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Home / Equine Research Bank / Animals (Basel) / Serum Vitamin D Level Is Unchanged in Equine Asthma.
Animals : an open access journal from MDPI2024; 14(22); doi: 10.3390/ani14223310

Serum Vitamin D Level Is Unchanged in Equine Asthma.

Abstract: Vitamin D deficiency is associated with asthma development and severity of symptoms in humans, but whether the same occurs in horses is unknown. We aimed to determine whether the serum vitamin D levels differ in horses with asthma compared to control animals and, secondarily, to explore clinical, respiratory, and environmental parameters associated with its concentration in equids in a retrospective cross-sectional study. The total serum vitamin D (25(OH)D) was measured by radioimmunoassay in 45 serum samples from the Equine Respiratory Tissue Biobank (15 control animals, 14 horses with mild or moderate asthma (MEA), and 16 horses with severe asthma (SEA)). Descriptive clinical and environmental parameters, bronchoalveolar lavage fluid cytology, and lung function data were extracted. There was no difference in serum 25(OH)D levels between healthy controls, horses with MEA, and horses with SEA (respectively, means of 57.9 ± 11.6, 55.6 ± 20.0, and 64.6 ± 14.5 nmol/L; p = 0.3), suggesting that this micronutrient does not play a major role in equine asthma pathophysiology.
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Publication Date: 2024-11-18 PubMed ID: 39595361PubMed Central: PMC11591496DOI: 10.3390/ani14223310Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the role of Vitamin D levels in horses suffering from asthma and concludes that there is no significant difference in vitamin D levels between healthy horses and those with varying severities of asthma.

Research Objective

  • The main aim of this study is to test the hypothesis that serum vitamin D levels differ in horses that suffer from asthma when compared to healthy ones, which is based on similar findings in human subjects.
  • As a secondary aim, the research also looks to identify any clinical, respiratory, and environmental parameters that might be linked to vitamin D concentration in horses.

Research Methodology

  • The research team conducted a retrospective cross-sectional study where they assessed the vitamin D levels (more specifically 25(OH)D) from 45 serum samples obtained from the Equine Respiratory Tissue Biobank.
  • The dataset included samples from 15 healthy controls, 14 horses with mild or moderate asthma, and 16 horses with severe asthma.
  • Alongside this, data related to environmental parameters, bronchoalveolar lavage fluid cytology, and lung function were analyzed and linked with respective vitamin D levels.

Research Findings

  • The research indicates that there is no significant difference in vitamin D levels in the serum of healthy horses when compared to those suffering from mild, moderate or severe asthma. The data points to similar mean vitamin D levels in all three groups.
  • As such, the study comes to the conclusion that vitamin D does not play a significant role in the development of equine asthma or the variation in its severity.

Implications of the Research

  • Contrary to the relationships observed in humans, where a deficiency in vitamin D is linked with asthma development and severity, the same does not hold true for equine subjects. This could mean that mechanisms of asthma in different species might vary significantly, which is an important insight for further studies.

Cite This Article

APA
Mainguy-Seers S, Holcombe SJ, Lavoie JP. (2024). Serum Vitamin D Level Is Unchanged in Equine Asthma. Animals (Basel), 14(22). https://doi.org/10.3390/ani14223310

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 22

Researcher Affiliations

Mainguy-Seers, Sophie
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Holcombe, Susan J
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823, USA.
Lavoie, Jean-Pierre
  • Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.

Grant Funding

  • None / Equine Research Funds of the Faculty of Veterinary Medicine of the Université de Montréal

Conflict of Interest Statement

The authors declare no conflicts of interest.

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