord.” The measurement was conducted using a quantitative radial immunodiffusion test.
  • This test allowed researchers to determine the concentration of both IgG and IgG(T) immunoglobulins in the horse’s blood serum.
  • Not only adult horses were studied, but the research also included investigations on 2 and 3 year old horses of the “Døle” breed, and foals of various ages.

Key Findings

  • The results revealed no significant difference in the levels of Immunoglobulins between the two Norwegian horse breeds.
  • The concentration of these immunoglobulins was roughly similar to those previously reported in Shetland ponies.
  • An interesting finding was that, while immunoglobulins could not be detected in newborn foals, these levels were found to rebound to those typical of adults within just 24 hours of birth.
  • However, there was a drop during the first month of life, after which immunoglobulin levels began to increase.
  • Among the two types of immunoglobulins studied, it was found that IgG(T) increased more rapidly and to a higher level than IgG.
  • The study revealed a significant change in IgG and IgG(T) levels in 2-year-old horses; IgG(T) was significantly higher and IgG was significantly lower compared to adult horses. This suggests that IgG(T) plays a crucial role for foals and young horses.

Conclusions

  • The study provides important insights into the functioning of the immune system in horses, particularly in the early stages of their life.
  • An understanding of the immunoglobulin response in horses is vital for their health management, especially in preventing diseases, making this research highly relevant for veterinary medicine.

Cite This Article

APA
Ek N. (1974). Serum levels of the immunoglobulins IgG and IgG(T) in horses. Acta Vet Scand, 15(4), 609-619. https://doi.org/10.1186/BF03547230

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 15
Issue: 4
Pages: 609-619

Researcher Affiliations

Ek, N

    MeSH Terms

    • Age Factors
    • Animals
    • Animals, Newborn
    • Horses / immunology
    • Immune Sera
    • Immunodiffusion
    • Immunoelectrophoresis
    • Immunoglobulin Fragments / analysis
    • Immunoglobulin G / analysis
    • Immunoglobulin Heavy Chains / analysis
    • Norway
    • Rabbits / immunology

    References

    This article includes 16 references
    1. Klinman NR, Rockey JH, Frauenberger G, Karush F. Equine anti-hapten antibody. 3. The comparative properties of gamma G- and gammaA-antibodies.. J Immunol 1966 Apr;96(4):587-95.
      pubmed: 5936286
    2. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion.. Immunochemistry 1965 Sep;2(3):235-54.
      doi: 10.1016/0019-2791(65)90004-2pubmed: 4956917google scholar: lookup
    3. McGuire TC, Perryman LE, Henson JB. Immunoglobulin composition of the hypergammaglobulinemia of equine infectious anemia.. Fed. Proc. 1970;29:435.
    4. Mc Guire TC, Crawford TB, Henson J. The isolation characterization, and functional properties of equine immunoglobulin classes and subclasses.. Proc. 3rd Conf. Equine Infectious Diseases, Paris 1972, pp. 364–381 (Karge, Basel 1973).
    5. Milstein CP, Feinstein A. Comparative studies of two types of bovine immunoglobulin G heavy chains.. Biochem J 1968 Apr;107(4):559-64.
      doi: 10.1042/bj1070559pmc: PMC1198699pubmed: 4173472google scholar: lookup
    6. Morgan DO. Serum proteins of neonatal foals. Changes in electrophoregrams and total protein of foals blood serum from birth through five months of age.. Proc. 3rd Conf. Equine Infectious Diseases, Paris 1972, pp. 410–418 (Karge, Basel 1973).
    7. MULLER-EBERHARD HJ. A new supporting medium for preparative electrophoresis.. Scand J Clin Lab Invest 1960;12:33-7.
      doi: 10.3109/00365516009046164pubmed: 13848687google scholar: lookup
    8. NAKAMURA H, KATSURA T. IMMUNOCHEMICAL STUDIES ON DIPHTHERIA ANTITOXIN. VI. COMPARATIVE STUDIES OF HORSE T AND GAMMA ANTITOXINS IN THE QUANTITATIVE PRECIPITIN REACTION, COMPLEMENT FIXATION, AND INDIRECT HEMAGGLUTINATION OF TANNED AND TOXIN-COATED ERYTHROCYTES.. Jpn J Exp Med 1964 Aug;34:167-96.
      pubmed: 14233269
    9. Nakamura H, Nakamura M. The reaction of diphtheria toxin with horse antitoxin in the region of antibody excess.. Jpn J Exp Med 1967 Oct;37(5):447-60.
      pubmed: 5303494
    10. Ouchterlony O. Handbook of Immunodiffusion and Immunoelectrophoresis.. Ann Arbor Science Publ. Ann Arbor Michigan. 1968.
    11. Prahl JW. In discussion on chemistry and biology of immunoglobulins.. Proc. roy. Soc. B. 1966;166:220.
    12. Rockey JH. Equine antihapten antibody. The subunits and fragments of anti-beta-lactoside antibody.. J Exp Med 1967 Feb 1;125(2):249-75.
      pmc: PMC2138359pubmed: 4959973doi: 10.1084/jem.125.2.249google scholar: lookup
    13. ROCKEY JH, KLINMAN NR, KARUSH F. EQUINE ANTIHAPTEN ANTIBODY. I. 7S BETA-2A- AND 1OS GAMMA-1- GLOBULIN COMPONENTS OF PURIFIED ANTI-BETA-LACTOSIDE ANTIBODY.. J Exp Med 1964 Oct 1;120(4):589-609.
      pmc: PMC2137781pubmed: 14212122doi: 10.1084/jem.120.4.589google scholar: lookup
    14. Rouse BT. The immunoglobulins of adult equine and foal sera: a quantitative study.. Br Vet J 1971 Jan;127(1):45-52.
      doi: 10.1016/S0007-1935(17)37788-6pubmed: 5541943google scholar: lookup
    15. Snedecor OW, Cochran WG. Statistical Methods.. The Iowa State College Press Ames, Iowa 1967.
    16. Weir RC, Porter RR. Comparison of the structure of the immunoglobulins from horse serum.. Biochem J 1966 Jul;100(1):63-8.
      pmc: PMC1265093pubmed: 5965260doi: 10.1042/bj1000063google scholar: lookup

    Citations

    This article has been cited 4 times.
    1. Pepin S, Lutsch C, Grandgeorge M, Scherrmann JM. Snake F(ab')2 antivenom from hyperimmunized horse: pharmacokinetics following intravenous and intramuscular administrations in rabbits. Pharm Res 1995 Oct;12(10):1470-3.
      doi: 10.1023/a:1016279219619pubmed: 8584483google scholar: lookup
    2. Ek N. Antigen-antibody crossed electrophoretic studies and quantitative comparisons of serum transferrin types in horses. Acta Vet Scand 1981;22(2):246-59.
      doi: 10.1186/BF03547514pubmed: 7304365google scholar: lookup
    3. Ek N. Identification of the PR prealbumin proteins in horse serum. Acta Vet Scand 1977;18(4):458-70.
      doi: 10.1186/BF03548409pubmed: 596326google scholar: lookup
    4. Ek N. The characterization of equine prealbumin (Pr) proteins by antigen-antibody crossed electrophoresis. Acta Vet Scand 1979;20(2):180-90.
      doi: 10.1186/BF03546610pubmed: 484403google scholar: lookup
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